The impact of gene-environment interaction on alcohol use disorders.
paper
Cited
Public
- Authors
- Dick, Danielle M; Kendler, Kenneth S
- Year
- 2012
- Journal
- Alcohol research : current reviews
- PMID
- 23134047
- DOI
- 10.35946/arcr.v34.3.06
- PMCID
- PMC3606909
This article describes three types of gene-environment interactions and the challenges inherent in interpreting these interactions. It also reports on what is known about gene-environment interactions in the field of alcohol use disorders (AUDs). Twin studies of the interaction of genetic and environmental influences on AUDs have resulted in relatively consistent findings and have suggested general mechanisms for interaction effects. These studies generally find that environments that exert more social control (e.g., higher parental monitoring, less migratory neighborhoods, etc.) tend to reduce genetic influences, whereas other environments allow greater opportunity to express genetic predispositions, such as those characterized by more deviant peers and greater alcohol availability. Conversely, the gene-environment literature that has been developed surrounding specific genes has focused largely on the role of stress as a moderator of genetic effects.
No figures extracted from this document.
← Prev
21–28 of 28
| Name | Type |
|---|---|
| 5-HTTLPR | variant |
| adolescent alcohol use | phenotype |
| adolescents | cohort |
| adolescent substance use | phenotype |
| adult alcohol dependence | phenotype |
| aggression | phenotype |
| alcohol | phenotype |
| alcohol availability | phenotype |
| alcohol dependence | phenotype |
| alcoholism | phenotype |
| alcohol-preferring rats | cohort |
| Alcohol Problems | phenotype |
| alcohol-related problems | phenotype |
| Alcohol seeking | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| Alcohol Use Disorder risk local | phenotype |
| alcohol use disorders | phenotype |
| aldehyde dehydrogenase local | drug |
| ALDH2 | gene |
| ANKK1 | gene |
| antisocial alcoholism | phenotype |
| AUD | phenotype |
| Beliefs about alcohol local | phenotype |
| binge drinking | phenotype |
| candidate genes | cohort |
| CHRM2 | gene |
| Collaborative Studies on Genetics of Alcoholism project local | cohort |
| college students | cohort |
| CRHR1 | gene |
| Current life events local | phenotype |
| depression | phenotype |
| deviant peers | phenotype |
| dopamine | drug |
| DRD2 | gene |
| DRD2 Taq1A polymorphism local | variant |
| drinking | phenotype |
| Drinking per occasion local | phenotype |
| drug dependence | phenotype |
| early-adolescent behavior problems local | phenotype |
| early alcohol use | phenotype |
| Early psychosocial stress local | phenotype |
| environment | drug |
| externalizing behavior | phenotype |
| facial flushing | phenotype |
| female subjects | cohort |
| Finnish twin data local | cohort |
| frequency of alcohol use | phenotype |
| GABRA2 | gene |
| genes | gene |
| genetic variants | cohort |
| hazardous drinking | phenotype |
| heavy drinking | phenotype |
| heterozygous long/short genotype local | variant |
| high-risk behavior local | phenotype |
| intoxication frequency | phenotype |
| l allele | variant |
| late-adolescent alcohol use local | phenotype |
| maltreated children | cohort |
| Mannheim Study of Children at Risk | cohort |
| MAOA | gene |
| MAOA long variant local | variant |
| MAOA low-activity allele | variant |
| MAOA promoter polymorphism local | variant |
| marijuana | phenotype |
| marital status | phenotype |
| migration | phenotype |
| monkeys | cohort |
| Multiple negative life events local | phenotype |
| norepinephrine | drug |
| novelty seeking | phenotype |
| older adolescent presence local | phenotype |
| parental monitoring | phenotype |
| peer substance use | phenotype |
| phenotype | phenotype |
| physical abuse | phenotype |
| Progression to heavy alcohol use local | phenotype |
| religiosity | phenotype |
| School attitudes local | phenotype |
| self-esteem | phenotype |
| serotonin | drug |
| sex | phenotype |
| sexual behavior | phenotype |
| SLC6A4 | gene |
| stress | phenotype |
| Stressful environment local | phenotype |
| substance use | phenotype |
| Swedish adolescents local | cohort |
| Twin cohort | cohort |
| Unfavorable environment local | phenotype |
| unmarried women | phenotype |
| urban environment | phenotype |
| women | cohort |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Associations of Romantic Partners' Characteristics with Alcohol Consumption and Binge Drinking: Examining Evidence for Gene-Environment Interaction. | Stephenson M et al. | — | 2025 | → |
| Gene-environment interaction between gaming addiction and perceived stress in late adolescents and young adults: A twin study. | Hur YM | — | 2024 | → |
| Problematic Alcohol Use Trajectories in U.S. Military Veterans during a Public Health Crisis: Results from a 3-year, Nationally Representative, Longitudinal Study. | Na PJ et al. | — | 2024 | → |
| Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction. | Savage JE et al. | — | 2024 | → |
| Serial mediating effects of childhood trauma and conduct behaviors on the impact of family history among patients with alcohol use disorder. | Han MJ et al. | — | 2024 | → |
| Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults. | Su J et al. | — | 2023 | → |
| Examining interactions between polygenic scores and interpersonal trauma exposure on alcohol consumption and use disorder in an ancestrally diverse college cohort. | Sheerin CM et al. | — | 2023 | → |
| Neurobiology and the Treatment of Alcohol Use Disorder: A Review of the Evidence Base. | Donato S et al. | — | 2023 | → |
| Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. | Na P et al. | — | 2023 | → |
| The collaborative study on the genetics of alcoholism: Brain function. | Meyers JL et al. | — | 2023 | → |
| The collaborative study on the genetics of alcoholism: Sample and clinical data. | Dick DM et al. | — | 2023 | → |
| Are prescription misuse and illicit drug use etiologically distinct? A genetically-informed analysis of opioids and stimulants. | Dash GF et al. | — | 2022 | → |
| Genotype-environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use. | Elam KK et al. | — | 2022 | → |
| Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study. | Silva HC et al. | — | 2022 | → |
| Alcohol use disorders among adult children of alcoholics (ACOAs): Gene-environment resilience factors. | Ossola P et al. | — | 2021 | → |
| A systematic review of gene-by-intervention studies of alcohol and other substance use. | Neale ZE et al. | — | 2021 | → |
| Intersection of familial risk and environmental social control on high-risk drinking and alcohol dependence in a US national sample of adults. | Karriker-Jaffe KJ et al. | — | 2021 | → |
| Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. | Kuo SI et al. | — | 2021 | → |
| Quantile-Dependent Expressivity and Gene-Lifestyle Interactions Involving High-Density Lipoprotein Cholesterol. | Williams PT | — | 2021 | → |
| Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD). | Rodriguez FD | — | 2021 | → |
| The ABCD study: understanding the development of risk for mental and physical health outcomes. | Karcher NR et al. | — | 2021 | → |
| The severity of the pathogen-induced acute sickness response is affected by polymorphisms in genes of the NLRP3 inflammasome pathway. | Valencia BM et al. | — | 2021 | → |
| A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction | Sun J et al. | — | 2020 | → |
| Does Neighborhood Alcohol Availability Moderate the Impact of Familial Liability and Marital Status on Risk for Alcohol Use Disorders? A Swedish National Study. | Kendler KS et al. | — | 2020 | → |
| Gene-environment interaction in chronic kidney disease among people with type 2 diabetes from The Malaysian Cohort project: a case-control study. | Ahmad N et al. | — | 2020 | → |
| Genetic feedback for psychiatric conditions: Where are we now and where are we going. | Driver MN et al. | — | 2020 | → |
| Mechanisms of Alcohol Addiction: Bridging Human and Animal Studies. | Kramer J et al. | — | 2020 | → |
| Neighborhood Deprivation Moderates Shared and Unique Environmental Influences on Hazardous Drinking: Findings from a Cross-Sectional Co-Twin Study. | Rhew IC et al. | — | 2020 | → |
| Recent advances in genetic studies of alcohol use disorders. | Gupta I et al. | — | 2020 | → |
| Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. | Meyers JL et al. | — | 2019 | → |
| Birth cohort effects on the quantity and heritability of alcohol consumption in adulthood: a Finnish longitudinal twin study. | Virtanen S et al. | — | 2019 | → |
| International Society of Psychiatric Genetics Ethics Committee: Issues facing us. | Lázaro-Muñoz G et al. | — | 2019 | → |
| Neighborhood density of alcohol outlets moderates genetic and environmental influences on alcohol problems. | Slutske WS et al. | — | 2019 | → |
| Pharmacogenetics of alcohol use disorder treatments: an update. | Hartwell EE et al. | — | 2019 | → |
| Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance. | Meyers JL et al. | — | 2019 | → |
| The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial. | Kuo SI et al. | — | 2019 | → |
| VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths. | Vrettou M et al. | — | 2019 | → |
| Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students. | Su J et al. | — | 2018 | → |
| Polygenic risk for alcohol consumption and its association with alcohol-related phenotypes: Do stress and life satisfaction moderate these relationships? | Mies GW et al. | — | 2018 | → |
| Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. | Savage JE et al. | — | 2018 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| The effect of water stress on phytochemical accumulation, bioactive compounds and expression of key genes involved in flavonoid biosynthesis in Chrysanthemum morifolium L. | Hodaei M et al. | — | 2018 | — |
| A developmental etiological model for drug abuse in men. | Kendler KS et al. | — | 2017 | → |
| Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity. | Elam KK et al. | — | 2017 | → |
| ALDH2*2 and peer drinking in East Asian college students. | O'Shea T et al. | — | 2017 | → |
| Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics. | Chartier KG et al. | — | 2017 | → |
| Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents. | Chang H et al. | — | 2017 | → |
| Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations. | Chartier KG et al. | — | 2017 | → |
| Review: Genetic research on alcohol use outcomes in African American populations: A review of the literature, associated challenges, and implications. | Dick DM et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | — | 2017 | → |
| All in the Family? A Twin-Based Analysis of Associations Between Occupational Risk Factors, Drinking, and Tobacco Use in Employed Men. | Bono RS et al. | — | 2016 | → |
| A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders. | Munn-Chernoff MA et al. | — | 2016 | → |
| Effect of Marriage on Risk for Onset of Alcohol Use Disorder: A Longitudinal and Co-Relative Analysis in a Swedish National Sample. | Kendler KS et al. | — | 2016 | → |
| Epigenetic Modifications, Alcoholic Brain and Potential Drug Targets. | Jangra A et al. | — | 2016 | → |
| Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. | Chartier KG et al. | — | 2016 | → |
| A Nonparametric, Multiple Imputation-Based Method for the Retrospective Integration of Data Sets. | Carrig MM et al. | — | 2015 | → |
| Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers. | Meyers JL et al. | — | 2015 | → |
| Gene-Environment Interaction Effects of Peer Deviance, Parental Knowledge and Stressful Life Events on Adolescent Alcohol Use. | Cooke ME et al. | — | 2015 | → |
| Genetic and Environmental Interplay in Adolescent Substance Use Disorders. | Hines LA et al. | — | 2015 | → |
| Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment. | Litten RZ et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | — | 2014 | → |
| Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. | Dick DM et al. | — | 2014 | → |
| Parental alcohol history differentially predicts offspring disorders in distinct subgroups in Israel. | Meyers JL et al. | — | 2014 | → |
| Spit for Science: launching a longitudinal study of genetic and environmental influences on substance use and emotional health at a large US university. | Dick DM et al. | — | 2014 | → |
| Gene × smoking interactions on human brain gene expression: finding common mechanisms in adolescents and adults. | Wolock SL et al. | — | 2013 | → |
| Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. | Chorlian DB et al. | — | 2013 | → |