Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.
paper
Cited
Public
- Authors
- Patel, Sachin; Kingsley, Philip J; Mackie, Ken; Marnett, Lawrence J; Winder, Danny G
- Year
- 2009
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 19675536
- DOI
- 10.1038/npp.2009.101
- PMCID
- PMC2881681
Psychosocial stress is a risk factor for development and exacerbation of neuropsychiatric illness. Repeated stress causes biochemical adaptations in endocannabinoid (eCB) signaling that contribute to stress-response habituation, however, the synaptic correlates of these adaptations have not been examined. Here, we show that the synthetic enzyme for the eCB 2-arachidonoylglycerol (2-AG), diacylglycerol (DAG) lipase alpha, is heterogeneously expressed in the amygdala, and that levels of 2-AG and precursor DAGs are increased in the basolateral amygdala (BLA) after 10 days, but not 1 day, of restraint stress. In contrast, arachidonic acid was decreased after both 1 and 10 days of restraint stress. To examine the synaptic correlates of these alterations in 2-AG metabolism, we used whole-cell electrophysiology to determine the effects of restraint stress on depolarization-induced suppression of inhibition (DSI) in the BLA. A single restraint stress exposure did not alter DSI compared with control mice. However, after 10 days of restraint stress, DSI duration, but not magnitude, was significantly prolonged. Inhibition of 2-AG degradation with MAFP also prolonged DSI duration; the effects of repeated restraint stress and MAFP were mutually occlusive. These data indicate that exposure to repeated, but not acute, stress produces neuroadaptations that confer BLA neurons with an enhanced capacity to elevate 2-AG content and engage in 2-AG-mediated short-term retrograde synaptic signaling. We suggest stress-induced enhancement of eCB-mediated suppression of inhibitory transmission in the BLA could contribute to affective dysregulation associated with chronic stress.
No figures extracted from this document.
β Prev
41β48 of 48
| Name | Type |
|---|---|
| 1-oleoyl-2-arachidonoylglycerol local | drug |
| 1-stearoyl-2-arachidonoylglycerol local | drug |
| 2-AG | drug |
| 2-AG-mediated short-term synaptic plasticity local | phenotype |
| 2-AG-mediated short-term synaptic suppression of GABAergic transmission local | phenotype |
| 2-AG-mediated synaptic signaling local | phenotype |
| 2-arachidonoylglycerol | drug |
| 4-(dimethylamino)pyridine local | drug |
| 70% ethanol local | drug |
| AA | cohort |
| ABHD12 local | gene |
| ABHD6 local | gene |
| acetic acid | drug |
| aCSF | drug |
| acute stress | phenotype |
| acute stress cohort local | cohort |
| Adobe Photoshop CS local | drug |
| affective disorders | phenotype |
| Affective illness local | phenotype |
| allocortex | anatomy |
| AM251 | drug |
| amygdala | anatomy |
| Amygdaloid complex | anatomy |
| Amygdaloid region local | anatomy |
| anandamide | drug |
| anxiety | phenotype |
| anxiety symptoms | phenotype |
| Aquamount local | drug |
| arachidonic acid | drug |
| artificial cerebrospinal fluid (ACSF) | drug |
| basolateral amygdala | anatomy |
| Basolateral amygdala (BLA) local | anatomy |
| Basolateral complex of the amygdala local | anatomy |
| Behavioral responses to stress local | phenotype |
| biocytin local | drug |
| biotin-conjugated donkey-anti rabbit local | drug |
| BLA | anatomy |
| BLA neurons local | anatomy |
| brain | anatomy |
| Brightfield photomicrographs local | drug |
| BSA | drug |
| CaCl2 | drug |
| calcium chelation local | drug |
| CB1 agonist | drug |
| CB1 antagonist | drug |
| CB1 receptor | drug |
| CB1 receptor antagonists local | drug |
| CeAL local | anatomy |
| CeAm | anatomy |
| Central extended amygdala local | anatomy |
| cerebellum | anatomy |
| Chronically stressed mice local | cohort |
| chronic stress | phenotype |
| chronic stress cohort local | cohort |
| CNQX | drug |
| Cnr1 | gene |
| CNR1 variants local | variant |
| Confocal images local | drug |
| control | cohort |
| Cy-3-conjugated donkey-anti rabbit local | drug |
| Cy-3-conjugated streptavidin local | drug |
| Cyclooxygenase-2 local | drug |
| d8-2-AG local | drug |
| d8-AA local | drug |
| d8-SAG local | drug |
| DAG | drug |
| DAGL | drug |
| DAGL local | gene |
| DAGLA | drug |
| DAGLΞ± | gene |
| DAG precursors local | drug |
| DAGs local | drug |
| depolarization-induced suppression of inhibition | phenotype |
| depressive illness | phenotype |
| depressive symptoms | phenotype |
| deuterated analogs local | drug |
| diaminobenzidine substrate local | drug |
| dihydroxyphenylglycine local | drug |
| d/l AP-5 | drug |
| donkey serum | drug |
| DSI duration local | phenotype |
| eCB-mediated short-term signaling local | drug |
| eCB signaling local | drug |
| EGTA | drug |
| eIPSC | phenotype |
| eIPSC amplitude local | phenotype |
| Emotional behavior local | phenotype |
| endocannabinoids | drug |
| endocannabinoid system | drug |
| enzymatic components of 2-AG metabolism local | drug |
| ethyl acetate | drug |
| ethylene glycol solution local | drug |
| FAAH | gene |
| Functional tolerance | phenotype |
| GABA | phenotype |
| glucocorticoids | drug |
| glucose | drug |
| glutamate | drug |
| Gq-coupled receptor local | gene |
| GRM5 | gene |
| HEPES | drug |
| hippocampus | anatomy |
| Homotypic stress local | phenotype |
| HPR-conjugated streptavidin local | drug |
| hydrogen peroxide | drug |
| ICM local | anatomy |
| ICMs local | anatomy |
| ICR mouse local | cohort |
| isoflurane | drug |
| KCl | drug |
| K-gluconate | drug |
| late DSI local | phenotype |
| Ld local | anatomy |
| Lv local | anatomy |
| MAFP local | drug |
| mature mouse local | cohort |
| maximal DSI local | phenotype |
| methanol | drug |
| MgCl2 | drug |
| MGL local | drug |
| MGLL | gene |
| MgSO4 | drug |
| mice | cohort |
| midbrain | anatomy |
| Monoacylglycerol lipase local | drug |
| mood disorders | phenotype |
| mouse brain | anatomy |
| N-(3-dimethylaminopropyl)-Nβ²-ethylcarbodiimide local | drug |
| Na-ATP | drug |
| Na-GTP | drug |
| NaH2PO4 | drug |
| NaHCO3 | drug |
| neocortex | anatomy |
| Neonatal rats | cohort |
| nickel/cobalt heavy metal intensification local | drug |
| OAG local | drug |
| oleic acid | drug |
| Olympus CMAD3 camera local | drug |
| Olympus SZX12 microscope local | drug |
| paraformaldehyde | drug |
| phosphate-buffered saline | drug |
| phospholipase C | drug |
| physiological and behavioral responses local | phenotype |
| Physiological responses to stress local | phenotype |
| prefrontal cortex | anatomy |
| Q-capture software local | drug |
| QX-314 | drug |
| rabbit-anti DAGLΞ± local | drug |
| reduced weight gain local | phenotype |
| repeated restraint stress local | phenotype |
| Repeated restraint stress local | phenotype |
| repeated stress local | phenotype |
| Repeated stress local | phenotype |
| rested animals local | cohort |
| SAG | drug |
| silver acetate local | drug |
| social defeat stress | phenotype |
| stress | phenotype |
| stressed animals local | cohort |
| stressed mice local | cohort |
| Stressed mice local | cohort |
| Stress-related neuropsychiatric disorders local | phenotype |
| striatum | anatomy |
| sucrose | drug |
| sucrose solution | drug |
| THL local | drug |
| toluene local | drug |
| tris-buffered saline local | drug |
| Triton X-100 | drug |
| water | drug |
| weight gain | phenotype |
| white matter | anatomy |
| wild-type mice | cohort |
| Win 55212-2 | drug |
| WIN 55,212-2 | drug |
| Zeiss LSM510 confocal microscope local | drug |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers. | Lunge AR et al. | β | 2026 | β |
| Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation. | Loomba N et al. | β | 2025 | β |
| Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaqueductal gray. | Coutens B et al. | β | 2025 | β |
| Distinct serum endocannabinoid profiles in treatment-naΓ―ve Han Chinese children with ADHD: a case-control pilot study. | Liao W et al. | β | 2025 | β |
| Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice. | Ramos-Medina L et al. | β | 2024 | β |
| The endocannabinoid system in the brain undergoes long-lasting changes following neuropathic pain. | Zhang M et al. | β | 2024 | β |
| 2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy. | Colangeli R et al. | β | 2023 | β |
| Endocannabinoid 2-Arachidonoylglycerol Levels in the Anterior Cingulate Cortex, Caudate Putamen, Nucleus Accumbens, and Piriform Cortex Were Upregulated by Chronic Restraint Stress. | Zhai Q et al. | β | 2023 | β |
| Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment. | Scheyer A et al. | β | 2023 | β |
| Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases. | Hosseinzadeh Anvar L et al. | β | 2023 | β |
| Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain. | Lee H et al. | β | 2023 | β |
| Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation. | Bouchet CA et al. | β | 2023 | β |
| Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviour and drinking in Marchigian Sardinian alcohol-preferring rats. | Vozella V et al. | β | 2023 | β |
| Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS. | Reemst K et al. | β | 2022 | β |
| GABA<sub>A</sub>(Ξ΄) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. | Qin X et al. | β | 2022 | β |
| Impact of cyclooxygenase-2 inhibition on cannabis withdrawal and circulating endocannabinoids in daily cannabis smokers. | Haney M et al. | β | 2022 | β |
| Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior. | Rieger NS et al. | β | 2022 | β |
| Integrated Transcriptomics and Metabolomics Analyses of Stress-Induced Murine Hair Follicle Growth Inhibition. | Wang X et al. | β | 2022 | β |
| Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders. | Navarro D et al. | β | 2022 | β |
| Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice. | Luchsinger JR et al. | β | 2021 | β |
| Depolarization-initiated endogenous cannabinoid release and underlying retrograde neurotransmission in interneurons of amygdala. | Kodirov SA et al. | β | 2021 | β |
| Endocannabinoids and Precision Medicine for Mood Disorders and Suicide. | Pinna G | β | 2021 | β |
| Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis. | Yong Y et al. | β | 2021 | β |
| Enriched Environment Enhances the Myelin Regulatory Factor by mTOR Signaling and Protects the Myelin Membrane Against Oxidative Damage in Rats Exposed to Chronic Immobilization Stress. | Thamizhoviya G et al. | β | 2021 | β |
| Lifestyle Interventions Improving Cannabinoid Tone During COVID-19 Lockdowns May Enhance Compliance With Preventive Regulations and Decrease Psychophysical Health Complications. | Brugnatelli V et al. | β | 2021 | β |
| Stress and Western diets increase vulnerability to neuropsychiatric disorders: A common mechanism. | Dagnino-Subiabre A | β | 2021 | β |
| The contributions of the endocannabinoid system and stress on the neural processing of reward stimuli. | Filbey FM et al. | β | 2021 | β |
| The endocannabinoid system in the amygdala and modulation of fear. | Gunduz-Cinar O | β | 2021 | β |
| 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. | Bedse G et al. | β | 2020 | β |
| Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening. | Marcus DJ et al. | β | 2020 | β |
| Long-Term Aberrations To Cerebellar Endocannabinoids Induced By Early-Life Stress. | Moussa-Tooks AB et al. | β | 2020 | β |
| Meet Your Stress Management Professionals: The Endocannabinoids. | deRoon-Cassini TA et al. | β | 2020 | β |
| The role of catecholamines in modulating responses to stress: Sex-specific patterns, implications, and therapeutic potential for post-traumatic stress disorder and opiate withdrawal. | Ross JA et al. | β | 2020 | β |
| Effects of the LPA<sub>1</sub> Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice. | Tabbai S et al. | β | 2019 | β |
| Endocannabinoids and Fear-Related Behavior in Mice Selectively Bred for High or Low Alcohol Preference. | Kirchhoff AM et al. | β | 2019 | β |
| Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder. | Bedse G et al. | β | 2019 | β |
| Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system. | Wyrofsky RR et al. | β | 2019 | β |
| Long-term aberrations to cerebellar endocannabinoids induced by early-life stress | Moussa-Tooks AB et al. | β | 2019 | β |
| Roles of multiple lipid mediators in stress and depression. | Furuyashiki T et al. | β | 2019 | β |
| Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. | Serrano A et al. | β | 2018 | β |
| Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders. | Tomas-Roig J et al. | β | 2018 | β |
| Endocannabinoid system, stress and HPA axis. | Micale V et al. | β | 2018 | β |
| Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System. | Augustin SM et al. | β | 2018 | β |
| Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice. | Cavener VS et al. | β | 2018 | β |
| Prenatal immune activation potentiates endocannabinoid-related plasticity of inhibitory synapses in the hippocampus of adolescent rat offspring. | Guo Z et al. | β | 2018 | β |
| Cannabinoid Modulation of the Stressed Hippocampus. | Scarante FF et al. | β | 2017 | β |
| Effects of the antipsychotic paliperidone on stress-induced changes in the endocannabinoid system in rat prefrontal cortex. | MacDowell KS et al. | β | 2017 | β |
| Endocannabinoid dysregulation in cognitive and stress-related brain regions in the Nrg1 mouse model of schizophrenia. | Clarke DJ et al. | β | 2017 | β |
| Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. | Bluett RJ et al. | β | 2017 | β |
| The Endocannabinoid System and Anxiety. | Lisboa SF et al. | β | 2017 | β |
| The Epac-Phospholipase CΞ΅ Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons. | Tong J et al. | β | 2017 | β |
| Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. | Di S et al. | β | 2016 | β |
| Dendritic Spines in Depression: What We Learned from Animal Models. | Qiao H et al. | β | 2016 | β |
| FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence. | Spagnolo PA et al. | β | 2016 | β |
| Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids. | Gunduz-Cinar O et al. | β | 2016 | β |
| G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. | Boortz KA et al. | β | 2016 | β |
| G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance. | Boortz KA et al. | β | 2016 | β |
| Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking. | Holleran KM et al. | β | 2016 | β |
| Neurobiological Interactions Between Stress and the Endocannabinoid System. | Morena M et al. | β | 2016 | β |
| Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice. | Tomas-Roig J et al. | β | 2016 | β |
| The impact of chronic stress on the rat brain lipidome. | Oliveira TG et al. | β | 2016 | β |
| The type-1 cannabinoid receptor modulates the hydroelectrolytic balance independently of the energy homeostasis during salt load. | Vechiato FM et al. | β | 2016 | β |
| Tianeptine, olanzapine and fluoxetine show similar restoring effects on stress induced molecular changes in mice brain: An FT-IR study. | TΓΌrker-Kaya S et al. | β | 2016 | β |
| Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. | Gray JM et al. | β | 2015 | β |
| Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease. | Wyrofsky R et al. | β | 2015 | β |
| Interactions between ethanol and the endocannabinoid system atΒ GABAergic synapses on basolateral amygdala principal neurons. | Talani G et al. | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| Neurodevelopment, GABA system dysfunction, and schizophrenia. | Schmidt MJ et al. | β | 2015 | β |
| The endocannabinoid system in guarding against fear, anxiety and stress. | Lutz B et al. | β | 2015 | β |
| The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. | Shonesy BC et al. | β | 2015 | β |
| Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats. | Morena M et al. | β | 2015 | β |
| Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system. | McPartland JM et al. | β | 2014 | β |
| Chronic stress impairs Ξ±1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus. | Haj-Dahmane S et al. | β | 2014 | β |
| Control of synaptic function by endocannabinoid-mediated retrograde signaling. | Kano M | β | 2014 | β |
| Endocannabinoid-mediated retrograde modulation of synaptic transmission. | Ohno-Shosaku T et al. | β | 2014 | β |
| Endogenous cannabinoid signaling at inhibitory interneurons. | Younts TJ et al. | β | 2014 | β |
| Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses. | Ramikie TS et al. | β | 2014 | β |
| Synaptic effects of cannabinoids: complexity, behavioral effects, and potential clinical implications. | Benarroch EE | β | 2014 | β |
| The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury. | Tchantchou F et al. | β | 2014 | β |
| Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity. | Reich CG et al. | β | 2013 | β |
| Age of stress exposure modulates the immediate and sustained effects of repeated stress on corticolimbic cannabinoid CBβ receptor binding in male rats. | Lee TT et al. | β | 2013 | β |
| Amygdala FAAH and anandamide: mediating protection and recovery from stress. | Gunduz-Cinar O et al. | β | 2013 | β |
| Anandamide deficiency and heightened neuropathic pain in aged mice. | Bishay P et al. | β | 2013 | β |
| CaMKII regulates diacylglycerol lipase-Ξ± and striatal endocannabinoid signaling. | Shonesy BC et al. | β | 2013 | β |
| Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear conditioning in adolescent rats. | Reich CG et al. | β | 2013 | β |
| Changing the tune: plasticity and adaptation of retrograde signals. | Iremonger KJ et al. | β | 2013 | β |
| Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. | Gunduz-Cinar O et al. | β | 2013 | β |
| Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure. | Hill MN et al. | β | 2013 | β |
| Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity. | Campolongo P et al. | β | 2013 | β |
| Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. | Hermanson DJ et al. | β | 2013 | β |
| Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses. | Hill MN et al. | β | 2013 | β |
| Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. | Wang M et al. | β | 2012 | β |
| Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. | Bowles NP et al. | β | 2012 | β |
| Endocannabinoid signaling and synaptic function. | Castillo PE et al. | β | 2012 | β |
| Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress. | Ramikie TS et al. | β | 2012 | β |
| Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. | Dubreucq S et al. | β | 2012 | β |
| Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. | HΓ€ring M et al. | β | 2012 | β |
| Repeated restraint stress increases basolateral amygdala neuronal activity in an age-dependent manner. | Zhang W et al. | β | 2012 | β |
| Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. | Roberts CJ et al. | β | 2012 | β |
| The intricate link between glucocorticoids and endocannabinoids at stress-relevant synapses in the hypothalamus. | Crosby KM et al. | β | 2012 | β |
| Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods. | Lee TT et al. | β | 2012 | β |
| Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats. | Hu W et al. | β | 2011 | β |
| Endocannabinoid-mediated synaptic plasticity and addiction-related behavior. | Sidhpura N et al. | β | 2011 | β |
| Endocannabinoids and stress. | Riebe CJ et al. | β | 2011 | β |
| Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis. | Tasker JG et al. | β | 2011 | β |
| Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants. | Gorzalka BB et al. | β | 2011 | β |
| Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. | Sumislawski JJ et al. | β | 2011 | β |
| Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala. | Kamprath K et al. | β | 2011 | β |
| Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. | Yoshida T et al. | β | 2011 | β |
| A synaptocentric view of the neuroendocrine response to stress. | Wamsteeker JI et al. | β | 2010 | β |
| Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. | Wang W et al. | β | 2010 | β |
| Endogenous cannabinoid signaling is essential for stress adaptation. | Hill MN et al. | β | 2010 | β |
| Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output. | Hill MN et al. | β | 2010 | β |
| Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus. | Wamsteeker JI et al. | β | 2010 | β |