Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
paper
Cited
Public
- Authors
- Comuzzie, Anthony G; Cole, Shelley A; Laston, Sandra L; Voruganti, V Saroja; Haack, Karin; Gibbs, Richard A; Butte, Nancy F
- Year
- 2012
- Journal
- PloS one
- PMID
- 23251661
- DOI
- 10.1371/journal.pone.0051954
- PMCID
- PMC3522587
Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259/APOA5, XPA/FOXE1 (TTF-2), DARC, CCR3, ABO); 2) localized novel genes in plausible biological pathways (PCSK2, ARHGAP11A, CHRNA3); and 3) revealed novel genes with unknown function in obesity pathogenesis (MATK, COL4A1). Salient findings include a nonsynonymous SNP (rs1056513) in INADL (p = 1.2E-07) for weight; an intronic variant in MTNR1B associated with fasting glucose (p = 3.7E-08); variants in the APOA5-ZNF259 region associated with triglycerides (p = 2.5-4.8E-08); an intronic variant in PCSK2 associated with total antioxidants (p = 7.6E-08); a block of 23 SNPs in XPA/FOXE1 (TTF-2) associated with serum TSH (p = 5.5E-08 to 1.0E-09); a nonsynonymous SNP (p = 1.3E-21), an intronic SNP (p = 3.6E-13) in DARC identified for MCP-1; an intronic variant in ARHGAP11A associated with sleep duration (p = 5.0E-08); and, after adjusting for body weight, variants in MATK for total energy expenditure (p = 2.7E-08) and in CHRNA3 for sleeping energy expenditure (p = 6.0E-08). Unprecedented phenotyping and high-density SNP genotyping enabled localization of novel genetic loci associated with the pathophysiology of childhood obesity.
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| Name | Type |
|---|---|
| 24-h calorimetry local | phenotype |
| 24-h urinary biochemistries local | drug |
| 24βh urinary dopamine:creatinine ratio local | phenotype |
| 24βh urinary nitrogen excretion local | phenotype |
| 3β²UTR variant in APOA5-ZNF259 region local | variant |
| 5'UTR variant in TSEN34 local | variant |
| ABO | gene |
| ABO blood group local | phenotype |
| ABO gene local | gene |
| ABO_intronic_variant local | variant |
| accelerometer-measured light activity local | phenotype |
| acetylcholine | drug |
| adipose tissue | phenotype |
| adiposity | phenotype |
| ad libitum energy intake at dinner local | phenotype |
| age | phenotype |
| anthropometric indices local | phenotype |
| anthropometry local | phenotype |
| Anthropometry local | phenotype |
| ApoA-1 local | phenotype |
| APOA5 local | gene |
| APOA5-ZNF259 region local | gene |
| APOC3 | gene |
| ARHGAP11A local | gene |
| ARHGAP11A intronic variant local | variant |
| ASS1P11 local | gene |
| blood pressure | phenotype |
| BMI | phenotype |
| BMI > 95th percentile local | phenotype |
| BMI percentile local | phenotype |
| BMI z-score | phenotype |
| body composition | phenotype |
| body mass index | phenotype |
| body weight | phenotype |
| brain | anatomy |
| C21orf34 local | gene |
| C21orf34 intronic SNP local | variant |
| cardiovascular disease | phenotype |
| Caucasian adults local | cohort |
| Caucasians | cohort |
| Ccr2 | gene |
| CCR3 | gene |
| CCR3_3UTR_variant local | variant |
| childhood obesity | phenotype |
| Chrna3 | gene |
| CHRNA3 sleeping energy expenditure variant local | variant |
| CHST8 | gene |
| COL4A1 | gene |
| COL4A1 intronic variant local | variant |
| comorbidity | phenotype |
| creatinine excretion local | phenotype |
| CRHR1 | gene |
| CRHR2 | gene |
| CTCFL local | gene |
| CTCFL 3β²UTR variant local | variant |
| CTCFL variant local | variant |
| DARC local | gene |
| DARC_intronic_SNP local | variant |
| deletion in 15q11-q13 local | variant |
| DFNB31 | gene |
| DFNB31_coding_variant local | variant |
| diabetes | phenotype |
| diet | drug |
| dietary intake local | phenotype |
| dinner local | phenotype |
| DNA | drug |
| dyslipidemia | phenotype |
| early-onset obesity | phenotype |
| eating behavior | phenotype |
| efficient energy storage local | phenotype |
| energy expenditure | phenotype |
| energy intake | phenotype |
| Energy storage local | phenotype |
| E-selectin local | drug |
| European adults with early-onset obesity local | cohort |
| European ancestry | cohort |
| European population | cohort |
| extreme obesity | phenotype |
| Factor VIII local | drug |
| FamilyBasedCohort local | cohort |
| Fasting blood local | drug |
| Fasting blood sampling local | phenotype |
| fasting glucose | phenotype |
| fasting serum glucose local | phenotype |
| fasting serum TSH local | phenotype |
| fatty liver | phenotype |
| fenofibrate | drug |
| FFM | phenotype |
| flanking 3β²UTR variant in ASS1P11 local | variant |
| flanking 3β²UTR variant in RNASE1 local | variant |
| flanking 5β²UTR block of XPA/FOXE1 local | variant |
| FOXE1 | gene |
| Framingham Heart Study GWAS local | cohort |
| free T4 local | phenotype |
| French children local | cohort |
| GCH1 local | gene |
| genetic loci | cohort |
| genetic variants | cohort |
| GenomeStudio software local | drug |
| German children local | cohort |
| GIANT consortium | cohort |
| glucose intolerance | phenotype |
| GREB1 local | gene |
| GREB1_coding_variant local | variant |
| growth local | phenotype |
| growth rate local | phenotype |
| HDL cholesterol | phenotype |
| heart rate | phenotype |
| height change local | phenotype |
| hip circumference | phenotype |
| Hispanic | phenotype |
| Hispanic children | cohort |
| Hispanic families local | cohort |
| hormones local | phenotype |
| HOXB5 | gene |
| HRmax local | phenotype |
| hypertension | phenotype |
| ICAM-1 local | drug |
| IL-6 | drug |
| IL-6 local | phenotype |
| Illumina BeadStation 500GX local | drug |
| Illumina HumanOmni1-Quad v1.0 BeadChips local | drug |
| INADL | gene |
| inflammation | phenotype |
| insulin | drug |
| insulin resistance | phenotype |
| intronic SNP in ARHGAP11A local | variant |
| intronic SNP in GCH1 local | variant |
| intronic SNP in MPRIP local | variant |
| intronic variant in APOA5-ZNF259 region local | variant |
| intronic variant in COL4A1 local | variant |
| intronic variant in MTNR1B local | variant |
| intronic variant in PCSK2 local | variant |
| KCTD15 | gene |
| KLKB1 local | gene |
| Kosrae local | cohort |
| Kosrae population local | cohort |
| MATK local | gene |
| MATK total energy expenditure variant local | variant |
| MC3R local | gene |
| MC4R | gene |
| MCHR1 | gene |
| MCP-1 | drug |
| MCP-1 local | phenotype |
| melatonin | drug |
| metabolites | drug |
| milder forms of obesity local | phenotype |
| MPRIP local | gene |
| MTCH2 | gene |
| MTNR1B | gene |
| novel genetic loci local | variant |
| nutrient partitioning local | phenotype |
| Obese proband local | phenotype |
| obesity | phenotype |
| obesity-related phenotype | phenotype |
| OLFM4 | gene |
| PCSK2 local | gene |
| PCSK2 variant local | variant |
| pediatric obesity local | phenotype |
| physical activity | phenotype |
| Physical fitness local | phenotype |
| plasma TSH local | phenotype |
| Pomc | gene |
| Prader Willi Syndrome local | phenotype |
| proinsulin local | drug |
| RASGEF1A local | gene |
| RASGEF1A_intronic_SNP local | variant |
| respiratory quotient during sleep local | phenotype |
| retina | anatomy |
| RNASE1 local | gene |
| RPL7P3 local | gene |
| RPL7P3 5β²UTR variant local | variant |
| rs1056513 local | variant |
| rs10830963 local | variant |
| rs12075 local | variant |
| rs12075 (G42D) local | variant |
| rs12104221 local | variant |
| rs1588635 local | variant |
| rs1877431 local | variant |
| rs2668804 local | variant |
| rs2805771 local | variant |
| rs2805809 local | variant |
| rs2808693 local | variant |
| rs2808699 local | variant |
| rs3733402 (KLKB1) local | variant |
| rs3741298 local | variant |
| rs579459 local | variant |
| rs7875482 local | variant |
| rs8040868 local | variant |
| rs925488 local | variant |
| sedentary-light activity local | phenotype |
| Sedentary-light physical activity local | phenotype |
| serum free IGFβ1 local | phenotype |
| serum IGFBPβ3 local | phenotype |
| serum TSH local | phenotype |
| sex | phenotype |
| SFRS10 | gene |
| SH2B1 | gene |
| single nucleotide polymorphisms (SNPs) local | variant |
| Sleep disturbance | phenotype |
| sleep duration | phenotype |
| sleeping energy expenditure local | phenotype |
| Sleeping energy expenditure local | phenotype |
| sleep patterns and disorders local | phenotype |
| snack local | phenotype |
| SNP | cohort |
| statins | drug |
| study cohort | cohort |
| substrate utilization local | phenotype |
| Temperature | phenotype |
| thrombomodulin local | drug |
| thyroid cancer | phenotype |
| TMEM18 | gene |
| TMEM229B local | gene |
| TMEM229B intronic variant local | variant |
| TNF-Ξ± | drug |
| total antioxidants local | phenotype |
| total energy expenditure local | phenotype |
| Total energy expenditure local | phenotype |
| triglycerides | phenotype |
| trunk FM local | phenotype |
| TSEN34 local | gene |
| TSEN34 5'UTR variant local | variant |
| type 1 diabetes | phenotype |
| vital signs | phenotype |
| VIVA cohort local | cohort |
| VIVA GWAS local | cohort |
| VIVA LA FAMILIA local | cohort |
| VIVA LA FAMILIA Study local | cohort |
| VO2max local | phenotype |
| von Willebrand factor local | drug |
| weight z-score change local | phenotype |
| xeroderma pigmentosum local | phenotype |
| XPA local | gene |
| ZNF259 local | gene |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A genome wide association study of fast beta EEG in families of European ancestry. | 2017 | 28040410 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Exploratory genome-wide analysis suggests potential associations of PPP1R12B, FSTL5, G5K3B, and GFRA2 loci with a derived HDL functionality score. | Braga RAM et al. | β | 2026 | β |
| Genetic co-regulation of neopterin and Parkinson's disease. | OrrΓΉ V et al. | β | 2026 | β |
| Genomic diversity and selection in the racing greyhound of Great Britain. | Han H et al. | β | 2026 | β |
| Macrophage Plg-R<sub>KT</sub> expression promotes diet-induced obesity and metabolic dysfunction-associated steatotic liver disease. | Miles LA et al. | β | 2026 | β |
| MAM and LDL Receptor Class A Domain Containing 1 Deficiency Aggravates Hepatic Fibrosis in Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis. | Bhattacharjee J et al. | β | 2026 | β |
| MAPK15 controls intracellular lipid uptake and protects mammalian liver from steatotic disease. | Inzalaco G et al. | β | 2026 | β |
| Admixture's impact on Brazilian population evolution and health. | Nunes K et al. | β | 2025 | β |
| CAMKK1 in Obesity and Type 2 Diabetes Mellitus: Evidence of Interaction With Appetite-Regulating, Metabolic and Inflammatory Factors. | Tarchi L et al. | β | 2025 | β |
| DNA methylation in cord blood partially mediates the effects of prepregnancy BMI on early childhood offspring BMI. | Maguolo A et al. | β | 2025 | β |
| Father's adolescent body silhouette is associated with offspring asthma, lung function and BMI through DNA methylation. | Kitaba NT et al. | β | 2025 | β |
| Genetic insights into CRP levels in Indian adolescents: confirming adult genetic associations. | Nair JM et al. | β | 2025 | β |
| Genetics of Common Obesity in Children and Adolescents. | LeΓ³n-Reyes G et al. | β | 2025 | β |
| Genetic susceptibility to oral and atherosclerotic cardiovascular diseases based on dental and heart SCORE studies. | Bezamat M et al. | β | 2025 | β |
| Genome-Wide Analysis of DNA Methylation Signatures Linking Prenatal Exposure to the Chinese Great Famine and Blood Lipids in Late Adulthood: The Genomic Research of the Chinese Famine (GRECF) Study. | Wang H et al. | β | 2025 | β |
| Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort. | Chebii VJ et al. | β | 2025 | β |
| Genome-wide associations with metabolic syndrome among UK Biobank participants reporting use of second-generation antipsychotics. | Rouby NE et al. | β | 2025 | β |
| Genomic correlation, shared loci, and causal association between obesity, periodontitis and tooth loss. | Chen L et al. | β | 2025 | β |
| Human genetic variation determines 24-hour rhythmic gene expression and disease risk. | Chen Y et al. | β | 2025 | β |
| Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma. | Zhang X et al. | β | 2025 | β |
| Mapping the landscape of childhood obesity: genomic insights and socioeconomic status in Indian school-going children. | Nair JM et al. | β | 2025 | β |
| Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity. | FernΓ‘ndez-Rhodes M et al. | β | 2025 | β |
| Pharmacogenetic study of antipsychotic-induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association Study. | Wong KC et al. | β | 2025 | β |
| Plasma Proteins Associated with the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Incident Dementia. | Yang J et al. | β | 2025 | β |
| The metabolic hypothesis for restrictive eating behaviors: A computational and evolutionary approach. | Tarchi L et al. | β | 2025 | β |
| Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects. | Downie CG et al. | β | 2025 | β |
| A genome-wide association study identified candidate regions and genes for commercial traits in a Landrace population. | Ma G et al. | β | 2024 | β |
| A genome-wide association study on growth traits of Korean commercial pig breeds using Bayesian methods. | Jung JH et al. | β | 2024 | β |
| A mammalian-specific Alex3/GΞ±<sub>q</sub> protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival. | Izquierdo-Villalba I et al. | β | 2024 | β |
| Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes. | Saucedo R et al. | β | 2024 | β |
| Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies. | Enduru N et al. | β | 2024 | β |
| Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study. | Shi R et al. | β | 2024 | β |
| Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies. | Keijer J et al. | β | 2024 | β |
| Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip. | Yang R et al. | β | 2024 | β |
| Protein kinase D (PKD) on the crossroad of lipid absorption, synthesis and utilization. | Wit M et al. | β | 2024 | β |
| SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation. | Sajic T et al. | β | 2024 | β |
| The dual role of SUSD2 in cancer development. | Bai H et al. | β | 2024 | β |
| Uncovering the architecture of selection in two <i>Bos taurus</i> cattle breeds. | Rowan TN et al. | β | 2024 | β |
| A critical update on the leptin-melanocortin system. | Lavoie O et al. | β | 2023 | β |
| A genome-wide association study identifies a possible role for cannabinoid signalling in the pathogenesis of diabetic kidney disease. | Osman W et al. | β | 2023 | β |
| A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank. | He D et al. | β | 2023 | β |
| A new SPRING in lipid metabolism. | Hendrix S et al. | β | 2023 | β |
| Development and verification of a combined diagnostic model for primary SjΓΆgren's syndrome by integrated bioinformatics analysis and machine learning. | Yang K et al. | β | 2023 | β |
| Development of genome-wide association studies on childhood obesity and its indicators: A scoping review and enrichment analysis. | Zhou F et al. | β | 2023 | β |
| Dietary Sugar Research in Preschoolers: Methodological, Genetic, and Cardiometabolic Considerations. | Yu J et al. | β | 2023 | β |
| Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model. | Loeffler M et al. | β | 2023 | β |
| Genomic Scan for Runs of Homozygosity and Selective Signature Analysis to Identify Candidate Genes in Large White Pigs. | Yin C et al. | β | 2023 | β |
| Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses. | Mansour A et al. | β | 2023 | β |
| Overexpression of Plg-R<sub>KT</sub> protects against adipose dysfunction and dysregulation of glucose homeostasis in diet-induced obese mice. | Miles LA et al. | β | 2023 | β |
| Precision Nutrition: Recent Advances in Obesity. | Voruganti VS | β | 2023 | β |
| The Association of the Polymorphisms in the <i>FUT8</i>-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder. | Tudor L et al. | β | 2023 | β |
| The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS. | Alemany-Navarro M et al. | β | 2023 | β |
| The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story. | Zhu H et al. | β | 2023 | β |
| Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes. | Rashid M et al. | β | 2023 | β |
| Admixture mapping of anthropometric traits in the Black Women's Health Study: evidence of a shared African ancestry component with birth weight and type 2 diabetes. | Wu Y et al. | β | 2022 | β |
| A draft genome of Drung cattle reveals clues to its chromosomal fusion and environmental adaptation. | Chen Y et al. | β | 2022 | β |
| A Genome-Wide Association Study of Prediabetes Status Change. | Liu T et al. | β | 2022 | β |
| A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men. | Kim HJ et al. | β | 2022 | β |
| Associations between Genetic Variants and Blood Biomarkers of One-Carbon Metabolism in Postmenopausal Women from the Women's Health Initiative Observational Study. | Cheng TD et al. | β | 2022 | β |
| A tree-based gene-environment interaction analysis with rare features. | Liu M et al. | β | 2022 | β |
| Deciphering signatures of natural selection via deep learning. | Qin X et al. | β | 2022 | β |
| DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances. | Ballesteros M et al. | β | 2022 | β |
| Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia. | Abramova M et al. | β | 2022 | β |
| Environmentally sensitive hotspots in the methylome of the early human embryo. | Silver MJ et al. | β | 2022 | β |
| Gamma-glutamyl-leucine levels are causally associated with elevated cardio-metabolic risks. | Wu Q et al. | β | 2022 | β |
| Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. | Krupenko SA et al. | β | 2022 | β |
| Genome-Wide Association Studies Revealed Significant QTLs and Candidate Genes Associated with Backfat and Loin Muscle Area in Pigs Using Imputation-Based Whole Genome Sequencing Data. | Li J et al. | β | 2022 | β |
| Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy. | Czapiewski R et al. | β | 2022 | β |
| Next-Generation Sequencing and Bioinformatics-Based Protocol for the Full-Length <i>CYP2E1</i> Gene Polymorphism Analysis. | Igumnova V et al. | β | 2022 | β |
| Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study. | Simons CCJM et al. | β | 2022 | β |
| Polymorphisms of hypertension susceptibility genes as a risk factors of preeclampsia in the Caucasian population of central Russia. | Churnosov M et al. | β | 2022 | β |
| Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan. | Saeed S et al. | β | 2022 | β |
| The plasminogen receptor Plg-R<sub>KT</sub> regulates adipose function and metabolic homeostasis. | Samad F et al. | β | 2022 | β |
| The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases. | Cristiano L | β | 2022 | β |
| Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line. | Arends D et al. | β | 2022 | β |
| Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes. | Scliar MO et al. | β | 2021 | β |
| Admixture mapping reveals loci for carcass mass in red deer x sika hybrids in Kintyre, Scotland. | McFarlane SE et al. | β | 2021 | β |
| A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases. | Liu X et al. | β | 2021 | β |
| Association between ABO and Duffy blood types and circulating chemokines and cytokines. | Van Alsten SC et al. | β | 2021 | β |
| Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711. | Fujihara K et al. | β | 2021 | β |
| Characterization of Hepatitis B Virus Integrations Identified in Hepatocellular Carcinoma Genomes. | Mathkar PP et al. | β | 2021 | β |
| Continental-scale genomic analysis suggests shared post-admixture adaptation in the Americas. | Ongaro L et al. | β | 2021 | β |
| Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank's Pilot Imaging Enhancement Study. | Livingstone KM et al. | β | 2021 | β |
| DNA methylation as the link between migration and theΒ major noncommunicable diseases: the RODAM study. | Chilunga FP et al. | β | 2021 | β |
| Exploring a Region on Chromosome 8p23.1 Displaying Positive Selection Signals in Brazilian Admixed Populations: Additional Insights Into Predisposition to Obesity and Related Disorders. | Secolin R et al. | β | 2021 | β |
| ExposiciΓ³n a quΓmicos disruptores endΓ³crinos obesogΓ©nicos y obesidad en niΓ±os y jΓ³venes de origen latino o hispano en Estados Unidos y LatinoamΓ©rica: una perspectiva del curso de la vida. | Perng W et al. | β | 2021 | β |
| Exposure to obesogenic endocrine disrupting chemicals and obesity among youth of Latino or Hispanic origin in the United States and Latin America: A lifecourse perspective. | Perng W et al. | β | 2021 | β |
| Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology. | Burt O et al. | β | 2021 | β |
| Genome-wide association study of circulating interleukin 6 levels identifies novel loci. | Ahluwalia TS et al. | β | 2021 | β |
| Genome-wide conditional association study reveals the influences of lifestyle cofactors on genetic regulation of body surface area in MESA population. | Khatun M et al. | β | 2021 | β |
| Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population. | Read RW et al. | β | 2021 | β |
| Identification of pleiotropic loci underlying hip bone mineral density and trunk lean mass. | Feng GJ et al. | β | 2021 | β |
| Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients. | Qu J et al. | β | 2021 | β |
| Interactions Between Adiponectin-Pathway Polymorphisms and Obesity on Postmenopausal Breast Cancer Risk Among African American Women: The WHI SHARe Study. | Nam GE et al. | β | 2021 | β |
| Lifestyle Genetics-Based Reports in the Treatment of Obesity. | Gasmi A et al. | β | 2021 | β |
| Mapping gene and gene pathways associated with coronary artery disease: a CARDIoGRAM exome and multi-ancestry UK biobank analysis. | Hariharan P et al. | β | 2021 | β |
| Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease. | Nikolaev G et al. | β | 2021 | β |
| Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. | Wang H et al. | β | 2021 | β |
| Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction. | Anguita-Ruiz A et al. | β | 2021 | β |
| Pleiotropic genetic influence on birth weight and childhood obesity. | Chatterjee S et al. | β | 2021 | β |
| Replication of European hypertension associations in a case-control study of 9,534 African Americans. | Kaur H et al. | β | 2021 | β |
| The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification. | Sailer S et al. | β | 2021 | β |
| Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line | Arends D et al. | β | 2021 | β |
| A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative. | Westerman K et al. | β | 2020 | β |
| A methodology for predicting tissue-specific metabolic roles of receptors applied to subcutaneous adipose. | Somekh J | β | 2020 | β |
| An in silico approach to identify and prioritize miRNAs target sites polymorphisms in colorectal cancer and obesity. | Gholami M et al. | β | 2020 | β |
| Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study. | Ceballos FC et al. | β | 2020 | β |
| CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. | Glessner JT et al. | β | 2020 | β |
| Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians. | Piaggi P et al. | β | 2020 | β |
| Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament. | Costilla R et al. | β | 2020 | β |
| Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders. | Barkhuizen W et al. | β | 2020 | β |
| Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. | Hou R et al. | β | 2020 | β |
| Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection. | Adebamowo SN et al. | β | 2020 | β |
| Genomewide Association Study of Severe Covid-19 with Respiratory Failure. | Severe Covid-19 GWAS Group et al. | β | 2020 | β |
| Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. | Anastassopoulou C et al. | β | 2020 | β |
| Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update. | Gambardella J et al. | β | 2020 | β |
| Molecular cloning of SLC35D3 and analysis of its role during porcine intramuscular preadipocyte differentiation. | Li W et al. | β | 2020 | β |
| Salivary epigenetic biomarkers as predictors of emerging childhood obesity. | Rushing A et al. | β | 2020 | β |
| The Effect Sizes of <i>PPARΞ³</i> rs1801282<i>, FTO</i> rs9939609, and <i>MC4R</i> rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study. | Bakhashab S et al. | β | 2020 | β |
| The Pathophysiological Role of CoA. | Czumaj A et al. | β | 2020 | β |
| WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System. | Kim Y et al. | β | 2020 | β |
| Whole-genome sequencing of European autochthonous and commercial pig breeds allows the detection of signatures of selection for adaptation of genetic resources to different breeding and production systems. | Bovo S et al. | β | 2020 | β |
| Adolescent obesity in the past decade: A systematic review of genetics and determinants of food choice. | Campbell ET et al. | β | 2019 | β |
| Alleles associated with physical activity levels are estimated to be older than anatomically modern humans. | Letsinger AC et al. | β | 2019 | β |
| Altered gene expression in antipsychotic-induced weight gain. | Crespo-Facorro B et al. | β | 2019 | β |
| Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects. | Ortega-AzorΓn C et al. | β | 2019 | β |
| Fine mapping of genome-wide association study signals to identify genetic markers of the plasma triglyceride response to an omega-3 fatty acid supplementation. | VallΓ©e Marcotte B et al. | β | 2019 | β |
| Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. | Best LG et al. | β | 2019 | β |
| Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine. | Doumatey AP et al. | β | 2019 | β |
| Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis. | BrΔiΔ L et al. | β | 2019 | β |
| Genome-wide association study reveals sex-specific genetic architecture of facial attractiveness. | Hu B et al. | β | 2019 | β |
| Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry. | Irvin MR et al. | β | 2019 | β |
| GWAS for Meat and Carcass Traits Using Imputed Sequence Level Genotypes in Pooled F2-Designs in Pigs. | Falker-Gieske C et al. | β | 2019 | β |
| Host genetic determinants of the gut microbiota of wild mice. | Suzuki TA et al. | β | 2019 | β |
| Integration of transcriptomic data in a genome-scale metabolic model to investigate the link between obesity and breast cancer. | Granata I et al. | β | 2019 | β |
| Meta-Analysis of Genome-Wide Association Studies Identifies Three Loci Associated With Stiffness Index of the Calcaneus. | Lu HF et al. | β | 2019 | β |
| MiR-505 promotes M2 polarization in choroidal neovascularization model mice by targeting transmembrane protein 229B. | Zhao S et al. | β | 2019 | β |
| Neighborhoods to Nucleotides - Advances and gaps for an obesity disparities systems epidemiology model. | Jankowska MM et al. | β | 2019 | β |
| Network Analysis of the Potential Role of DNA Methylation in the Relationship between Plasma Carotenoids and Lipid Profile. | Tremblay BL et al. | β | 2019 | β |
| Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia. | Mastrangelo S et al. | β | 2019 | β |
| Original tumour suppressor gene polycystic kidney and hepatic disease 1-like 1 is associated with thyroid cancer cell progression. | Zheng C et al. | β | 2019 | β |
| The <i>ANKS1B</i> gene and its associated phenotypes: focus on CNS drug response. | Younis RM et al. | β | 2019 | β |
| Transcriptome profiling of four candidate milk genes in milk and tissue samples of temperate and tropical cattle. | Morenikeji OB et al. | β | 2019 | β |
| Upregulated expression of ACTL8 contributes to invasion and metastasis and indicates poor prognosis in colorectal cancer. | Han Q et al. | β | 2019 | β |
| Whole-exome sequencing identified four loci influencing craniofacial morphology in northern Han Chinese. | Wu W et al. | β | 2019 | β |
| A genome scan for genes underlying adult body size differences between Central African hunter-gatherers and farmers. | Pemberton TJ et al. | β | 2018 | β |
| A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci. | Hoffmann TJ et al. | β | 2018 | β |
| AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle. | Lassiter DG et al. | β | 2018 | β |
| Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables. | Iniesta R et al. | β | 2018 | β |
| Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2. | Lin C et al. | β | 2018 | β |
| Direct and indirect genetic effects on triglycerides through omics and correlated phenotypes. | Justice AE et al. | β | 2018 | β |
| Epigenome-wide association in adipose tissue from the METSIM cohort. | Orozco LD et al. | β | 2018 | β |
| Epigenome wide association study of SNP-CpGΒ interactions on changes in triglyceride levels after pharmaceutical intervention: a GAW20 analysis. | Veenstra J et al. | β | 2018 | β |
| Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. | Horak M et al. | β | 2018 | β |
| Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at <i>PLEKHG1</i>. | Gray KJ et al. | β | 2018 | β |
| Genetic Variants Associated With Obesity and Insulin Resistance in Hispanic Boys With Nonalcoholic Fatty Liver Disease. | Rausch JC et al. | β | 2018 | β |
| Genetic variants in nuclear DNA along with environmental factors modify mitochondrial DNA copy number: a population-based exome-wide association study. | Li Z et al. | β | 2018 | β |
| Genetic variants in SEC16B are associated with body composition in black South Africans. | Sahibdeen V et al. | β | 2018 | β |
| Genome organization: connecting the developmental origins of disease and genetic variation. | Jacobson E et al. | β | 2018 | β |
| Genome-wide association study for growth traits in Nelore cattle. | Terakado APN et al. | β | 2018 | β |
| Genome-wide association study for multiple phenotype analysis. | Deng X et al. | β | 2018 | β |
| Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci. | Khanshour AM et al. | β | 2018 | β |
| Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice. | Nammo T et al. | β | 2018 | β |
| Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans. | Gao C et al. | β | 2018 | β |
| Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey. | Spracklen CN et al. | β | 2018 | β |
| Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach. | Kotnik P et al. | β | 2018 | β |
| Impact of genetic polymorphisms determining leukocyte/neutrophil count on chemotherapy toxicity. | Glisovic SJ et al. | β | 2018 | β |
| Impact on birthΒ weight of maternal smoking throughout pregnancy mediated by DNA methylation. | Witt SH et al. | β | 2018 | β |
| Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa. | Huckins LM et al. | β | 2018 | β |
| Localization of adaptive variants in human genomes using averaged one-dependence estimation. | Sugden LA et al. | β | 2018 | β |
| Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring. | Martin LJ et al. | β | 2018 | β |
| Metabolic Syndrome Prediction Using Machine Learning Models with Genetic and Clinical Information from a Nonobese Healthy Population. | Choe EK et al. | β | 2018 | β |
| The Genetics and Genomics of Asthma. | Willis-Owen SAG et al. | β | 2018 | β |
| Type 2 Diabetes Mellitus: Integrative Analysis of Multiomics Data for Biomarker Discovery. | Ge S et al. | β | 2018 | β |
| Uncovering association networks through an eQTL analysis involving human miRNAs and lincRNAs. | Branco PR et al. | β | 2018 | β |
| Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. | Earp M et al. | β | 2018 | β |
| Voltage-gated calcium channel activity and complex related genes and schizophrenia: A systematic investigation based on Han Chinese population. | Zhang T et al. | β | 2018 | β |
| WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. | Kim YJ et al. | β | 2018 | β |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | β | 2017 | β |
| Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study. | Tabb KL et al. | β | 2017 | β |
| Association of established hypothyroidism-associated genetic variants with Hashimoto's thyroiditis. | BariΔ A et al. | β | 2017 | β |
| Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults. | Hellwege JN et al. | β | 2017 | β |
| DNA-Methylation and Body Composition in Preschool Children: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study. | Rzehak P et al. | β | 2017 | β |
| Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System. | Wood BM et al. | β | 2017 | β |
| Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7. | Lanfray D et al. | β | 2017 | β |
| EPHA6 rs4857055 Cβ>βT polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population. | Kim M et al. | β | 2017 | β |
| Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. | Hinney A et al. | β | 2017 | β |
| Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. | Sabo A et al. | β | 2017 | β |
| Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder. | Ribeiro EA et al. | β | 2017 | β |
| Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. | Chittoor G et al. | β | 2017 | β |
| Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. | Sniekers S et al. | β | 2017 | β |
| Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle. | Seabury CM et al. | β | 2017 | β |
| Genome-Wide Association Study of Dietary Pattern Scores. | GuΓ©nard F et al. | β | 2017 | β |
| Genome-wide integrative analysis identified SNP-miRNA-mRNA interaction networks in peripheral blood mononuclear cells. | Lin X et al. | β | 2017 | β |
| Genome-Wide Interaction Study of Omega-3 PUFAs and Other Fatty Acids on Inflammatory Biomarkers of Cardiovascular Health in the Framingham Heart Study. | Veenstra J et al. | β | 2017 | β |
| Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. | Liu Y et al. | β | 2017 | β |
| Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. | van Rooij FJA et al. | β | 2017 | β |
| Genomic divergence across ecological gradients in the Central African rainforest songbird (Andropadus virens). | Zhen Y et al. | β | 2017 | β |
| Genomic variants at 20p11 associated with body fat mass in the European population. | Pei YF et al. | β | 2017 | β |
| Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis. | Zhao JV et al. | β | 2017 | β |
| Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells. | Mo XB et al. | β | 2017 | β |
| Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. | Warren CR et al. | β | 2017 | β |
| Lack of replication of previous autism spectrum disorder GWAS hits in European populations. | Torrico B et al. | β | 2017 | β |
| Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. | Oelsner KT et al. | β | 2017 | β |
| Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. | Sharp GC et al. | β | 2017 | β |
| Molecular genetics of human obesity: A comprehensive review. | Singh RK et al. | β | 2017 | β |
| Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder. | NaΓ J et al. | β | 2017 | β |
| Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans. | VallΓ©e Marcotte B et al. | β | 2017 | β |
| Population and allelic variation of A-to-I RNA editing in human transcriptomes. | Park E et al. | β | 2017 | β |
| Revealing phenotype-associated functional differences by genome-wide scan of ancient haplotype blocks. | Onuki R et al. | β | 2017 | β |
| Revisiting the Relationship Between Ethnicity and Outcome in Glioblastoma Patients. | Shah AH et al. | β | 2017 | β |
| Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis. | Sigurdsson S et al. | β | 2017 | β |
| Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population. | Chen S et al. | β | 2017 | β |
| Spontaneously Hypertensive Rat Chromosome 2 with Mutant Connexin 50 Triggers Divergent Effects on Metabolic Syndrome Components. | Ε eda O et al. | β | 2017 | β |
| The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis. | Fewings NL et al. | β | 2017 | β |
| Whole-exome sequencing study reveals common copy number variants in protocadherin genes associated with childhood obesity in Koreans. | Moon S et al. | β | 2017 | β |
| A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits. | Volkov P et al. | β | 2016 | β |
| A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies. | Irvin MR et al. | β | 2016 | β |
| A GWA study reveals genetic loci for body conformation traits in Chinese Laiwu pigs and its implications for human BMI. | Zhou L et al. | β | 2016 | β |
| An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population. | Hwang JY et al. | β | 2016 | β |
| A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14β131 Pakistani adults. | Ahmad S et al. | β | 2016 | β |
| A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. | Ried JS et al. | β | 2016 | β |
| Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. | Das M et al. | β | 2016 | β |
| CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates. | Zhong S et al. | β | 2016 | β |
| Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. | Sun W et al. | β | 2016 | β |
| Determinants of Obesity in the Hispanic Preschool Population: An Integrative Review. | Innella N et al. | β | 2016 | β |
| Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents. | Langlois C et al. | β | 2016 | β |
| Exploring the Major Sources and Extent of Heterogeneity in a Genome-Wide Association Meta-Analysis. | Pei YF et al. | β | 2016 | β |
| Fine Mapping of the Body Fat QTL on Human Chromosome 1q43. | Aissani B et al. | β | 2016 | β |
| Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. | Conomos MP et al. | β | 2016 | β |
| Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. | Kim S et al. | β | 2016 | β |
| Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. | Felix JF et al. | β | 2016 | β |
| Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. | Bigdeli TB et al. | β | 2016 | β |
| Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study. | Li C et al. | β | 2016 | β |
| Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics. | Below JE et al. | β | 2016 | β |
| Health Issues in Hispanic/Latino Youth. | Isasi CR et al. | β | 2016 | β |
| Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium. | Marinelli M et al. | β | 2016 | β |
| Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network. | Li R et al. | β | 2016 | β |
| Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. | Lanfray D et al. | β | 2016 | β |
| LOC100287225, novel long intergenic non-coding RNA, misregulates in colorectal cancer. | Kazemzadeh M et al. | β | 2016 | β |
| MC3R gene polymorphisms are associated with early childhood adiposity gain and infant appetite in an Asian population. | Aris IM et al. | β | 2016 | β |
| Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation. | VallΓ©e Marcotte B et al. | β | 2016 | β |
| PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases. | Hribal ML et al. | β | 2016 | β |
| Primary Cell Culture Systems for Human Thyroid Studies. | Wang Y et al. | β | 2016 | β |
| Protein Kinase D1 Signaling in Angiogenic Gene Expression and VEGF-Mediated Angiogenesis. | Ren B | β | 2016 | β |
| Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus). | Lea AJ et al. | β | 2016 | β |
| RNA-binding proteins, neural development and the addictions. | Bryant CD et al. | β | 2016 | β |
| Smaug variants in neural and non-neuronal cells. | FernΓ‘ndez-Alvarez AJ et al. | β | 2016 | β |
| Strong Selection at MHC in Mexicans since Admixture. | Zhou Q et al. | β | 2016 | β |
| SUGP1 is a novel regulator of cholesterol metabolism. | Kim MJ et al. | β | 2016 | β |
| The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans. | Kovacs P et al. | β | 2016 | β |
| A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS). | Gao C et al. | β | 2015 | β |
| A genome-wide association study of asthma symptoms in Latin American children. | Costa GN et al. | β | 2015 | β |
| A genome-wide association study of periodontitis in a Japanese population. | Shimizu S et al. | β | 2015 | β |
| Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms. | Mascarenhas R et al. | β | 2015 | β |
| A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers. | Benton MC et al. | β | 2015 | β |
| A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1. | Lidral AC et al. | β | 2015 | β |
| Association of HMOX1 gene promoter polymorphisms with hyperbilirubinemia in the early neonatal period. | Katayama Y et al. | β | 2015 | β |
| Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-Ξ± Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1Ξ± and Mitochondrial Homeostasis. | Wang Y et al. | β | 2015 | β |
| Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans. | Pant SD et al. | β | 2015 | β |
| DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture. | GrΓΌnvogel O et al. | β | 2015 | β |
| Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis. | Reue K et al. | β | 2015 | β |
| Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia. | Liu X et al. | β | 2015 | β |
| Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding lociβ . | Kirsten H et al. | β | 2015 | β |
| Following the footprints of polymorphic inversions on SNP data: from detection to association tests. | CΓ‘ceres A et al. | β | 2015 | β |
| Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort. | Wilson CL et al. | β | 2015 | β |
| Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume. | Giri A et al. | β | 2015 | β |
| Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status β The HUNT Study. | KvalΓΈy K et al. | β | 2015 | β |
| Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains. | Wang Q et al. | β | 2015 | β |
| Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2. | He H et al. | β | 2015 | β |
| Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome. | Tekola-Ayele F et al. | β | 2015 | β |
| Genome-Wide Association Study of Staphylococcus aureus Carriage in a Community-Based Sample of Mexican-Americans in Starr County, Texas. | Brown EL et al. | β | 2015 | β |
| Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat. | Ollikainen M et al. | β | 2015 | β |
| Influences of gestational obesity on associations between genotypes and gene expression levels in offspring following maternal gastrointestinal bypass surgery for obesity. | GuΓ©nard F et al. | β | 2015 | β |
| Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses. | Demirkan A et al. | β | 2015 | β |
| Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis. | John SE et al. | β | 2015 | β |
| Modulation of genetic associations with serum urate levels by body-mass-index in humans. | Huffman JE et al. | β | 2015 | β |
| Molecular cloning, sequence characteristics, and tissue expression analysis of ECE1 gene in Tibetan pig. | Wang YD et al. | β | 2015 | β |
| Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury. | Haghighi F et al. | β | 2015 | β |
| Prospecting major genes in dairy buffaloes. | de Camargo GM et al. | β | 2015 | β |
| Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study. | Voruganti VS et al. | β | 2015 | β |
| The ethnoepidemiology of obesity. | Valera B et al. | β | 2015 | β |
| Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families. | Shetty PB et al. | β | 2015 | β |
| A genome-wide association study identifies a LEPR gene as a novel predisposing factor for childhood fasting plasma glucose. | Go MJ et al. | β | 2014 | β |
| A genomewide study of body mass index and its genetic correlation with thromboembolic risk. Results from the GAIT project. | Souto JC et al. | β | 2014 | β |
| An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site. | Caussy C et al. | β | 2014 | β |
| Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study. | Park SL et al. | β | 2014 | β |
| Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants. | Hohenadel MG et al. | β | 2014 | β |
| DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. | Aslibekyan S et al. | β | 2014 | β |
| Gene-education interactions identify novel blood pressure loci in the Framingham Heart Study. | Basson J et al. | β | 2014 | β |
| Genetic modifiers of obesity and bariatric surgery outcomes. | Sevilla S et al. | β | 2014 | β |
| Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. | Scannell Bryan M et al. | β | 2014 | β |
| Genome-wide association study of metabolic syndrome in koreans. | Jeong SW et al. | β | 2014 | β |
| G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease. | Billard MJ et al. | β | 2014 | β |
| Impact of Nox5 polymorphisms on basal and stimulus-dependent ROS generation. | Wang Y et al. | β | 2014 | β |
| Schizophrenia gene expression profile reverted to normal levels by antipsychotics. | Crespo-Facorro B et al. | β | 2014 | β |
| Shared molecular pathways and gene networks for cardiovascular disease and type 2 diabetes mellitus in women across diverse ethnicities. | Chan KH et al. | β | 2014 | β |
| Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers. | Saadatian Z et al. | β | 2014 | β |
| Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network, and pathway analyses. | Kogelman LJ et al. | β | 2014 | β |
| The roles of Jumonji-type oxygenases in human disease. | Johansson C et al. | β | 2014 | β |
| Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents. | Zhu WF et al. | β | 2014 | β |
| Genetic and environmental correlations between body mass index and waist circumference in China: the Qingdao adolescent twin study. | Ning F et al. | β | 2013 | β |
| Genetics of the first seven proprotein convertase enzymes in health and disease. | Turpeinen H et al. | β | 2013 | β |
| Role of plasma kallikrein in diabetes and metabolism. | Feener EP et al. | β | 2013 | β |