IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

paper Cited Public

Authors: Lerner, Alana G; Upton, John-Paul; Praveen, P V K; Ghosh, Rajarshi; Nakagawa, Yoshimi; Igbaria, Aeid; Shen, Sarah; Nguyen, Vinh; Backes, Bradley J; Heiman, Myriam; Heintz, Nathaniel; Greengard, Paul; Hui, Simon; Tang, Qizhi; Trusina, Ala; Oakes, Scott A; Papa, Feroz R
Year: 2012
Journal: Cell metabolism
PMID: 22883233
DOI: 10.1016/j.cmet.2012.07.007
PMCID: PMC4014071

Figure 1

TXNIP mRNA and protein are rapidly induced in cells undergoing endoplasmic reticulum stress(A) Schematic of affinity purification of poly-ribosomes using a translational fusion of enhanced green fluorescent protein (EGFP) to the large ribosomal subunit protein L10a (EGFP-L10a). (B) Immunoblot analysis of whole cell extracts from 24 hour untreated and 1μg/ml doxycycline (Dox)- treated insulinoma (INS-1) cell lines expressing EGFP, or a EGFP translational fusion to the large ribosomal subunit protein L10a (EGFP-L10a) under a Dox inducible promoter. (C) Confocal images of INS-1 cells expressing EGFP or EGFP-L10a. Prior to imaging, cells were induced with 1μg/ml Dox for 24 hours, fixed with paraformaldehyde, and stained with 4′,6-diamidino-2-phenylindo (DAPI). (D) Immunoblot analysis of ribosomal protein L7 (RPL7) after anti-EGFP immunoprecipitation (i.p) confirms co-immunoprecipitation of ribosomes in INS-1 cells expressing EGFP-L10a (but not in cells expressing EGFP) following 24 hours treatment with 1μg/ml Dox. (E) Hierarchical clustering analysis of gene expression changes in INS-1 EGFP-L10a-expressing cells (Dox 1μg/ml for 24 hours) under ER stress through the use of DNA microarrays. cDNAs for hybridization were generated from total cellular mRNAs, or from mRNAs collected from anti-EGFP-L10a affinity-purified ribosomes. Indicated genes are those whose expression increased (red) or decreased (green) at least 2 fold under 1 μM thapsigargin (Tg) for 30 minutes (compared to no treatment). See Table S1 for gene identities, log2 expression changes, and statistics. (F & G) Time course analysis of TXNIP mRNA expression (normalized to GAPDH) during ER stress (1 μM Tg) in INS-1 cells by Northern blot, (F), or quantitative real-time PCR (Q-PCR), (G). (H) Analysis of TXNIP mRNA expression (normalized to GAPDH) during ER stress with 5 μg/ml tunicamycin (Tm) or 1 μM Tg in INS-1 cells by Q-PCR. (I) Poly-ribosome profiling demonstrates recruitment of TXNIP mRNA from monosomes into poly-ribosomes under treatment with 2.5 μg/ml brefeldin A (BFA) at 30 minutes. (J) Immunoblot detection of TXNIP protein in INS-1 cells during ER stress (1 μM Tg). (K) Immunoblot detection of TXNIP protein in INS-1 cells during ER stress (5 μg/ml Tm). Three independent biological samples were used for Q-PCR experiments. Data are shown as mean ± SD. **p < 0.005.

LLM interpretation

This multi-panel figure demonstrates the induction of TXNIP mRNA and protein during ER stress in INS-1 cells. It includes a schematic of ribosome purification (A), validation of EGFP-L10a expression and ribosome co-immunoprecipitation via immunoblots and confocal imaging (B-D), and a heatmap showing gene expression changes under thapsigargin (Tg) treatment (E). Quantitative data from Northern blots, Q-PCR, and poly-ribosome profiling (F-I) show a significant increase in TXNIP mRNA and its recruitment to poly-ribosomes, while immunoblots (J-K) confirm increased TXNIP protein levels following Tg and tunicamycin (Tm) treatment (**p < 0.005).

Figure 2

Robust induction of TXNIP requires activation of IRE1α’s bifunctional kinase and RNase domains(A) Analysis of TXNIP mRNA expression (normalized to GAPDH) by Q-PCR during ER stress treatment in UPR sensor signaling mutants. Atf6α −/−, Perk−/−, and Ire1α−/− MEFs (and wild-type counterparts) were treated with 1 μM Tg, or 5 μg/ml Tm, for 6 hours. (B) Immunoblot for TXNIP protein from whole cell lysates of wild-type, Ire1α−/− and Perk−/− MEFs untreated or treated with 1 μM Tg or 5 μg/ml Tm for 3 hrs. (C) Schematic representation of IRE1α variants used in this study, and chemical structure of 1NM-PP1. (D) Time course analysis of TXNIP mRNA expression (normalized to GAPDH) by Q-PCR through ER stress-independent forcible activation of IRE1α and mutants, and forced expression of XBP1s, in INS-1 cells with 1μg/ml Dox and 5μM 1NM-PP1. (E) Time course analysis of TXNIP proteins (by immunoblot) following forced activation of IRE1α and mutants, and forced expression of XBP1s, in INS-1 cells untreated or treated with 1μg/ml Dox and 5μM 1NM-PP1. Three independent biological samples were used for Q-PCR experiments. Data are shown as mean ± SD. **p < 0.005, *p < 0.01.

LLM interpretation

This figure consists of multiple panels analyzing the role of IRE1$\alpha$ in TXNIP induction. Panels A, D, and E are bar charts showing relative TXNIP mRNA expression, where induction by ER stress (Tg, Tm) or forced IRE1$\alpha$ activation is significantly reduced in $Ire1\alpha^{-/-}$ MEFs and IRE1$\alpha$ kinase/RNase mutants (N906A, I642G) compared to wild-type, with significance markers (*p < 0.01, **p < 0.005). Panels B, F, and G are immunoblots showing TXNIP protein levels, confirming that TXNIP expression is absent or diminished in $Ire1\alpha^{-/-}$ MEFs and specific IRE1$\alpha$ mutants following stress or activation. Panel C is a schematic diagram illustrating the domain structure of IRE1$\alpha$ variants and the chemical structure of the activator 1NM-PP1.

Figure 3

IRE1α Increases TXNIP mRNA Stability Through Decreasing miR-17(A and B) Analysis by Northern blotting and Q-PCR shows that TXNIP mRNA is short lived, but becomes stabilized under ER stress. Total RNA extracts from INS-1 cells treated with 5 μg/ml Actinomycin D plus/minus 1 μM Tg were probed for TXNIP mRNA (or GAPDH). B) Early time course (1st hour) Q-PCR of TXNIP mRNA levels (relative to GAPDH) in INS-1 cells treated with 5 μg/ml Actinomycin D plus/minus 1 μM Tg with best fit line. (C) Schematic showing miR-17 binding sites within the 3′-UTR of TXNIP mRNA across multiple species. (D) Q-PCR of miR-17 levels from HEK293 cells untreated or treated with 1 μM Tg, or 5 μg/ml Tm, for 6 hours. (E) TXNIP mRNA levels as analyzed by Q-PCR from HEK293 cells 24 hrs post transfection with scrambled or miR-17 anti-miR. (F) TXNIP mRNA levels as analyzed by Q-PCR from HEK293 cells 24 hrs post transfection with scrambled or miR-17 mimic. (G) Immunoblot analysis of miR-17 mCherry sensor in wild-type and Ire1α−/− MEFs (36 post-transfection) following treatment with DMSO control or 1 μM Tg for 12 hours. (H) IRE1α induction of TXNIP luciferase reporter is dependent on miR-17 binding sites. Dox-inducible WT-IRE1α HEK293 cells were transfected (24 hours) with a luciferase reporter construct containing wild-type or miR-17 binding mutant TXNIP 3′-UTR. The cells were treated with DMSO control or 1μg/ml Dox for 24 hours, lysed and then analyzed for luciferase activity. Three independent biological samples were used for Q-PCR and luciferase experiments. Data are shown as mean ± SD. **p < 0.005, ns = not significant.

LLM interpretation

This figure consists of multiple panels (A-I) analyzing the regulation of TXNIP mRNA by IRE1$\alpha$ and miR-17. Panels A and B use Northern blotting and a line graph to show that TXNIP mRNA degradation is slowed (stabilized) in INS-1 cells treated with Thapsigargin (Tg) compared to Actinomycin D (Act D) alone. Panels D, E, and F use bar charts to demonstrate that ER stress (Tg, Tm) decreases miR-17 levels, while miR-17 anti-miR increases and miR-17 mimics decrease TXNIP mRNA levels. Panels G, H, and I utilize immunoblots and bar charts to show that IRE1$\alpha$ increases a miR-17 sensor and a TXNIP luciferase reporter, with the latter effect being abolished when miR-17 binding sites are mutated.

Figure 4

Loss of Txnip protects MEFs and pancreatic islets against ER stress-induced apoptosis(A) Wild-type and Txnip−/− MEFs were challenged with 1 μM Tg or 5 μg/ml Tm for 24hrs and assessed for apoptosis by flow cytometry for Annexin-V binding. (B) Pancreatic islets were isolated from 6 week old C57BL/6 mice and left untreated or treated with 1 μM Tg for 6hrs. TXNIP mRNA (relative to GAPDH) was measured by Q-PCR. (C) Pancreatic islets were isolated from 6 week old Txnip+/+ and Txnip−/− mice, cultured in the absence or presence of 5 μg/ml Tm for 12hrs, and then subjected to DAPI, anti-insulin and TUNEL staining. (D) Quantification of TUNEL positive β-cells from C. Bar graphs represent three independent biological samples. All mice were on C57BL/6 genetic background. Data are shown as mean ± SD. **p < 0.005.

LLM interpretation

This figure consists of four panels evaluating the role of Txnip in ER stress-induced apoptosis. Panels A, B, and D are bar charts showing that Txnip deficiency significantly reduces apoptosis in MEFs (Annexin-V positive cells) and pancreatic islets (TUNEL positive $\beta$-cells) following treatment with Tg or Tm (**p < 0.005), while Panel B shows that Tg treatment increases TXNIP mRNA in islets. Panel C provides representative microscopy images of pancreatic islets stained for DAPI (blue), Insulin (green), and TUNEL (red), visually demonstrating a higher density of TUNEL-positive cells in $Txnip^{+/+}$ islets treated with Tm compared to $Txnip^{-/-}$ islets.

Figure 5

Txnip deficiency protects against β-cell loss and diabetes in the Ins2WT/C96Y mouse(A–C) Pancreatic islets from 3 week old Ins2WT/C96Y mice show evidence of ER stress at baseline, including increased XBP-1 splicing, decreased miR-17, and elevated TXNIP mRNA as assessed by Q-PCR. (D) Indicated genotypes showed no significant differences in body weight up to 12 weeks of age. For the 12 week timecourse, N=9 for Txnip+/+ Ins2WT/C96Y mice, N=10 for Txnip+/+Ins2WT/WT, and N=8 for both Txnip−/−Ins2WT/WT and Txnip−/−Ins2WT/C96Ymice. (E) Body glucose levels for indicated genotypes up to 12 weeks of age. Note that Txnip−/− Ins2WT/C96Ymice have significantly lower blood glucose levels compared to Txnip+/+ Ins2WT/C96Ymice at all time points. (F) Pancreatic islets were isolated from mice of indicated genotypes at 5 weeks of age and assessed by DAPI, anti-insulin and TUNEL staining. (G) Quantification of TUNEL positive β-cells from experiments in F. Bar graphs represent three independent biological samples. All mice were on C57BL/6 genetic background. Data are shown as mean ± SD. **p < 0.005.

LLM interpretation

This figure consists of multiple panels evaluating the effect of Txnip deficiency on the $Ins2^{WT/C96Y}$ mouse model. Panels A–C are bar charts showing increased XBP-1 splicing, decreased miR-17, and elevated TXNIP mRNA in $Ins2^{WT/C96Y}$ mice compared to $Ins2^{WT/WT}$ controls (**p < 0.005). Panels D and E are line graphs showing no significant difference in body weight across genotypes, but significantly lower blood glucose levels in $Txnip^{-/-}$ $Ins2^{WT/C96Y}$ mice compared to $Txnip^{+/+}$ $Ins2^{WT/C96Y}$ mice (**p < 0.005). Panels F and G provide microscopy images and a corresponding bar chart demonstrating a significant reduction in TUNEL-positive $\beta$-cells in $Txnip^{-/-}$ $Ins2^{WT/C96Y}$ mice compared to $Txnip^{+/+}$ $Ins2^{WT/C96Y}$ mice (**p < 0.005).

Figure 6

ER stress leads to IRE1 α-dependent TXNIP upregulation, NLRP3 inflammasome activation, Caspase-1 cleavage, and IL-1β secretion(A) IL-1β secretion from C57BL/6 murine islets exposed to 1μM Tg or 33 mM glucose. (B) IL-1β secretion from human THP-1 cells after 4hr treatment with DMSO control, 10μg/ml Tm, 1μM Tg, or 5 mM ATP as assessed by ELISA. (C) Caspase-1 cleavage from Pro-caspase-1 in THP_1 cells (detected by immunoblot) in response to ER stress 1μM Tg (at 2 hours and 4 hours), or 5 mM ATP at 4 hours. (D) Caspase-1 cleavage in response to ER stress (1μM Tg) is abrogated in THP-1 cells lacking the NLRP3 inflammasome (THP1-defNLRP3); compare to THP1-null positive control cells. Control DAMP, ATP, is at 5 mM. (E) (E) IL-1β secretion in response to ER stress (1μM Tg) is abrogated in THP-1 cells lacking the NLRP3 inflammasome (THP1-defNLRP3); compare to THP1-null positive control cells. Control DAMP ATP is at 5 mM. (F) STF-083010 blocks IRE1α RNase. Shown is an EtBr-stained agarose gel of XBP1 cDNA amplicons after induction of ER stress for 4 hrs in THP-1 cells using 1 μM Tg, with or without pre-treatment with STF-083010 at 50μM for 2 hours. The cDNA amplicon of unspliced XBP1 mRNA is cleaved by a PstI site within a 26 nucleotide intron to give 2U and 3U. IRE1α-mediated cleavage of the intron and re-ligation in vivo removes the PstI site to give the 1S (spliced) amplicon. *is a spliced/unspliced XBP1 hybrid amplicon. The ratio of spliced over (spliced + unspliced) amplicons—1S/(1S+2U+3U)—is reported as % spliced XBP1 amplicons. STF-083010 blocks: TXNIP mRNA upregulation in WT- IRE1α-overexpressing INS-1 cells (G), and IL-1β secretion from THP-1 cells (H). IL-1β secretion in response to 5mM ATP is unaffected by STF-083010. (E–F) Bar graphs represent three independent biological samples. Data are shown as mean ± SD. **p < 0.005, ns = not significant.

LLM interpretation

This figure consists of multiple panels (A–H) using bar charts, immunoblots, and an agarose gel to show that ER stress induces NLRP3 inflammasome activation. Bar charts (A, B, E, G, H) demonstrate increased IL-1β secretion and TXNIP mRNA levels following treatment with Tg, Tm, or high glucose, effects that are abrogated in NLRP3-deficient cells (E) or by the IRE1α inhibitor STF-083010 (H). Immunoblots (C, D) show increased Caspase-1 cleavage under ER stress (Tg) and ATP stimulation, which is absent in NLRP3-deficient cells (D). An agarose gel and corresponding graph (F) show that STF-083010 blocks Tg-induced XBP1 splicing.

Figure 7

Illustrative models of adaptive (A) and terminal (B) UPR signalingA. Under remediable levels of ER stress, adaptive UPR outputs through XBP1 mRNA splicing reduces ER stress, in turn closing negative feedback loops to shut down low-level IRE1α signaling. B. Alternatively, under irremediable levels of ER stress, hyperactivated IRE1α induces TXNIP as a potentiating step in the Terminal UPR, in part through stabilizing TXNIP mRNA by reducing levels of a repressive miR that targets TXNIP mRNA. This event combines with de novo transcription of TXNIP, through PERK kinase and ChREBP, to result in rapid elevation of TXNIP mRNA to new steady-state levels. TXNIP protein activates the NLRP3 inflammasome, which cleaves Pro-Caspase-1 to its active form, in turn causing maturation and secretion of Interleukin 1-β (IL-1β), thus promoting sterile inflammation and programmed cell death. Moreoever, ER-localized mRNA decay by hyperactivated IRE1α (requiring both a functional kinase and RNase activity) furthers—rather than corrects—ER stress, thus promoting vicious cycles of cell destruction. Also shown is the RNAse inhibitor—STF-083010—which reduces terminal UPR endpoints by inhibiting IRE1α RNAse activity.

LLM interpretation

This figure consists of two schematic diagrams illustrating the adaptive (A) and terminal (B) Unfolded Protein Response (UPR) signaling pathways. Panel A shows that remediable ER stress leads to restricted-specificity IRE1$\alpha$ RNase activation and XBP1 mRNA splicing, resulting in decreased ER stress. Panel B depicts how irremediable ER stress causes IRE1$\alpha$ hyper-activation and PERK kinase activation, leading to TXNIP protein elevation, NLRP3 inflammasome activation, and programmed cell death, while noting that the inhibitor STF-083010 blocks IRE1$\alpha$ RNase activity.

#	Section	Preview
40	EXPERIMENTAL PROCEDURES — Detection of IL-1β	Human THP-1 cells were grown in RPMI-1640 media supplemented with 10% (vol/vol) FBS and 50 μM…
41	EXPERIMENTAL PROCEDURES — Western Blots and Antibodies	For protein analysis, cells were lyzed in 1x M-PER buffer (#78501, Pierce) plus 10U protease…
42	EXPERIMENTAL PROCEDURES — RNA isolation, RT-qPCR, and Primers	RNA was isolated from whole cells using either the Qiagen RNeasy kit (#74104), or the ZR RNA…
43	EXPERIMENTAL PROCEDURES — Flow Cytometry	For assaying apoptosis by Annexin V staining, cells were plated two days prior to FACS in 6-well…
44	EXPERIMENTAL PROCEDURES — Animal Studies	C567BL/6 and C57BL/6 Ins2 WT/C96Y were obtained from Jackson Laboratories. Txnip−/− mice were…

Citation	PMID	DOI	Status
Aragon, T et al., Nature, 2009, Messenger RNA targeting to endoplasmic reticulum stress signalling sites	19079237	10.1038/nature07641	Cited
Calfon, M et al., Nature, 2002, IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA	11780124	10.1038/415092a	Cited
Cha-Molstad, H et al., J Biol Chem, 2009, Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells	19411249	10.1074/jbc.M109.010504	Cited
Chen, J et al., Diabetes, 2008, Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis	18171713	10.2337/db07-0715	Cited
Credle, JJ et al., Proc Natl Acad Sci U S A, 2005, Inaugural Article: On the mechanism of sensing unfolded protein in the endoplasmic reticulum	16365312	10.1073/pnas.0509487102	Cited
Fabian, MR et al., Annu Rev Biochem, 2010, Regulation of mRNA translation and stability by microRNAs	20533884	10.1146/annurev-biochem-060308-103103	Cited
Gardner, BM et al., Science, 2011, Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response	21852455	10.1126/science.1209126	Cited
Gething, MJ et al., Semin Cell Biol, 1990, Transport and assembly processes in the endoplasmic reticulum	1983272	—	Cited
Han, D et al., Biochem Biophys Res Commun, 2008, A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress	18035051	10.1016/j.bbrc.2007.11.040	Cited
Han, D et al., Cell, 2009, IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates	19665977	10.1016/j.cell.2009.07.017	Cited
Harding, HP et al., Cold Spring Harb Symp Quant Biol, 2001, Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum	12762052	10.1101/sqb.2001.66.499	Cited
Harding, HP et al., Nature, 1999, Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase [published erratum appears in Nature 1999 Mar 4;398(6722):90] [see comments]	9930704	10.1038/16729	Cited
Heiman, M et al., Cell, 2008, A translational profiling approach for the molecular characterization of CNS cell types	19013281	10.1016/j.cell.2008.10.028	Cited
Hui, ST et al., Proc Natl Acad Sci U S A, 2008, Txnip balances metabolic and growth signaling via PTEN disulfide reduction	18322014	10.1073/pnas.0800293105	Cited
Hui, TY et al., J Biol Chem, 2004, Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals	15047687	10.1074/jbc.M401280200	Cited
Jousse, C et al., Nucleic Acids Res, 2001, Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5′UTR	11691921	10.1093/nar/29.21.4341	Cited
Lee, AH et al., Mol Cell Biol, 2003, XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response	14559994	10.1128/MCB.23.21.7448-7459.2003	Cited
Lee, AH et al., Science, 2008, Regulation of hepatic lipogenesis by the transcription factor XBP1	18556558	10.1126/science.1158042	Cited
Lipson, KL et al., Cell Metab, 2006, Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1	16950141	10.1016/j.cmet.2006.07.007	Cited
Merksamer, PI et al., Cell, 2008, Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions	19026441	10.1016/j.cell.2008.10.011	Cited
Merksamer, PI et al., J Cell Sci, 2010, The UPR and cell fate at a glance	20332117	10.1242/jcs.035832	Cited
Minn, AH et al., Endocrinology, 2005, Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis	15705778	10.1210/en.2004-1378	Cited
Nishiyama, A et al., J Biol Chem, 1999, Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression	10419473	10.1074/jbc.274.31.21645	Cited
Oyadomari, S et al., J Clin Invest, 2002, Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes	11854325	10.1172/JCI14550	Cited
Palam, LR et al., J Biol Chem, 2011, Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation	21285359	10.1074/jbc.M110.216093	Cited
Papa, FR et al., Science, 2003, Bypassing a kinase activity with an ATP-competitive drug	14564015	10.1126/science.1090031	Cited
Papandreou, I et al., Blood, 2011, Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma	21081713	10.1182/blood-2010-08-303099	Cited
Parikh, H et al., PLoS Med, 2007, TXNIP regulates peripheral glucose metabolism in humans	17472435	10.1371/journal.pmed.0040158	Cited
Patwari, P et al., J Biol Chem, 2006, The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange	16766796	10.1074/jbc.M600427200	Cited
Ron, D, J Clin Invest, 2002, Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse	11854314	10.1172/JCI15020	Cited
Rutkowski, DT et al., PLoS Biol, 2006, Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins	17090218	10.1371/journal.pbio.0040374	Cited
Scheuner, D et al., Endocr Rev, 2008, The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes	18436705	10.1210/er.2007-0039	Cited
Shalev, A et al., Endocrinology, 2002, Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway	12193586	10.1210/en.2002-220564	Cited
Shalev, A, Biochem Soc Trans, 2008, Lack of TXNIP protects beta-cells against glucotoxicity	18793170	10.1042/BST0360963	Cited
Shore, GC et al., Curr Opin Cell Biol, 2011, Signaling cell death from the endoplasmic reticulum stress response	21146390	10.1016/j.ceb.2010.11.003	Cited
Stoy, J et al., Proc Natl Acad Sci U S A, 2007, Insulin gene mutations as a cause of permanent neonatal diabetes	17855560	10.1073/pnas.0707291104	Cited
Strowig, T et al., Nature, 2012, Inflammasomes in health and disease	22258606	10.1038/nature10759	Cited
Thomas, H et al., Nucleic Acids Res, 2004, Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line	15520459	10.1093/nar/gnh144	Cited
Tirasophon, W et al., Genes and Development, 1998, A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells	9637683	10.1101/gad.12.12.1812	Cited
Vembar, SS et al., Nat Rev Mol Cell Biol, 2008, One step at a time: endoplasmic reticulum-associated degradation	19002207	10.1038/nrm2546	Cited
Volkmann, K et al., J Biol Chem, 2011, Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease	21303903	10.1074/jbc.M110.199737	Cited
Wang, J et al., J Clin Invest, 1999, A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse	9884331	10.1172/JCI4431	Cited
Wang, XZ et al., EMBO J, 1998, Cloning of mammalian Ire1 reveals diversity in the ER stress responses	9755171	10.1093/emboj/17.19.5708	Cited
Yamanaka, H et al., Biochem Biophys Res Commun, 2000, A possible interaction of thioredoxin with VDUP1 in HeLa cells detected in a yeast two-hybrid system	10814541	10.1006/bbrc.2000.2699	Cited
Yoshida, H et al., Cell, 2001, XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor	11779464	10.1016/s0092-8674(01)00611-0	Cited
Yoshida, H et al., Journal of Biological Chemistry, 1998, Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors [published erratum appears in J Biol Chem 1999 Jan 22;274(4):2592]	9837962	10.1074/jbc.273.50.33741	Cited
Yu, FX et al., PLoS ONE, 2009, Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules	20027290	10.1371/journal.pone.0008397	Cited
Zhou, J et al., Proc Natl Acad Sci U S A, 2006, The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response	16973740	10.1073/pnas.0606480103	Cited
Zhou, R et al., Nat Immunol, 2010, Thioredoxin-interacting protein links oxidative stress to inflammasome activation	20023662	10.1038/ni.1831	Cited

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Endoplasmic reticulum stress: A key player in immune cell regulation and autoimmune disorders.	Moreews M et al.	—	2025	→
Enterotoxigenic <i>Escherichia coli</i> (ETEC) Infection Triggers Pyroptosis Through ER Stress Response-Mediated Mitochondrial Impairment and STING Activation in Intestinal Epithelial Cells.	Yang W et al.	—	2025	→
Exacerbated endoplasmic reticulum stress transmitted by endometrial stromal cells alters the conditioning of tolerogenic dendritic cells affecting trophoblast migration.	Soczewski E et al.	—	2025	→
Focus on Cell Apoptosis, Pyroptosis and Ferroptosis to Explore Strategic Breakthrough for GDM.	Li J et al.	—	2025	→
From Obesity to Muscle Insulin Resistance: The Mediating Roles of Intramyocellular Lipids, Inflammation, and Oxidative Stress.	Razi O et al.	—	2025	→
G protein-coupled estrogen receptor reduces the breast cancer cell survival by regulating the IRE1α/miR-17-5p/TXNIP pathway.	Mohammad-Sadeghipour M et al.	—	2025	→
Gut microbiota modulate intestinal inflammation by endoplasmic reticulum stress-autophagy-cell death signaling axis.	He F et al.	—	2025	→
Homeostasis control in health and disease by the unfolded protein response.	Acosta-Alvear D et al.	—	2025	→
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure.	Sun J et al.	—	2025	→
Impact of excessive hypercholesterolemia in pregnancy on the placentas of the male and female offspring.	de Oliveira AA et al.	—	2025	→
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes.	Bhushan A et al.	—	2025	→
Less is better: various means to reduce protein load in the endoplasmic reticulum.	Dabsan S et al.	—	2025	→
Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein-Barr virus in diffuse large B-cell lymphomas.	Xu H et al.	—	2025	→
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.	Zhang H et al.	—	2025	→
Manganese suppresses tumor growth through hyper-activating IRE1α.	Shi R et al.	—	2025	→
Oral TIX100 protects against obesity-associated glucose intolerance and diet-induced adiposity.	Jo S et al.	—	2025	→
Oridonin alleviates SiNPs-induced pulmonary fibrosis by inhibiting pyroptosis via IRE1α-XBP1s-NLRP3 pathway.	Ban J et al.	—	2025	→
PARP-16 regulates the PERK and IRE-1α Mediated Unfolded Protein Response in Japanese Encephalitis Virus-Infected Neural Stem/Progenitor Cells.	Sharma S et al.	—	2025	→
PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease.	Liu X et al.	—	2025	→
Prenatal Inflammatory Exposure Predisposes Offspring to Chronic Kidney Diseases Via the Activation of the eIF2α-ATF4 Pathway.	Liu J et al.	—	2025	→
Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts.	Sellin ML et al.	—	2025	→
Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation.	Spector L et al.	—	2025	→
Roles of X-box binding protein 1 in liver pathogenesis.	Tak J et al.	—	2025	→
ROS-Dependent Endoplasmic Reticulum Stress Is Involved in Silica-Induced Pulmonary Fibrosis through the GRP78/CHOP/TXNIP/NLRP3 Signaling Pathway in Rats.	Han GZ et al.	—	2025	→
Semaglutide Ameliorates Hepatocyte Steatosis in a Cell Co-Culture System by Downregulating the IRE1α-XBP1-C/EBPα Signaling Pathway in Macrophages.	Hu Q et al.	—	2025	→
Tanshinone IIA suppresses endoplasmic reticulum stress-mediated IRE1α/TXNIP/NLRP3 pathway to mitigate pyroptosis in type 2 diabetic osteoporosis.	Jiang Z et al.	—	2025	→
Target Discovery to Diabetes Therapy-TXNIP From Bench to Bedside With NIDDK.	Shalev A	—	2025	→
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice.	Wu D et al.	—	2025	→
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes.	Hansen MS et al.	—	2025	→
The Destructive Cycle in Bronchopulmonary Dysplasia: The Rationale for Systems Pharmacology Therapeutics.	Teng M et al.	—	2025	→
The endoplasmic reticulum-mitochondrial crosstalk involved in nanoplastics and di(2-ethylhexyl) phthalate co-exposure induced the damage to mouse mammary epithelial cells.	Wang C et al.	—	2025	→
The Inflammatory Bridge Between Type 2 Diabetes and Neurodegeneration: A Molecular Perspective.	Kacem H et al.	—	2025	→
The Unfolded Protein Response-Novel Mechanisms, Challenges, and Key Considerations for Therapeutic Intervention.	Mai PMQ et al.	—	2025	→
Thioredoxin-Interacting Protein (TXNIP) in Gestational Diabetes Mellitus.	Kokkinopoulou I et al.	—	2025	→
TXNIP in cancer: Unlocking biological insights and tackling clinical challenges.	Del Console P et al.	—	2025	→
TXNIP mediates ferroptosis in a bronchopulmonary dysplasia mouse model by regulating the SLC7A11/GPX4 pathway.	Chen D et al.	—	2025	→
Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities.	Abdel Mageed SS et al.	—	2025	→
Wild-Type and rtA181T/sW172* Mutant Strains of Hepatitis B Virus Drive Hepatocarcinogenesis via Distinct GRP78-Mediated ER Stress Pathways.	Liu M et al.	—	2025	→
4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis.	Xiong F et al.	—	2024	→
A metabolic redox relay supports ER proinsulin export in pancreatic islet β cells.	Rohli KE et al.	—	2024	→
A novel class of oral, non-immunosuppressive, beta cell-targeting, TXNIP-inhibiting T1D drugs is emerging.	Jing G et al.	—	2024	→
A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages.	Sasaki I et al.	—	2024	→
Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord.	Wang B et al.	—	2024	→
Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death.	Blanc M et al.	—	2024	→
Beyond insulin: Unraveling the complex interplay of ER stress, oxidative damage, and CFTR modulation in CFRD.	Umashankar B et al.	—	2024	→
Combination therapy enhances efficacy and overcomes toxicity of metal-based anti-diabetic agent.	Shang B et al.	—	2024	→
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.	Nong WJ et al.	—	2024	→
Comprehensive overview of disease models for Wolfram syndrome: toward effective treatments.	Morikawa S et al.	—	2024	→
Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy.	He J et al.	—	2024	→
Endoplasmic reticulum stress and associated apoptosis are linked with the pathogenesis of white striping in broiler breast muscles.	İpek E et al.	—	2024	→
Endoplasmic Reticulum Stress and Obesity.	Yilmaz E	—	2024	→
Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens.	Lu H et al.	—	2024	→
ER stress promotes mitochondrial calcium overload and activates the ROS/NLRP3 axis to mediate fatty liver ischemic injury.	Li F et al.	—	2024	→
Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress.	Capolupo I et al.	—	2024	→
Exploring the IRE1 interactome: From canonical signaling functions to unexpected roles.	Le Goupil S et al.	—	2024	→
Expression and correlation analysis of silent information regulator 1 (SIRT1), sterol regulatory element-binding protein-1 (SREBP1), and pyroptosis factor in gestational diabetes mellitus.	Han N et al.	—	2024	→
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.	Jia L et al.	—	2024	→
Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response.	Xue M et al.	—	2024	→
Inducers and Inhibitors of Pyroptotic Death of Granulosa Cells in Models of Premature Ovarian Insufficiency and Polycystic Ovary Syndrome.	Berkel C	—	2024	→
Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury.	Diaz-Bulnes P et al.	—	2024	→
IRE1α pathway: A potential bone metabolism mediator.	Yu C et al.	—	2024	→
Luteolin, apigenin, and chrysin inhibit lipotoxicity-induced NLRP3 inflammasome activation and autophagy damage in macrophages by suppressing endoplasmic reticulum stress.	Lo CW et al.	—	2024	→
MicroRNA-322 overexpression reduces neural tube defects in diabetic pregnancies.	Wang G et al.	—	2024	→
MicroRNA Regulation for Inflammasomes in High Glucose-Treated ARPE-19 Cells.	Kim JH et al.	—	2024	→
miR-217 Regulates Normal and Tumor Cell Fate Following Induction of Endoplasmic Reticulum Stress.	Dey N et al.	—	2024	→
Nano‑selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway.	Jiang Y et al.	—	2024	→
Navigating the landscape of the unfolded protein response in CD8<sup>+</sup> T cells.	Nair KA et al.	—	2024	→
NLRP3 inflammasome activation triggers severe inflammatory liver injury in N, N-dimethylformamide-exposed mice.	Zhang XN et al.	—	2024	→
Oxidative stress, defective proteostasis and immunometabolic complications in critically ill patients.	Galli F et al.	—	2024	→
Profiling of Unfolded Protein Response Markers and Effect of IRE1α-specific Inhibitor in Pituitary Neuroendocrine Tumor.	Morita S et al.	—	2024	→
Recent progress of endoplasmic reticulum stress in the mechanism of atherosclerosis.	Ni L et al.	—	2024	→
Redox regulation of UPR signalling and mitochondrial ER contact sites.	Casas-Martinez JC et al.	—	2024	→
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype.	Payea MJ et al.	—	2024	→
Senoinflammation as the underlying mechanism of aging and its modulation by calorie restriction.	Noh SG et al.	—	2024	→
Sox9 regulates alternative splicing and pancreatic beta cell function.	Puri S et al.	—	2024	→
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice	Wu D et al.	—	2024	—
Targeting the IRE1α-XBP1s axis confers selective vulnerability in hepatocellular carcinoma with activated Wnt signaling.	Zhang T et al.	—	2024	→
The endoplasmic reticulum protein HSPA5/BiP is essential for decidual transformation of human endometrial stromal cells.	Fernández L et al.	—	2024	→
The gasdermin family: emerging therapeutic targets in diseases.	Zhu C et al.	—	2024	→
The proteasome as a drug target for treatment of parasitic diseases.	Liu LJ et al.	—	2024	→
The Role of Endoplasmic Reticulum Stress in Metabolic Diseases.	Sak F et al.	—	2024	→
The role of endoplasmic reticulum stress, mitochondrial dysfunction and their crosstalk in intervertebral disc degeneration.	Yao D et al.	—	2024	→
The transcriptomic landscape of canonical activation of NLRP3 inflammasome from bone marrow-derived macrophages.	Zuo Z et al.	—	2024	→
Tipping-point transition from transient to persistent inflammation in pancreatic islets.	Holst-Hansen T et al.	—	2024	→
Toxoplasma-host endoplasmic reticulum interaction: How <i>T. gondii</i> activates unfolded protein response and modulates immune response.	Cudjoe O et al.	—	2024	→
Unraveling the complex interplay between Mitochondria-Associated Membranes (MAMs) and cardiovascular Inflammation: Molecular mechanisms and therapeutic implications.	Chen X et al.	—	2024	→
Unravelling the interplay between ER stress, UPR and the cGAS-STING pathway: Implications for osteoarthritis pathogenesis and treatment strategy.	Soh LJ et al.	—	2024	→
Advances in the Functions of Thioredoxin System in Central Nervous System Diseases.	Jia J et al.	—	2023	→
Antioxidant and anti-inflammatory properties of ginsenoside Rg1 for hyperglycemia in type 2 diabetes mellitus: systematic reviews and meta-analyses of animal studies.	Xie Q et al.	—	2023	→
Antioxidant System and Endoplasmic Reticulum Stress in Cataracts.	Zhang X et al.	—	2023	→
Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells.	Ihim SA et al.	—	2023	→
Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis.	Bradfield CJ et al.	—	2023	→
Celastrol targets the ChREBP-TXNIP axis to ameliorates type 2 diabetes mellitus.	Zhou D et al.	—	2023	→
Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis.	Sharma S et al.	—	2023	→
Convergence of Fructose-Induced NLRP3 Activation with Oxidative Stress and ER Stress Leading to Hepatic Steatosis.	Singh S et al.	—	2023	→
Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.	Kline GM et al.	—	2023	→
Dual RNase activity of IRE1 as a target for anticancer therapies.	Bartoszewska S et al.	—	2023	→
Endoplasmic reticulum as a therapeutic target in type 2 diabetes: Role of phytochemicals.	Sajadimajd S et al.	—	2023	→
Endoplasmic reticulum stress and the inflammatory response in allergic contact dermatitis.	Esser PR et al.	—	2023	→
Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression.	Lee JH et al.	—	2023	→
Exploring microglia and their phenomenal concatenation of stress responses in neurodegenerative disorders.	Asveda T et al.	—	2023	→
Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy <i>via</i> lipid modulation of the tumor microenvironment.	Surendran A et al.	—	2023	→
Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications.	Rabbani N et al.	—	2023	→
Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia.	Lv W et al.	—	2023	→
How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk.	Camaya I et al.	—	2023	→
Induction of Vesicular Trafficking and JNK-Mediated Apoptotic Signaling in Mononuclear Leukocytes Marks the Immuno-Proteostasis Response to Uremic Proteins.	Bartolini D et al.	—	2023	→
Insights into the Molecular Mechanisms of NRF2 in Kidney Injury and Diseases.	Lin DW et al.	—	2023	→
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Alleviates Sepsis-Induced Cardiomyopathy by Inhibiting Pyroptosis.	Liu G et al.	—	2023	→
miRNAs associated with endoplasmic reticulum stress and unfolded protein response during decidualization.	Soczewski E et al.	—	2023	→
Mitophagy, Inflammasomes and Their Interaction in Kidney Diseases: A Comprehensive Review of Experimental Studies.	Wang Y et al.	—	2023	→
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors.	Xu Y et al.	—	2023	→
Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress.	Chen M et al.	—	2023	→
Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF-kB pathway.	Sun T et al.	—	2023	→
Pathological implications of cellular stress in cardiovascular diseases.	Ulaganathan T et al.	—	2023	→
Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism.	Dagdeviren S et al.	—	2023	→
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway.	Ma ZY et al.	—	2023	→
Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications.	Vijayalalitha R et al.	—	2023	→
SARS-CoV-2 <i>ORF3A</i> interacts with the Clic-like chloride channel-1 (<i>CLCC1</i>) and triggers an unfolded protein response.	Gruner HN et al.	—	2023	→
Silicon dioxide-induced endoplasmic reticulum stress of alveolar macrophages and its role on the formation of silicosis fibrosis: a review article.	Li S et al.	—	2023	→
The NLRP3 inflammasome: contributions to inflammation-related diseases.	Chen Y et al.	—	2023	→
The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control.	Deng J et al.	—	2023	→
Thioredoxin/Glutaredoxin Systems and Gut Microbiota in NAFLD: Interplay, Mechanism, and Therapeutical Potential.	Zhu M et al.	—	2023	→
Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress.	Ong G et al.	—	2023	→
What the BTBR/J mouse has taught us about diabetes and diabetic complications.	Keller MP et al.	—	2023	→
4-PBA Attenuates Fat Accumulation in Cultured Spotted Seabass Fed High-Fat-Diet via Regulating Endoplasmic Reticulum Stress.	Xia T et al.	—	2022	→
Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection.	Weingartner M et al.	—	2022	→
Anti-inflammatory effect of glucagon-like Peptide-1 receptor agonist on the neurosensory retina in an acute optic nerve injury rat model.	Chung YW et al.	—	2022	→
An Updated View of the Importance of Vesicular Trafficking and Transport and Their Role in Immune-Mediated Diseases: Potential Therapeutic Interventions.	Ortega MA et al.	—	2022	→
Balancing energy and protein homeostasis at ER-mitochondria contact sites.	Carreras-Sureda A et al.	—	2022	→
Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells.	Alsamri H et al.	—	2022	→
Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice.	Wang SW et al.	—	2022	→
Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.	Xie X et al.	—	2022	→
Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells.	Khilji MS et al.	—	2022	→
Early life PCB138 exposure induces kidney injury secondary to hyperuricemia in male mice.	Ruan F et al.	—	2022	→
Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.	Rabbani N et al.	—	2022	→
Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption.	Campeau MA et al.	—	2022	→
Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?	Keylani K et al.	—	2022	→
Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic β-Cell Dysfunction and Senescence in Type 2 Diabetes.	Lee JH et al.	—	2022	→
Endoplasmic Reticulum Stress and Oxidative Stress in Inflammatory Diseases.	Tang Y et al.	—	2022	→
Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD).	Flessa CM et al.	—	2022	→
Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetic rats.	Yang R et al.	—	2022	→
Epstein-Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor.	Zhang T et al.	—	2022	→
Exogenous administration of unacylated ghrelin attenuates hepatic steatosis in high-fat diet-fed rats by modulating glucose homeostasis, lipogenesis, oxidative stress, and endoplasmic reticulum stress.	Alharbi S	—	2022	→
Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome.	Hu J et al.	—	2022	→
Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer's Disease Therapy.	Moreira P et al.	—	2022	→
From decidualization to pregnancy progression: An overview of immune and metabolic effects of VIP.	Ramhorst R et al.	—	2022	→
GRP94 Inhabits the Immortalized Porcine Hepatic Stellate Cells Apoptosis under Endoplasmic Reticulum Stress through Modulating the Expression of IGF-1 and Ubiquitin.	Wang X et al.	—	2022	→
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis-Driver of Insulin Resistance and Development of Vascular Complications of Diabetes.	Rabbani N et al.	—	2022	→
<i>Brucella</i> activates the host RIDD pathway to subvert BLOS1-directed immune defense.	Wells KM et al.	—	2022	→
Inflammasome activation: from molecular mechanisms to autoinflammation.	Lara-Reyna S et al.	—	2022	→
Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis.	Kulkarni A et al.	—	2022	→
Involvement of Inflammasome Components in Kidney Disease.	Aranda-Rivera AK et al.	—	2022	→
<i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy.	Liu C et al.	—	2022	→
IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis.	Huang R et al.	—	2022	→
IRE1/XBP1 and endoplasmic reticulum signaling - from basic to translational research for cardiovascular disease.	Fu F et al.	—	2022	→
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.	Auyeung VC et al.	—	2022	→
IRE1α Inhibitors as a Promising Therapeutic Strategy in Blood Malignancies.	Wiese W et al.	—	2022	→
LC-MS-Based Lipidomic Analysis of Serum Samples from Patients with Type 2 Diabetes Mellitus (T2DM).	Liu J et al.	—	2022	→
Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.	Morikawa S et al.	—	2022	→
Luteolin ameliorates depression-like behaviors by suppressing ER stress in a mouse model of Alzheimer's disease.	Tana et al.	—	2022	→
miR-17-5p Promotes Glucose Uptake of HTR8/SVneo Trophoblast Cells by Inhibiting TXNIP/NLRP3 Inflammasome Pathway.	Jiang Y et al.	—	2022	→
Multidimensional analysis and therapeutic development using patient iPSC-derived disease models of Wolfram syndrome.	Kitamura RA et al.	—	2022	→
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.	Hong Q et al.	—	2022	→
New Frontiers on ER Stress Modulation: Are TRP Channels the Leading Actors?	Vestuto V et al.	—	2022	→
NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics.	Lu N et al.	—	2022	→
Pharmacologic IRE1α kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis.	Zhang W et al.	—	2022	→
Pyroptosis-Induced Inflammation and Tissue Damage.	Wei Y et al.	—	2022	→
Pyroptosis in Kidney Disease.	Wang Y et al.	—	2022	→
Redoxisome and diabetic retinopathy: Pathophysiology and therapeutic interventions.	Sharma I et al.	—	2022	→
Regulation of influenza A virus infection by Lnc-PINK1-2:5.	Pushparaj S et al.	—	2022	→
Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy.	Wang H et al.	—	2022	→
Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer.	Mora-Molina R et al.	—	2022	→
ROS and Endoplasmic Reticulum Stress in Pulmonary Disease.	Cui X et al.	—	2022	→
ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways.	de Almeida AJPO et al.	—	2022	→
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.	Papaioannou A et al.	—	2022	→
Tanshinone IIA alleviates NLRP3 inflammasome-mediated pyroptosis in Mycobacterium tuberculosis-(H37Ra-) infected macrophages by inhibiting endoplasmic reticulum stress.	Li Y et al.	—	2022	→
Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis.	Marek-Iannucci S et al.	—	2022	→
Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway.	Liu H et al.	—	2022	→
The biology of pancreatic cancer morphology.	McDonald OG	—	2022	→
The endoplasmic reticulum participated in drug metabolic toxicity.	Huang Q et al.	—	2022	→
The endoplasmic reticulum stress sensor IRE1α modulates macrophage metabolic function during <i>Brucella abortus</i> infection.	Guimarães ES et al.	—	2022	→
The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury.	Cai J et al.	—	2022	→
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress.	Chen L et al.	—	2022	→
The Role of ER Stress in Diabetes: Exploring Pathological Mechanisms Using Wolfram Syndrome.	Morikawa S et al.	—	2022	→
The Role of the Thioredoxin System in Brain Diseases.	Bjørklund G et al.	—	2022	→
The Unfolded Protein Responses in Health, Aging, and Neurodegeneration: Recent Advances and Future Considerations.	Wodrich APK et al.	—	2022	→
The "Yin and Yang" of Unfolded Protein Response in Cancer and Immunogenic Cell Death.	Rufo N et al.	—	2022	→
Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain.	Ohmori I et al.	—	2022	→
Thioredoxin-Interacting Protein in Cancer and Diabetes.	Masutani H	—	2022	→
Tidy up - The unfolded protein response in sepsis.	Vivas W et al.	—	2022	→
Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss.	Hall BE et al.	—	2022	→
Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria.	Chen Q et al.	—	2022	→
TXNIP Links Anticipatory Unfolded Protein Response to Estrogen Reprogramming Glucose Metabolism in Breast Cancer Cells.	Wang Y et al.	—	2022	→
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.	Liu Z et al.	—	2022	→
A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells.	Karmi O et al.	—	2021	→
Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses.	Suagee-Bedore J et al.	—	2021	→
An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis.	Sahin GS et al.	—	2021	→
A small molecule UPR modulator for diabetes identified by high throughput screening.	Marrocco V et al.	—	2021	→
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.	Feldman HC et al.	—	2021	→
Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy.	Wang Y et al.	—	2021	→
Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis.	Kim HK et al.	—	2021	→
Chinese Herbal Medicine Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress.	Liang WL et al.	—	2021	→
Cholesterol Induces Pyroptosis and Matrix Degradation <i>via</i> mSREBP1-Driven Endoplasmic Reticulum Stress in Intervertebral Disc Degeneration.	Yan J et al.	—	2021	→
Chrysin prevents lipopolysaccharide-induced acute lung injury in mice by suppressing the IRE1α/TXNIP/NLRP3 pathway.	Chen M et al.	—	2021	→
Circulating microRNA alternations in primary hyperuricemia and gout.	Bohatá J et al.	—	2021	→
Crosstalk Between ER Stress, Autophagy and Inflammation.	Chipurupalli S et al.	—	2021	→
Diabetic nephropathy in mice is aggravated by the absence of podocyte IRE1 and is correlated with reduced kidney ADH1 expression.	Xie L et al.	—	2021	→
Dicarbonyl stress, protein glycation and the unfolded protein response.	Rabbani N et al.	—	2021	→
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome.	Barrera MJ et al.	—	2021	→
Early Predictors in the Onset of Type 2 Diabetes at Different Fasting Blood Glucose Levels.	Xie X et al.	—	2021	→
Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives.	Flessa CM et al.	—	2021	→
Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases.	Shi M et al.	—	2021	→
Endoplasmic reticulum stress in biological processing and disease.	Koksal AR et al.	—	2021	→
Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus.	Sule G et al.	—	2021	→
ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk-Signaling Beyond (ER) Stress Response.	Kumar V et al.	—	2021	→
Ethanol, neurosteroids and cellular stress responses: Impact on central nervous system toxicity, inflammation and autophagy.	Fujii C et al.	—	2021	→
Evolution and function of the epithelial cell-specific ER stress sensor IRE1β.	Cloots E et al.	—	2021	→
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue.	Waldhart AN et al.	—	2021	→
Exosomes Regulate NLRP3 Inflammasome in Diseases.	Li Z et al.	—	2021	→
Gut Microbiota in NSAID Enteropathy: New Insights From Inside.	Wang X et al.	—	2021	→
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.	Duwaerts CC et al.	—	2021	→
Inhibition of histone acetyltransferase by naringenin and hesperetin suppresses Txnip expression and protects pancreatic β cells in diabetic mice.	Wang SW et al.	—	2021	→
Inhibition of the PERK/TXNIP/NLRP3 Axis by Baicalin Reduces NLRP3 Inflammasome-Mediated Pyroptosis in Macrophages Infected with <i>Mycobacterium tuberculosis</i>.	Fu Y et al.	—	2021	→
Inositol Requiring Enzyme (IRE), a multiplayer in sensing endoplasmic reticulum stress.	Zhou Z et al.	—	2021	→
Integrated signaling system under endoplasmic reticulum stress in eukaryotic microorganisms.	Cao T et al.	—	2021	→
IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation.	Gómora-García JC et al.	—	2021	→
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.	Li L et al.	—	2021	→
MiR-17-5p Inhibits TXNIP/NLRP3 Inflammasome Pathway and Suppresses Pancreatic β-Cell Pyroptosis in Diabetic Mice.	Liu S et al.	—	2021	→
Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity.	van Anken E et al.	—	2021	→
Neurodegenerative Disease and the NLRP3 Inflammasome.	Holbrook JA et al.	—	2021	→
NOD-Like Receptors: Guards of Cellular Homeostasis Perturbation during Infection.	Pei G et al.	—	2021	→
Nuclear Receptors in the Control of the NLRP3 Inflammasome Pathway.	Duez H et al.	—	2021	→
OSMI-1 Enhances TRAIL-Induced Apoptosis through ER Stress and NF-κB Signaling in Colon Cancer Cells.	Lee SJ et al.	—	2021	→
Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis.	Toren E et al.	—	2021	→
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.	Ma J et al.	—	2021	→
Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells.	Bilekova S et al.	—	2021	→
PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway.	Samidurai M et al.	—	2021	→
Reactive Oxygen Species in Macrophages: Sources and Targets.	Canton M et al.	—	2021	→
Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis.	Qiao D et al.	—	2021	→
Reversal of Insulin Resistance in Overweight and Obese Subjects by <i>trans</i>-Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation.	Rabbani N et al.	—	2021	→
Role of pyroptosis in spinal cord injury and its therapeutic implications.	Al Mamun A et al.	—	2021	→
Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook.	Qayyum N et al.	—	2021	→
Roles of XBP1s in Transcriptional Regulation of Target Genes.	Park SM et al.	—	2021	→
Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity.	Gong T et al.	—	2021	→
Signal Transduction and Molecular Regulation in Fatty Liver Disease.	Dong XC et al.	—	2021	→
Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases.	Vong CT et al.	—	2021	→
Structural and Functional Significance of the Endoplasmic Reticulum Unfolded Protein Response Transducers and Chaperones at the Mitochondria-ER Contacts: A Cancer Perspective.	Amodio G et al.	—	2021	→
Taohuajing reduces oxidative stress and inflammation in diabetic cardiomyopathy through the sirtuin 1/nucleotide-binding oligomerization domain-like receptor protein 3 pathway.	Yao R et al.	—	2021	→
Targeted regulation of lymphocytic ER stress response with an overall immunosuppression to alleviate allograft rejection.	Shi Y et al.	—	2021	→
Targeting Inflammasomes to Treat Neurological Diseases.	Lünemann JD et al.	—	2021	→
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling.	Bhattarai KR et al.	—	2021	→
The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency.	Pan X et al.	—	2021	→
The molecular mechanism and functional diversity of UPR signaling sensor IRE1.	Bashir S et al.	—	2021	→
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus.	Yong J et al.	—	2021	→
Therapeutic Role of Sirtuins Targeting Unfolded Protein Response, Coagulation, and Inflammation in Hypoxia-Induced Thrombosis.	Sadia K et al.	—	2021	→
The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases.	Arioz BI et al.	—	2021	→
The Role of Mondo Family Transcription Factors in Nutrient-Sensing and Obesity.	Ke H et al.	—	2021	→
The Role of the Effects of Endoplasmic Reticulum Stress on NLRP3 Inflammasome in Diabetes.	Lv S et al.	—	2021	→
The special unfolded protein response in plasma cells.	Ricci D et al.	—	2021	→
The Uncovered Function of the <i>Drosophila GBA1a</i>-Encoded Protein.	Cabasso O et al.	—	2021	→
The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation.	Fernández D et al.	—	2021	→
Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response.	Mohamed IN et al.	—	2021	→
Titanium Dioxide Nanoparticles Exacerbate Allergic Airway Inflammation via TXNIP Upregulation in a Mouse Model of Asthma.	Lim JO et al.	—	2021	→
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.	Sicari D et al.	—	2020	→
Arthropods Under Pressure: Stress Responses and Immunity at the Pathogen-Vector Interface.	Rosche KL et al.	—	2020	→
Atorvastatin inhibits endoplasmic reticulum stress through AMPK signaling pathway in atherosclerosis in mice.	Xiong W et al.	—	2020	→
Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes.	Lee H et al.	—	2020	→
Beta Cell Therapies for Preventing Type 1 Diabetes: From Bench to Bedside.	Brawerman G et al.	—	2020	→
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components.	Lindner P et al.	—	2020	→
Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development.	Ignat SR et al.	—	2020	→
Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model.	Mohamed IN et al.	—	2020	→
Endoplasmic Reticulum Stress and Intestinal Inflammation: A Perilous Union.	Eugene SP et al.	—	2020	→
Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation.	Ding R et al.	—	2020	→
Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease.	Mou Z et al.	—	2020	→
Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia.	Yang Y et al.	—	2020	→
Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases.	Gorbatyuk MS et al.	—	2020	→
Endoplasmic reticulum stress related factor IRE1α regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy.	Ke R et al.	—	2020	→
[Endoplasmic reticulum stress response and pathogenesis of non-alcoholic steatohepatitis].	Vallée D et al.	—	2020	→
Endoplasmic Reticulum Stress Signaling in Cancer Cells.	Oakes SA	—	2020	→
Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.	Wei J et al.	—	2020	→
ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.	Salminen A et al.	—	2020	→
Folded or Degraded in Endoplasmic Reticulum.	Li C et al.	—	2020	→
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.	Dufey E et al.	—	2020	→
Ginsenoside Rg1 and the control of inflammation implications for the therapy of type 2 diabetes: A review of scientific findings and call for further research.	Alolga RN et al.	—	2020	→
GW0742 activates miR-17-5p and inhibits TXNIP/NLRP3-mediated inflammation after hypoxic-ischaemic injury in rats and in PC12 cells.	Gamdzyk M et al.	—	2020	→
Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis.	Overi D et al.	—	2020	→
<i>Brucella</i> Infection Regulates Thioredoxin-Interacting Protein Expression to Facilitate Intracellular Survival by Reducing the Production of Nitric Oxide and Reactive Oxygen Species.	Hu H et al.	—	2020	→
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action.	Thielen LA et al.	—	2020	→
Immunomodulatory Effects of Diterpenes and Their Derivatives Through NLRP3 Inflammasome Pathway: A Review.	Islam MT et al.	—	2020	→
Immunoregulation of the decidualization program: focus on the endoplasmic reticulum stress.	Soczewski E et al.	—	2020	→
Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes.	Liu L et al.	—	2020	→
Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting.	Brocker CN et al.	—	2020	→
MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System.	Pakarinen E et al.	—	2020	→
Mechanism of nonthermal induction of apoptosis by high-intensity focused electromagnetic procedure: Biochemical investigation in a porcine model.	Halaas Y et al.	—	2020	→
Mechanisms of Photoreceptor Death in Retinitis Pigmentosa.	Newton F et al.	—	2020	→
Mechanisms, regulation and functions of the unfolded protein response.	Hetz C et al.	—	2020	→
MicroRNAs as important regulators of the NLRP3 inflammasome.	Zamani P et al.	—	2020	→
Neuroplastin Modulates Anti-inflammatory Effects of MANF.	Yagi T et al.	—	2020	→
Nicotinic acetylcholine receptor signaling regulates inositol-requiring enzyme 1α activation to protect β-cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress.	Ishibashi T et al.	—	2020	→
Nonesterified free fatty acids enhance the inflammatory response in renal tubules by inducing extracellular ATP release.	Sun H et al.	—	2020	→
Novel Forms of Immunomodulation for Cancer Therapy.	Serrano-Del Valle A et al.	—	2020	→
Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis.	Zeng X et al.	—	2020	→
Phosphatidylinositol 3-kinase-δ controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice.	Lee HY et al.	—	2020	→
Regulation of autophagy by canonical and non-canonical ER stress responses.	Bhardwaj M et al.	—	2020	→
RIPK3-mediated inflammation is a conserved β cell response to ER stress.	Yang B et al.	—	2020	→
Role of Damage-Associated Molecular Patterns in Light of Modern Environmental Research: A Tautological Approach.	Land WG	—	2020	→
Role of Endoplasmic Reticulum Stress in Atherosclerosis and Its Potential as a Therapeutic Target.	Yang S et al.	—	2020	→
Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation.	Riaz TA et al.	—	2020	→
Roles of Noncoding RNAs in Islet Biology.	Guay C et al.	—	2020	→
Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer.	Lafont E	—	2020	→
Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib.	Yamashita Y et al.	—	2020	→
Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges.	Barua D et al.	—	2020	→
The ageing lung under stress.	Korfei M et al.	—	2020	→
The Anti-Inflammatory Effects of Glucagon-Like Peptide Receptor Agonist Lixisenatide on the Retinal Nuclear and Nerve Fiber Layers in an Animal Model of Early Type 2 Diabetes.	Chung YW et al.	—	2020	→
The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.	Kobiita A et al.	—	2020	→
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.	Zhang IX et al.	—	2020	→
The Impact of the ER Unfolded Protein Response on Cancer Initiation and Progression: Therapeutic Implications.	Lebeaupin C et al.	—	2020	→
The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.	Khilji MS et al.	—	2020	→
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.	Wilson RB et al.	—	2020	→
The NLRP3-inflammasome as a sensor of organelle dysfunction.	Seoane PI et al.	—	2020	→
The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes.	Wang J et al.	—	2020	→
The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.	Okamoto T et al.	—	2020	→
The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation.	Zhou Y et al.	—	2020	→
The UPR in Neurodegenerative Disease: Not Just an Inside Job.	van Ziel AM et al.	—	2020	→
Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases.	Tsubaki H et al.	—	2020	→
Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated apoptotic cell death in liver cancer cells.	Li Z et al.	—	2020	→
Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective.	Wang Z et al.	—	2020	→
Type I interferons and endoplasmic reticulum stress in health and disease.	Sprooten J et al.	—	2020	→
Up-regulation of Thioredoxin 1 by aerobic exercise training attenuates endoplasmic reticulum stress and cardiomyocyte apoptosis following myocardial infarction.	Cai M et al.	—	2020	→
VIP conditions human endometrial receptivity by privileging endoplasmic reticulum stress through ATF6α pathway.	Soczewski E et al.	—	2020	→
At the crossway of ER-stress and proinflammatory responses.	Reverendo M et al.	—	2019	→
CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule.	Sauzay C et al.	—	2019	→
Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.	Ohe K et al.	—	2019	→
Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases.	Duvigneau JC et al.	—	2019	→
Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.	Feldman HC et al.	—	2019	→
Dicer regulates activation of the NLRP3 inflammasome.	Ojcius DM et al.	—	2019	→
Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases.	Boxberger N et al.	—	2019	→
Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease.	Huang S et al.	—	2019	→
Endoplasmic reticulum stress and NLRP3 inflammasome: Crosstalk in cardiovascular and metabolic disorders.	Ji T et al.	—	2019	→
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes.	Ghosh R et al.	—	2019	→
ER-Mitochondria Communication in Cells of the Innate Immune System.	Namgaladze D et al.	—	2019	→
ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis.	Chen X et al.	—	2019	→
Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis.	Panganiban RA et al.	—	2019	→
HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection.	Tseng PC et al.	—	2019	→
Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β.	Talty A et al.	—	2019	→
Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer's Disease.	Llanos-González E et al.	—	2019	→
IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.	Yan C et al.	—	2019	→
JUND regulates pancreatic β cell survival during metabolic stress.	Good AL et al.	—	2019	→
Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response.	Rutkowski DT	—	2019	→
Mechanisms protecting host cells against bacterial pore-forming toxins.	Brito C et al.	—	2019	→
Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.	Chan KR et al.	—	2019	→
MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis.	Zhu Y et al.	—	2019	→
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.	Takeda K et al.	—	2019	→
Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion.	Coucha M et al.	—	2019	→
Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.	Ding S et al.	—	2019	→
Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1.	Romer AI et al.	—	2019	→
Non-del(5q) myelodysplastic syndromes-associated loci detected by SNP-array genome-wide association meta-analysis.	McGraw KL et al.	—	2019	→
Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.	Moore PC et al.	—	2019	→
Plant Sterol Ester of <i>α</i>-Linolenic Acid Attenuates Nonalcoholic Fatty Liver Disease by Rescuing the Adaption to Endoplasmic Reticulum Stress and Enhancing Mitochondrial Biogenesis.	Han H et al.	—	2019	→
Proteostasis In The Endoplasmic Reticulum: Road to Cure.	Nam SM et al.	—	2019	→
Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors.	Cheng SB et al.	—	2019	→
Reactive oxygen species-mediated endoplasmic reticulum stress response induces apoptosis of Mycobacterium avium-infected macrophages by activating regulated IRE1-dependent decay pathway.	Go D et al.	—	2019	→
Recent advances in signal integration mechanisms in the unfolded protein response.	Karagöz GE et al.	—	2019	→
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept.	Chung HY et al.	—	2019	→
Right place, right time: localisation and assembly of the NLRP3 inflammasome.	Hamilton C et al.	—	2019	→
ROR2 induces cell apoptosis via activating IRE1α/JNK/CHOP pathway in high-grade serous ovarian carcinoma in vitro and in vivo.	Li R et al.	—	2019	→
Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells.	Chou X et al.	—	2019	→
Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.	Thamsen M et al.	—	2019	→
Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of <i>Sec63</i> in Collecting Ducts.	Ishikawa Y et al.	—	2019	→
Targeting innate immune mediators in type 1 and type 2 diabetes.	Donath MY et al.	—	2019	→
The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms.	Korbecki J et al.	—	2019	→
The multiple roles of the unfolded protein response regulator IRE1α in cancer.	Chalmers F et al.	—	2019	→
Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to <i>Escherichia coli</i> Through Inflammasome-Mediated Caspase-1 Activation in Macrophages.	Yoon SJ et al.	—	2019	→
Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells.	Flores-Santibáñez F et al.	—	2019	→
Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice.	Lebeaupin C et al.	—	2018	→
Biosynthesis, structure, and folding of the insulin precursor protein.	Liu M et al.	—	2018	→
Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance.	Onyango AN	—	2018	→
Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response.	Chandrahas VK et al.	—	2018	→
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.	Chang TK et al.	—	2018	→
Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition.	Ding XQ et al.	—	2018	→
Deactivation of the NLRP3 inflammasome in infiltrating macrophages by duodenal-jejunal bypass surgery mediates improvement of beta cell function in type 2 diabetes.	Wu D et al.	—	2018	→
Decoding cold ischaemia time impact on kidney graft: the kinetics of the unfolded protein response pathways.	Le Pape S et al.	—	2018	→
Developmental origins of nonalcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.	Spradley FT et al.	—	2018	→
Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP.	Thielen L et al.	—	2018	→
Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling.	Papaioannou A et al.	—	2018	→
Eating the Beast: Dietary Protein and Anticancer Immunity.	Green DR	—	2018	→
Effects of proinsulin misfolding on β-cell dynamics, differentiation and function in diabetes.	Riahi Y et al.	—	2018	→
Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes.	Danilova T et al.	—	2018	→
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjögren's syndrome.	Barrera MJ et al.	—	2018	→
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease.	Lebeaupin C et al.	—	2018	→
Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.	Sullivan WJ et al.	—	2018	→
Fermentation Products of <i>Paenibacillus bovis</i> sp. nov. BD3526 Alleviates the Symptoms of Type 2 Diabetes Mellitus in GK Rats.	Qiao Z et al.	—	2018	→
FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury.	Han CY et al.	—	2018	→
Ginsenoside Rg1 Protects against Non-alcoholic Fatty Liver Disease by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation.	Xu Y et al.	—	2018	→
Globular adiponectin protects rat hepatocytes against acetaminophen-induced cell death via modulation of the inflammasome activation and ER stress: Critical role of autophagy induction.	Kim EH et al.	—	2018	→
Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins.	Gong T et al.	—	2018	→
Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes.	Li M et al.	—	2018	→
Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells.	Grasso E et al.	—	2018	→
Inflammation initiated by stressed organelles.	Martinon F	—	2018	→
Inhibition of ER stress-related IRE1α/CREB/NLRP1 pathway promotes the apoptosis of human chronic myelogenous leukemia cell.	Xu Z et al.	—	2018	→
Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases.	García-González P et al.	—	2018	→
Intravenous human endothelial progenitor cell administration into aged mice enhances embryo development and oocyte quality by reducing inflammation, endoplasmic reticulum stress and apoptosis.	Kim GA et al.	—	2018	→
IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8<sup>+</sup> T Cell Priming.	Medel B et al.	—	2018	→
IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.	Junjappa RP et al.	—	2018	→
IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats.	Chen D et al.	—	2018	→
Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress.	Guo M et al.	—	2018	→
Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.	Szpigel A et al.	—	2018	→
MALAT1 via microRNA-17 regulation of insulin transcription is involved in the dysfunction of pancreatic β-cells induced by cigarette smoke extract.	Sun Q et al.	—	2018	→
Metabolic Syndrome, Brain Insulin Resistance, and Alzheimer's Disease: Thioredoxin Interacting Protein (TXNIP) and Inflammasome as Core Amplifiers.	Nasoohi S et al.	—	2018	→
miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function.	Jo S et al.	—	2018	→
miR-346 functions as a pro-survival factor under ER stress by activating mitophagy.	Guo J et al.	—	2018	→
Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets.	Rovira-Llopis S et al.	—	2018	→
Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs.	Kinoshita C et al.	—	2018	→
New insights into Nod-like receptors (NLRs) in liver diseases.	Xu T et al.	—	2018	→
Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice.	Mukai S et al.	—	2018	→
Old and Young Actors Playing Novel Roles in the Drama of Multiple Myeloma Bone Marrow Microenvironment Dependent Drug Resistance.	Manni S et al.	—	2018	→
Paraptosis in human glioblastoma cell line induced by curcumin.	Garrido-Armas M et al.	—	2018	→
Potentials of Gene Therapy for Diabetic Retinopathy: The Use of Nucleic Acid Constructs Containing a TXNIP Promoter.	Lalit PS et al.	—	2018	→
Protein Quality Control in the Endoplasmic Reticulum and Cancer.	Moon HW et al.	—	2018	→
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.	Forrester SJ et al.	—	2018	→
Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity.	Smith JA	—	2018	→
Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress.	Masciarelli S et al.	—	2018	→
Roles of Endoplasmic Reticulum Stress in Immune Responses.	So JS	—	2018	→
Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly.	Komatsu T et al.	—	2018	→
Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction.	Amodio G et al.	—	2018	→
The kinase receptor-interacting protein 1 is required for inflammasome activation induced by endoplasmic reticulum stress.	Tao L et al.	—	2018	→
Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice.	Mukai S et al.	—	2018	→
The role of mitochondria in NLRP3 inflammasome activation.	Liu Q et al.	—	2018	→
The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses.	Martinvalet D	—	2018	→
The Unfolded Protein Response and Cell Fate Control.	Hetz C et al.	—	2018	→
The unknown face of IRE1α - Beyond ER stress.	Abdullah A et al.	—	2018	→
Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication.	Nasoohi S et al.	—	2018	→
Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.	Wu Y et al.	—	2018	→
Understanding the Unfolded Protein Response in the Pathogenesis of Asthma.	Pathinayake PS et al.	—	2018	→
Allergy-Inducing Chromium Compounds Trigger Potent Innate Immune Stimulation Via ROS-Dependent Inflammasome Activation.	Adam C et al.	—	2017	→
Altered Expression of Endoplasmic Reticulum Stress-Related Genes in the Middle Frontal Cortex of Subjects with Autism Spectrum Disorder.	Crider A et al.	—	2017	→
Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.	Chan SMH et al.	—	2017	→
Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury.	Yuan X et al.	—	2017	→
Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation.	Zhang J et al.	—	2017	→
Causes and consequences of endoplasmic reticulum stress in rheumatic disease.	Navid F et al.	—	2017	→
Correction of intermittent hypoxia reduces inflammation in obese subjects with obstructive sleep apnea.	Perrini S et al.	—	2017	→
Differential processing of small RNAs during endoplasmic reticulum stress.	Mesitov MV et al.	—	2017	→
Elovl6 Deficiency Improves Glycemic Control in Diabetic <i>db</i>/<i>db</i> Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.	Zhao H et al.	—	2017	→
Endoplasmic reticulum proteostasis: a key checkpoint in cancer.	Oakes SA	—	2017	→
Endoplasmic Reticulum Stress, a Driver or an Innocent Bystander in Endothelial Dysfunction Associated with Hypertension?	Cunard R	—	2017	→
Endoplasmic Reticulum Stress and Obesity.	Yilmaz E	—	2017	→
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Nexus Implicated in Bowel Disease Pathophysiology.	Chong WC et al.	—	2017	→
Endoplasmic reticulum stress and the development of endothelial dysfunction.	Battson ML et al.	—	2017	→
Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers.	Avril T et al.	—	2017	→
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras.	Blazanin N et al.	—	2017	→
Expression of urinary miRNAs targeting NLRs inflammasomes in bladder cancer.	Mearini E et al.	—	2017	→
Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis.	Medinas DB et al.	—	2017	→
From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration.	Erpapazoglou Z et al.	—	2017	→
Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome.	Weh E et al.	—	2017	→
High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress.	Coucha M et al.	—	2017	→
Identification of transcriptome signature for myocardial reductive stress.	Quiles JM et al.	—	2017	→
Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review.	Ma X et al.	—	2017	→
IRE1 signaling exacerbates Alzheimer's disease pathogenesis.	Duran-Aniotz C et al.	—	2017	→
IRE1α promotes viral infection by conferring resistance to apoptosis.	Fink SL et al.	—	2017	→
MicroRNAs as stress regulators in pancreatic beta cells and diabetes.	LaPierre MP et al.	—	2017	→
Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins.	Zhuang X et al.	—	2017	→
MondoA/ChREBP: The usual suspects of transcriptional glucose sensing; Implication in pathophysiology.	Richards P et al.	—	2017	→
mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress.	Chau GC et al.	—	2017	→
(Neuro)degenerated Mitochondria-ER contacts.	De Mario A et al.	—	2017	→
NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy.	Luo B et al.	—	2017	→
Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.	Mukai S et al.	—	2017	→
Potent NLRP3 Inflammasome Activation by the HIV Reverse Transcriptase Inhibitor Abacavir.	Toksoy A et al.	—	2017	→
Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions.	Ilacqua N et al.	—	2017	→
Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons.	Zaragoza-Campillo MA et al.	—	2017	→
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.	Tavernier SJ et al.	—	2017	→
Regulation of the unfolded protein response by noncoding RNA.	McMahon M et al.	—	2017	→
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.	Morita S et al.	—	2017	→
Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.	Clark AL et al.	—	2017	→
Targeting IRE1 with small molecules counteracts progression of atherosclerosis.	Tufanli O et al.	—	2017	→
The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD⁺ Levels and Attenuation of NLRP3 Inflammasome Activation in High-Fat-Diet-Treated Mice.	Wang X et al.	—	2017	→
The pivotal role of extracellular signal-regulated kinase in gap junction-mediated regulation of TXNIP.	Gao S et al.	—	2017	→
The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise.	Hong J et al.	—	2017	→
The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy.	Rufo N et al.	—	2017	→
Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage.	Zhao Q et al.	—	2017	→
Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage.	Zhao Q et al.	—	2017	→
Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.	Pagliassotti MJ et al.	—	2017	→
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer.	Cubillos-Ruiz JR et al.	—	2017	→
Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity.	Yoo YS et al.	—	2017	→
Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer.	Cubillos-Ruiz JR et al.	—	2017	→
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.	Di Micco A et al.	—	2016	→
An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response.	Brown M et al.	—	2016	→
A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?	Herbert TP et al.	—	2016	→
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.	García de la Cadena S et al.	—	2016	→
Cell Signaling and Stress Responses.	Hotamisligil GS et al.	—	2016	→
Cellular stress and innate inflammation in organ-specific autoimmunity: lessons learned from vitiligo.	Harris JE	—	2016	→
Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries.	Nakka VP et al.	—	2016	→
Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.	Hong K et al.	—	2016	→
Endocannabinoid regulation of β-cell functions: implications for glycaemic control and diabetes.	Jourdan T et al.	—	2016	→
Endoplasmic reticulum proteostasis in hepatic steatosis.	Baiceanu A et al.	—	2016	→
Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.	Meyerovich K et al.	—	2016	→
Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing.	Heindryckx F et al.	—	2016	→
Endoplasmic reticulum stress in beta cells and autoimmune diabetes.	Clark AL et al.	—	2016	→
Epithelial ER Stress in Crohn's Disease and Ulcerative Colitis.	Cao SS	—	2016	→
ER stress and development of type 1 diabetes.	Engin F	—	2016	→
ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes.	Brozzi F et al.	—	2016	→
ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis.	Zhang J et al.	—	2016	→
Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression.	Gomez JA et al.	—	2016	→
Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.	Sun H et al.	—	2016	→
Innate immunity in diabetes and diabetic nephropathy.	Wada J et al.	—	2016	→
Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses.	Valadão AL et al.	—	2016	→
IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma.	Tan HY et al.	—	2016	→
Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice.	Li A et al.	—	2016	→
MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes.	Li XF et al.	—	2016	→
MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis.	Dong D et al.	—	2016	→
miR-204 Targets PERK and Regulates UPR Signaling and β-Cell Apoptosis.	Xu G et al.	—	2016	→
Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1<i>β</i> Production.	Tőzsér J et al.	—	2016	→
Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes.	Hasnain SZ et al.	—	2016	→
PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.	Eletto D et al.	—	2016	→
PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury.	Han CY et al.	—	2016	→
Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation.	Çimen I et al.	—	2016	→
Protein misfolding in the endoplasmic reticulum as a conduit to human disease.	Wang M et al.	—	2016	→
Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay.	Sieber J et al.	—	2016	→
Reprint of: Signaling the Unfolded Protein Response in primary brain cancers.	Le Reste PJ et al.	—	2016	→
RNA sequence analyses of r-Moj-DM treated cells: TXNIP is required to induce apoptosis of SK-Mel-28.	McBride TD et al.	—	2016	→
Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases.	Thoudam T et al.	—	2016	→
Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells.	Robblee MM et al.	—	2016	→
Signaling the Unfolded Protein Response in primary brain cancers.	Le Reste PJ et al.	—	2016	→
Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.	Feldman HC et al.	—	2016	→
The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury.	Yue S et al.	—	2016	→
The unfolded protein response in immunity and inflammation.	Grootjans J et al.	—	2016	→
Transplantation and Damage-Associated Molecular Patterns (DAMPs).	Land WG et al.	—	2016	→
Adaptation of the secretory pathway in cancer through IRE1 signaling.	Lhomond S et al.	—	2015	→
Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium.	Zhao Y et al.	—	2015	→
ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells.	Odisho T et al.	—	2015	→
Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?	Celli J et al.	—	2015	→
Controlling the unfolded protein response-mediated life and death decisions in cancer.	Maurel M et al.	—	2015	→
Derivatives containing both coumarin and benzimidazole potently induce caspase-dependent apoptosis of cancer cells through inhibition of PI3K-AKT-mTOR signaling.	Liu H et al.	—	2015	→
Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress.	Rosales-Corral S et al.	—	2015	→
Dysfunction in protein clearance by the proteasome: impact on autoinflammatory diseases.	Brehm A et al.	—	2015	→
Early Life Exposure to Fructose Alters Maternal, Fetal and Neonatal Hepatic Gene Expression and Leads to Sex-Dependent Changes in Lipid Metabolism in Rat Offspring.	Clayton ZE et al.	—	2015	→
Endocrine aspects of organelle stress—cell non-autonomous signaling of mitochondria and the ER.	Schinzel R et al.	—	2015	→
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.	Chevet E et al.	—	2015	→
Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.	Bronner DN et al.	—	2015	→
Endoplasmic reticulum stress and unfolded protein response in inflammatory bowel disease.	Cao SS	—	2015	→
Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer's disease.	Huang HC et al.	—	2015	→
Endoplasmic reticulum stress in immunity.	Bettigole SE et al.	—	2015	→
ENDOPLASMIC RETICULUM STRESS IN SEPSIS.	Khan MM et al.	—	2015	→
Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly.	Cunard R	—	2015	→
Erratum: Proteostasis control by the unfolded protein response.	Hetz C et al.	—	2015	→
ER stress induces NLRP3 inflammasome activation and hepatocyte death.	Lebeaupin C et al.	—	2015	→
Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease.	Verdile G et al.	—	2015	→
Initiation and perpetuation of NLRP3 inflammasome activation and assembly.	Elliott EI et al.	—	2015	→
Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway.	Lencer WI et al.	—	2015	→
Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells.	Song J et al.	—	2015	→
New mechanisms of metformin action: Focusing on mitochondria and the gut.	Hur KY et al.	—	2015	→
New players driving inflammation in monogenic autoinflammatory diseases.	Martinon F et al.	—	2015	→
NLRP3 at the interface of metabolism and inflammation.	Haneklaus M et al.	—	2015	→
NOD-like receptors: versatile cytosolic sentinels.	Motta V et al.	—	2015	→
Proteostasis control by the unfolded protein response.	Hetz C et al.	—	2015	→
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?	Abais JM et al.	—	2015	→
Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit.	Mohamed IN et al.	—	2015	→
Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.	Yang CS et al.	—	2015	→
Stress responses during ageing: molecular pathways regulating protein homeostasis.	Kyriakakis E et al.	—	2015	→
Targeting endoplasmic reticulum stress in insulin resistance.	Salvadó L et al.	—	2015	→
The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production.	Abuaita BH et al.	—	2015	→
The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic β-cell damage in Akita mice.	Wang J et al.	—	2015	→
The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine.	Land WG	—	2015	→
The role of endoplasmic reticulum stress in human pathology.	Oakes SA et al.	—	2015	→
The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding.	Zhang SX et al.	—	2015	→
Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.	D'Osualdo A et al.	—	2015	→
Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition.	Hameed I et al.	—	2015	→
Viral infection of engrafted human islets leads to diabetes.	Gallagher GR et al.	—	2015	→
γ-Oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice.	Kozuka C et al.	—	2015	→
12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.	Tersey SA et al.	—	2014	→
Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.	Wali JA et al.	—	2014	→
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.	Ghosh R et al.	—	2014	→
AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease.	Steinberg GR et al.	—	2014	→
A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.	van Anken E et al.	—	2014	→
ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury.	Rao J et al.	—	2014	→
Calcium efflux from the endoplasmic reticulum leads to β-cell death.	Hara T et al.	—	2014	→
Caspases and inflammasomes in metabolic inflammation.	Skeldon AM et al.	—	2014	→
CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis.	Li C et al.	—	2014	→
Druggable sensors of the unfolded protein response.	Maly DJ et al.	—	2014	→
Emerging functions of the unfolded protein response in immunity.	Janssens S et al.	—	2014	→
Endoplasmic reticulum: an interface between the immune system and metabolism.	Unanue ER et al.	—	2014	→
Endoplasmic reticulum proteins quality control and the unfolded protein response: the regulative mechanism of organisms against stress injuries.	Fu XL et al.	—	2014	→
Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease.	Cao SS et al.	—	2014	→
Endoplasmic reticulum stress associated responses in cancer.	Wang WA et al.	—	2014	→
Endoplasmic reticulum stress in cerebral ischemia.	Xin Q et al.	—	2014	→
Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases.	Guo B et al.	—	2014	→
Epigenetics and the unfolded protein response in the lung: emerging role for microRNAs.	Nana-Sinkam SP et al.	—	2014	→
[ER stress and β cell death - therapeutic approach to combat ER stress].	Hara T et al.	—	2014	→
Feroz Papa: Saving cells from themselves.	Sedwick C et al.	—	2014	→
Getting RIDD of RNA: IRE1 in cell fate regulation.	Maurel M et al.	—	2014	→
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.	Hasnain SZ et al.	—	2014	→
Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment.	Ackerman D et al.	—	2014	→
Inflammasomes.	de Zoete MR et al.	—	2014	→
Inflammasomes and metabolic disorders: old genes in modern diseases.	Robbins GR et al.	—	2014	→
IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.	Zhang L et al.	—	2014	→
Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.	Biden TJ et al.	—	2014	→
Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.	Ip BC et al.	—	2014	→
MicroRNA regulation of mitochondrial and ER stress signaling pathways: implications for lipoprotein metabolism in metabolic syndrome.	Christian P et al.	—	2014	→
MICRORNAs IN ER STRESS: DIVERGENT ROLES IN CELL FATE DECISIONS.	Malhi H	—	2014	→
Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic β-cell.	Shalev A	—	2014	→
Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression.	Li H et al.	—	2014	→
Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia.	Abais JM et al.	—	2014	→
p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.	Winnay JN et al.	—	2014	→
Pro-inflammatory/Th1 gene expression shift in high glucose stimulated mesangial cells and tubular epithelial cells.	Iwata Y et al.	—	2014	→
Redox controls UPR to control redox.	Eletto D et al.	—	2014	→
Regulatory crosstalk within the mammalian unfolded protein response.	Brewer JW	—	2014	→
Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model.	Luo B et al.	—	2014	→
Targeting inflammation in diabetes: Newer therapeutic options.	Agrawal NK et al.	—	2014	→
Targeting inflammation in the treatment of type 2 diabetes: time to start.	Donath MY	—	2014	→
The endoplasmic reticulum-mitochondria connection: one touch, multiple functions.	Marchi S et al.	—	2014	→
The impact of the endoplasmic reticulum protein-folding environment on cancer development.	Wang M et al.	—	2014	→
Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet.	Mohamed IN et al.	—	2014	→
Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo.	Park MJ et al.	—	2014	→
Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes.	Chong CR et al.	—	2014	→
Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.	Lee S et al.	—	2014	→
Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop.	Chen J et al.	—	2014	→
Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases.	Yoshihara E et al.	—	2014	→
THP-1 cell line: an in vitro cell model for immune modulation approach.	Chanput W et al.	—	2014	→
Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells.	Luo Y et al.	—	2014	→
Unfolded protein response signaling and metabolic diseases.	Lee J et al.	—	2014	→
Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer.	Pluquet O et al.	—	2014	→
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.	Jourdan T et al.	—	2013	→
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells.	Boslem E et al.	—	2013	→
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.	Wu N et al.	—	2013	→
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.	Teske BF et al.	—	2013	→
Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks.	O'Shea JM et al.	—	2013	→
Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy.	Devi TS et al.	—	2013	→
[Endoplasmic reticulum stress: from physiology to pathogenesis of type 2 diabetes].	Flamment M et al.	—	2013	→
Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.	Miani M et al.	—	2013	→
Endoplasmic reticulum stress signaling: the microRNA connection.	Maurel M et al.	—	2013	→
ER stress-induced cell death mechanisms.	Sano R et al.	—	2013	→
Global cellular response to chemotherapy-induced apoptosis.	Wiita AP et al.	—	2013	→
IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells.	Hasnain SZ et al.	—	2013	→
Interleukin-1 antagonists for diabetes.	Mandrup-Poulsen T et al.	—	2013	→
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.	Yamaguchi K et al.	—	2013	→
IRE1: ER stress sensor and cell fate executor.	Chen Y et al.	—	2013	→
Islet inflammation: a unifying target for diabetes treatment?	Imai Y et al.	—	2013	→
Islet β cell mass in diabetes and how it relates to function, birth, and death.	Weir GC et al.	—	2013	→
Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetes.	Wali JA et al.	—	2013	→
Live or let die: posttranscriptional gene regulation in cell stress and cell death.	Thomas MP et al.	—	2013	→
Mechanisms of NOD-like receptor-associated inflammasome activation.	Wen H et al.	—	2013	→
Mechanistic target of rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia.	Wong RW et al.	—	2013	→
Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state.	Marin T et al.	—	2013	→
Micro(RNA)managing endoplasmic reticulum stress.	Byrd AE et al.	—	2013	→
Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.	Binet F et al.	—	2013	→
NLR activation takes a direct route.	Monie TP	—	2013	→
Nlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?	Dixit VD	—	2013	→
Pathogenesis of acute stroke and the role of inflammasomes.	Fann DY et al.	—	2013	→
Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes.	Yang C et al.	—	2013	→
Posttranslational regulation of thioredoxin-interacting protein.	Robinson KA et al.	—	2013	→
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.	Arensdorf AM et al.	—	2013	→
Regulation of the unfolded protein response by microRNAs.	Bartoszewska S et al.	—	2013	→
Role of pancreatic β-cell death and inflammation in diabetes.	Quan W et al.	—	2013	→
Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.	Eizirik DL et al.	—	2013	→
Small-molecule inhibition of inflammatory β-cell death.	Lundh M et al.	—	2013	→
Specific inflammasomes in complex diseases.	Masters SL	—	2013	→
Stress-response pathways are altered in the hippocampus of chronic alcoholics.	McClintick JN et al.	—	2013	→
Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells.	Ikeda A et al.	—	2013	→
Targeting endoplasmic reticulum stress in metabolic disease.	Cao SS et al.	—	2013	→
The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders.	Benetti E et al.	—	2013	→
The role of the unfolded protein response in diabetes mellitus.	Iwawaki T et al.	—	2013	→
The therapeutic potential of modifying inflammasomes and NOD-like receptors.	Di Virgilio F	—	2013	→
The UPR in atherosclerosis.	Zhou AX et al.	—	2013	→
Thioredoxin Interacting Protein (TXNIP) and Pathogenesis of Diabetic Retinopathy.	Singh LP	—	2013	→
Transcriptomic changes induced by mycophenolic acid in gastric cancer cells.	Dun B et al.	—	2013	→
TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.	Park YJ et al.	—	2013	→
Type 2 diabetes mellitus: a metabolic autoinflammatory disease.	Mandrup-Poulsen T	—	2013	→
When ER stress reaches a dead end.	Urra H et al.	—	2013	→
X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis.	Valentine CD et al.	—	2013	→
Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes.	Mandrup-Poulsen T	—	2012	→
IRE1, a double-edged sword in pre-miRNA slicing and cell death.	Hassler J et al.	—	2012	→
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.	Upton JP et al.	—	2012	→