Recent advances in obesity: genetics and beyond.
paper
Cited
Public
- Authors
- Cheung, Wai W; Mao, Peizhong
- Year
- 2012
- Journal
- ISRN endocrinology
- PMID
- 22474595
- DOI
- 10.5402/2012/536905
- PMCID
- PMC3313574
The prevalence of obesity, which is a heritable trait that arises from the interactions of multiple genes and lifestyle factors, continues to increase worldwide, causing serious health problems and imposing a substantial economic burden on societies. For the past several years, various genetic epidemiological approaches have been utilized to identify genetic loci for obesity. Recent evidence suggests that development of obesity involves hormones and neurotransmitters (such as leptin, cocaine- and amphetamine-regulated transcript (CART), and ghrelin) that regulate appetite and energy expenditure. These hormones act on specific centers in the brain that regulate the sensations of satiety. Mutations in these hormones or their receptors can lead to obesity. Aberrant circadian rhythms and biochemical pathways in peripheral organs or tissues have also been implicated in the pathology of obesity. More interestingly, increasing evidence indicates a potential relation between obesity and central nervous system disorders (such as cognitive deficits). This paper discusses recent advances in the field of genetics of obesity with an emphasis on several established loci that influence obesity. These recently identified loci may hold the promise to substantially improve our insights into the pathophysiology of obesity and open up new therapeutic strategies to combat growing obesity epidemic facing the human population today.
No figures extracted from this document.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The genetic epidemiology of substance use disorder: A review. | 2017 | 28938182 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Nutrigenomics of Obesity: Integrating Genomics, Epigenetics, and Diet-Microbiome Interactions for Precision Nutrition. | Farzand A et al. | — | 2025 | → |
| Critical Correlation Between Obesity and Cardiovascular Diseases and Recent Advancements in Obesity. | Pakhare M et al. | — | 2024 | → |
| Obesity in Children. | Nagpal N et al. | — | 2022 | → |
| Effects of Tyrosine and Tryptophan Supplements on the Vital Indicators in Mice Differently Prone to Diet-Induced Obesity. | Gmoshinski IV et al. | — | 2021 | → |
| High-fat diet increases the level of circulating Monocyte Chemoattractant Protein-1 in Wistar rats, independent of obesity. | Syarif et al. | — | 2021 | → |
| Metabolic and Molecular Subacute Effects of a Single Moderate-Intensity Exercise Bout, Performed in the Fasted State, in Obese Male Rats. | Vogt ÉL et al. | — | 2021 | → |
| The Relationship Between Paternal Preconception Obesity and Health Behaviors and Childhood Obesity: Protocol for a Systematic Review. | Laforest ME et al. | — | 2021 | → |
| Changes in Body Composition and <i>FTO</i> Whole Blood DNA Methylation Among Japanese Women: A Randomized Clinical Trial of Weight-Loss Program. | Nishida H et al. | — | 2020 | → |
| Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age. | Morgan PT et al. | — | 2020 | → |
| Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS). | Gharooi Ahangar O et al. | — | 2020 | → |
| Insights into the multifactorial causation of obesity by integrated genetic and epigenetic analysis. | Diels S et al. | — | 2020 | → |
| Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children. | Suriyaprom K et al. | — | 2020 | → |
| Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity. | Yupanqui-Lozno H et al. | — | 2019 | → |
| Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue. | An SM et al. | — | 2019 | → |
| A Genomewide Integrative Analysis of GWAS and eQTLs Data Identifies Multiple Genes and Gene Sets Associated with Obesity. | Liu L et al. | — | 2018 | → |
| Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review. | Lichtveld K et al. | — | 2018 | → |
| The rs9939609 polymorphism in the fat mass and obesity associated (FTO) gene is associated with obesity in Tunisian population. | Ben Halima M et al. | — | 2018 | → |
| Gene-by-environment interactions of the CLOCK, PEMT, and GHRELIN loci with average sleep duration in relation to obesity traits using a cohort of 643 New Zealand European children. | Krishnan M et al. | — | 2017 | → |
| Role of MicroRNA Regulation in Obesity-Associated Breast Cancer: Nutritional Perspectives. | Kasiappan R et al. | — | 2017 | → |
| rs3751812, a common variant in fat mass and obesity-associated (FTO) gene, is associated with serum high- and low-density lipoprotein cholesterol in Pakistani individuals. | Qureshi SA et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group. | Logan M et al. | — | 2016 | → |
| A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin". | Jalili M et al. | — | 2016 | → |
| Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects. | Shabana et al. | — | 2016 | → |
| Mismatch Amplification Mutation Assay Real-Time PCR Analysis of the Leptin Gene G2548A and A19G Polymorphisms and Serum Leptin in Infancy: A Preliminary Investigation. | Savino F et al. | — | 2016 | → |
| Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice. | Nyima T et al. | — | 2016 | → |
| Obesity, More than a 'Cosmetic' Problem. Current Knowledge and Future Prospects of Human Obesity Genetics. | Shabana et al. | — | 2016 | → |
| Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance. | Bock PM et al. | — | 2016 | → |
| Adipocyte secreted factors enhance aggressiveness of prostate carcinoma cells. | Moreira  et al. | — | 2015 | → |
| Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects. | Shabana NA et al. | — | 2015 | → |
| Clinically relevant known and candidate genes for obesity and their overlap with human infertility and reproduction. | Butler MG et al. | — | 2015 | → |
| Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study. | Shabana et al. | — | 2015 | → |
| Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. | Vaughan LK et al. | — | 2015 | → |
| Milk Leptin Surge and Biological Rhythms of Leptin and Other Regulatory Proteins in Breastmilk. | Nozhenko Y et al. | — | 2015 | → |
| The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis. | Shabana et al. | — | 2015 | → |
| CART in the brain of vertebrates: circuits, functions and evolution. | Subhedar NK et al. | — | 2014 | → |
| Education and WHO recommendations for fruit and vegetable intake are associated with better cognitive function in a disadvantaged Brazilian elderly population: a population-based cross-sectional study. | Pastor-Valero M et al. | — | 2014 | → |
| Investigation of melanocortin system gene variants in antipsychotic-induced weight gain. | Chowdhury NI et al. | — | 2014 | → |
| Pesticides in mixture disrupt metabolic regulation: in silico and in vivo analysis of cumulative toxicity of mancozeb and imidacloprid on body weight of mice. | Bhaskar R et al. | — | 2014 | → |
| A meta-analysis of reference values of leptin concentration in healthy postmenopausal women. | Zhou X et al. | — | 2013 | → |
| Clinical phenotype of bipolar disorder with comorbid binge eating disorder. | McElroy SL et al. | — | 2013 | → |
| Conceptual heuristic models of the interrelationships between obesity and the occupational environment. | Pandalai SP et al. | — | 2013 | → |
| Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence. | Suchankova P et al. | — | 2013 | → |
| Identification of pleiotropic genetic effects on obesity and brain anatomy. | Curran JE et al. | — | 2013 | → |
| Molecular approaches in obesity studies. | Zamanian-Azodi M et al. | — | 2013 | → |
| Morbid obesity-the new pandemic: medical and surgical management, and implications for the practicing gastroenterologist. | Cello JP et al. | — | 2013 | → |
| Biological clocks: The coming of age. | Apte CV | — | 2012 | → |
| Copy number variants in obesity-related syndromes: review and perspectives on novel molecular approaches. | D'Angelo CS et al. | — | 2012 | → |