Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders.
paper
Cited
Public
- Authors
- Andersen, Allan M; Dogan, Meeshanthini V; Beach, Steven R H; Philibert, Robert A
- Year
- 2015
- Journal
- Genes
- PMID
- 26473933
- DOI
- 10.3390/genes6040991
- PMCID
- PMC4690026
Substance abuse has an enormous impact on economic and quality of life measures throughout the world. In more developed countries, overutilization of the most common forms of substances of abuse, alcohol and tobacco, is addressed primarily through prevention of substance use initiation and secondarily through the treatment of those with substance abuse or dependence. In general, these therapeutic approaches to substance abuse are deemed effective. However, there is a broad consensus that the development of additional tools to aid diagnosis, prioritize treatment selection and monitor treatment response could have substantial impact on the effectiveness of both substance use prevention and treatment. The recent demonstrations by a number of groups that substance use exposure is associated with robust changes in DNA methylation signatures of peripheral blood cells suggests the possibility that methylation assessments of blood or saliva could find broad clinical applications. In this article, we review recent progress in epigenetic approaches to substance use assessment with a particular emphasis on smoking (and alcohol) related applications. In addition, we highlight areas, such as the epigenetics of psychostimulant, opioid and cannabis abuse, which are markedly understudied and could benefit from intensified collaborative efforts to define epigenetic biomarkers of abuse and dependence.
Global disability-adjusted life years (DALYs) annually by risk factor.
Global deaths annually by risk factor.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The genetic epidemiology of substance use disorder: A review. | 2017 | 28938182 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Biochemical Diagnosis in Substance and Non-substance Addiction. | Shen W et al. | — | 2025 | → |
| Current advances in multi-strategy collaborative sensitization for self-powered electrochemical biosensors and their applications in disease biomarker detection. | Gao YP et al. | — | 2025 | → |
| Drug-Induced Epigenetic Alterations: A Set of Forensic Toxicological Fingerprints?-A Systematic Review. | Grassi S et al. | — | 2025 | → |
| Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control. | Perry S et al. | — | 2025 | → |
| Predicting Completion of Ecological Momentary Assessments Among Substance-Using Women Experiencing Intimate Partner Violence. | Yang M et al. | — | 2024 | → |
| Epigenetic Regulation of <i>F2RL3</i> Associates With Myocardial Infarction and Platelet Function. | Corbin LJ et al. | — | 2022 | → |
| An Examination of Risk Factors for Tobacco and Cannabis Smoke Exposure in Adolescents Using an Epigenetic Biomarker. | Andersen A et al. | — | 2021 | → |
| Cost-utility analysis of an integrated genetic/epigenetic test for assessing risk for coronary heart disease. | Jung Y et al. | — | 2021 | → |
| DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. | Carleial S et al. | — | 2021 | → |
| Emerging Single-Cell Technological Approaches to Investigate Chromatin Dynamics and Centromere Regulation in Human Health and Disease. | Leo L et al. | — | 2021 | → |
| Epigenome-wide analysis uncovers a blood-based DNA methylation biomarker of lifetime cannabis use. | Markunas CA et al. | — | 2021 | → |
| Epigenome-wide study of brain DNA methylation following acute opioid intoxication. | Shu C et al. | — | 2021 | → |
| LINE-1 methylation mediates the inverse association between body mass index and breast cancer risk: A pilot study in the Lebanese population. | Awada Z et al. | — | 2021 | → |
| MTHFR promoter methylation might mitigate the effect of smoking at the level of LINE-1 in cleft lip tissues: A preliminary study. | Khan MFJ et al. | — | 2021 | → |
| Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health. | Traversi D et al. | — | 2021 | → |
| The relationship of smoking to cg05575921 methylation in blood and saliva DNA samples from several studies. | Dawes K et al. | — | 2021 | → |
| AHRR methylation predicts smoking status and smoking intensity in both saliva and blood DNA. | Philibert R et al. | — | 2020 | → |
| Cigarette and Cannabis Smoking Effects on GPR15+ Helper T Cell Levels in Peripheral Blood: Relationships with Epigenetic Biomarkers. | Andersen AM et al. | — | 2020 | → |
| DNA Methylation-Based Biomarkers of Environmental Exposures for Human Population Studies. | Nwanaji-Enwerem JC et al. | — | 2020 | → |
| Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples. | Aberg KA et al. | — | 2020 | → |
| Opioid use disorder research and the Council for the Advancement of Nursing Science priority areas. | Eckardt P et al. | — | 2020 | → |
| Refinement of cg05575921 demethylation response in nascent smoking. | Dawes K et al. | — | 2020 | → |
| The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome. | Chung FF et al. | — | 2020 | → |
| A Direct Comparison of the Relationship of Epigenetic Aging and Epigenetic Substance Consumption Markers to Mortality in the Framingham Heart Study. | Mills JA et al. | — | 2019 | → |
| A Four Marker Digital PCR Toolkit for Detecting Heavy Alcohol Consumption and the Effectiveness of Its Treatment. | Philibert R et al. | — | 2019 | → |
| AHRR Methylation is a Significant Predictor of Mortality Risk in Framingham Heart Study. | Philibert RA et al. | — | 2019 | → |
| Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse. | Tay N et al. | — | 2019 | → |
| Epigenetic pharmacotherapy for substance use disorder. | Sartor GC | — | 2019 | → |
| Epigenome-wide analysis uncovers a blood-based DNA methylation biomarker of lifetime cannabis use | Markunas CA et al. | — | 2019 | — |
| Exposure-induced changes of plasma metabolome and gene expression in patients with panic disorder. | Martins J et al. | — | 2019 | → |
| How alcohol drinking affects our genes: an epigenetic point of view. | Ciafrè S et al. | — | 2019 | → |
| Saliva DNA Methylation Detects Nascent Smoking in Adolescents. | Dawes K et al. | — | 2019 | → |
| Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration: The Veterans Affairs Normative Aging Study. | Yang Y et al. | — | 2019 | → |
| The epigenetic modulation of alcohol/ethanol and cannabis exposure/co-exposure during different stages. | Dobs YE et al. | — | 2019 | → |
| A Droplet Digital PCR Assay for Smoking Predicts All-Cause Mortality. | Andersen AM et al. | — | 2018 | → |
| A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies. | Clark SL et al. | — | 2018 | → |
| Cell-type-specific disturbance of DNA methylation pattern: a chance to get more benefit from and to minimize cohorts for epigenome-wide association studies. | Bauer M | — | 2018 | → |
| DNA methylation analysis from saliva samples for epidemiological studies. | Nishitani S et al. | — | 2018 | → |
| DNA methylation assay based on pyrosequencing for determination of smoking status. | Alghanim H et al. | — | 2018 | → |
| DNA methylation signatures: Biomarkers of drug and alcohol abuse. | Mahna D et al. | — | 2018 | → |
| Dose Response and Prediction Characteristics of a Methylation Sensitive Digital PCR Assay for Cigarette Consumption in Adults. | Philibert R et al. | — | 2018 | → |
| Effect of stress on human biology: Epigenetics, adaptation, inheritance, and social significance. | Denhardt DT | — | 2018 | → |
| iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation. | Komaki S et al. | — | 2018 | → |
| Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation. | Witt SH et al. | — | 2018 | → |
| Methylation of <i>MTHFR</i> Moderates the Effect of Smoking on Genomewide Methylation Among Middle Age African Americans. | Andersen AM et al. | — | 2018 | → |
| RaMWAS: fast methylome-wide association study pipeline for enrichment platforms. | Shabalin AA et al. | — | 2018 | → |
| Accuracy and utility of an epigenetic biomarker for smoking in populations with varying rates of false self-report. | Andersen AM et al. | — | 2017 | → |
| Biochemical Diagnosis in Substance and Non-substance Addiction. | Shen W et al. | — | 2017 | → |
| Challenges in the analysis of epigenetic biomarkers in clinical samples. | García-Giménez JL et al. | — | 2017 | → |
| DNA modifications in models of alcohol use disorders. | Tulisiak CT et al. | — | 2017 | → |
| Emerging Role of Epigenetic Mechanisms in Alcohol Addiction. | Berkel TD et al. | — | 2017 | → |
| Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory. | García-Giménez JL et al. | — | 2017 | → |
| Epigenetic mediators and consequences of excessive alcohol consumption. | Mahnke AH et al. | — | 2017 | → |
| Epigenetic programming of the neuroendocrine stress response by adult life stress. | Dirven BCJ et al. | — | 2017 | → |
| Genetically contextual effects of smoking on genome wide DNA methylation. | Dogan MV et al. | — | 2017 | → |
| Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies. | Hachiya T et al. | — | 2017 | → |
| Potential Mechanisms Underlying the Therapeutic Effects of Electroconvulsive Therapy. | Jiang J et al. | — | 2017 | → |
| Sodium bisulfite pyrosequencing revealed that developmental exposure to environmental contaminant mixtures does not affect DNA methylation of DNA repeats in Sprague-Dawley rats. | Desaulniers D et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| Forensic DNA methylation profiling from evidence material for investigative leads. | Lee HY et al. | — | 2016 | → |
| Making Sense of Epigenetics. | Schuebel K et al. | — | 2016 | → |
| Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration. | Gao X et al. | — | 2016 | → |
| Reversion of AHRR Demethylation Is a Quantitative Biomarker of Smoking Cessation. | Philibert R et al. | — | 2016 | → |