SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.
paper
Cited
Public
- Authors
- Hoft, N R; Corley, R P; McQueen, M B; Huizinga, D; Menard, S; Ehringer, M A
- Year
- 2009
- Journal
- Genes, brain, and behavior
- PMID
- 19500157
- DOI
- 10.1111/j.1601-183X.2009.00495.x
- PMCID
- PMC2880622
The CHRNA6 and CHRNB3 genes have been associated with nicotine dependence and early subjective response to nicotine. Here we present evidence, using a nationally representative sample of adults, that this region is also associated with alcohol behaviors. Six SNPs (single nucleotide polymorphisms) spanning the CHRNB3/A6 genes were analyzed using the statistical genetics software FBAT-PC, which allows one to examine a collection of multiple phenotypes to generate a maximally heritable composite phenotype for each SNP. The six SNPs were tested using FBAT-PC including four alcohol phenotypes: average number of drinks, blackouts, total number of DSM-IV abuse and dependence symptoms endorsed, and quit attempts. Three SNPs in CHRNA6 (rs1072003, P = 0.015; rs892413, P = 0.0033 and rs2304297, P = 0.012) and one SNP in CHRNB3 (rs13280604, P = 0.0053) were associated with a composite of the alcohol phenotypes. The association was primarily driven by the average number of drinks.
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