Subcortical volumes are reduced in short-term and long-term abstinent alcoholics but not those with a comorbid stimulant disorder.
- Authors
- Fein, George; Fein, David
- Year
- 2013
- Journal
- NeuroImage. Clinical
- PMID
- 24179848
- DOI
- 10.1016/j.nicl.2013.06.018
- PMCID
- PMC3791275
Chronic alcohol abuse affects brain structure and function. We examined subcortical structure volumes in 77 short (6-15 week) and 90 long (multi-year) term abstinent alcoholics, along with 74 controls. We used a 3T Siemens MPRAGE sequence for image acquisition and FSL FIRST software for measuring subcortical volumes. When examining alcoholics without a comorbid stimulant disorder we found reduced hippocampal, pallidum and thalamus volumes in short term abstinence compared to a non-substance abusing control sample with numerically smaller yet still significant reductions compared to controls in long term abstinence. When examining alcoholics with a comorbid stimulant disorder, no difference from controls was found for any subcortical volume. Alcoholics with a stimulant disorder had significantly larger subcortical volumes than alcoholics without a stimulant disorder. This study replicates past research showing that chronic alcohol abuse is associated with lower subcortical volumes in short-term abstinent chronic alcoholics and extends this finding, although with smaller effects to long-term abstinent samples. The absence of this effect in the presence of a comorbid stimulant disorder suggests either a protective effect of stimulant abuse/dependence or that the measurements reflect the aggregate of alcohol dependence associated atrophy and stimulant abuse associated inflammation. Associations with function suggest the second of these two alternatives.
Volumes and effect sizes of the seven subcortical structures for the various subject groups.Abbreviations: LTAA, Long-Term Abstinent Alcoholics; NSAC, NonSubstance Abusing Controls; STAA, Short-Term Abstinent Alcoholics; DAO, Dependent on Alcohol Only; DASD, Dependent on Alcohol with a Stimulant Disorder (abuse or dependence).
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | 2015 | 26236574 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Caudate gray matter volumes and risk of relapse in Type A alcohol-dependent patients: A 7-year MRI follow-up study. | Martelli C et al. | — | 2023 | → |
| Testing the consequences of alcohol, cannabis, and nicotine use on hippocampal volume: a quasi-experimental cotwin control analysis of young adult twins. | Harper J et al. | — | 2023 | → |
| Shapes of subcortical structures in adolescents with and without familial history of substance use disorder. | Wang Z et al. | — | 2022 | → |
| Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis. | Zhornitsky S et al. | — | 2021 | → |
| Cognitive Dysfunction, Brain Volumes, and Traumatic Brain Injury in Homeless Persons. | Cusimano MD et al. | — | 2021 | → |
| Memory impairment in alcohol use disorder is associated with regional frontal brain volumes. | Fama R et al. | — | 2021 | → |
| Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder. | Sawyer KS et al. | — | 2020 | → |
| Hippocampal Volume in Psychiatric Diagnoses: Should Psychiatry Biomarker Research Account for Comorbidities? | Gosnell SN et al. | — | 2020 | → |
| Striatal and white matter volumes in chronic ketamine users with or without recent regular stimulant use. | Liang H et al. | — | 2020 | → |
| The Neurological Consequences of Engaging in Australian Collision Sports. | Symons GF et al. | — | 2020 | → |
| Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients. | Shim JH et al. | — | 2019 | → |
| Cortical thickness and subcortical brain volumes in professional rugby league players. | Wojtowicz M et al. | — | 2018 | → |
| Testing associations between cannabis use and subcortical volumes in two large population-based samples. | Gillespie NA et al. | — | 2018 | → |
| Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety. | Herrington JD et al. | — | 2017 | → |
| Decreased subcortical volumes in alcohol dependent individuals: effect of polysubstance use disorder. | Grodin EN et al. | — | 2017 | → |
| Problematic alcohol use and reduced hippocampal volume: a meta-analytic review. | Wilson S et al. | — | 2017 | → |
| Resting state synchrony in long-term abstinent alcoholics: Effects of a current major depressive disorder diagnosis. | Fein G et al. | — | 2017 | → |
| Structural Neuroimaging in Polysubstance Users. | Meyerhoff DJ | — | 2017 | → |
| Wine Flavonoids in Health and Disease Prevention. | Fernandes I et al. | — | 2017 | → |
| Cortical and subcortical gray matter shrinkage in alcohol-use disorders: a voxel-based meta-analysis. | Yang X et al. | — | 2016 | → |
| Thinking after Drinking: Impaired Hippocampal-Dependent Cognition in Human Alcoholics and Animal Models of Alcohol Dependence. | Staples MC et al. | — | 2016 | → |
| Conflict anticipation in alcohol dependence - A model-based fMRI study of stop signal task. | Hu S et al. | — | 2015 | → |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | — | 2015 | → |
| Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls. | Cservenka A et al. | — | 2015 | → |