Gender-related influences of parental alcoholism on the prevalence of psychiatric illnesses: analysis of the National Epidemiologic Survey on Alcohol and Related Conditions.
paper
Cited
Public
- Authors
- Morgan, Peter T; Desai, Rani A; Potenza, Marc N
- Year
- 2010
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 20645936
- DOI
- 10.1111/j.1530-0277.2010.01263.x
- PMCID
- PMC2950877
BACKGROUND: Offspring of individuals with alcoholism are at increased risk for psychiatric illness, but the effects of gender on this risk are not well known. In this study, we tested the hypothesis that the gender of the parent with alcoholism and the gender of offspring affect the association between parental alcoholism and offspring psychiatric illness. METHOD: We analyzed the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) data to examine the gender-specific prevalence of axis I and axis II disorders in 23,006 male and 17,368 female respondents with and without a history of paternal or maternal alcoholism. Adjusted odds ratios were calculated for the disorders based on gender and presence of maternal or paternal alcoholism. RESULTS: Maternal or paternal alcoholism was associated with a higher prevalence of every disorder examined, regardless of the gender of offspring. Gender-related differences in prevalences were present in nearly all examined disorders, and the association between parental alcoholism and offspring psychiatric disorders was significantly different in men and women. These differences included stronger associations in female offspring of men with alcoholism (alcohol abuse without dependence); in female offspring of women with alcoholism (mania, nicotine dependence, alcohol abuse, and schizoid personality disorder); in male offspring of men with alcoholism (mania); and in male offspring of women with alcoholism (panic disorder). CONCLUSIONS: Interactions between gender and parental alcoholism were specific to certain disorders but varied in their effects, and in general female children of women with alcoholism appear at greatest risk for adult psychopathology.
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| Name | Type |
|---|---|
| age | phenotype |
| agoraphobia | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcoholic fathers local | cohort |
| Alcoholic mothers local | cohort |
| alcoholism | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use disorders | phenotype |
| Annual household income local | phenotype |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| Any anxiety disorder local | phenotype |
| Any mood disorder local | phenotype |
| any substance use disorder | phenotype |
| avoidant personality disorder | phenotype |
| axis I disorder | phenotype |
| Axis II disorders | phenotype |
| Biological parents | cohort |
| bipolar disorder | phenotype |
| both biological parents local | phenotype |
| children | cohort |
| Cluster A local | phenotype |
| Cluster B local | phenotype |
| cluster B personality disorder | phenotype |
| Cluster C local | phenotype |
| college degree | phenotype |
| college students | cohort |
| Co-morbid psychiatric disorder local | phenotype |
| conduct disorder | phenotype |
| Daughters local | cohort |
| Daughters of women with Alcohol Use Disorder local | cohort |
| death | phenotype |
| dependent personality disorder | phenotype |
| depression | phenotype |
| drug dependence | phenotype |
| dysthymia | phenotype |
| education | phenotype |
| employment | phenotype |
| externalizing behavior | phenotype |
| externalizing disorders | phenotype |
| family history of alcoholism | phenotype |
| fathers | cohort |
| full sample | cohort |
| generalized anxiety disorder | phenotype |
| harm avoidance | phenotype |
| Hispanic | phenotype |
| histrionic personality disorder | phenotype |
| hypomania | phenotype |
| inconsistent parental discipline local | phenotype |
| internalizing disorders | phenotype |
| major depressive disorder | phenotype |
| mania | phenotype |
| Maternal history of alcoholism local | cohort |
| men | cohort |
| mood disorders | phenotype |
| mothers | cohort |
| National Epidemiologic Survey on Alcohol and Related Conditions | cohort |
| National Institute of Mental Health Epidemiologic Catchment Area Program local | cohort |
| negative outcomes | phenotype |
| Negative psychosocial outcomes local | phenotype |
| NESARC | cohort |
| NESARC data set local | cohort |
| nicotine dependence | phenotype |
| novelty seeking | phenotype |
| obsessive-compulsive personality disorder | phenotype |
| offspring | cohort |
| Offspring mental health local | phenotype |
| panic disorder | phenotype |
| panic disorder with agoraphobia local | phenotype |
| paranoid personality disorder | phenotype |
| parental alcoholism | phenotype |
| parental divorce/separation | phenotype |
| parental monitoring | phenotype |
| Parent-child relations local | phenotype |
| Parent mental illness local | phenotype |
| Parent substance use local | phenotype |
| paternal alcoholism | phenotype |
| Paternal history of alcoholism local | cohort |
| pathological gambling | phenotype |
| Personality variables local | phenotype |
| psychiatric disorders | phenotype |
| race/ethnicity | phenotype |
| schizoid personality disorder | phenotype |
| sex | phenotype |
| sex differences | phenotype |
| Social maladjustment local | phenotype |
| social phobia | phenotype |
| sons | cohort |
| Specific anxiety disorder local | phenotype |
| specific phobia | phenotype |
| Stanger et al 2004 local | cohort |
| substance use | phenotype |
| unemployment | phenotype |
| Violence involvement local | phenotype |
| women | cohort |
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