Performance of the Self-Report of the Effects of Alcohol Questionnaire Across Sexes and Generations.
paper
Cited
Public
- Authors
- Schuckit, Marc A; Smith, Tom L; Rana, Brinda K; Mendoza, Lee Ann; Clarke, Dennis; Kawamura, Mari
- Year
- 2019
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 30933364
- DOI
- 10.1111/acer.14038
- PMCID
- PMC6602840
BACKGROUND: Low level of responses (low LRs) to alcohol established using the Self-Report of the Effects of Alcohol (SRE) questionnaire are genetically influenced phenotypes related to heavy drinking and alcohol problems. To date, most studies using SREs focused on scores for the number of drinks needed for effects across the first 5 times of drinking (SRE-5), and few evaluated scores that also included the prior 3 months and heaviest drinking periods (SRE-T). This paper evaluates characteristics of SRE-5 and SRE-T within and across generations. METHODS: Data were extracted from 407 participants across 2 generations of 107 families in the San Diego Prospective Study (SDPS). Pearson's product-moment correlations for SRE-5 and SRE-T were determined across first-degree relatives both within and across generations and sexes, as well as correlations of each measure to maximum drinking quantities and alcohol problems. RESULTS: Responding to 4 hypotheses, first the analyses demonstrated significant within-generation positive correlations for both SRE measures across brother-brother and sister-sister pairs as well as cross-generation correlations for fathers and sons, although correlations for mothers and daughters were not robust. Second, both SRE-5 and SRE-T correlated with maximum drinks and alcohol problems for both sexes and both generations. Third, within parental and offspring generations SRE-T correlated more robustly than SRE-5 to maximum drinks and alcohol problems. Fourth, across generations SRE values for sons were more closely related to drinking quantities and problems than for their fathers, but the mother-daughter SRE relationships to adverse alcohol characteristics were not different. CONCLUSIONS: Both the SRE-5 and SRE-T offered useful information about propensities toward heavier drinking and alcohol problems in SDPS families. Correlations with adverse alcohol outcomes were greater for the more broad-based SRE-T, but both scores appeared to be genetically influenced and continue to operate in a robust manner in both generations of these families.
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| Survey measures of subjective response to alcohol are improved by incorporating questions about the intensity of alcohol effects. | Wang FL et al. | — | 2026 | → |
| The 10-year stability of three subscale scores of the Self-Report of the Effects of Alcohol measure and their relationship to changes in drinking quantities over the same period. | Schuckit MA et al. | — | 2026 | → |
| Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample. | Moe JS et al. | — | 2025 | → |
| Body Mass Index Is Inversely Associated With Level of Response to Alcohol: Role of Total Body Water. | Vergeer RR et al. | — | 2025 | → |
| Evaluations of potential sex differences in alcohol use and problems in 454 offspring from the San Diego Prospective Study. | Schuckit MA et al. | — | 2025 | → |
| High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study. | Schuckit MA et al. | — | 2025 | → |
| The level of response to alcohol is related to level of se-phosphate in the general population. | Bramness JG et al. | — | 2025 | → |
| Genetic influences on alcohol sensitivity: A critical review. | Yeung EW et al. | — | 2024 | → |
| Changes over time in endorsement of 11 DSM-IV alcohol use disorder (AUD) criteria in young adults with persistent or recurrent AUD in The Collaborative Study on the Genetics of Alcoholism. | Schuckit MA et al. | — | 2023 | → |
| Do personality characteristics predict future alcohol problems after considering current demography, substance use, and alcohol response? | Schuckit MA et al. | — | 2023 | → |
| Self-report assessment of alcohol sensitivity: An examination of the effects of different probes. | Boness CL et al. | — | 2023 | → |
| The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol. | Bramness JG et al. | — | 2023 | → |
| AUD Risk, Diagnoses, and Course in a Prospective Study Across Two Generations: Implications for Prevention. | Schuckit MA | — | 2022 | → |
| Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges. | Schuckit MA et al. | — | 2021 | → |
| Relationship between level of response to alcohol and acute tolerance. | Anthenelli RM et al. | — | 2021 | → |
| Characteristics associated with denial of problem drinking among two generations of individuals with alcohol use disorders. | Schuckit MA et al. | — | 2020 | → |
| The Search for Contributors to Low Rates of Recognition of Paternal Alcohol Use Disorders in Offspring From the San Diego Prospective Study. | Schuckit MA et al. | — | 2020 | → |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | — | 2019 | → |