Co-occurring risk factors for alcohol dependence and habitual smoking.
paper
Primary
Public
- Authors
- Bierut, L J; Schuckit, M A; Hesselbrock, V; Reich, T
- Year
- 2000
- Journal
- Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
- PMID
- 15986718
- PMCID
- PMC6709743
Smoking and alcohol dependence frequently occur together, and both behaviors are determined in part by genetic influences. The Collaborative Study on the Genetics of Alcoholism (COGA), which is investigating the genetic factors contributing to alcohol dependence, also allows for analyses of the genetic factors determining smoking. Using a sample comprised of alcoholics and their closest (i.e., first-degree) relatives as well as a community-based control sample, COGA investigators found that both alcohol dependence and habitual smoking were transmitted within families. This familial transmission resulted from both common and drug-specific influences, which likely include genetic factors. Further genetic studies (i.e., candidate gene studies and genomic screening approaches) have identified several DNA regions that may contain genes that confer a susceptibility for alcoholism. Some of those genes also may contribute to the risk for habitual smoking.
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| # | Section | Preview |
|---|---|---|
| 20 | Genomic Screening by Linkage Analysis | In summary, the COGA study provided evidence that certain regions of chromosomes 1 and 7 were linked… |
| 21 | Genomic Screening by Linkage Analysis | The COGA genome screen data were also used in the Genetic Analysis Workshop (GAW),6 conducted in… |
| 22 | Genomic Screening by Linkage Analysis | In summary, the COGA investigators have completed a comprehensive search for the genetic linkage of… |
| 23 | Future Directions | Numerous developments, such as the increasing identification of human genes and their functions, the… |
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