DRD2 gene
Evidence from:
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all sources
Related entities (12)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| DRD2 | risk_factor_for | alcoholism | — | 1 |
| DRD2 | associated_with | ANKK1 | — | 1 |
| DRD2 | risk_factor_for | AUD | — | 1 |
| DRD2 | risk_factor_for | borderline personality disorder | 0.002 | 1 |
| DRD2 | associated_with | borderline personality disorder | — | 1 |
| DRD2 | biomarker_for | D2 receptor density | — | 1 |
| DRD2 | expressed_in | dorsal striatum | — | 1 |
| DRD2 | interacts_with | DRD4 7-repeat allele | — | 1 |
| DRD2 | associated_with | impulsivity | — | 2 |
| DRD2 | risk_factor_for | novelty seeking | — | 1 |
| DRD2 | risk_factor_for | pathological gambling | — | 1 |
| DRD2 | risk_factor_for | substance abuse | — | 1 |
Mentioned in (111)
Papers in which this entity is mentioned.
- Mapping the genetic landscape across 14 psychiatric disorders. (2026)
- Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. (2025)
- Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. (2025)
- Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. (2025)
- Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence. (2024)
- Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder. (2024)
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. (2024)
- Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. (2023)
- Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. (2022)
- Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk. (2022)
- Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans. (2022)
- Genetic variants associated with longitudinal changes in brain structure across the lifespan. (2022)
- Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. (2021)
- Transcriptional and anatomical diversity of medium spiny neurons in the primate striatum. (2021)
- Genetics of substance use disorders in the era of big data. (2021)
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years. (2021)
- TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease. (2020)
- Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. (2020)
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. (2020)
- DNA methylation and brain structure and function across the life course: A systematic review. (2020)
- Effects of chronic intermittent ethanol exposure and withdrawal on neuroblastoma cell transcriptome. (2020)
- Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. (2020)
- Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction. (2019)
- Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019)
- Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. (2019)
- Psychiatric Genomics: An Update and an Agenda. (2018)
- mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. (2018)
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (2018)
- Neuroepigenetics and addiction. (2018)
- Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. (2018)
- Regional Differences and Similarities in the Brain Transcriptome for Mice Selected for Ethanol Preference From HS-CC Founders. (2018)
- An Update on Non-CB, Non-CB Cannabinoid Related G-Protein-Coupled Receptors. (2017)
- Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017)
- Genetic studies of alcohol dependence in the context of the addiction cycle. (2017)
- Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits. (2017)
- Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017)
- Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. (2016)
- CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. (2016)
- Effects of early life stress on amygdala and striatal development. (2016)
- Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. (2015)
- Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. (2015)
- Mechanisms of retinoic acid signalling and its roles in organ and limb development. (2015)
- Candidate gene-environment interaction research: reflections and recommendations. (2015)
- Functional Connectivity Disruption in Neonates with Prenatal Marijuana Exposure. (2015)
- Evaluating historical candidate genes for schizophrenia. (2015)
- Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015)
- The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction. (2014)
- Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development. (2014)
- Dissecting impulsivity and its relationships to drug addictions. (2014)
- Cannabis controversies: how genetics can inform the study of comorbidity. (2014)
- Genome-wide association discoveries of alcohol dependence. (2014)
- Epigenetics, microRNA, and addiction. (2014)
- Rethinking schizophrenia in the context of normal neurodevelopment. (2013)
- ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (2013)
- Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. (2013)
- Impact of combined prenatal ethanol and prenatal stress exposure on anxiety and hippocampal-sensitive learning in adult offspring. (2013)
- Synaptic effects induced by alcohol. (2013)
- Strain dependent gene expression and neurochemical levels in the brain of zebrafish: focus on a few alcohol related targets. (2012)
- Does moderate drinking harm the fetal brain? Insights from animal models. (2012)
- Predictors of relapse in a bupropion trial for smoking cessation in recently-abstinent alcoholics: preliminary results using an aggregate genetic risk score. (2012)
- The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. (2012)
- Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. (2012)
- Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans. (2012)
- The genetics of alcohol dependence: advancing towards systems-based approaches. (2012)
- The genetic basis of addictive disorders. (2012)
- The impact of gene-environment interaction on alcohol use disorders. (2012)
- Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. (2012)
- Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (2012)
- Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012)
- Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice. (2011)
- DISC1 at 10: connecting psychiatric genetics and neuroscience. (2011)
- The effects of prenatal alcohol exposure on behavior: rodent and primate studies. (2011)
- TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (2011)
- Early adolescent cocaine use as determined by hair analysis in a prenatal cocaine exposure cohort. (2011)
- Gene-environment interaction in psychological traits and disorders. (2011)
- Human aggression across the lifespan: genetic propensities and environmental moderators. (2011)
- Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. (2011)
- Prenatal and postnatal cocaine exposure predict teen cocaine use. (2011)
- AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. (2011)
- Pharmacological treatment of cannabis dependence. (2011)
- Transcriptional and epigenetic mechanisms of addiction. (2011)
- Recent research on impulsivity in individuals with drug use and mental health disorders: implications for alcoholism. (2010)
- Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. (2010)
- Adolescent development of the reward system. (2010)
- Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. (2010)
- Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. (2010)
- Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. (2010)
- Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. (2010)
- Neurobiology of the adolescent brain and behavior: implications for substance use disorders. (2010)
- Cocaine exposure modulates dopamine and adenosine signaling in the fetal brain. (2010)
- Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell. (2009)
- Prenatal exposure to drugs: effects on brain development and implications for policy and education. (2009)
- Cannabis and psychosis/schizophrenia: human studies. (2009)
- Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. (2009)
- Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. (2009)
- Genome-wide association studies in ADHD. (2009)
- Neuroimaging of children following prenatal drug exposure. (2009)
- Protein kinases and addiction. (2008)
- Sensory processing disorder in a primate model: evidence from a longitudinal study of prenatal alcohol and prenatal stress effects. (2008)
- Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. (2008)
- Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. (2008)
- Association study of Wnt signaling pathway genes in bipolar disorder. (2008)
- EEG biofeedback as a treatment for substance use disorders: review, rating of efficacy, and recommendations for further research. (2008)
- Genetic and environmental factors in complex neurodevelopmental disorders. (2007)
- Efficiency and cost of economical brain functional networks. (2007)
- Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors. (2007)
- Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. (2007)
- Effects of chronic alcohol and repeated deprivations on dopamine D1 and D2 receptor levels in the extended amygdala of inbred alcohol-preferring rats. (2006)
- In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons. (2000)
- Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. (1998)
- Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. (1997)
Merged raw entities (24)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| drd2 | gene | 111 | 341 |
| d2 receptor | gene | 2 | 2 |
| drd2 a1 | variant | 2 | 2 |
| drd2 a1 allele | variant | 2 | 3 |
| drd2 variant | variant | 2 | 2 |
| d2 | gene | 1 | 1 |
| d2r | gene | 1 | 2 |
| a1 allele | gene | — | — |
| brain dopamine d2 receptor | gene | — | — |
| d2 dopamine receptor | gene | — | — |
| d2-dopamine receptor | gene | — | — |
| d2 dopamine receptor gene | gene | — | — |
| d2-like dopamine receptor | gene | — | — |
| d2l receptor | gene | — | — |
| d2 receptor binding | gene | — | — |
| da d2 receptor | gene | — | — |
| dopamine d2-like receptor | gene | — | — |
| dopamine d2 receptor gene | gene | — | — |
| dopamine receptor 2 | gene | — | — |
| dopamine receptor d2 | gene | — | — |
| dopamine type 2 receptor | gene | — | — |
| drd2 a1 | gene | — | — |
| drd2 a1-allele | gene | — | — |
| drd2 taqia | gene | — | — |