The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women.
- Authors
- Xia, Jing; He, Qiang; Li, Yihan; Xie, Dong; Zhu, Suoyu; Chen, Jing; Shen, Yuan; Zhang, Ning; Wei, Yan; Chen, Chunfeng; Shen, Jianhua; Zhang, Yan; Gao, Chengge; Li, Youhui; Ding, Jihong; Shen, Wenwu; Wang, Qian; Cao, Meiyue; Liu, Tiebang; Zhang, Jinbei; Duan, Huijun; Bao, Cheng; Ma, Ping; Zhou, Cong; Luo, Yanfang; Zhang, Fengzhi; Liu, Ying; Li, Yi; Jin, Guixing; Zhang, Yutang; Liang, Wei; Chen, Yunchun; Zhao, Changyin; Li, Haiyan; Chen, Yiping; Shi, Shenxun; Kendler, Kenneth S; Flint, Jonathan; Wang, Xumei
- Year
- 2011
- Journal
- Journal of affective disorders
- PMID
- 21824661
- DOI
- 10.1016/j.jad.2011.06.053
- PMCID
- PMC3220767
OBJECTIVE: The personality trait of neuroticism is a risk factor for major depressive disorder (MDD), but this relationship has not been demonstrated in clinical samples from Asia. METHODS: We examined a large-scale clinical study of Chinese Han women with recurrent major depression and community-acquired controls. RESULTS: Elevated levels of neuroticism increased the risk for lifetime MDD (with an odds ratio of 1.37 per SD), contributed to the comorbidity of MDD with anxiety disorders, and predicted the onset and severity of MDD. Our findings largely replicate those obtained in clinical populations in Europe and US but differ in two ways: we did not find a relationship between melancholia and neuroticism; we found lower mean scores for neuroticism (3.6 in our community control sample). LIMITATIONS: Our findings do not apply to MDD in community-acquired samples and may be limited to Han Chinese women. It is not possible to determine whether the association between neuroticism and MDD reflects a causal relationship. CONCLUSIONS: Neuroticism acts as a risk factor for MDD in Chinese women, as it does in the West and may particularly predispose to comorbidity with anxiety disorders. Cultural factors may have an important effect on its measurement.
Distribution of neuroticism score in Chinese women with MDD and matched controls.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. | 2015 | 25993607 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Associations between borderline personality disorder symptomatology and major depressive disorder: Insights from a general population study. | Eigenhuis E et al. | — | 2026 | → |
| Depression and Associated Factors Among Patients with Spinocerebellar Ataxia. | Jekpoo S et al. | — | 2025 | → |
| The etiological relationship between the general factors of psychopathology and personality; a longitudinal twin study from adolescence into young adulthood. | Waaktaar T et al. | — | 2025 | → |
| Distinct associations between gratitude, self-esteem, and optimism with subjective and psychological well-being among Japanese individuals. | Nawa NE et al. | — | 2024 | → |
| Evaluating the Impact of Obsessive-Compulsive Symptoms and Personality Types on Perinatal Depressive Symptoms. | Neda-Stepan O et al. | — | 2024 | → |
| No association between serotonin 4 receptor brain binding and personality trait Neuroticism - A positron emission tomography study in depressed patients and healthy individuals. | Mikkelsen AT et al. | — | 2024 | → |
| Pet attachment and owner personality. | Wells DL et al. | — | 2024 | → |
| The Depressiveness, Quality of Life and NEO-FFI Scale in Patients with Selected Genodermatoses. | Wawrzycki B et al. | — | 2024 | → |
| Preliminary Evidence for Genetic Nurture in Depression and Neuroticism Through Polygenic Scores. | Tubbs JD et al. | — | 2023 | → |
| Behavioral Patterns of Depression Patients and Control Population. | Carreira-Míguez M et al. | — | 2022 | → |
| Moderating role of observing the five precepts of Buddhism on neuroticism, perceived stress, and depressive symptoms. | Wongpakaran N et al. | — | 2022 | → |
| Air pollution interacts with genetic risk to influence cortical networks implicated in depression. | Li Z et al. | — | 2021 | → |
| Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores. | Rao S et al. | — | 2021 | → |
| Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality. | Adewuyi EO et al. | — | 2021 | → |
| Role of Equanimity on the Mediation Model of Neuroticism, Perceived Stress and Depressive Symptoms. | Wongpakaran N et al. | — | 2021 | → |
| A genome-wide multiphenotypic association analysis identified common candidate genes for subjective well-being, depressive symptoms and neuroticism. | Chu X et al. | — | 2020 | → |
| Data mining algorithm predicts a range of adverse outcomes in major depression. | van Loo HM et al. | — | 2020 | → |
| Molecular mechanisms of psychiatric diseases. | Blokhin IO et al. | — | 2020 | → |
| Preclinical Considerations about Affective Disorders and Pain: A Broadly Intertwined, yet Often Under-Explored, Relationship Having Major Clinical Implications. | Antioch I et al. | — | 2020 | → |
| Specificity of trait anxiety in anxiety and depression: Meta-analysis of the State-Trait Anxiety Inventory. | Knowles KA et al. | — | 2020 | → |
| Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder. | Wang X et al. | — | 2020 | → |
| Neuroticism and Frontal EEG Asymmetry Correlated With Dynamic Facial Emotional Processing in Adolescents. | Moshirian Farahi SM et al. | — | 2019 | → |
| The UKB envirome of depression: from interactions to synergistic effects. | Hullam G et al. | — | 2019 | → |
| The Predictive Value of Personality Traits for Psychological Problems (Stress, Anxiety and Depression): Results from a Large Population Based Study. | Alizadeh Z et al. | — | 2018 | → |
| Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. | Genetics of Personality Consortium et al. | — | 2015 | → |
| The psychosocial indicators related to neuroticism in both sexes: A study of incoming university students. | Chang WH et al. | — | 2015 | → |
| The similarity of the structure of DSM-IV criteria for major depression in depressed women from China, the United States and Europe. | Kendler KS et al. | — | 2015 | → |
| The structure of the symptoms of major depression: exploratory and confirmatory factor analysis in depressed Han Chinese women. | Li Y et al. | — | 2014 | → |
| Comorbidity between personality disorders and depressive symptomatology in women: A cross-sectional study of three different transitional life stages. | Enfoux A et al. | — | 2013 | → |