GABA A receptors: subtypes provide diversity of function and pharmacology.

paper Cited Public

Authors: Olsen, Richard W; Sieghart, Werner
Year: 2009
Journal: Neuropharmacology
PMID: 18760291
DOI: 10.1016/j.neuropharm.2008.07.045
PMCID: PMC3525320

#	Section	Preview
0	GABAA Receptors	Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates rapid…
1	Heterogeneity of GABAA receptors	GABAA receptors are composed of five protein subunits that can belong to different subunit classes.…
2	Heterogeneity of GABAA receptors	The assembly of GABAA-R as heteropentamers produces complex heterogeneity in their structure, which…
3	Identification of native GABAA receptor subtypes by their regional and cellular distribution	In situ hybridization (Wisden et al., 1992; Persohn et al., 1992) and immunohistochemical studies…
4	Identification of native GABAA receptor subtypes by their regional and cellular distribution	An important criterion for association of subunit isoforms into oligomeric native receptors is…
5	Identification of native GABAA receptor subtypes by their regional and cellular distribution	In the raphe nuclei the vast majority of serotonergic neurons express strong α3 subunit…
6	Identification of native GABAA receptor subtypes by their synaptic and extrasynaptic localization	Other studies indicated that the individual subunits exhibit a distinct subcellular distribution.…
7	Identification of native GABAA receptor subtypes by their synaptic and extrasynaptic localization	Extrasynaptic receptors have been identified also in other brain regions. In the forebrain it is…
8	Identification of native GABAA receptor subtypes by their subunit composition	A variety of GABAA receptor subunit-specific antibodies have been generated and have been used for…
9	Identification of native GABAA receptor subtypes by their subunit composition	in the same receptors (for review see Sieghart and Sperk, 2002). From these results a subunit…
10	Identification of native GABAA receptor subtypes by their subunit composition	Studies investigating the abundance of GABAA-R subtypes using subunit-specific antibodies, confirmed…
11	Structural basis of GABAA receptor pharmacology	The GABAA-R are members of the Cys-loop pentameric LGIC superfamily, including nicotinic…
12	Structural basis of GABAA receptor pharmacology	& Buhr, 1997; Li et al., 2006; Bali & Akabas,2004; Hosie et al., 2006). Each subunit consists of a…
13	Structural basis of GABAA receptor pharmacology	The homologous sequence and structure allows homology modeling of the various functional domains of…
14	Structural basis of GABAA receptor pharmacology	et al., 2003). Residues homologous to those in the agonist binding loops at the β/α interface, are…
15	Structural basis of GABAA receptor pharmacology	Homology modeling of the extracellular as well as the transmembrane domain of the GABAA receptor was…
16	Identification of native GABAA receptor subtypes by their pharmacology — Benzodiazepines	GABAA-R are the site of action of a variety of pharmacologically and clinically important drugs.…
17	Identification of native GABAA receptor subtypes by their pharmacology — Benzodiazepines	cinolazepam (Sieghart, 1989) or non-benzodiazepines such as zolpidem, Cl218872, abecarnil, zaleplon…
18	Identification of native GABAA receptor subtypes by their pharmacology — Benzodiazepines	Other benzodiazepine site ligands, such as the imidazobenzodiazepines flumazenil or Ro15-4513, are…
19	Identification of native GABAA receptor subtypes by their pharmacology — Benzodiazepines	The function of at least some GABAA-R subtypes in the brain recently has been identified using a…

Name	Type
abecarnil local	drug
acetylcholine	drug
acetylcholine-binding protein local	drug
Acetylcholine binding protein local	drug
alcohol sensitivity	phenotype
anesthetic local	phenotype
anesthetics	drug
Anterograde amnestic local	phenotype
anti-absence effect local	phenotype
anticonvulsant	drug
antiepileptic local	phenotype
anxiety	phenotype
anxiogenic actions local	phenotype
anxiolytic	phenotype
associated proteins local	drug
Bacterial membrane LGIC receptor local	drug
barbiturates	drug
benzodiazepines	drug
bicuculline	drug
biogenic amines local	drug
brain	anatomy
CA1 pyramidal neurons	anatomy
Calbindin-D28k local	drug
calretinin	drug
cerebellar granule cells	anatomy
cerebellar Purkinje cells local	anatomy
cerebellum	anatomy
Cholecystokinin	drug
cholinergic neurons	phenotype
cinolazepam local	drug
circuit activity local	phenotype
Cl218872 local	drug
clonazepam	drug
CNS depressants local	drug
cortex (outer layers) local	anatomy
Cys-loop pentameric LGIC subunits local	drug
Cys-loop pentameric LGIC superfamily local	drug
dentate granule cells	anatomy
dentate molecular layer local	anatomy
diazepam	drug
DMCM	drug
dopamine receptor local	drug
dopaminergic neurons	anatomy
dorsal lateral geniculate nucleus local	anatomy
dorsal raphe nucleus	anatomy
ethanol consumption	phenotype
etomidate	drug
etomidate sensitivity local	phenotype
extrasynaptic dendritic membrane local	anatomy
extrasynaptic membrane local	anatomy
flumazenil	drug
flunitrazepam	drug
forebrain	anatomy
GABA	phenotype
GABAA-R local	gene
GABAA receptor	drug
GABAA rho subunit local	gene
GABAA-Rs local	drug
GABAA-R subtype α1-6βγ2 local	drug
GABAA-R subtype α4βδ local	drug
GABAA-R subtype α6βδ local	drug
GABAC receptor local	drug
GABAergic Golgi synapses local	anatomy
GABRA	gene
Gabra1	gene
GABRA2	gene
GABRA3	gene
Gabra4	gene
GABRA5	gene
GABRA6	gene
GABRB	gene
GABRB1	gene
Gabrb2	gene
Gabrb3	gene
Gabrd	gene
GABRE	gene
GABRG	gene
Gabrg1	gene
Gabrg2	gene
Gabrg3	gene
GABRP	gene
GABRQ	gene
GABRR1	gene
GABRR2	gene
GABRR3	gene
glomeruli local	anatomy
glutamate	drug
heteromeric ligand-gated ion channels local	drug
hippocampus	anatomy
hyperdopaminergic phenotype local	phenotype
hypnotic properties local	phenotype
indiplon local	drug
inhibitory glycine receptors local	drug
intravenous anesthetics local	drug
ionotropic 5-HT3 receptors local	drug
isoflurane	drug
knock-in mice	cohort
knockout mice	cohort
L-655 708 local	drug
L-838,417 local	drug
learning and memory	phenotype
LGIC genes local	gene
locus coeruleus	anatomy
long-chain alcohols local	drug
loreclezole local	drug
Loreclezole local	drug
memory-enhancing properties local	phenotype
muscimol	drug
Muscle nicotinic acetylcholine receptor local	drug
muscle relaxant activity local	phenotype
mutant mice	cohort
network activity	phenotype
neuroactive steroids	drug
neuronal excitability	phenotype
neuropeptide Y	drug
neurosteroids	drug
nicotinic acetylcholine receptor	drug
noradrenergic neurons local	phenotype
norepinephrine receptor local	drug
ocinaplon local	drug
other receptors local	drug
parvalbumin-positive GABAergic neurons local	phenotype
peptide receptor local	drug
pharmacological profile local	phenotype
phosphatases	drug
picrotoxin	drug
propofol	drug
protein kinases	drug
psychotic-like symptoms	phenotype
quazepam local	drug
raphe nuclei	anatomy
rat hippocampal pyramidal neurons local	anatomy
receptor containing 2 distinct α subunits local	drug
receptor containing 2 distinct β subunits local	drug
reduced sensitivity to anesthetic actions of etomidate local	phenotype
reduced sensitivity to sedative actions of etomidate local	phenotype
retina	anatomy
Ro15-4513	drug
salicylidene salicylhydrazide local	drug
sedative effects	phenotype
sedative/hypnotic local	phenotype
sedative properties local	phenotype
Sensitivity to anesthetics local	phenotype
serotonergic neurons local	phenotype
serotonin receptor local	drug
SL651498 local	drug
somatic membrane local	anatomy
Somatostatin local	drug
spatial memory	phenotype
Steroid local	drug
striatum	anatomy
superior colliculus local	anatomy
taurine	drug
tetrameric glutamate receptors local	drug
thalamic relay nuclei local	anatomy
thalamus	anatomy
THIP	drug
tonic current	phenotype
TPA023 local	drug
trace fear conditioning	phenotype
trimeric purine receptors local	drug
Vasoactive intestinal peptide local	drug
volatile anesthetic	drug
wild-type mice	cohort
zaleplon	drug
zolpidem	drug
α1 knockout mice local	cohort
α1 subunit local	drug
α1β local	drug
α1β2γ2 local	drug
α1β3γ2 receptor local	drug
α1βγ2 receptor local	gene
α1βδ receptor local	drug
α2βγ2 local	drug
α2βγ2 receptor local	gene
α3 global knockout mice local	cohort
α3IA local	drug
α3 subunit local	drug
α3βγ2 local	drug
α3βγ2 receptor local	gene
α4 subunit local	drug
α4βγ2 local	drug
α4βδ local	drug
α5 knockin mouse local	cohort
α5β3γ2 receptor local	drug
α5βγ2 local	drug
α6 subunit local	drug
α6βγ2 local	drug
α6βδ local	drug
αM1-11’ local	variant
α subunit	drug
αxαyβγ2 local	drug
αβ receptor local	phenotype
αβγ1 local	drug
αβγ3 local	drug
αβε local	drug
αβθ local	drug
αβπ local	drug
β2N265S local	variant
β3N265M local	variant
βM3-4’ local	variant
β subunit	drug
γ2 knockout mice local	cohort
γ subunit	drug
δ knockout mice local	cohort
δ subunit local	drug
ε subunit local	drug
θ subunit local	drug
ρ subunit local	drug

Citation	PMID	DOI	Status
Atack, JR et al., Br J Pharmacol, 2005, Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABAA receptors	15655523	10.1038/sj.bjp.0706056	Cited
Atack, JR et al., J Pharmacol Exp Ther, 2006, TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluor ophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates	16183706	10.1124/jpet.105.089920	Cited
Atack, JR, Expert Opin Investig Drugs, 2005, The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics	15926867	10.1517/13543784.14.5.601	Cited
Bali, M et al., Mol Pharmacol, 2004, Defining the propofol binding site location on the GABAA receptor	14722238	10.1124/mol.65.1.68	Cited
Bali, M et al., SfN abstracts, 2007, Spatial relationship between the GABAA receptor β2 M3 region and the α1 subunit preM1 region	—	—	—
Barnard, EA et al., Pharmacol Rev, 1998, International Union of Pharmacology. XV. Subtypes of γ-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function	9647870	—	Cited
Basile, AS et al., Eur J Pharmacol, 2004, Anxioselective anxiolytics: can less be more?	15464051	10.1016/j.ejphar.2004.07.043	Cited
Baumann, SW et al., J Biol Chem, 2002, Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement	12324466	10.1074/jbc.M207663200	Cited
Belelli, D et al., Proc Natl Acad Sci U S A, 1997, The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid	9380754	10.1073/pnas.94.20.11031	Cited
Bencsits, E et al., J Biol Chem, 1999, A significant part of native gamma -aminobutyric acidA receptors containing alpha 4 subunits do not contain gamma or delta subunits	10391897	10.1074/jbc.274.28.19613	Cited
Benke, D et al., J Biol Chem, 2004, Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits	15304513	10.1074/jbc.M407154200	Cited
Bohlhalter, S et al., J Neurosci, 1996, Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical study	8613794	10.1523/JNEUROSCI.16-01-00283.1996	Cited
Boue-Grabot, E et al., J Neurochem, 1998, Expression of GABA receptor rho subunits in rat brain	9489708	10.1046/j.1471-4159.1998.70030899.x	Cited
Brejc, K et al., Nature, 2001, Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors	11357122	10.1038/35077011	Cited
Brickley, SG et al., J Neurosci, 1999, Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes	10191314	10.1523/JNEUROSCI.19-08-02960.1999	Cited
Brown, N et al., Br J Pharmacol, 2002, Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors	12145096	10.1038/sj.bjp.0704795	Cited
Burgard, EC et al., Mol Pharmacol, 1996, Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype	8700104	—	Cited
Caraiscos, VB et al., Proc Natl Acad Sci U S A, 2004, Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors	14993607	10.1073/pnas.0307231101	Cited
Cestari, IN et al., Neuroreport, 1996, The agonistic action of pentobarbital on GABAA beta-subunit homomeric receptors	8724679	10.1097/00001756-199603220-00023	Cited
Chambers, MS et al., J Med Chem, 2004, An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties	15537339	10.1021/jm040863t	Cited
Chandra, D et al., Proc Natl Acad Sci U S A, 2006, GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol	17005728	10.1073/pnas.0604304103	Cited
Collingridge, GL et al., Neuropharmacology, 2009, A nomenclature for ligand-gated ion channels	18655795	10.1016/j.neuropharm.2008.06.063	Cited
Collinson, N et al., J Neurosci, 2002, Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor	12097508	10.1523/JNEUROSCI.22-13-05572.2002	Cited
Corringer, PJ et al., Annu Rev Pharmacol Toxicol, 2000, Nicotinic receptors at the amino acid level	10836143	10.1146/annurev.pharmtox.40.1.431	Cited
Crestani, F et al., Proc Nat Acad Sci USA, 2002, Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors	12084936	10.1073/pnas.142288699	Cited
Cromer, BA et al., Trends Biochem Sci, 2002, Anxiety over GABAA receptor structure relieved by AChBP	12069787	10.1016/s0968-0004(02)02092-3	Cited
Dellisanti, CD et al., Nat Neurosci, 2007, Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution	17643119	10.1038/nn1942	Cited
Dias, R et al., J Neurosci, 2005, Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines	16291941	10.1523/JNEUROSCI.1166-05.2005	Cited
Enz, R et al., J Neurosci, 1996, Immunocytochemical localization of the GABAC receptor rho subunits in the mammalian retina	8699258	10.1523/JNEUROSCI.16-14-04479.1996	Cited
Ernst, M et al., Mol Pharmacol, 2005, Comparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function	16103045	10.1124/mol.105.015982	Cited
Ernst, M et al., Neuroscience, 2003, Comparative modeling of GABAA receptors: limits, insights, future developments	12831854	10.1016/s0306-4522(03)00288-4	Cited
Farrant, M et al., Nat Rev Neurosci, 2005, Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors	15738957	10.1038/nrn1625	Cited
Fritschy, JM et al., Proc Natl Acad Sci U S A, 1992, Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies	1323116	10.1073/pnas.89.15.6726	Cited
Gao, B et al., Eur J Neurosci, 1994, Selective allocation of GABAA receptors containing the alpha 1 subunit to neurochemically distinct subpopulations of rat hippocampal interneurons	8075825	10.1111/j.1460-9568.1994.tb00994.x	Cited
Gao, B et al., Neuroscience, 1993, Neuron-specific expression of GABAA receptor subtypes: differential association of the alpha 1 and alpha 3 subunits with serotonergic and GABAergic neurons	8393540	10.1016/0306-4522(93)90582-z	Cited
Gao, B et al., Neuroscience, 1995, Identification of distinct GABAA-receptor subtypes in cholinergic and parvalbumin-positive neurons of the rat and marmoset medial septum-diagonal band complex	7753393	10.1016/0306-4522(94)00480-s	Cited
Glykys, J et al., Nat Neurosci, 2007, A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol	17159992	10.1038/nn1813	Cited
Griebel, G et al., CNS Drug Rev, 2003, SL651498, a GABAA receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms	12595909	10.1111/j.1527-3458.2003.tb00241.x	Cited
Gunther, U et al., Proc Natl Acad Sci USA, 1995, Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors	7644489	10.1073/pnas.92.17.7749	Cited
Hanchar, HJ et al., Proc Natl Acad Sci USA, 2006, Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to α4/6β3δ GABAA receptors	16581914	10.1073/pnas.0509903103	Cited
Herd, MB et al., J Physiol, 2008, The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells	18079158	10.1113/jphysiol.2007.146746	Cited
Hevers, W et al., Mol Neurobiol, 1998, The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes	9824848	10.1007/BF02741459	Cited
Hilf, RJ et al., Nature, 2008, X-ray structure of a prokaryotic pentameric ligand-gated ion channel	18322461	10.1038/nature06717	Cited
Hosie, AM et al., Nature, 2006, Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites	17108970	10.1038/nature05324	Cited
Jansen, M et al., J Neurosci, 2006, State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments	16641228	10.1523/JNEUROSCI.0224-06.2006	Cited
Jechlinger, M et al., J Neurosci, 1998, Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits	9502805	10.1523/JNEUROSCI.18-07-02449.1998	Cited
Jia, F et al., J Neurosci, 2008, Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus	18171928	10.1523/JNEUROSCI.3996-07.2008	Cited
Jurd, R et al., Faseb J, 2003, General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit	12475885	10.1096/fj.02-0611fje	Cited
Korpi, ER et al., Neuroscience, 2002, Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits	11927155	10.1016/s0306-4522(01)00527-9	Cited
Koulen, P et al., Eur J Neurosci, 1998, Synaptic clustering of GABA(C) receptor rho-subunits in the rat retina	9753119	10.1046/j.1460-9568.1998.00005.x	Cited
Li, G-D et al., J. Neurosci, 2006, GABAA receptor anesthetic binding sites identified at subunit interfaces by photolabeling	17093081	10.1523/JNEUROSCI.3467-06.2006	Cited
Liang, J et al., J Neurosci, 2006, Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors	16467523	10.1523/JNEUROSCI.4702-05.2006	Cited
Low, K et al., Science, 2000, Molecular and neuronal substrate for the selective attenuation of anxiety	11021797	10.1126/science.290.5489.131	Cited
Macdonald, RL et al., Annu Rev Neurosci, 1994, GABAA receptor channels	7516126	10.1146/annurev.ne.17.030194.003033	Cited
McClellan, AM et al., J Physiol, 1999, Receptor system response kinetics reveal functional subtypes of native murine and recombinant human GABAA receptors	10066899	10.1111/j.1469-7793.1999.711ab.x	Cited
McKernan, RM et al., Nat Neurosci, 2000, Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype	10816315	10.1038/75761	Cited
Mihic, SJ et al., Nature, 1997, Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors	9311780	10.1038/38738	Cited
Milligan, CJ et al., J Neurosci, 2004, Evidence for inhibition mediated by coassembly of GABAA and GABAC receptor subunits in native central neurons	15317850	10.1523/JNEUROSCI.1979-04.2004	Cited
Mody, I et al., Trends Neurosci, 2004, Diversity of inhibitory neurotransmission through GABA(A) receptors	15331240	10.1016/j.tins.2004.07.002	Cited
Moragues, N et al., Eur J Neurosci, 2000, cDNA cloning and expression of a gamma-aminobutyric acid A receptor epsilon-subunit in rat brain	11122342	—	Cited
Moragues, N et al., Neuroscience, 2002, Localisation of GABA(A) receptor epsilon-subunit in cholinergic and aminergic neurones and evidence for co-distribution with the theta-subunit in rat brain	12031352	10.1016/s0306-4522(02)00033-7	Cited
Mortensen, M et al., J Physiol, 2006, Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons	17023503	10.1113/jphysiol.2006.117952	Cited
Möhler, H, Cell Tissue Res, 2006, GABAA receptor diversity and pharmacology	16937111	10.1007/s00441-006-0284-3	Cited
Nusser, Z et al., Eur J Neurosci, 1995, Immunocytochemical localization of the alpha 1 and beta 2/3 subunits of the GABAA receptor in relation to specific GABAergic synapses in the dentate gyrus	7620614	10.1111/j.1460-9568.1995.tb00667.x	Cited
Nusser, Z et al., J Neurophysiol, 2002, Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells	11976398	10.1152/jn.2002.87.5.2624	Cited
Nusser, Z et al., J Neurosci, 1998, Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells	9464994	10.1523/JNEUROSCI.18-05-01693.1998	Cited
Ogris, W et al., J Neurochem, 2006, Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice	16277610	10.1111/j.1471-4159.2005.03509.x	Cited
Olsen, RW et al., 2008, International Union of Pharmacology. (***) Subtypes of γ-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology, and function	—	—	—
Olsen, RW et al., In GABA in the Nervous System: The View at 50 Years, 2000, Function of GABAA receptors: insights from mutant and knockout mice	—	—	—
Pan, ZH et al., Eur J Neurosci, 2000, Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro	10998097	10.1046/j.1460-9568.2000.00198.x	Cited
Persohn, E et al., J Comp Neurol, 1992, Comparative molecular neuroanatomy of cloned GABAA receptor subunits in the rat CNS	1336019	10.1002/cne.903260204	Cited
Pirker, S et al., Neuroscience, 2000, GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain	11113332	10.1016/s0306-4522(00)00442-5	Cited
Poltl, A et al., J Neurochem, 2003, Subunit composition and quantitative importance of GABAA receptor subtypes in the cerebellum of mouse and rat	14713300	10.1046/j.1471-4159.2003.02135.x	Cited
Reynolds, DS et al., J Neurosci, 2003, Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms	13679430	10.1523/JNEUROSCI.23-24-08608.2003	Cited
Rossi, DJ et al., J Physiol, 2003, Multiple modes of GABAergic inhibition of rat cerebellar granule cells	12588900	10.1113/jphysiol.2002.036459	Cited
Rudolph, U et al., Annu Rev Pharmacol Toxicol, 2004, Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics	14744255	10.1146/annurev.pharmtox.44.101802.121429	Cited
Rudolph, U et al., Nat Rev Neurosci, 2004, Molecular and neuronal substrates for general anaesthetics	15322529	10.1038/nrn1496	Cited
Rudolph, U et al., Nature, 1999, Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes	10548105	10.1038/44579	Cited
Saxena, NC et al., J Neurosci, 1994, Assembly of GABAA receptor subunits: role of the delta subunit	7525894	10.1523/JNEUROSCI.14-11-07077.1994	Cited
Semyanov, A et al., Trends Neurosci, 2004, Tonically active GABAA receptors: modulating gain and maintaining the tone	15111008	10.1016/j.tins.2004.03.005	Cited
Sieghart, W et al., Curr Top Med Chem, 2002, Subunit composition, distribution and function of GABAA receptor subtypes	12171572	10.2174/1568026023393507	Cited
Sieghart, W, Pharmacol Rev, 1995, Structure and pharmacology of γ-aminobutyric acidA receptor subtypes	7568326	—	Cited
Sieghart, W, Trends Pharmacol Sci, 1989, Multiplicity of GABAA--benzodiazepine receptors	2559519	10.1016/0165-6147(89)90189-2	Cited
Sigel, E et al., Trends Pharmacol Sci, 1997, The benzodiazepine binding site of GABAA receptors	9426470	10.1016/s0165-6147(97)01118-8	Cited
Simon, J et al., J Biol Chem, 2004, Analysis of the set of GABA(A) receptor genes in the human genome	15258161	10.1074/jbc.M401354200	Cited
Sine, SM et al., Nature, 2006, Recent advances in Cys-loop receptor structure and function	16554804	10.1038/nature04708	Cited
Smith, GB et al., Trends Pharmacol Sci, 1995, Functional domains of GABAA receptors	7624971	10.1016/s0165-6147(00)89009-4	Cited
Sohal, VS et al., J Neurosci, 2003, Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations	12736336	10.1523/JNEUROSCI.23-09-03649.2003	Cited
Somogyi, P et al., Neuropharmacology, 1996, The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus	9014159	10.1016/s0028-3908(96)00086-x	Cited
Stell, BM et al., Proc Natl Acad Sci U S A, 2003, Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors	14623958	10.1073/pnas.2435457100	Cited
Sternfeld, F et al., J Med Chem, 2004, Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers	15084116	10.1021/jm031076j	Cited
Sur, C et al., Mol Pharmacol, 1998, Rat and human hippocampal alpha5 subunit-containing gamma-aminobutyric AcidA receptors have alpha5 beta3 gamma2 pharmacological characteristics	9804628	10.1124/mol.54.5.928	Cited
Tretter, V et al., J Biol Chem, 2001, Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells	11136737	10.1074/jbc.M011054200	Cited
Tretter, V et al., J Neurosci, 1997, Stoichiometry and assembly of a recombinant GABAA receptor subtype	9092594	10.1523/JNEUROSCI.17-08-02728.1997	Cited
Unwin, N, FEBS Lett, 2003, Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy	14630325	10.1016/s0014-5793(03)01084-6	Cited
Unwin, N, J Mol Biol, 2005, Refined structure of the nicotinic acetylcholine receptor at 4A resolution	15701510	10.1016/j.jmb.2004.12.031	Cited
Wallner, M et al., Proc Natl Acad Sci U S A, 2003, Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans	14625373	10.1073/pnas.2435171100	Cited
Wegelius, K et al., Eur J Neurosci, 1998, Distribution of GABA receptor rho subunit transcripts in the rat brain	9753143	10.1046/j.1460-9568.1998.00023.x	Cited
Whiting, PJ, Curr Opin Pharmacol, 2006, GABA-A receptors: a viable target for novel anxiolytics?	16359919	10.1016/j.coph.2005.08.005	Cited
Wisden, W et al., J Neurosci, 1992, The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon	1312131	10.1523/JNEUROSCI.12-03-01040.1992	Cited
Wohlfarth, KM et al., J Neurosci, 2002, Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit	11880484	10.1523/JNEUROSCI.22-05-01541.2002	Cited
Yamakura, T et al., Annu Rev Pharmacol Toxicol, 2001, Anesthetics and ion channels: molecular models and sites of action	11264449	10.1146/annurev.pharmtox.41.1.23	Cited
Yee, BK et al., Proc Natl Acad Sci U S A, 2005, A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction	16284244	10.1073/pnas.0508752102	Cited

In this knowledge base

Title	Year	PMID
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	2019	30087005
Examining the effects of alcohol on GABA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells.	2018	29156239
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.	2015	26250693
The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress.	2009	19455309

External

Title	Authors	Journal	Year	Link
Effect of perioperative preemptive analgesia on hippocampal GABAA receptor α1/α5 balance in aged mild cognitive impairment rats.	Ren H et al.	—	2026	→
Exploring the DS2 Scaffold for GABA<sub>A</sub> Receptor Modulation: Progress toward the Development of a GABA<sub>A</sub> δ-Subunit Preferring Negative Allosteric Modulator.	Jensen NN et al.	—	2026	→
Impact of Anesthesia With Propofol on Epileptic Discharges Recorded by Stereo-Electroencephalography in Pediatric Epilepsy Surgery.	Liu C et al.	—	2026	→
Multisession epidural direct current stimulation of the auditory cortex mitigates age-related transcriptomic dysregulation in Wistar rats.	Fernández Del Campo IS et al.	—	2026	→
Neuronal Inhibition in Epilepsy: Native Human GABA-A Receptors and Pharmacological Chaperones Restoring Expression of Disease Associated Variants.	Durisic N et al.	—	2026	→
Neurotransmitters: Key regulators of the tumor immune microenvironment.	Zhang L et al.	—	2026	→
Sevoflurane alters α5β3GABA<sub>A</sub> receptor trafficking via calcium/calmodulin-dependent protein kinase II-dependent β3 subunit phosphorylation to produce cognitive impairment in aged mice.	Wan T et al.	—	2026	→
Targeting γ-aminobutyric acid type A receptors to mitigate perioperative neurocognitive disorders: a narrative review.	Ba J et al.	—	2026	→
The β-amyloid-induced increased tonic conductance, impaired long-term potentiation and cognitive deficits characteristic of Alzheimer's disease are reversed by an α5 inverse agonist of the GABA type A receptor.	O'Connell A et al.	—	2026	→
Zornia Latifolia as an emerging orphan medicinal plant: Molecular pharmacology, bioactive scaffolds and prospects for drug discovery.	Bonifacio D et al.	—	2026	→
A Comparison of Positive and Negative Allosteric Modulators of α5-Containing GABA<sub>A</sub> Receptors in the Treatment of Affective Disease.	Troppoli TA et al.	—	2025	→
Application of in silico methods to predict the acute toxicity of bicyclic organophosphorus compounds as potential chemical weapon.	Noga M et al.	—	2025	→
Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.	Moe JS et al.	—	2025	→
Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABA<sub>A</sub>R subsynaptic reorganization.	Chapman CA et al.	—	2025	→
Clinical characterisation of the novel benzodiazepine bromazolam-data from the ASSIST (A Surveillance Study of Illicit Substance Toxicity) study.	Dunlop LC et al.	—	2025	→
Comparative electrophysiological study of neuroactive steroid-induced hypnosis in mice: sex and drug-specific differences.	Martin A et al.	—	2025	→
Cryo-EM structures of ρ1 GABA<sub>A</sub> receptors with antagonist and agonist drugs.	Fan C et al.	—	2025	→
Decoding the structural and functional diversity of GABA<sub>A</sub> receptors: from ensemble logic to therapeutic opportunities.	Treviño M et al.	—	2025	→
Dynamic and Homeostatic Neuron-Astrocyte Interactions at GABAergic Synapses.	Clarke D et al.	—	2025	→
Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents.	Mazza F et al.	—	2025	→
ENX-101, a GABA<sub>A</sub> receptor α2,3,5-selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models.	Serrats J et al.	—	2025	→
Epigenetic insights into physiological resilience: Multigenerational readouts of CO<sub>2</sub>-induced seawater acidification effects on fish embryos.	Liu TY et al.	—	2025	→
Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABA<sub>A</sub> receptor compounds.	Reeves-Darby JA et al.	—	2025	→
Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights.	Bishwas D et al.	—	2025	→
Failure of intravenous flumazenil to antagonize alfaxalone anesthesia in cats.	Kloft HM et al.	—	2025	→
From bugs to brain: unravelling the GABA signalling networks in the brain-gut-microbiome axis.	Belelli D et al.	—	2025	→
From Discovery to Innovative Translational Approaches in 80 Years of Fragile X Syndrome Research.	van der Lei MB et al.	—	2025	→
Functional and molecular insights into muscle proprioceptors.	Lallemend F et al.	—	2025	→
GABA<sub>A</sub> receptor π forms channels that stimulate ERK through a G-protein-dependent pathway.	Wang Y et al.	—	2025	→
GABRA2-related encephalopathy: Identification of two phenotypes with distinctive electroclinical features.	Adamo-Croux M et al.	—	2025	→
Gamma-aminobutyric acid and glutamate system dysregulation in a small population of Egyptian children with autism spectrum disorder.	Meguid N et al.	—	2025	→
Genetic and Epigenetic Approaches to Opioid Use Disorder.	Ranadeva ND et al.	—	2025	→
Inferred developmental origins of brain tumors from single-cell RNA-sequencing data.	Wang S et al.	—	2025	→
Iridium-Catalyzed Direct and Site-Selective C-H Heteroarylation, Alkenylation, and Alkylation of Indoles.	Cao T et al.	—	2025	→
Ligand Binding and Functional Effect of Novel Bicyclic α5 GABA<sub>A</sub> Receptor Negative Allosteric Modulators.	Krámos B et al.	—	2025	→
Orphan Three-Finger Toxins from Snake Venoms: Unexplored Library of Novel Biological Ligands with Potential New Structures and Functions.	Koh CY et al.	—	2025	→
Paired Pulse Suppression and Prepulse Inhibition in Patients with Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.	Suzuki D et al.	—	2025	→
Peripheral cyclical expression of GABA-A receptor subunit genes and menstrual cycle affective change: a dimensional, transdiagnostic study.	Barone JC et al.	—	2025	→
Peripheral GABA<sub>A</sub> receptors - Physiological relevance and therapeutic implications.	Gajić Bojić M et al.	—	2025	→
Progesterone attenuates the effects of cocaine on hypermobility and dopaminergic transmission in the nucleus accumbens.	Sánchez WN et al.	—	2025	→
Proteostasis regulation of GABA<sub>A</sub> receptors in neuronal function and disease.	Chen X et al.	—	2025	→
Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors.	Rosas-Arellano A	—	2025	→
Release your inhibitions: The cell biology of GABAergic postsynaptic plasticity.	Welle TM et al.	—	2025	→
Resolving native GABA<sub>A</sub> receptor structures from the human brain.	Zhou J et al.	—	2025	→
Selectively counteracting cerebellar adaptations to chronic alcohol exposure reduces acute alcohol withdrawal severity in C57BL6/N mice.	McLean NA et al.	—	2025	→
Sleep Aid Effect and Mechanism of Semen Zizyphi Spinosae Extract Enriched With Jujuboside and Jujubogenin in Sleep-Deprived Zebrafish.	Wang W et al.	—	2025	→
Status epilepticus: Updates on mechanisms and treatments.	Joshi S et al.	—	2025	→
Synthesis and Evaluation of a Novel Zuranolone Analog with High GABA<sub>A</sub> Receptor PAM Activity and Excellent Pharmacokinetic Profiles.	Yang Y et al.	—	2025	→
Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis.	Lambiase C et al.	—	2025	→
The Role of Nanotechnology in Understanding the Pathophysiology of Traumatic Brain Injury.	Selvaraj S et al.	—	2025	→
The Serotonergic Dorsal Raphe Promotes Emergence from Propofol Anesthesia in Zebrafish.	Yang X et al.	—	2025	→
Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics.	Ecker C et al.	—	2025	→
A bupropion modulatory site in the Gloeobacter violaceus ligand-gated ion channel.	Do HQ et al.	—	2024	→
Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment.	Bäckström T et al.	—	2024	→
A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules.	McCarroll MN et al.	—	2024	→
An alpha 5-GABA<sub>A</sub> receptor positive allosteric modulator attenuates social and cognitive deficits without changing dopamine system hyperactivity in rats exposed to valproic acid in utero.	Souza AJ et al.	—	2024	→
An Update on Stiripentol Mechanisms of Action: A Narrative Review.	Bacq A et al.	—	2024	→
ANXIOLYTICS: Origins, drug discovery, and mechanisms.	Witkin JM et al.	—	2024	→
Chemogenetic Modulation of Preoptic <i>Gabre</i> Neurons Decreases Body Temperature and Heart Rate.	Wang Z et al.	—	2024	→
Clinical applications of small-molecule GABA<sub>A</sub>R modulators for neurological disorders.	Chen G et al.	—	2024	→
COMPARISON OF THREE MIDAZOLAM-BASED SEDATION PROTOCOLS IN BUDGERIGARS (<i>MELOPSITTACUS UNDULATUS</i>) AND BLACK-CHEEKED LOVEBIRDS (<i>AGAPORNIS NIGRIGENIS</i>).	Abreu SA et al.	—	2024	→
Crosstalk between GABA<sub>A</sub> receptors in astrocytes and neurons triggered by general anesthetic drugs.	Wang DS et al.	—	2024	→
Discovering the Intriguing Properties of Extrasynaptic γ-Aminobutyric Acid Type A Receptors.	Orser BA	—	2024	→
Distribution of gamma-aminobutyric acid immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri): Comparison with other fishes.	Anadón R et al.	—	2024	→
Established and emerging GABA<sub>A</sub> receptor pharmacotherapy for epilepsy.	Richardson RJ et al.	—	2024	→
Estradiol modulates the role of the spinal α<sub>6</sub>-subunit containing GABA<sub>A</sub> receptors in female rats with neuropathic pain.	Rodríguez-Palma EJ et al.	—	2024	→
Extrasynaptic localization is essential for α5GABA<sub>A</sub> receptor modulation of dopamine system function.	McCoy AM et al.	—	2024	→
GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors.	Bhattacharya D et al.	—	2024	→
GABAA Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study.	Steinholtz L et al.	—	2024	→
GABA<sub>A</sub> receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis.	Sui Y et al.	—	2024	→
GABA-mediated inhibition of human CD4<sup>+</sup> T cell functions is enhanced by insulin but impaired by high glucose levels.	Jin Z et al.	—	2024	→
GABA<sub>A</sub> receptors in epilepsy: Elucidating phenotypic divergence through functional analysis of genetic variants.	Absalom NL et al.	—	2024	→
Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum.	Wang YJ et al.	—	2024	→
Identification of neural-relevant toxcast high-throughput assay intended gene targets: Applicability to neurotoxicity and neurotoxicant putative molecular initiating events.	Mack CM et al.	—	2024	→
Insights and progress on the biosynthesis, metabolism, and physiological functions of gamma-aminobutyric acid (GABA): a review.	Zhang Q et al.	—	2024	→
Integrated workflow for the identification of new GABA<sub>A</sub> R positive allosteric modulators based on the in silico screening with further in vitro validation. Case study using Enamine's stock chemical space.	Platonov M et al.	—	2024	→
In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth.	Zhang S et al.	—	2024	→
Mapping GABAergic projections that mediate feeding.	Wang J et al.	—	2024	→
MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons.	Sharma B et al.	—	2024	→
New Insights Into Pharmacology of GABAA Receptor Alpha Subunits-Selective Modulators.	Moraru MV et al.	—	2024	→
Nonsedating anxiolytics.	Cerne R et al.	—	2024	→
Oxytocin Exhibits Neuroprotective Effects on Hippocampal Cultures under Severe Oxygen-Glucose Deprivation Conditions.	Ionescu MI et al.	—	2024	→
PET imaging of GABA<sub>A</sub> receptors in pancreatic islets by [<sup>11</sup>C]flumazenil.	Maloum-Rami F et al.	—	2024	→
Phenols and GABA<sub>A</sub> receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae.	Menzikov SA et al.	—	2024	→
Reducing the harms of alcohol: nutritional interventions and functional alcohol alternatives.	Belelli D et al.	—	2024	→
Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression.	Bundy J et al.	—	2024	→
SIADH and mixed delirium following the abrupt cessation of long-acting benzodiazepines: a case report.	Alenezi AF et al.	—	2024	→
Structural Basis for Molecular Recognition of Cannabinoids by Inhibitory Cys-Loop Channels.	Alvarez LD et al.	—	2024	→
Structural insights into GABA<sub>A</sub> receptor potentiation by Quaalude.	Chojnacka W et al.	—	2024	→
Structure-function and pharmacologic aspects of ion channels relevant to neurologic channelopathies.	Mӓnnikkӧ R et al.	—	2024	→
Synergistic effect between citalopram and muscimol upon induction of anxiolytic- and antidepressant-like effects in male mice: An isobologram analysis.	Amini E et al.	—	2024	→
"Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression.	Bortolato M et al.	—	2024	→
What Is the Role of the "GABA Tone" in Normal and Pathological Conditions?	Benarroch E	—	2024	→
Ablation of <i>Gabra5</i> Influences Corticosterone Levels and Anxiety-like Behavior in Mice.	Syding LA et al.	—	2023	→
Activation of α 6 -containing GABA A receptors induces antinociception under physiological and pathological conditions.	Rodríguez-Palma EJ et al.	—	2023	→
Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function.	Cramer TML et al.	—	2023	→
Advances in understanding the pathogenesis of post-traumatic epilepsy: a literature review.	Fang M et al.	—	2023	→
A neolignan from Connarus tuberosus as an allosteric GABA<sub>A</sub> receptor modulator at the neurosteroid binding site.	Faleschini T et al.	—	2023	→
A Review of Neuroreceptors for Clinical and Experimental Neuropharmacology in Central Nervous System Disorders.	McKarns SC	—	2023	→
Association of GABA receptor delta subunit gene variations with increased risk of methamphetamine dependence.	Xie X et al.	—	2023	→
Brain Region Differences in α1- and α5-Subunit-Containing GABA<sub>A</sub> Receptor Proteomes Revealed with Affinity Purification and Blue Native PAGE Proteomics.	Chen M et al.	—	2023	→
CGP7930 - An allosteric modulator of GABA<sub>B</sub>Rs, GABA<sub>A</sub>Rs and inwardly-rectifying potassium channels.	Hannan SB et al.	—	2023	→
Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABA<sub>A</sub> Receptor Point Mutations.	Abdulzahir A et al.	—	2023	→
Chloride transporters controlling neuronal excitability.	Pressey JC et al.	—	2023	→
Clptm1, a new target in suppressing epileptic seizure by regulating GABA<sub>A</sub> R-mediated inhibitory synaptic transmission in a PTZ-induced epilepsy model.	Zhang XL et al.	—	2023	→
DARK Classics in Chemical Neuroscience: Methaqualone.	Inger JA et al.	—	2023	→
Designer Benzodiazepines: Effects, Toxicity, and Interactions.	El Balkhi S et al.	—	2023	→
Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer's disease.	Carrero L et al.	—	2023	→
Functional properties of GABA<sub>A</sub> receptors of AII amacrine cells of the rat retina.	Beltrán-Matas P et al.	—	2023	→
Fundamental Neurochemistry Review: GABA<sub>A</sub> receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy.	Bryson A et al.	—	2023	→
GABAergic signaling as a potential therapeutic target in cancers.	Yang Y et al.	—	2023	→
GABAergic signaling beyond synapses: an emerging target for cancer therapy.	Huang et al.	—	2023	→
GABA tone regulation and its cognitive functions in the brain.	Koh W et al.	—	2023	→
Gamma-aminobutyric acid type A receptor alpha 4 coordinates autophagy, inflammation, and immunometabolism to promote innate immune activation.	Kim JK et al.	—	2023	→
General anesthetic binding mode via hydration with weak affinity and molecular discrimination: General anesthetic dissolution in interfacial water of the common binding site of GABA<sub>A</sub> receptor.	Seto T	—	2023	→
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) causes seizure activity in larval zebrafish via antagonism of γ-aminobutyric acid type A receptor α1β2γ2.	Mundy PC et al.	—	2023	→
Impact of Developmental Changes of GABA<sub>A</sub> Receptors on Interneuron-NG2 Glia Transmission in the Hippocampus.	Patt L et al.	—	2023	→
Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain.	Lorenz-Guertin JM et al.	—	2023	→
Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury.	Saruta K et al.	—	2023	→
Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition.	Nuwer JL et al.	—	2023	→
Navigating the complex landscape of benzodiazepine- and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond.	Koniuszewski F et al.	—	2023	→
Novel imidazo[1,5-a]quinoxaline derivatives: SAR, selectivity and modeling challenges en route to the identification of an α5-GABAA receptor NAM.	Károlyi BI et al.	—	2023	→
Pathophysiological Effects of Autoantibodies in Autoimmune Encephalitides.	Ryding M et al.	—	2023	→
Pregnenolone sulfate analogues differentially modulate GABA<sub>A</sub> receptor closed/desensitised states.	Mortensen M et al.	—	2023	→
Synthesis and Receptor Binding Studies of α5 GABA<sub>A</sub>R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders.	Sharmin D et al.	—	2023	→
The GABA and GABA-Receptor System in Inflammation, Anti-Tumor Immune Responses, and COVID-19.	Tian J et al.	—	2023	→
The GABA system, a new target for medications against cognitive impairment-Associated with neuroactive steroids.	Bäckström T et al.	—	2023	→
The potential role of astroglial GABA<sub>A</sub> receptors in autoimmune encephalitis associated with GABA<sub>A</sub> receptor antibodies and seizures.	Ismail FS et al.	—	2023	→
Transcriptional and bioinformatic analysis of GABA<sub>A</sub> receptors expressed in oligodendrocyte progenitor cells from the human brain.	Gutierrez BA et al.	—	2023	→
Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder.	Cutler AJ et al.	—	2023	→
Abnormal Expression of Synaptic and Extrasynaptic GABA<sub>A</sub> Receptor Subunits in the Dystrophin-Deficient <i>mdx</i> Mouse.	Zarrouki F et al.	—	2022	→
A developmental reduction of the excitation:inhibition ratio in association cortex during adolescence.	Larsen B et al.	—	2022	→
Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence.	Zavala-Tecuapetla C et al.	—	2022	→
A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice.	Tian J et al.	—	2022	→
Analyzing the mechanisms that facilitate the subtype-specific assembly of <i>γ</i>-aminobutyric acid type A receptors.	Choi C et al.	—	2022	→
Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABA<sub>A</sub> receptor.	Kuanyshbek A et al.	—	2022	→
Astrocytes: GABAceptive and GABAergic Cells in the Brain.	Liu J et al.	—	2022	→
Can GABAkines quiet the noise? The GABA<sub>A</sub> receptor neurobiology and pharmacology of tinnitus.	Witkin JM et al.	—	2022	→
Circuits and components of delta wave regulation.	Uygun DS et al.	—	2022	→
CO2 induced seawater acidification impacts survival and development of European eel embryos.	Sganga DE et al.	—	2022	→
Different Peas in the Same Pod: The Histaminergic Neuronal Heterogeneity.	Provensi G et al.	—	2022	→
Evaluation of site-selective drug effects on GABA receptors using nanovesicle-carbon nanotube hybrid devices.	Park I et al.	—	2022	→
GABA facilitates spike propagation through branch points of sensory axons in the spinal cord.	Hari K et al.	—	2022	→
GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABA<sub>A</sub> receptors.	Cerne R et al.	—	2022	→
GABA<sub>A</sub> Receptor Autoantibodies Decrease GABAergic Synaptic Transmission in the Hippocampal CA3 Network.	Menke AF et al.	—	2022	→
GABRG1 variant as a potential novel cause of epileptic encephalopathy, hypotonia, and global developmental delay.	Williams A et al.	—	2022	→
<i>Combretum lanceolatum</i> extract reverses anxiety and seizure behavior in adult zebrafish through GABAergic neurotransmission: an <i>in vivo and in silico</i> study.	da Silva AW et al.	—	2022	→
Interrogating the function of GABA<sub>A</sub> receptors in the brain with optogenetic pharmacology.	Kramer RH et al.	—	2022	→
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App<sup>NL-G-F/NL-G-F</sup> mice.	Emre C et al.	—	2022	→
Knockdown of GABA<sub>A</sub> alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice.	Uygun DS et al.	—	2022	→
Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether.	De Rosa R et al.	—	2022	→
Median raphe region GABAergic neurons contribute to social interest in mouse.	Chaves T et al.	—	2022	→
Molecular Pathophysiological Mechanisms in Huntington's Disease.	Jurcau A	—	2022	→
Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABA<sub>A</sub> Receptor Negative Allosteric Modulators.	Szabó G et al.	—	2022	→
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy.	Gatta E et al.	—	2022	→
Polycystic Ovary Syndrome and the Neuroendocrine Consequences of Androgen Excess.	Silva MSB et al.	—	2022	→
Positive Allosteric Modulation of α5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle.	McCoy AM et al.	—	2022	→
Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway.	Heli Z et al.	—	2022	→
Relating neurosteroid modulation of inhibitory neurotransmission to behaviour.	Belelli D et al.	—	2022	→
Sevoflurane Ameliorates Schizophrenia in a Mouse Model and Patients: A Pre-Clinical and Clinical Feasibility Study.	Zhao T et al.	—	2022	→
Shisa7-Dependent Regulation of GABA<sub>A</sub> Receptor Single-Channel Gating Kinetics.	Castellano D et al.	—	2022	→
Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors.	Wu K et al.	—	2022	→
Stereological estimations and neurochemical characterization of neurons expressing GABAA and GABAB receptors in the rat pedunculopontine and laterodorsal tegmental nuclei.	Luquin E et al.	—	2022	→
Synthesis of novel thiazolidinic-phthalimide derivatives evaluated as new multi-target antiepileptic agents.	de Oliveira MCVA et al.	—	2022	→
Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future.	Manzella FM et al.	—	2022	→
Systemic LPS-induced microglial activation results in increased GABAergic tone: A mechanism of protection against neuroinflammation in the medial prefrontal cortex in mice.	Jiang J et al.	—	2022	→
Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder.	Fish KN et al.	—	2022	→
The Development of GABAergic Network in Depression in Recent 17 Years: A Visual Analysis Based on CiteSpace and VOSviewer.	Lin J et al.	—	2022	→
The role of GABA in islet function.	Hagan DW et al.	—	2022	→
The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABA<sub>A</sub> receptor.	Pressly B et al.	—	2022	→
Virally-induced expression of GABA<sub>A</sub> receptor δ subunits following their pathological loss reveals their role in regulating GABA<sub>A</sub> receptor assembly.	Sun Y et al.	—	2022	→
Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus.	Burman RJ et al.	—	2022	→
β subunits of GABA<sub>A</sub> receptors form proton-gated chloride channels: Insights into the molecular basis.	Garifulina A et al.	—	2022	→
Basmisanil, a highly selective GABA<sub>A</sub>-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.	Hipp JF et al.	—	2021	→
Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect.	Griessner J et al.	—	2021	→
Characterization of Source-Localized EEG Activity During Sustained Deep-Tissue Pain.	Völker JM et al.	—	2021	→
Characterization of the Functional Cross-Talk between Surface GABA<sub>A</sub> and Dopamine D5 Receptors.	Maingret F et al.	—	2021	→
Decreased abundance of Akkermansia after adrenocorticotropic hormone therapy in patients with West syndrome.	Xu L et al.	—	2021	→
Diazepam Impairs Innate and Adaptive Immune Responses and Ameliorates Experimental Autoimmune Encephalomyelitis.	Falcón CR et al.	—	2021	→
Diurnal properties of tonic and synaptic GABA<sub>A</sub> receptor-mediated currents in suprachiasmatic nucleus neurons.	Moldavan M et al.	—	2021	→
Electrophysiology of ionotropic GABA receptors.	Sallard E et al.	—	2021	→
Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Ca<sub>v</sub>3.2 T-type voltage-gated calcium channel.	Arshaad MI et al.	—	2021	→
Eszopiclone and Zolpidem Produce Opposite Effects on Hippocampal Ripple Density.	Becker LA et al.	—	2021	→
Femoral blood concentrations of the designer benzodiazepine etizolam in post-mortem cases.	Hikin LJ et al.	—	2021	→
Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity.	Warm D et al.	—	2021	→
GABA<sub>A</sub>-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice.	Tian J et al.	—	2021	→
GABA<sub>A</sub> receptors in GtoPdb v.2021.3.	Belelli D et al.	—	2021	→
GABA<sub>A</sub> receptors: structure, function, pharmacology, and related disorders.	Ghit A et al.	—	2021	→
GABA<sub>A</sub> Receptor Subunit Composition Drives Its Sensitivity to the Insecticide Fipronil.	Soualah Z et al.	—	2021	→
GABA<sub>A</sub> receptor β<sub>1</sub> -subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep.	Lie MEK et al.	—	2021	→
GABA<sub>B</sub>-Receptor Agonist-Based Immunotherapy for Type 1 Diabetes in NOD Mice.	Tian J et al.	—	2021	→
Gamma-Aminobutyric Acid (GABA) Inhibits α-Melanocyte-Stimulating Hormone-Induced Melanogenesis through GABA<sub>A</sub> and GABA<sub>B</sub> Receptors.	Molagoda IMN et al.	—	2021	→
Genetic Code Expansion and Click-Chemistry Labeling to Visualize GABA-A Receptors by Super-Resolution Microscopy.	Kuhlemann A et al.	—	2021	→
Hemiconvulsion-hemiplegia-epilepsy syndrome with 5q33.3q34 microdeletion: Causal or chance association.	Xue J et al.	—	2021	→
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank.	Li F et al.	—	2021	→
Hippocampal β2-GABA<sub>A</sub> receptors mediate LTP suppression by etomidate and contribute to long-lasting feedback but not feedforward inhibition of pyramidal neurons.	Figueroa AG et al.	—	2021	→
Inhibition of microRNA-129-2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1.	Wang GY et al.	—	2021	→
Lighting Up the Plasma Membrane: Development and Applications of Fluorescent Ligands for Transmembrane Proteins.	Borgarelli C et al.	—	2021	→
Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.	Richardson BD et al.	—	2021	→
Mice Lacking GABA<sub>A</sub> Receptor <i>δ</i> Subunit Have Altered Pharmaco-EEG Responses to Multiple Drugs.	Grotell M et al.	—	2021	→
Modelling the functional roles of synaptic and extra-synaptic γ-aminobutyric acid receptor dynamics in circadian timekeeping.	Sueviriyapan N et al.	—	2021	→
Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1.	Kickinger S et al.	—	2021	→
Natural Products for Neurodegeneration: Regulating Neurotrophic Signals.	Uddin MS et al.	—	2021	→
Nelumbo nucifera promotes non-rapid eye movement sleep by regulating GABAergic receptors in rat model.	Jo K et al.	—	2021	→
Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice.	Li X et al.	—	2021	→
Neurobiology of alcohol seeking behavior.	Domi E et al.	—	2021	→
Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management.	Gros M et al.	—	2021	→
Photopharmacology of Ion Channels through the Light of the Computational Microscope.	Nin-Hill A et al.	—	2021	→
Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine.	Manna SSS	—	2021	→
Progesterone modulates neuronal excitability bidirectionally.	Kapur J et al.	—	2021	→
'Proximity frequencies' a new parameter to evaluate the profile of GABA<sub>A</sub>R modulators.	Crocetti L et al.	—	2021	→
Regulation of GABA<sub>A</sub>Rs by Transmembrane Accessory Proteins.	Han W et al.	—	2021	→
Rosmarinic Acid, a Bioactive Phenolic Compound, Inhibits Glutamate Release from Rat Cerebrocortical Synaptosomes through GABA<sub>A</sub> Receptor Activation.	Wang CC et al.	—	2021	→
Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA<sub>A</sub> receptor: In vitro and in vivo studies.	McGrath M et al.	—	2021	→
Sesquiterpenes and sesquiterpenoids harbor modulatory allosteric potential and affect inhibitory GABA<sub>A</sub> receptor function in vitro.	Janzen D et al.	—	2021	→
Sex specific correlation between GABAergic disruption in the dorsal hippocampus and flurothyl seizure susceptibility after neonatal hypoxic-ischemic brain injury.	Lechner CR et al.	—	2021	→
Stigmasterol can be new steroidal drug for neurological disorders: Evidence of the GABAergic mechanism via receptor modulation.	Karim N et al.	—	2021	→
Structural basis of GABARAP-mediated GABA<sub>A</sub> receptor trafficking and functions on GABAergic synaptic transmission.	Ye J et al.	—	2021	→
Structural determinants and regulation of spontaneous activity in GABA<sub>A</sub> receptors.	Sexton CA et al.	—	2021	→
Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.	Nuwer JL et al.	—	2021	→
The effect of GABA-B receptors in the basolateral amygdala on passive avoidance memory impairment induced by MK-801 in rats.	Khakpoor M et al.	—	2021	→
The Effects of General Anaesthesia and Light on Behavioural Rhythms and GABA<sub>A</sub> Receptor Subunit Expression in the Mouse SCN.	Chong J et al.	—	2021	→
The efficacy of γ-aminobutyric acid type A receptor (GABA <sub>A</sub>R) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation.	Mundy PC et al.	—	2021	→
The STARS Phase 2 Study: A Randomized Controlled Trial of Gaboxadol in Angelman Syndrome.	Bird LM et al.	—	2021	→
The α3 subunit of GABA<sub>A</sub> receptors promotes formation of inhibitory synapses in the absence of collybistin.	Wagner S et al.	—	2021	→
Transcriptome comparative analysis of ovarian follicles reveals the key genes and signaling pathways implicated in hen egg production.	Sun X et al.	—	2021	→
Allopregnanolone Enhances GABAergic Inhibition in Spinal Motor Networks.	Drexler B et al.	—	2020	→
A potent photoreactive general anesthetic with novel binding site selectivity for GABA<sub>A</sub> receptors.	Shalabi AR et al.	—	2020	→
A Targeted Bioinformatics Assessment of Adrenocortical Carcinoma Reveals Prognostic Implications of GABA System Gene Expression.	Knott EL et al.	—	2020	→
Branching points of primary afferent fibers are vital for the modulation of fiber excitability by epidural DC polarization and by GABA in the rat spinal cord.	Li Y et al.	—	2020	→
Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord.	Hughes DI et al.	—	2020	→
Contribution of GABA<sub>A</sub> receptor subunits to attention and social behavior.	Paine TA et al.	—	2020	→
Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.	Di Capua A et al.	—	2020	→
Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABA<sub>A</sub> receptors.	Tikhonova TA et al.	—	2020	→
Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA<sub>A</sub> receptors.	Falk-Petersen CB et al.	—	2020	→
GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?	Bengtsson SKS et al.	—	2020	→
GABA<sub>A</sub>R isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation.	Hannan S et al.	—	2020	→
GABA<sub>A</sub> receptor subtype modulators in medicinal chemistry: an updated patent review (2014-present).	Crocetti L et al.	—	2020	→
Gimmicks of gamma-aminobutyric acid (GABA) in pancreatic β-cell regeneration through transdifferentiation of pancreatic α- to β-cells.	Yi Z et al.	—	2020	→
Heterogeneous expression of GABA receptor-like subunits LCCH3 and GRD reveals functional diversity of GABA receptors in the honeybee Apis mellifera.	Henry C et al.	—	2020	→
Immunohistochemical distribution of 10 GABA<sub>A</sub> receptor subunits in the forebrain of the rhesus monkey Macaca mulatta.	Sperk G et al.	—	2020	→
Inactivation of the Ventral Pallidum by GABA<sub>A</sub> Receptor Agonist Promotes Non-rapid Eye Movement Sleep in Rats.	Zhang X et al.	—	2020	→
Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics.	Obal D et al.	—	2020	→
Isoflurane Potentiation of GABA<sub>A</sub> Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation.	Lor C et al.	—	2020	→
Lipid-based nanodelivery approaches for dopamine-replacement therapies in Parkinson's disease: From preclinical to translational studies.	Karthivashan G et al.	—	2020	→
Looking for Novelty in an "Old" Receptor: Recent Advances Toward Our Understanding of GABA<sub>A</sub>Rs and Their Implications in Receptor Pharmacology.	Castellano D et al.	—	2020	→
Mechanisms of action of currently used antiseizure drugs.	Sills GJ et al.	—	2020	→
Paroxysmal Discharges in Tissue Slices From Pediatric Epilepsy Surgery Patients: Critical Role of GABA<sub>B</sub> Receptors in the Generation of Ictal Activity.	Levinson S et al.	—	2020	→
Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α<sub>1</sub>β<sub>2</sub>γ<sub>2L</sub> GABA<sub>A</sub> receptor and spontaneous neuronal network function in vitro.	Tukker AM et al.	—	2020	→
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA<sub>A</sub> receptor positive allosteric modulator.	Althaus AL et al.	—	2020	→
Prenatal stress increased γ2 GABAA receptor subunit gene expression in hippocampus and potentiated pentylenetetrazol-induced seizure in rats.	Bagheri M et al.	—	2020	→
Realising the therapeutic potential of neuroactive steroid modulators of the GABA<sub>A</sub> receptor.	Belelli D et al.	—	2020	→
Regional transcriptome analysis of AMPA and GABA<sub>A</sub> receptor subunit expression generates E/I signatures of the human brain.	Shen K et al.	—	2020	→
Role of GABRD Gene Methylation in the Nucleus Accumbens in Heroin-Seeking Behavior in Rats.	Hong Q et al.	—	2020	→
Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats.	Gáll Z et al.	—	2020	→
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.	Christian CA et al.	—	2020	→
Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABA<sub>A</sub> Receptors.	Fabjan J et al.	—	2020	→
Subregional differences in GABA<sub>A</sub> receptor subunit expression in the rostral ventrolateral medulla of sedentary versus physically active rats.	Mueller PJ et al.	—	2020	→
The Effects of pH on the Structure and Bioavailability of Imidazobenzodiazepine-3-Carboxylate MIDD0301.	Roni MSR et al.	—	2020	→
Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome.	Rueda N et al.	—	2020	→
Activity-dependent development of GABAergic synapses.	Oh WC et al.	—	2019	→
A half century of γ-aminobutyric acid.	Smart TG et al.	—	2019	→
A structural perspective on GABA<sub>A</sub> receptor pharmacology.	Scott S et al.	—	2019	→
Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model.	Fujii M et al.	—	2019	→
Cryo-EM structure of the human α1β3γ2 GABA<sub>A</sub> receptor in a lipid bilayer.	Laverty D et al.	—	2019	→
CSF reactivity in GABA<sub>A</sub> receptor antibody encephalitis - Immunocytochemical distribution in the murine brain.	Nikolaus M et al.	—	2019	→
Current Opinions and Consensus for Studying Tremor in Animal Models.	Kuo SH et al.	—	2019	→
Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers.	Bhandage AK et al.	—	2019	→
Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA<sub>A</sub>) Receptor Modulators.	Stadler M et al.	—	2019	→
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.	Krall J et al.	—	2019	→
Dopaminergic-GABAergic interplay and alcohol binge drinking.	Leggio GM et al.	—	2019	→
Down syndrome: Neurobiological alterations and therapeutic targets.	Vacca RA et al.	—	2019	→
Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits.	Yang X et al.	—	2019	→
Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam.	Moerke MJ et al.	—	2019	→
Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA<sub>A</sub> receptors.	Limon A et al.	—	2019	→
GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators.	Solomon VR et al.	—	2019	→
GABA(A) receptor-targeted drug development -New perspectives in perioperative anesthesia.	Antkowiak B et al.	—	2019	→
GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.	Untereiner A et al.	—	2019	→
GABA<sub>A</sub> Receptors Are Well Preserved in the Hippocampus of Aged Mice.	Palpagama TH et al.	—	2019	→
Gender-dependent regulation of anxiety-like behavior by δ subunit-containing GABAA receptor during postnatal development.	He Y et al.	—	2019	→
Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABA<sub>A</sub>R subunits.	Sequeira A et al.	—	2019	→
Identification of a functional non-coding variant in the GABA<sub>A</sub> receptor α2 subunit of the C57BL/6J mouse reference genome: Major implications for neuroscience research	Mulligan MK et al.	—	2019	—
Identification of a Functional Non-coding Variant in the GABA <sub><i>A</i></sub> Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research.	Mulligan MK et al.	—	2019	→
Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.	Wu B et al.	—	2019	→
Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats.	Zhao ZF et al.	—	2019	→
In Search of GABA<sub>A</sub> Receptor's Neurosteroid Binding Sites.	Alvarez LD et al.	—	2019	→
Involvement of the GABA<sub>A</sub> receptor α subunit in the mode of action of etifoxine.	Mattei C et al.	—	2019	→
Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington's Disease Mice.	Holley SM et al.	—	2019	→
MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABA<sub>A</sub> receptors without causing systemic immune suppression.	Zahn NM et al.	—	2019	→
Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant <i>α</i>1<i>β</i>3<i>γ</i>2L GABA<sub>A</sub> Receptors Indicates Selectivity and Crosstalk among Intersubunit Transmembrane Anesthetic Sites.	Szabo A et al.	—	2019	→
Multiple actions of fenamates and other nonsteroidal anti-inflammatory drugs on GABA<sub>A</sub> receptors.	Mansikkamäki S et al.	—	2019	→
Multiple functional neurosteroid binding sites on GABAA receptors.	Chen ZW et al.	—	2019	→
Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors.	Jacob TC	—	2019	→
Neurosteroid regulation of GABA<sub>A</sub> receptors: A role in catamenial epilepsy.	Joshi S et al.	—	2019	→
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond.	Zorumski CF et al.	—	2019	→
Novel GABRA2 variants in epileptic encephalopathy and intellectual disability with seizures.	Maljevic S et al.	—	2019	→
Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders.	Sartori SB et al.	—	2019	→
Prenatal stress and elevated seizure susceptibility: Molecular inheritable changes.	Saboory E et al.	—	2019	→
Resilience and Vulnerability to Trauma: Early Life Interventions Modulate Aversive Memory Reconsolidation in the Dorsal Hippocampus.	Couto-Pereira NS et al.	—	2019	→
Selective stimulation of central GABA<sub>A</sub>α2,3,5 receptors increases intake and motivation to consume sucrose solution in rats.	Nelson TS et al.	—	2019	→
Sex- and age-related changes in GABA signaling components in the human cortex.	Pandya M et al.	—	2019	→
Some effects of a chrysin bromide-derivative on GABA-A receptors and on Caenorhabditis elegans.	Téllez-Arreola J et al.	—	2019	→
Synthesis and Pharmacological Evaluation of [<sup>11</sup>C]4-Methoxy-<i>N</i>-[2-(thiophen-2-yl)imidazo[1,2-<i>a</i>]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors.	L'Estrade ET et al.	—	2019	→
Targeting GABA<sub>A</sub>R-Associated Proteins: New Modulators, Labels and Concepts.	Khayenko V et al.	—	2019	→
The Delta-Subunit Selective GABA <sub><i>A</i></sub> Receptor Modulator, DS2, Improves Stroke Recovery via an Anti-inflammatory Mechanism.	Neumann S et al.	—	2019	→
The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.	Barzroodi Pour M et al.	—	2019	→
The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia.	Clarkson AN et al.	—	2019	→
The signaling role for chloride in the bidirectional communication between neurons and astrocytes.	Wilson CS et al.	—	2019	→
The α5-Containing GABA<sub>A</sub> Receptors-a Brief Summary.	Mohamad FH et al.	—	2019	→
TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.	Li KX et al.	—	2019	→
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	Scarnati MS et al.	—	2019	→
Variations on a scaffold - Novel GABA<sub>A</sub> receptor modulators.	Iorio MT et al.	—	2019	→
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site.	Giraudo A et al.	—	2018	→
Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors.	Ziemba AM et al.	—	2018	→
Alteration of GABAergic neurotransmission in Huntington's disease.	Garret M et al.	—	2018	→
Anxiolytics targeting GABA<sub>A</sub> receptors: Insights on etifoxine.	Poisbeau P et al.	—	2018	→
Comparison of αβδ and αβγ GABA<sub>A</sub> receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.	Feng HJ et al.	—	2018	→
Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice.	Siivonen MS et al.	—	2018	→
Decreasing the Expression of GABA<sub>A</sub> α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome.	Vidal V et al.	—	2018	→
De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy.	Butler KM et al.	—	2018	→
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABA<sub>A</sub>R) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.	Knutson DE et al.	—	2018	→
Discriminative Stimulus Effects of Abused Inhalants.	Shelton KL	—	2018	→
Diversity matters: combinatorial information coding by GABA<sub>A</sub> receptor subunits during spatial learning and its allosteric modulation.	Szodorai E et al.	—	2018	→
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.	Atkin T et al.	—	2018	→
Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-predominant Irritable Bowel Syndrome.	Aggarwal S et al.	—	2018	→
Early-life adversity selectively impairs α2-GABA<sub>A</sub> receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine.	Mitchell SJ et al.	—	2018	→
Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder.	Bixo M et al.	—	2018	→
Endogenous neurosteroids influence synaptic GABA<sub>A</sub> receptors during postnatal development.	Belelli D et al.	—	2018	→
Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.	Cao LQ et al.	—	2018	→
Examining the effects of alcohol on GABA<sub>A</sub> receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells.	Lieberman R et al.	—	2018	→
Expression and purification of a functional heteromeric GABAA receptor for structural studies.	Claxton DP et al.	—	2018	→
Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system.	Monesson-Olson B et al.	—	2018	→
Extrasynaptic α<sub>5</sub>GABA<sub>A</sub> receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord.	Lucas-Osma AM et al.	—	2018	→
Functional Characterization of Native, High-Affinity GABA<sub>A</sub> Receptors in Human Pancreatic β Cells.	Korol SV et al.	—	2018	→
GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum.	Cuzon Carlson VC	—	2018	→
GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA<sub>A</sub> receptors.	Lagrange AH et al.	—	2018	→
GABAergic over-inhibition, a promising hypothesis for cognitive deficits in Down syndrome.	Zorrilla de San Martin J et al.	—	2018	→
GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4<sup>+</sup> T Cells and Is Immunosuppressive in Type 1 Diabetes.	Bhandage AK et al.	—	2018	→
GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era.	Koulentaki M et al.	—	2018	→
GABA<sub>A</sub> receptor subtype selectivity of the proconvulsant rodenticide TETS.	Pressly B et al.	—	2018	→
GABA<sub>A</sub> receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.	Kwakowsky A et al.	—	2018	→
GABA<sub>A</sub> receptor subunits in the human amygdala and hippocampus: Immunohistochemical distribution of 7 subunits.	Stefanits H et al.	—	2018	→
GABA type a receptor trafficking and the architecture of synaptic inhibition.	Lorenz-Guertin JM et al.	—	2018	→
Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy.	Chuang SH et al.	—	2018	→
Gephyrin: a key regulatory protein of inhibitory synapses and beyond.	Groeneweg FL et al.	—	2018	→
High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing α4β3δ subunits.	Zhou X et al.	—	2018	→
Identification and expression of a unique neonatal variant of the GABA<sub>A</sub> receptor α<sub>3</sub> subunit.	Miller SM et al.	—	2018	→
Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.	Woll KA et al.	—	2018	→
Insights into GABA<sub>A</sub>ergic system alteration in Huntington's disease.	Hsu YT et al.	—	2018	→
Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol Effects <i>in Vivo</i>.	García-Martín E et al.	—	2018	→
Negative modulation of the GABA<sub>A</sub> ρ1 receptor function by l-cysteine.	Beltrán González AN et al.	—	2018	→
Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons.	Li Z et al.	—	2018	→
Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity.	Fan HR et al.	—	2018	→
SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABA<sub>A</sub> Receptor γ2 Subunit.	Durisic N et al.	—	2018	→
Sex and β-Endorphin Influence the Effects of Ethanol on Limbic <i>Gabra2</i> Expression in a Mouse Binge Drinking Model.	Rhinehart EM et al.	—	2018	→
Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation.	Rycek L et al.	—	2018	→
Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases.	Jie F et al.	—	2018	→
Structural basis of neurosteroid anesthetic action on GABA<sub>A</sub> receptors.	Chen Q et al.	—	2018	→
Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation.	Milanos S et al.	—	2018	→
Synthesis of chiral GABA<sub>A</sub> receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression.	Li G et al.	—	2018	→
The effect of intrathecal injection of irisin on pain threshold and expression rate of GABAB receptors in peripheral neuropathic pain model.	Dameni S et al.	—	2018	→
The emergence of new psychoactive substance (NPS) benzodiazepines: A review.	Manchester KR et al.	—	2018	→
The fifth subunit in α3β4 nicotinic receptor is more than an accessory subunit.	Crespi A et al.	—	2018	→
Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function.	Dijkstra AA et al.	—	2018	→
γ2 GABA<sub>A</sub>R Trafficking and the Consequences of Human Genetic Variation.	Lorenz-Guertin JM et al.	—	2018	→
Acute Cortical Transhemispheric Diaschisis after Unilateral Traumatic Brain Injury.	Le Prieult F et al.	—	2017	→
Anxiety like behavior due to perinatal exposure to Bisphenol-A is associated with decrease in excitatory to inhibitory synaptic density of male mouse brain.	Kumar D et al.	—	2017	→
Anxiolytic effect of fatty acids and terpenes fraction from Aloysia triphylla: Serotoninergic, GABAergic and glutamatergic implications.	Jiménez-Ferrer E et al.	—	2017	→
Cognate Ligand Chaperoning: a Novel Mechanism for the Post-translational Regulation of Neurotransmitter Receptor Biogenesis.	Leidenheimer NJ	—	2017	→
Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding.	Yamaura K et al.	—	2017	→
Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.	Liu YM et al.	—	2017	→
Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α<sub>4</sub> β<sub>1/3</sub> δ GABA<sub>A</sub> Receptor Subtypes.	Falk-Petersen CB et al.	—	2017	→
Differential Alteration in Expression of Striatal GABA<sub>A</sub>R Subunits in Mouse Models of Huntington's Disease.	Du Z et al.	—	2017	→
Effects of the benzodiazepine GABA<sub>A</sub> α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons.	Holtyn AF et al.	—	2017	→
Emerging strategies in the management of essential tremor.	Hedera P	—	2017	→
Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice.	Lim CS et al.	—	2017	→
Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABA<sub>A</sub> Receptors with Different γ Subunits.	Ye Z et al.	—	2017	→
GABA Australis, some reflections on the history of GABA receptor research in Australia.	Johnston GAR	—	2017	→
GABA<sub>A</sub> receptor subtype involvement in addictive behaviour.	Stephens DN et al.	—	2017	→
GABA<sub>A</sub> receptor occupancy by subtype selective GABA<sub>Aα2,3</sub> modulators: PET studies in humans.	Jucaite A et al.	—	2017	→
GABA-ρ receptors: distinctive functions and molecular pharmacology.	Naffaa MM et al.	—	2017	→
Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.	Van Assche E et al.	—	2017	→
Inhibitory synapse deficits caused by familial α1 GABA<sub>A</sub> receptor mutations in epilepsy.	Chen X et al.	—	2017	→
Interaction between the serotoninergic and GABAergic systems in frog retina as revealed by electroretinogram.	Popova E et al.	—	2017	→
Methylmercury induces an initial increase in GABA-evoked currents in Xenopus oocytes expressing α<sub>1</sub> and α<sub>6</sub> subunit-containing GABA<sub>A</sub> receptors.	Tsai T et al.	—	2017	→
Molecular Targets for Components of Essential Oils in the Insect Nervous System-A Review.	Jankowska M et al.	—	2017	→
Neurobiological correlates of state-dependent context fear.	Meyer MAA et al.	—	2017	→
Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression.	Naoi M et al.	—	2017	→
Novel Molecule Exhibiting Selective Affinity for GABA<sub>A</sub> Receptor Subtypes.	Borghese CM et al.	—	2017	→
Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABA<sub>A</sub> receptors.	Chen X et al.	—	2017	→
Reduced expression of α5GABA<sub>A</sub> receptors elicits autism-like alterations in EEG patterns and sleep-wake behavior.	Mesbah-Oskui L et al.	—	2017	→
Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABA<sub>A</sub> γ2 R43Q mouse model of absence epilepsy.	Currie SP et al.	—	2017	→
Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome.	Caraci F et al.	—	2017	→
Stressful life events increase aggression and alcohol use in young carriers of the GABRA2 rs279826/rs279858 A-allele.	Kiive E et al.	—	2017	→
Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.	Savechenkov PY et al.	—	2017	→
Temporal Regulation of GABA<sub>A</sub> Receptor Subunit Expression: Role in Synaptic and Extrasynaptic Communication in the Suprachiasmatic Nucleus.	Walton JC et al.	—	2017	→
The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA<sub>A</sub> receptors.	Bakas T et al.	—	2017	→
The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.	Albers HE et al.	—	2017	→
Therapeutic Action of Honokiol on Postoperative Ileus via Downregulation of iNOS Gene Expression.	Mihara T et al.	—	2017	→
A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors.	Stern AT et al.	—	2016	→
Additive effect of BLA GABAA receptor mechanism and (+)-MK-801 on memory retention deficit, an isobologram analysis.	Khakpoor M et al.	—	2016	→
A Recombinant Human Pluripotent Stem Cell Line Stably Expressing Halide-Sensitive YFP-I152L for GABAAR and GlyR-Targeted High-Throughput Drug Screening and Toxicity Testing.	Kuenzel K et al.	—	2016	→
Autoimmune synaptopathies.	Crisp SJ et al.	—	2016	→
A weight of evidence assessment approach for adverse outcome pathways.	Collier ZA et al.	—	2016	→
Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats.	Zanettini C et al.	—	2016	→
Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytes.	Xu XJ et al.	—	2016	→
Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB.	Amlong CA et al.	—	2016	→
Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry.	Yamaura K et al.	—	2016	→
Effects of common anesthetic agents on [<sup>18</sup>F]flumazenil binding to the GABA<sub>A</sub> receptor.	Palner M et al.	—	2016	→
Effects of gaboxadol on the expression of cocaine sensitization in rats.	Silverman NS et al.	—	2016	→
Essential Tremor: What We Can Learn from Current Pharmacotherapy.	Ondo W	—	2016	→
Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids.	Werner DF et al.	—	2016	→
Ethanol Regulation of Synaptic GABAA α4 Receptors Is Prevented by Protein Kinase A Activation.	Carlson SL et al.	—	2016	→
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization.	Kuver A et al.	—	2016	→
Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease.	Weick JP	—	2016	→
Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.	Livesey MR et al.	—	2016	→
GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis.	Wearne TA et al.	—	2016	→
Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry.	Levran O et al.	—	2016	→
Hypothermic activity of acetaminophen; involvement of GABAA receptor, theoretical and experimental studies.	Ahangar N et al.	—	2016	→
Instant Integrated Ultradeep Quantitative-structural Membrane Proteomics Discovered Post-translational Modification Signatures for Human Cys-loop Receptor Subunit Bias.	Zhang X	—	2016	→
Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.	Forman SA et al.	—	2016	→
Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet.	Rogawski MA et al.	—	2016	→
Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy.	Agusti A et al.	—	2016	→
Neonatal seizures are associated with redistribution and loss of GABA<sub>A</sub> α-subunits in the hypoxic-ischaemic pig.	Miller SM et al.	—	2016	→
Potentiating effect of glabridin from <i>Glycyrrhiza glabra</i> on GABA<sub>A</sub> receptors.	Hoffmann KM et al.	—	2016	→
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus.	Yang L et al.	—	2016	→
Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures.	Jaenisch N et al.	—	2016	→
RNA binding protein Nova1 promotes tumor growth in vivo and its potential mechanism as an oncogene may due to its interaction with GABA<sub>A</sub> Receptor-γ2.	Zhang YA et al.	—	2016	→
Surface expression of GABAA receptors in the rat nucleus accumbens is increased in early but not late withdrawal from extended-access cocaine self-administration.	Purgianto A et al.	—	2016	→
Synthesis and pharmacological evaluation of functionalized isoindolinones on GABA-activated chloride currents in rat cerebellum granule cells in culture.	Di Mola A et al.	—	2016	→
The basolateral amygdala γ-aminobutyric acidergic system in health and disease.	Prager EM et al.	—	2016	→
The importance of the chemical structure of pregnanes in the concurrent inhibition of estrous behavior in the female rat.	Kubli-Garfias C et al.	—	2016	→
The Role of Benzodiazepines in the Treatment of Epilepsy.	Ochoa JG et al.	—	2016	→
To what extent is it possible to dissociate the anxiolytic and sedative/hypnotic properties of GABAA receptors modulators?	Chagraoui A et al.	—	2016	→
Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.	Nourmahnad A et al.	—	2016	→
Abnormal subcellular localization of GABAA receptor subunits in schizophrenia brain.	Mueller TM et al.	—	2015	→
A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition.	Lin WC et al.	—	2015	→
Adolescent-onset GABAA α1 silencing regulates reward-related decision making.	Butkovich LM et al.	—	2015	→
Advances in the pharmacology of lGICs auxiliary subunits.	Galaz P et al.	—	2015	→
Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific manner.	Wong LW et al.	—	2015	→
Closing the gap between the molecular and systemic actions of anesthetic agents.	Antkowiak B	—	2015	→
Comprehensive analysis of the GABAergic system gene expression profile in the anterior cingulate cortex of mice with Paclitaxel-induced neuropathic pain.	Masocha W	—	2015	→
Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex.	Datta D et al.	—	2015	→
Diazepam Inhibits Proliferation of Lymph Node Cells Isolated from Rats with Experimental Autoimmune Encephalomyelitis.	Fernández Hurst N et al.	—	2015	→
Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice.	Nunes D et al.	—	2015	→
Distinct amygdalar AMPAergic/GABAergic mechanisms promote anxiolitic-like effects in an unpredictable stress model of the hamster.	Alò R et al.	—	2015	→
Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing.	Zhang X et al.	—	2015	→
Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.	Tong X et al.	—	2015	→
Effect of non-genomic actions of thyroid hormones on the anaesthetic effect of propofol.	Wang Y et al.	—	2015	→
Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma.	Babateen O et al.	—	2015	→
Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.	Burgos CF et al.	—	2015	→
Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health.	Bhandage AK et al.	—	2015	→
Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors.	Estrada-Mondragon A et al.	—	2015	→
Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.	Hammer H et al.	—	2015	→
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.	Zhang Q et al.	—	2015	→
Functional properties of GABA synaptic inputs onto GABA neurons in monkey prefrontal cortex.	Rotaru DC et al.	—	2015	→
GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response.	Gunn BG et al.	—	2015	→
GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology.	Krall J et al.	—	2015	→
GABAAα1 and GABAAρ1 subunits are expressed in cultured human RPE cells and GABAA receptor agents modify the intracellular calcium concentration.	Cheng ZY et al.	—	2015	→
GABAergic neurotransmission and retinal ganglion cell function.	Popova E	—	2015	→
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.	Lieberman R et al.	—	2015	→
Generation of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits.	Dixon CL et al.	—	2015	→
Glutamate and GABA imbalance following traumatic brain injury.	Guerriero RM et al.	—	2015	→
Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.	Luger D et al.	—	2015	→
Interactions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes.	Westergard T et al.	—	2015	→
Investigating complex basal ganglia circuitry in the regulation of motor behaviour, with particular focus on orofacial movement.	Ikeda H et al.	—	2015	→
Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.	Yuan H et al.	—	2015	→
Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers.	Gong P et al.	—	2015	→
Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus.	Corteen NL et al.	—	2015	→
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse.	Korpi ER et al.	—	2015	→
Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands.	Rycek L et al.	—	2015	→
MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.	Rosso JP et al.	—	2015	→
Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors.	Adams JM et al.	—	2015	→
Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.	Wang P et al.	—	2015	→
Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse.	Sabaliauskas N et al.	—	2015	→
Neurosteroids increase tonic GABAergic inhibition in the lateral section of the central amygdala in mice.	Romo-Parra H et al.	—	2015	→
New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.	Arrojo e Drigo R et al.	—	2015	→
Postnatal down-regulation of the GABAA receptor γ2 subunit in neocortical NG2 cells accompanies synaptic-to-extrasynaptic switch in the GABAergic transmission mode.	Balia M et al.	—	2015	→
Regulation of the Neurodegenerative Process Associated to Parkinson's Disease by CD4+ T-cells.	González H et al.	—	2015	→
Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling.	Gallos G et al.	—	2015	→
Synaptic inhibition and disinhibition in the spinal dorsal horn.	Prescott SA	—	2015	→
The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.	Treven M et al.	—	2015	→
The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons.	Korol SV et al.	—	2015	→
The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation.	Cecchini M et al.	—	2015	→
δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine.	Klinger F et al.	—	2015	→
Acute and chronic effects of ethanol on learning-related synaptic plasticity.	Zorumski CF et al.	—	2014	→
A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice.	Strommer B et al.	—	2014	→
Alcohol use disorders and current pharmacological therapies: the role of GABA(A) receptors.	Liang J et al.	—	2014	→
Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective.	Taly A et al.	—	2014	→
Altered GABAA receptor expression and seizure threshold following acute ethanol challenge in mice lacking the RIIβ subunit of PKA.	Carlson SL et al.	—	2014	→
Amino acids--a life between metabolism and signaling.	Häusler RE et al.	—	2014	→
A mouse model mimicking human first night effect for the evaluation of hypnotics.	Xu Q et al.	—	2014	→
Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem.	Avolio E et al.	—	2014	→
Benzodiazepine modulation of homomeric GABAAρ1 receptors: differential effects of diazepam and 4'-chlorodiazepam.	Beltrán González AN et al.	—	2014	→
Brain γ-aminobutyric acid: a neglected role in impulsivity.	Hayes DJ et al.	—	2014	→
Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABAA receptors.	Gong QH et al.	—	2014	→
Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits.	Lo WY et al.	—	2014	→
Could α5-GABA-A receptor activation be used as a target for managing medulloblastomas?	Sengupta S et al.	—	2014	→
CXCL12 chemokine and GABA neurotransmitter systems crosstalk and their putative roles.	Guyon A	—	2014	→
Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons.	Groen MR et al.	—	2014	→
Dietary acetylenic oxylipin falcarinol differentially modulates GABAA receptors.	Czyzewska MM et al.	—	2014	→
Discovery of novel insomnia leads from screening traditional Chinese medicine database.	Chen HY et al.	—	2014	→
Discriminative stimulus effects of pregnanolone in rhesus monkeys.	Gerak LR et al.	—	2014	→
Distinct anxiogenic/anxiolytic effects exerted by the hamster lateral amygdalar nucleus injected with ORX-A or ORX-B in the presence of a GABAergic agonist.	Avolio E et al.	—	2014	→
Effect of sedative-hypnotics, anesthetics and analgesics on sleep architecture in obstructive sleep apnea.	McEntire DM et al.	—	2014	→
Excitatory/inhibitory equilibrium of the central amygdala nucleus gates anti-depressive and anxiolytic states in the hamster.	Alò R et al.	—	2014	→
GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics.	Bhandage AK et al.	—	2014	→
GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area.	Vashchinkina E et al.	—	2014	→
GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies.	Silveri MM	—	2014	→
Generation of recombinant antibodies to rat GABAA receptor subunits by affinity selection on synthetic peptides.	Koduvayur SP et al.	—	2014	→
Genetics of opiate addiction.	Reed B et al.	—	2014	→
GHB receptor targets in the CNS: focus on high-affinity binding sites.	Bay T et al.	—	2014	→
Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence.	Shi Y et al.	—	2014	→
Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.	Dostalova Z et al.	—	2014	→
Integration and regulation of glomerular inhibition in the cerebellar granular layer circuit.	Mapelli L et al.	—	2014	→
Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases.	Marchetti C	—	2014	→
International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.	Christopoulos A et al.	—	2014	→
Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects: an isobologram analysis.	Naseri MH et al.	—	2014	→
Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.	James OT et al.	—	2014	→
Molecular and behavioral characterization of adolescent protein kinase C following high dose ethanol exposure.	Santerre JL et al.	—	2014	→
Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.	Seifi M et al.	—	2014	→
Multifunctional aspects of allopregnanolone in stress and related disorders.	Bali A et al.	—	2014	→
Neonatal allopregnanolone levels alteration: effects on behavior and role of the hippocampus.	Darbra S et al.	—	2014	→
Neonatal finasteride administration alters hippocampal α4 and δ GABAAR subunits expression and behavioural responses to progesterone in adult rats.	Modol L et al.	—	2014	→
Neuroactive steroids in pregnancy: key regulatory and protective roles in the foetal brain.	Hirst JJ et al.	—	2014	→
Nitric oxide in the dorsal hippocampal area is involved on muscimol state-dependent memory in the step-down passive avoidance test.	Jafari-Sabet M et al.	—	2014	→
Peripheral GABAA receptor activation modulates rat tongue afferent mechanical sensitivity.	Tan SN et al.	—	2014	→
Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions.	Comenencia-Ortiz E et al.	—	2014	→
Regulating hippocampal hyperexcitability through GABAB Receptors.	Lang M et al.	—	2014	→
Sex dimorphism in seizure-controlling networks.	Giorgi FS et al.	—	2014	→
The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition.	Herd MB et al.	—	2014	→
The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II.	Labrakakis C et al.	—	2014	→
The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity.	Gassel M et al.	—	2014	→
Treating enhanced GABAergic inhibition in Down syndrome: use of GABA α5-selective inverse agonists.	Martínez-Cué C et al.	—	2014	→
Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.	Kakehashi A et al.	—	2014	→
α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth.	Sengupta S et al.	—	2014	→
Γ-aminobutyric acid receptors affect the progression and migration of tumor cells.	Zhang X et al.	—	2014	→
Advantages of an antagonist: bicuculline and other GABA antagonists.	Johnston GA	—	2013	→
Age-related GABAA receptor changes in rat auditory cortex.	Caspary DM et al.	—	2013	→
Alterations in Purkinje cell GABAA receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of β1 -subunit-containing receptors.	Kelley MH et al.	—	2013	→
A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.	Shen H et al.	—	2013	→
Benzodiazepine receptor ligands: a patent review (2006-2012).	Guerrini G et al.	—	2013	→
Comparing development of synaptic proteins in rat visual, somatosensory, and frontal cortex.	Pinto JG et al.	—	2013	→
Cysteine-terminated B-domain of Staphylococcus aureus protein A as a scaffold for targeting GABA(A) receptors.	Qtaishat NM et al.	—	2013	→
Determination of GABA(Aα1) and GABA (B1) receptor subunits expression in tissues of gilts during the late gestation.	Fan Z et al.	—	2013	→
Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons.	Kaminski BJ et al.	—	2013	→
Expression of gamma-aminobutyric acid receptors on neoplastic growth and prediction of prognosis in non-small cell lung cancer.	Zhang X et al.	—	2013	→
Expression of the γ2-subunit distinguishes synaptic and extrasynaptic GABA(A) receptors in NG2 cells of the hippocampus.	Passlick S et al.	—	2013	→
Expression variations of chromogranin A and α1,2,4 GABA(A)Rs in discrete limbic and brainstem areas rescue cardiovascular alterations.	Avolio E et al.	—	2013	→
Formaldehyde in brain: an overlooked player in neurodegeneration?	Tulpule K et al.	—	2013	→
GABAA receptor membrane insertion rates are specified by their subunit composition.	Joshi S et al.	—	2013	→
GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.	Nguyen TQ et al.	—	2013	→
GABAergic dysfunction in pediatric neuro-developmental disorders.	Smith-Hicks CL	—	2013	→
GABAergic transmission in hepatic encephalopathy.	Sergeeva OA	—	2013	→
GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids.	Joshi S et al.	—	2013	→
GABA is an effective immunomodulatory molecule.	Jin Z et al.	—	2013	→
GABA<sub>A</sub> Receptors of Cerebellar Granule Cells in Culture: Interaction with Benzodiazepines.	Cupello A et al.	—	2013	→
Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARs.	Mou L et al.	—	2013	→
In intact islets interstitial GABA activates GABA(A) receptors that generate tonic currents in α-cells.	Jin Y et al.	—	2013	→
Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.	Haenisch B et al.	—	2013	→
ISPMD consensus on the management of premenstrual disorders.	Nevatte T et al.	—	2013	→
Large scale expression changes of genes related to neuronal signaling and developmental processes found in lateral septum of postpartum outbred mice.	Eisinger BE et al.	—	2013	→
Lead-induced neurodegenerative events and abnormal behaviors occur via ORXRergic/GABA(A)Rergic mechanisms in a marine teleost.	Zizza M et al.	—	2013	→
Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro.	Ishibashi H et al.	—	2013	→
Modulation of human corticospinal excitability by paired associative stimulation.	Carson RG et al.	—	2013	→
Modulation of muscimol state-dependent memory by α2-adrenoceptors of the dorsal hippocampal area.	Jafari-Sabet M et al.	—	2013	→
Modulation of native GABA(A) receptor activity by triazolo 1,5-benzodiazepines.	Nikas P et al.	—	2013	→
Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni.	Dufour V et al.	—	2013	→
Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.	Caioli S et al.	—	2013	→
Myo-inositol treatment and GABA-A receptor subunit changes after kainate-induced status epilepticus.	Solomonia R et al.	—	2013	→
Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.	Carver CM et al.	—	2013	→
Neurosteroids, stress and depression: potential therapeutic opportunities.	Zorumski CF et al.	—	2013	→
New GABA amides activating GABAA-receptors.	Raster P et al.	—	2013	→
Partial agonism of taurine at gamma-containing native and recombinant GABAA receptors.	Kletke O et al.	—	2013	→
Quantum dot conjugates of GABA and muscimol: binding to α1β2γ2 and ρ1 GABA(A) receptors.	Gussin HA et al.	—	2013	→
Respiratory and behavioral dysfunction following loss of the GABAA receptor α4 subunit.	Loria CJ et al.	—	2013	→
Restoring ionotropic inhibition as an analgesic strategy.	Bonin RP et al.	—	2013	→
SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.	Heidelberg LS et al.	—	2013	→
Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor.	Guerrini G et al.	—	2013	→
The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.	Alexander SP et al.	—	2013	→
The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor.	Smith SS	—	2013	→
The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.	Hoestgaard-Jensen K et al.	—	2013	→
The role of behavior in translational models for psychopathology: functionality and dysfunctional behaviors.	Blanchard DC et al.	—	2013	→
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.	Pribiag H et al.	—	2013	→
Tonic inhibition sets the state of excitability in olfactory bulb granule cells.	Labarrera C et al.	—	2013	→
α4βδ GABAA receptors and tonic inhibitory current during adolescence: effects on mood and synaptic plasticity.	Smith SS	—	2013	→
2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.	Karim N et al.	—	2012	→
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.	Saliba RS et al.	—	2012	→
Amygdalar excitatory/inhibitory circuits interacting with orexinergic neurons influence differentially feeding behaviors in hamsters.	Avolio E et al.	—	2012	→
A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface.	Sieghart W et al.	—	2012	→
Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes.	Smith KS et al.	—	2012	→
Autoradiographic evidence for the transmeningeal diffusion of muscimol into the neocortex in rats.	Ludvig N et al.	—	2012	→
Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice.	Smith KS et al.	—	2012	→
Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation.	Mulligan MK et al.	—	2012	→
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia.	Lewis DA et al.	—	2012	→
Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry.	Chen ZW et al.	—	2012	→
Differential effect of transient global ischaemia on the levels of γ-aminobutyric acid type A (GABA(A)) receptor subunit mRNAs in young and older rats.	Montori S et al.	—	2012	→
Differentiation of human neural progenitor cells in functionalized hydrogel matrices.	Liedmann A et al.	—	2012	→
Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes.	Mendu SK et al.	—	2012	→
Distinct properties of glycine receptor β+/α- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric protein.	Shan Q et al.	—	2012	→
Drug-induced sleep: theoretical and practical considerations.	Ellenbogen JM et al.	—	2012	→
Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.	Hood JL et al.	—	2012	→
Ethanol Activation of Protein Kinase A Regulates GABA(A) Receptor Subunit Expression in the Cerebral Cortex and Contributes to Ethanol-Induced Hypnosis.	Kumar S et al.	—	2012	→
Expression of functional γ-aminobutyric acid type A receptors in Schwann-like adult stem cells.	Faroni A et al.	—	2012	→
Expression of gamma-aminobutyric acid type A receptor α2 subunit in the dorsal root ganglion of rats with sciatic nerve injury.	Lian Y et al.	—	2012	→
Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease.	Brickley SG et al.	—	2012	→
Fast synaptic inhibition in spinal sensory processing and pain control.	Zeilhofer HU et al.	—	2012	→
Flavonoids as GABAA receptor ligands: the whole story?	Wasowski C et al.	—	2012	→
GABA(A) receptor modulators from Chinese herbal medicines traditionally applied against insomnia and anxiety.	Singhuber J et al.	—	2012	→
GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice.	Shen Q et al.	—	2012	→
GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.	Zecharia AY et al.	—	2012	→
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.	Ring H et al.	—	2012	→
Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain.	Bali M et al.	—	2012	→
Histamine neurons in the tuberomamillary nucleus: a whole center or distinct subpopulations?	Blandina P et al.	—	2012	→
Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	Ryu K et al.	—	2012	→
Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing.	Askland K et al.	—	2012	→
Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.	Sabaliauskas N et al.	—	2012	→
Ligand-gated ion channels: new insights into neurological disorders and ligand recognition.	Lemoine D et al.	—	2012	→
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors.	Huang SH et al.	—	2012	→
Modulation of recombinant GABA(A) receptors by neurosteroid dehydroepiandrosterone sulfate.	Svob Štrac D et al.	—	2012	→
Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors.	Rye DB et al.	—	2012	→
New insights into the structural bases of activation of Cys-loop receptors.	Bouzat C	—	2012	→
Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation.	Addolorato G et al.	—	2012	→
Perisynaptic GABA Receptors The Overzealous Protector.	Clarkson AN	—	2012	→
Quantitative Analysis of GABAA Gamma Receptor Subunits in the Developing Embryonic Chick Forebrain.	Zaker SR et al.	—	2012	→
Receptor targets of amacrine cells.	Zhang C et al.	—	2012	→
Regulation of the surface expression of α4β2δ GABAA receptors by high efficacy states.	Kuver A et al.	—	2012	→
Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.	Yue L et al.	—	2012	→
Scaling proprioceptor gene transcription by retrograde NT3 signaling.	Lee J et al.	—	2012	→
Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation.	Gallos G et al.	—	2012	→
The biochemical anatomy of cortical inhibitory synapses.	Heller EA et al.	—	2012	→
The effect of pentobarbital sodium and propofol anesthesia on multifocal electroretinograms in rhesus macaques.	Kim CB et al.	—	2012	→
The GABA system in anxiety and depression and its therapeutic potential.	Möhler H	—	2012	→
The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.	Švob Štrac D et al.	—	2012	→
Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.	Guitchounts G et al.	—	2012	→
Zolpidem for insomnia.	Greenblatt DJ et al.	—	2012	→
γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting.	Wu X et al.	—	2012	→
2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors.	Xie A et al.	—	2011	→
3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels.	Baenziger JE et al.	—	2011	→
Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA.	Gavazzo P et al.	—	2011	→
Altered GABA transmission in a mouse model of increased trait anxiety.	Tasan RO et al.	—	2011	→
Assembly of nicotinic and other Cys-loop receptors.	Tsetlin V et al.	—	2011	→
Astrocytes are GABAergic cells that modulate microglial activity.	Lee M et al.	—	2011	→
Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes.	Rudolph U et al.	—	2011	→
Clinical and molecular pharmacology of etomidate.	Forman SA	—	2011	→
Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome.	Broadbelt KG et al.	—	2011	→
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief.	Guerrini G et al.	—	2011	→
Distinct α GABA(A)R subunits influence structural and transcriptional properties of CA1 hippocampal neurons.	Di Vito A et al.	—	2011	→
Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake.	Nie H et al.	—	2011	→
Feeding behaviors and ORXR-β-GABA A R subunit interactions in Carassius auratus.	Facciolo RM et al.	—	2011	→
Flavonoid modulation of GABA(A) receptors.	Hanrahan JR et al.	—	2011	→
GABAA receptors in the posterior, but not anterior, ventral tegmental area mediate Ro15-4513-induced attenuation of binge-like ethanol consumption in C57BL/6J female mice.	Melón LC et al.	—	2011	→
GABA(A) Receptors: Post-Synaptic Co-Localization and Cross-Talk with Other Receptors.	Shrivastava AN et al.	—	2011	→
GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia.	Gonzalez-Burgos G et al.	—	2011	→
HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes.	Zaugg J et al.	—	2011	→
Identification and characterization of anesthetic targets by mouse molecular genetics approaches.	Drexler B et al.	—	2011	→
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.	Zaugg J et al.	—	2011	→
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease.	Rissman RA et al.	—	2011	→
Inhibition of learning and memory by general anesthetics.	Wang DS et al.	—	2011	→
Insights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarins.	Singhuber J et al.	—	2011	→
Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats.	Khajehpour L et al.	—	2011	→
Involvement of dorsal hippocampal muscarinic cholinergic receptors on muscimol state-dependent memory of passive avoidance in mice.	Jafari-Sabet M	—	2011	→
Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia.	Beneyto M et al.	—	2011	→
Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice.	Innos J et al.	—	2011	→
Lungfish aestivating activities are locked in distinct encephalic γ-aminobutyric acid type A receptor α subunits.	Giusi G et al.	—	2011	→
Molecular dissection of Cl--selective Cys-loop receptor points to components that are dispensable or essential for channel activity.	Bar-Lev DD et al.	—	2011	→
Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress.	Gunn BG et al.	—	2011	→
Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy.	Lachance-Touchette P et al.	—	2011	→
Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo.	Kim KH et al.	—	2011	→
Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling.	Zaugg J et al.	—	2011	→
Potentiating action of propofol at GABAA receptors of retinal bipolar cells.	Yue L et al.	—	2011	→
Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover.	Bright DP et al.	—	2011	→
Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways.	Mou L et al.	—	2011	→
Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors.	Shrivastava AN et al.	—	2011	→
Regulation of orofacial movement: amino acid mechanisms and mutant models.	Tomiyama K et al.	—	2011	→
Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA(A) receptors in vitro.	Jiang R et al.	—	2011	→
Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor.	Akk G et al.	—	2011	→
Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice.	Suryanarayanan A et al.	—	2011	→
Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance.	Kim KJ et al.	—	2011	→
The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT(2C) receptor.	Hayes DJ et al.	—	2011	→
Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.	Nilsson J et al.	—	2011	→
Understanding the molecular diversity of GABAergic synapses.	Sassoè-Pognetto M et al.	—	2011	→
Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function.	Lewis RW et al.	—	2011	→
Agonist function of the recombinant alpha 4 beta 3 delta GABAA receptor is dependent on the human and rat variants of the alpha 4-subunit.	Wang MD et al.	—	2010	→
An efficient and information-rich biochemical method design for fragment library screening on ion channels.	Thompson AJ et al.	—	2010	→
A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.	Williams CA et al.	—	2010	→
A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.	McCracken ML et al.	—	2010	→
Atypical behavioural effects of lorazepam: clues to the design of novel therapies?	Giersch A et al.	—	2010	→
Dihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant.	Lewis RW et al.	—	2010	→
Distinct α subunit variations of the hypothalamic GABAA receptor triplets (αβγ) are linked to hibernating state in hamsters.	Alò R et al.	—	2010	→
Early developmental alterations in GABAergic protein expression in fragile X knockout mice.	Adusei DC et al.	—	2010	→
Expression of GABAergic receptors in mouse taste receptor cells.	Starostik MR et al.	—	2010	→
Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors.	Sergeeva OA et al.	—	2010	→
Functional impact of serial deletions at the C-terminus of the human GABArho1 receptor.	Reyes-Ruiz JM et al.	—	2010	→
Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit.	Jurd R et al.	—	2010	→
GABAergic influences on ORX receptor-dependent abnormal motor behaviors and neurodegenerative events in fish.	Facciolo RM et al.	—	2010	→
General anesthetic actions on GABA(A) receptors.	Garcia PS et al.	—	2010	→
High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors.	Dostalova Z et al.	—	2010	→
Influence of 17beta-estradiol and progesterone on GABAergic gene expression in the arcuate nucleus, amygdala and hippocampus of the rhesus macaque.	Noriega NC et al.	—	2010	→
Mechanism of Allosteric Modulation of the Cys-loop Receptors.	Chang Y et al.	—	2010	→
Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.	Blednov YA et al.	—	2010	→
Mixed GABA-glycine synapses delineate a specific topography in the nucleus tractus solitarii of adult rat.	Dufour A et al.	—	2010	→
Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs.	Calza A et al.	—	2010	→
New 1,5-benzodiazepine compounds: activity at native GABA(A) receptors.	Gatta E et al.	—	2010	→
New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular modeling investigation.	Guerrini G et al.	—	2010	→
Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D(1) dopamine receptor agonist SKF 83959.	Tomiyama K et al.	—	2010	→
Perinatal development of inhibitory synapses in the nucleus tractus solitarii of the rat.	Dufour A et al.	—	2010	→
Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation.	Pittel I et al.	—	2010	→
Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice.	Kaufman KR et al.	—	2010	→
Role of the central amygdala GABA-A receptors in morphine state-dependent memory.	Rassouli Y et al.	—	2010	→
The cell biology of synaptic inhibition in health and disease.	Smith KR et al.	—	2010	→
The structural basis of function in Cys-loop receptors.	Thompson AJ et al.	—	2010	→
Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus.	Gibson CJ et al.	—	2010	→
Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization.	Khom S et al.	—	2010	→
Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone.	Buckingham SD et al.	—	2009	→
Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors.	Drexler B et al.	—	2009	→
Distinct alpha subunits of the GABAA receptor are responsible for early hippocampal silent neuron-related activities.	Giusi G et al.	—	2009	→
Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation.	McElroy B et al.	—	2009	→
Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord.	Pape JR et al.	—	2009	→
GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.	Charych EI et al.	—	2009	→
GABA(A) receptors of cerebellar granule cells in culture: explanation of overall insensitivity to ethanol.	Gatta E et al.	—	2009	→
Plasticity of the alpha4betadelta GABAA receptor.	Shen H et al.	—	2009	→
Relation between increased anxiety and reduced expression of alpha1 and alpha2 subunits of GABA(A) receptors in Wfs1-deficient mice.	Raud S et al.	—	2009	→
Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.	Bartos M et al.	—	2009	→
Studying Cerebellar Circuits by Remote Control of Selected Neuronal Types with GABA(A) Receptors.	Wisden W et al.	—	2009	→
Subtype-selective GABA(A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023.	Atack JR	—	2009	→
The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress.	Kumar S et al.	—	2009	→