E
Edenberg, Howard J
Also known as: Edenberg, H, Edenberg, Howard, Edenberg, H J
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
Research Summary
Howard J. Edenberg’s research centers on the genetics and neurobiology of substance‑use disorders, especially alcohol use disorder (AUD), using large‑scale GWAS, polygenic‑score analyses, and functional genomics. He has contributed dozens of genome‑wide risk loci for AUD, nicotine dependence, and obsessive‑compulsive disorder, demonstrated how AUD‑associated variants drive cell‑type‑specific transcriptional and chromatin changes in the human caudate (including dysregulated medium‑spiny neurons, microglia, and astrocytes), and linked polygenic risk to clinical outcomes such as suicide attempts, remission trajectories, developmental patterns of drinking, and gene‑environment interplay (e.g., genetic nurture, social support). His work also bridges genetics to mechanistic studies in human iPSC‑derived neurons and microglia, revealing how variants in genes like KCNJ6 (GIRK2) modulate neuronal excitability and ethanol responses.
Resolved affiliation
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
May be outdated — new papers have been added.
Raw imported affiliations (112)
| Affiliation |
|---|
| Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. |
| Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States. |
| Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA. |
| Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
| Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. |
| Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. edenberg@iu.edu. |
| Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana. |
| Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN. |
| Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA. |
| Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. |
| Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA. |
| Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. |
| Department of Molecular Biology, Indiana University, Indianapolis, IN, United States of America. |
| Department of Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. |
| Department of Psychiatry and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA. |
| Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA. |
| Department of Psychology, University of Texas at Austin (Mallard, Grotzinger, Harden); Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam (Savage); Department of Psychiatry, Washington University School of Medicine, Saint Louis (Johnson, Anokhin, Agrawal); Department of Psychiatry (Huang, Jennings, Palmer, Sanchez-Roige) and Institute for Genomic Medicine (Palmer), University of California San Diego, La Jolla; Virginia Institute for Psychiatric and Behavioral Genetics, Richmond (Edwards); Department of Biological Psychiatry, Vrije Universiteit Amsterdam (Hottenga, Nivard, de Geus, Boomsma); Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tenn. (Gustavson, Davis, Sanchez-Roige); Department of Psychology, Virginia Commonwealth University, Richmond (Dick); Department of Biochemistry and Molecular Biology (Edenberg) and Department of Medical and Molecular Genetics (Lai), Indiana University School of Medicine, Indianapolis; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City (Kramer); Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, N.Y. (Meyers, Pandey); Department of Psychiatry and Behavioral Sciences and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tenn. (Davis); Division of Psychiatry, University of Edinburgh, Edinburgh, U.K. (Clarke). |
| Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA. |
| Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. |
| Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: edenberg@iu.edu. |