Childhood sexual abuse and early substance use in adolescent girls: the role of familial influences.
paper
Cited
Public
- Authors
- Sartor, Carolyn E; Waldron, Mary; Duncan, Alexis E; Grant, Julia D; McCutcheon, Vivia V; Nelson, Elliot C; Madden, Pamela A F; Bucholz, Kathleen K; Heath, Andrew C
- Year
- 2013
- Journal
- Addiction (Abingdon, England)
- PMID
- 23316725
- DOI
- 10.1111/add.12115
- PMCID
- PMC3628962
AIM: To assess the extent to which the association between childhood sexual abuse (CSA) and early use of alcohol, cigarettes and cannabis in adolescent girls is mediated by risk factors that tend to cluster in families where CSA occurs. DESIGN: An abridged version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) was administered by telephone. PARTICIPANTS: A total of 3761 female twins aged 18-29 (14.6% African American, 85.4% European American). MEASUREMENTS: CSA experiences and history of substance use were queried in the SSAGA-based interviews. FINDINGS: After controlling for familial influences on early substance use by including co-twin early use status in models, separate Cox proportional hazards regression analyses predicting onset of alcohol, cigarette and cannabis use revealed a significant association with CSA. The effect was observed to age 19 years for cigarettes and to age 21 years for cannabis, but was limited to age 14 years or younger for alcohol, with the most pronounced risk before age 10 [hazard ratio (HR) = 4.59; confidence interval (CI): 1.96-10.74]. CSA-associated risk for initiation of cigarette and cannabis use was also highest in the youngest age range, but the decline with age was much more gradual and the hazard ratios significantly lower (HR: 1.70; CI: 1.13-2.56 for cigarettes and HR: 2.34, CI: 1.57-3.48 for cannabis). CONCLUSIONS: Childhood sexual abuse history is a distinct risk factor for use of cigarettes and cannabis, and a very strong predictor of early age at first drink.
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| Name | Type |
|---|---|
| 13 year-old female twin pairs local | cohort |
| 13 year-old twins (new cohorts) local | cohort |
| 15 year-old female twin pairs local | cohort |
| 17 year-old female twin pairs local | cohort |
| 19 year-old female twin pairs local | cohort |
| adolescent alcohol use | phenotype |
| adolescents | cohort |
| age at first drink | phenotype |
| age at first use | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use initiation | phenotype |
| birth cohort | cohort |
| cannabis dependence | phenotype |
| cannabis use | phenotype |
| cannabis use disorder | phenotype |
| Cannabis use onset | phenotype |
| child sexual abuse local | phenotype |
| Child sexual abuse local | phenotype |
| cigarettes | phenotype |
| Cigarette use onset local | phenotype |
| Concordant twins local | cohort |
| Co-twin early cigarette use local | phenotype |
| co-twin early use local | phenotype |
| Co-twin early use local | phenotype |
| Co‑twin early use local | phenotype |
| CSA experience local | phenotype |
| CSA status local | phenotype |
| depression | phenotype |
| DSM-IV psychiatric disorders | phenotype |
| Early age at first cigarette local | phenotype |
| early alcohol use | phenotype |
| early cannabis use | phenotype |
| early cigarette use local | phenotype |
| Early cigarette use local | phenotype |
| Early initiation of cannabis use local | phenotype |
| Early initiation of cigarette use local | phenotype |
| early substance use | phenotype |
| Early use of cigarettes local | phenotype |
| emotional abuse | phenotype |
| Familial conflict local | phenotype |
| Familial influences local | phenotype |
| familial risk | cohort |
| Familial Risk for Substance Use local | phenotype |
| First cannabis use | phenotype |
| First cigarette local | phenotype |
| Genetic liability to substance use disorders local | phenotype |
| Heavy episodic drinking before age 15 local | phenotype |
| initiation of alcohol use ages 10-14 local | phenotype |
| initiation of alcohol use ages 15-19 local | phenotype |
| initiation of alcohol use before age 10 local | phenotype |
| Kendler et al. study | cohort |
| Missouri Adolescent Female Twin Study | cohort |
| MOAFTS | cohort |
| MOAFTS Wave 1 local | cohort |
| MOAFTS Wave 3 local | cohort |
| MOAFTS Wave 4 local | cohort |
| MOAFTS Wave 5 local | cohort |
| negative affect | phenotype |
| neglect | phenotype |
| Nelson et al. study local | cohort |
| nicotine | drug |
| nicotine dependence | phenotype |
| parental alcoholism | phenotype |
| parental divorce/separation | phenotype |
| parental monitoring | phenotype |
| parental psychopathology | phenotype |
| Parental violence local | phenotype |
| participants | cohort |
| physical abuse | phenotype |
| posttraumatic stress disorder | phenotype |
| Post-Traumatic Stress Disorder | phenotype |
| psychiatric disorders | phenotype |
| quality of parent-child relationships local | phenotype |
| Regular drinking before age 10 local | phenotype |
| regular smoking | phenotype |
| sex | phenotype |
| substance | phenotype |
| substance abuse | phenotype |
| substance use | phenotype |
| substance use history local | phenotype |
| Twin cohort | cohort |
| Unaffected twin local | cohort |
| use/age at first use local | phenotype |
| wave 2 | cohort |
| women | cohort |
| Women in United States local | cohort |
| zygosity | phenotype |
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