Edenberg, Howard J

Also known as: Edenberg, H, Edenberg, Howard, Edenberg, H J

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

Research Summary

Howard J. Edenberg’s research centers on the genetics and neurobiology of substance‑use disorders, especially alcohol use disorder (AUD), using large‑scale GWAS, polygenic‑score analyses, and functional genomics. He has contributed dozens of genome‑wide risk loci for AUD, nicotine dependence, and obsessive‑compulsive disorder, demonstrated how AUD‑associated variants drive cell‑type‑specific transcriptional and chromatin changes in the human caudate (including dysregulated medium‑spiny neurons, microglia, and astrocytes), and linked polygenic risk to clinical outcomes such as suicide attempts, remission trajectories, developmental patterns of drinking, and gene‑environment interplay (e.g., genetic nurture, social support). His work also bridges genetics to mechanistic studies in human iPSC‑derived neurons and microglia, revealing how variants in genes like KCNJ6 (GIRK2) modulate neuronal excitability and ethanol responses.

Title	Year	PMID
Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12.	1997	9184306
Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism.	1997	9347089
Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.	1991	2014795
Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.	1989	2562960

Resolved affiliation

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

May be outdated — new papers have been added.

Raw imported affiliations (112)

Affiliation
Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Biochemistry and Molecular Biology.
Department of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Biochemistry and Molecular Biology and the Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Biochemistry and Molecular Biology, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Biochemistry and Molecular Biology, (HE), Indiana University School of Medicine, Indianapolis, Indiana.
Department of Biochemistry and Molecular Biology, Indiana University.
Department of Biochemistry and Molecular Biology , Indiana University, Bloomington, Indiana.
Department of Biochemistry and Molecular Biology,Indiana University,Bloomington,Indiana,47405,USA.
Department of Biochemistry and Molecular Biology, Indiana University, Bloomington, Indiana, USA.
Department of Biochemistry and Molecular Biology, Indiana University, Bloomington, IN, USA.
Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis.
Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, Indiana, USA.
Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, USA. edenberg@iupui.edu
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis.