Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.
- Authors
- Latendresse, Shawn J; Bates, John E; Goodnight, Jackson A; Lansford, Jennifer E; Budde, John P; Goate, Alison; Dodge, Kenneth A; Pettit, Gregory S; Dick, Danielle M
- Year
- 2011
- Journal
- Child development
- PMID
- 21883161
- DOI
- 10.1111/j.1467-8624.2011.01640.x
- PMCID
- PMC3218245
The present study characterized prototypical patterns of development in self-reported externalizing behavior, between 12 and 22 years of age, within a community sample of 452 genotyped individuals. A Caucasian subset (n = 378) was then examined to determine whether their probabilities of displaying discrete trajectories were differentially associated with CHRM2, a gene implicated in self-regulatory processes across a range of externalizing behaviors, and if affiliating with antisocial peers moderated these associations. Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2, and that this association was exacerbated among those exposed to higher levels of peer group antisocial behavior.
Location of genotyped SNPs within the CHRM2 gene (not drawn to scale; kb represents 1000 base pairs). Dark gray box represents coding sequence (CDS), light gray boxes represent exons encoding untranslated sequences, and the black bar represents intronic sequences.
LLM interpretation
This is a schematic diagram illustrating the locations of genotyped single nucleotide polymorphisms (SNPs) within the *CHRM2* gene. The gene structure is depicted with exons (light gray for untranslated sequences, dark gray for the coding sequence/CDS) and introns (black bar), with specific distances between certain regions labeled in kilobases (81.7 kb, 41.1 kb, and 22.6 kb). Several SNPs are mapped to specific intronic regions, including a cluster of six SNPs (rs978437 through rs1378646) and individual SNPs rs1824024, rs324650, and rs8191992.
Three-class quadratic solution for trajectories of self-reported externalizing problems from 12 to 22 years of age.
LLM interpretation
This line graph displays three quadratic trajectories of self-reported externalizing problems from age 12 to 22. The "Decreasing Low" (57.8%) and "Decreasing Moderate" (33.4%) groups show a steady decline in problems over time, while the "Stable High" group (8.8%) shows an increase that peaks around age 17 before slightly declining. The y-axis measures the level of externalizing problems, and the x-axis represents age in years.
Expected trajectory class membership as a function of CHRM2 genotype (rs978437) and peer group antisocial behavior, wherein “A” represents the minor allelic variant.
LLM interpretation
This grouped bar chart shows the expected trajectory class membership for externalizing behavior based on CHRM2 genotype (GG, AG, AA) and peer group antisocial behavior (Low vs. High). For both peer groups, the "decreasing low externalizing" class is the most prevalent, though its percentage decreases as the number of minor alleles (A) increases, particularly in the high peer group. Conversely, the "decreasing moderate" and "stable high" externalizing classes show an increase in membership as the genotype shifts from GG to AA, most notably within the high peer group antisocial behavior condition.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The impact of gene-environment interaction on alcohol use disorders. | 2012 | 23134047 |
| Gene-environment interaction in psychological traits and disorders. | 2011 | 21219196 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Exploring the influence of the DRD2 gene on mathematical ability: perspectives of gene association and gene-environment interaction. | Yang Q et al. | — | 2024 | → |
| Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects. | Trucco EM et al. | — | 2020 | → |
| Genes, Roommates, and Residence Halls: A Multidimensional Study of the Role of Peer Drinking on College Students' Alcohol Use. | Smith RL et al. | — | 2019 | → |
| Patterns of Sensitivity to Parenting and Peer Environments: Early Temperament and Adolescent Externalizing Behavior. | Tung I et al. | — | 2019 | → |
| Social-ecological predictors of externalizing behavior trajectories in at-risk youth. | Figge CJ et al. | — | 2018 | → |
| Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors. | Li JJ | — | 2017 | → |
| Dimensionality and Genetic Correlates of Problem Behavior in Low-Income African American Adolescents. | Latendresse SJ et al. | — | 2017 | → |
| Latent trajectories of adolescent antisocial behavior: Serotonin transporter linked polymorphic region (5-HTTLPR) genotype influences sensitivity to perceived parental support. | Tung I et al. | — | 2017 | → |
| Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents. | Chang H et al. | — | 2017 | → |
| African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. | Levran O et al. | — | 2016 | → |
| Aggressive behavior in humans: Genes and pathways identified through association studies. | Fernàndez-Castillo N et al. | — | 2016 | → |
| Genetics of aggressive behavior: An overview. | Veroude K et al. | — | 2016 | → |
| Sensation seeking, peer deviance, and genetic influences on adolescent delinquency: Evidence for person-environment correlation and interaction. | Mann FD et al. | — | 2016 | → |
| Biological Risk for the Development of Problem Behavior in Adolescence: Integrating Insights from Behavioral Genetics and Neuroscience. | Harden KP et al. | — | 2015 | → |
| Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting. | Wiggins JL et al. | — | 2015 | → |
| Peer Experiences in Short-Term Residential Treatment: Individual and Group-Moderated Prediction of Behavioral Responses to Peers and Adults. | Cardoos SL et al. | — | 2015 | → |
| RORA and posttraumatic stress trajectories: main effects and interactions with childhood physical abuse history. | Lowe SR et al. | — | 2015 | → |
| Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression. | Ceremuga TE et al. | — | 2014 | → |
| Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes. | Lichenstein SD et al. | — | 2014 | → |
| Gene-environment interaction. | Manuck SB et al. | — | 2014 | → |
| Neural and genetic correlates of binge drinking among college women. | Bauer LO et al. | — | 2014 | → |
| The Association Between Peer and own Aggression is Moderated by the <i>BDNF</i> Val-met Polymorphism. | Kretschmer T et al. | — | 2014 | → |
| Behavior genetics: past, present, future. | Jaffee SR et al. | — | 2013 | → |
| Dopamine receptor D4 gene moderates the effect of positive and negative peer experiences on later delinquency: the Tracking Adolescents' Individual Lives Survey study. | Kretschmer T et al. | — | 2013 | → |
| Genotype by environment interaction and neurodevelopment III. Focus on the child's broader social ecology. | Bellani M et al. | — | 2013 | → |
| Optimizing efficiency of psychopathology assessment through quantitative modeling: development of a brief form of the Externalizing Spectrum Inventory. | Patrick CJ et al. | — | 2013 | → |
| The impact of gene-environment interaction on alcohol use disorders. | Dick DM et al. | — | 2012 | → |
| An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. | Dick DM | — | 2011 | → |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | — | 2011 | → |
| Incorporating genetics into your studies: a guide for social scientists. | Dick DM et al. | — | 2011 | → |
| Nature and nurture in neuropsychiatric genetics: where do we stand? | Dick DM et al. | — | 2010 | → |