Exploring the relationship between genetic and environmental influences on initiation and progression of substance use.
paper
Cited
Public
- Authors
- Fowler, Tom; Lifford, Kate; Shelton, Katherine; Rice, Frances; Thapar, Anita; Neale, Michael C; McBride, Andrew; van den Bree, Marianne B M
- Year
- 2007
- Journal
- Addiction (Abingdon, England)
- PMID
- 17298649
- DOI
- 10.1111/j.1360-0443.2006.01694.x
- PMCID
- PMC1974769
AIMS: To examine the genetic and environmental contributions to the initiation of use and progression to more serious use of alcohol, cigarettes and marijuana during adolescence, and to examine the relationship between initiation and progression of substance use. DESIGN: The study used a twin-based design and a new theoretical model, the causal-common-contingent (CCC) model. This allows modelling of the relationship between initiation of use and progression to heavier use as a two-stage model and the examination of genetic and environmental influences on both stages, while taking into account their relationship. PARTICIPANTS: The participants consisted of 1214 twin pairs (69% response rate) aged 11-19 years sampled from the UK population-based Cardiff Study of All Wales and North-west of England Twins (CaStANET). MEASUREMENTS: Data on adolescent initiation and progression to more serious use of alcohol, cigarettes and marijuana were obtained using self-report questionnaires. FINDINGS: Initiation of alcohol and progression to heavier alcohol use had separate but related underlying aetiologies. For cigarette and marijuana use the relation between initiation and progression to heavier use was stronger, suggesting greater overlap in aetiologies. For all three substances, environmental influences that make twins more similar (common environment) tended to be greater for initiation, while genetic influences were stronger for heavier use. CONCLUSIONS: These findings have implications for policy decisions aimed at an adolescent and early adult age group. Specifically, these findings suggest that it may be more efficacious to focus alcohol interventions on risk factors for the development of heavier use rather than initiation of use. In contrast, interventions aimed at reducing the initiation of cigarettes and marijuana use may be more appropriate.
Causal–common–contingent (CCC) model. The model allows the estimation of a2 (additive genetic variance), c2 (common environmental variance) and e2 (unique environmental variance) for initiation and progression of substance use, while controlling for the influence of initiation on progression. This model also allows the modelling of the relationship (beta coefficient value) between the initiation and progression
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| Adolescent Externalizing Psychopathology and Its Prospective Relationship to Marijuana Use Development from Age 14 to 30: Replication Across Independent Longitudinal Twin Samples. | Zellers SM et al. | — | 2020 | → |
| A review of psychosocial factors linked to adolescent substance use. | Trucco EM | — | 2020 | → |
| Is E-cigarette use a gateway to marijuana use? Longitudinal examinations of initiation, reinitiation, and persistence of e-cigarette and marijuana use. | Wong SW et al. | — | 2020 | → |
| Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction. | Wittenberg RE et al. | — | 2020 | → |
| Genetic and environmental influences on developmental trajectories of adolescent alcohol use. | Zheng Y et al. | — | 2019 | → |
| Onset of regular cannabis use and adult sleep duration: Genetic variation and the implications of a predictive relationship. | Winiger EA et al. | — | 2019 | → |
| Rethinking Addiction. | Ewald DR et al. | — | 2019 | → |
| The Impact of Genes on Adolescent Substance Use: A Developmental Perspective. | Trucco EM et al. | — | 2019 | → |
| Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families. | McCutcheon VV et al. | — | 2018 | → |
| Blackouts among male and female youth seeking emergency department care. | Voloshyna DM et al. | — | 2018 | → |
| Factors associated with tobacco, alcohol, and other drug use among youth living in West Central Mexico. | Campollo O et al. | — | 2018 | → |
| Has the Genetic Contribution to the Propensity to Gamble Increased? Evidence From National Twin Studies Conducted in 1962 and 2002. | Slutske WS | — | 2018 | → |
| Media/Marketing Influences on Adolescent and Young Adult Substance Abuse. | Jackson KM et al. | — | 2018 | → |
| Neuroepigenetics and addiction. | Walker DM et al. | — | 2018 | → |
| Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design. | Hines LA et al. | — | 2018 | → |
| Polygenic Score × Intervention Moderation: an Application of Discrete-Time Survival Analysis to Model the Timing of First Marijuana Use Among Urban Youth. | Musci RJ et al. | — | 2018 | → |
| Predictors of initiation of nicotine, alcohol, cannabis, and cocaine use: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). | Blanco C et al. | — | 2018 | → |
| The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study. | Huggett SB et al. | — | 2018 | → |
| Age of Drinking Initiation as a Risk Factor for Alcohol Use Disorder Symptoms is Moderated by ALDH2*2 and Ethnicity. | Luczak SE et al. | — | 2017 | → |
| From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process. | Deutsch AR et al. | — | 2017 | → |
| Genetic and environmental sources of covariation between early drinking and adult functioning. | Waldron JS et al. | — | 2017 | → |
| Marijuana use trajectories among drug-using youth presenting to an urban emergency department: Violence and social influences. | Walton MA et al. | — | 2017 | → |
| Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students. | Webb BT et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| The potential of neuroimaging for identifying predictors of adolescent alcohol use initiation and misuse. | O'Halloran L et al. | — | 2017 | → |
| Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis. | Richmond-Rakerd LS et al. | — | 2016 | → |
| Contextual influences on early drinking: Characteristics of drinking and nondrinking days. | Jackson KM et al. | — | 2016 | → |
| Does the familial transmission of drinking patterns persist into young adulthood? A 10-year follow up. | Karlsson P et al. | — | 2016 | → |
| Genetic and environmental components to self-induced vomiting. | Peterson CM et al. | — | 2016 | → |
| Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. | Melroy-Greif WE et al. | — | 2016 | → |
| Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence? | Spear LP | — | 2015 | → |
| Developmental Changes in Genetic and Shared Environmental Contributions to Smoking Initiation and Subsequent Smoking Quantity in Adolescence and Young Adulthood. | Bares CB et al. | — | 2015 | → |
| Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan. | Ting TT et al. | — | 2015 | → |
| Genetic and environmental influences on adolescents' smoking involvement: a multi-informant twin study. | Seglem KB et al. | — | 2015 | → |
| Genetic and Environmental Influences on Smoking Behavior across Adolescence and Young Adulthood in the Virginia Twin Study of Adolescent Behavioral Development and the Transitions to Substance Abuse Follow-Up. | Do EK et al. | — | 2015 | → |
| Genomic influences on alcohol problems in a population-based sample of young adults. | Edwards AC et al. | — | 2015 | → |
| Interaction effects between the 5-hydroxy tryptamine transporter-linked polymorphic region (5-HTTLPR) genotype and family conflict on adolescent alcohol use and misuse. | Kim J et al. | — | 2015 | → |
| Progression in substance use initiation: A multilevel discordant monozygotic twin design. | Richmond-Rakerd LS et al. | — | 2015 | → |
| The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. | Hines LA et al. | — | 2015 | → |
| Transition probabilities for four states of alcohol use in adolescence and young adulthood: what factors matter when? | Probst C et al. | — | 2015 | → |
| A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol. | Ware JJ et al. | — | 2014 | → |
| Cannabis controversies: how genetics can inform the study of comorbidity. | Agrawal A et al. | — | 2014 | → |
| Have the genetics of cannabis involvement gone to pot? | Agrawal A et al. | — | 2014 | → |
| Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. | Carmiol N et al. | — | 2014 | → |
| Addictive behaviors and addiction-prone personality traits: associations with a dopamine multilocus genetic profile. | Davis C et al. | — | 2013 | → |
| Alcohol consumption in men is influenced by qualitatively different genetic factors in adolescence and adulthood. | Edwards AC et al. | — | 2013 | → |
| Are there differences between young African-American and European-American women in the relative influences of genetics versus environment on age at first drink and problem alcohol use? | Sartor CE et al. | — | 2013 | → |
| Causal influence of age at first drink on alcohol involvement in adulthood and its moderation by familial context. | Deutsch AR et al. | — | 2013 | → |
| Childhood sexual abuse and early substance use in adolescent girls: the role of familial influences. | Sartor CE et al. | — | 2013 | → |
| Dual growth of adolescent smoking and drinking: evidence for an interaction between the mu-opioid receptor (OPRM1) A118G polymorphism and sex. | Kleinjan M et al. | — | 2013 | → |
| Why is adolescence a key period of alcohol initiation and who is prone to develop long-term problem use?: A review of current available data. | Petit G et al. | — | 2013 | → |
| Adolescent drinking, academic achievement and leisure time use by secondary education students in a rural area of Crete. | Koutra K et al. | — | 2012 | → |
| Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence. | Korhonen T et al. | — | 2012 | → |
| Genetic variations in the dopaminergic system and alcohol use: a system-level analysis. | Chen C et al. | — | 2012 | → |
| Trends in adolescent alcohol use: effects of age, sex and cohort on prevalence and heritability. | Geels LM et al. | — | 2012 | → |
| Addiction as a systems failure: focus on adolescence and smoking. | Baler RD et al. | — | 2011 | → |
| Age moderates non-genetic influences on the initiation of cannabis use: a twin-sibling study in Dutch adolescents and young adults. | Distel MA et al. | — | 2011 | → |
| Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. | Ware JJ et al. | — | 2011 | → |
| Conditional substance abuse and dependence by diagnosis of mood or anxiety disorder or schizophrenia in the U.S. population. | Martins SS et al. | — | 2011 | → |
| Dizziness and the genetic influences on subjective experiences to initial cigarette use. | Haberstick BC et al. | — | 2011 | → |
| DRD2 and DRD4 in relation to regular alcohol and cannabis use among adolescents: does parenting modify the impact of genetic vulnerability? The TRAILS study. | Creemers HE et al. | — | 2011 | → |
| Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies. | Hicks BM et al. | — | 2011 | → |
| Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. | Langley K et al. | — | 2010 | → |
| Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis. | Johnson BA et al. | — | 2010 | → |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | — | 2010 | → |
| Does religious involvement protect against early drinking? A behavior genetic approach. | Harden KP | — | 2010 | → |
| Genetically informative research on adolescent substance use: methods, findings, and challenges. | Lynskey MT et al. | — | 2010 | → |
| Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies. | Verweij KJ et al. | — | 2010 | → |
| Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction. | van der Zwaluw CS et al. | — | 2010 | → |
| Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins. | Agrawal A et al. | — | 2010 | → |
| Peer substance involvement modifies genetic influences on regular substance involvement in young women. | Agrawal A et al. | — | 2010 | → |
| The Moderating Effects of Pubertal Timing on the Longitudinal Associations Between Parent-Child Relationship Quality and Adolescent Substance Use. | Shelton KH et al. | — | 2010 | → |
| Candidate genes for cannabis use disorders: findings, challenges and directions. | Agrawal A et al. | — | 2009 | → |
| Common genetic influences on the timing of first use for alcohol, cigarettes, and cannabis in young African-American women. | Sartor CE et al. | — | 2009 | → |
| Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts. | Agrawal A et al. | — | 2009 | → |
| Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. | Saraceno L et al. | — | 2009 | → |
| Incorporating the family as a critical context in genetic studies of children: implications for understanding pathways to risky behavior and substance use. | Rende R et al. | — | 2009 | → |
| Similarities in drinking behavior of twin's friends: moderation of heritability of alcohol use. | Poelen EA et al. | — | 2009 | → |
| The relationship between local clean indoor air policies and smoking behaviours in Minnesota youth. | Klein EG et al. | — | 2009 | → |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | — | 2009 | → |
| Adolescents at risk for substance use disorders: role of psychological dysregulation, endophenotypes, and environmental influences. | Thatcher DL et al. | — | 2008 | → |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | — | 2008 | → |
| Gene-environment correlation and interaction in peer effects on adolescent alcohol and tobacco use. | Harden KP et al. | — | 2008 | → |
| Genetic and environmental influences on the rate of progression to alcohol dependence in young women. | Sartor CE et al. | — | 2008 | → |
| Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study. | Sartor CE et al. | — | 2008 | → |
| Smoking status of step-parents as a risk factor for smoking in adolescence. | Fidler JA et al. | — | 2008 | → |
| The genetics of nicotine addiction liability: ethical and social policy implications. | Hall WD et al. | — | 2008 | → |
| The relative contribution of genes and environment to alcohol use in early adolescents: are similar factors related to initiation of alcohol use and frequency of drinking? | Poelen EA et al. | — | 2008 | → |
| Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents. | Fowler T et al. | — | 2007 | → |