Second-generation PLINK: rising to the challenge of larger and richer datasets.
paper
Cited
Public
- Authors
- Chang, Christopher C; Chow, Carson C; Tellier, Laurent Cam; Vattikuti, Shashaank; Purcell, Shaun M; Lee, James J
- Year
- 2015
- Journal
- GigaScience
- PMID
- 25722852
- DOI
- 10.1186/s13742-015-0047-8
- PMCID
- PMC4342193
BACKGROUND: PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (GWAS) and research in population genetics. However, the steady accumulation of data from imputation and whole-genome sequencing studies has exposed a strong need for faster and scalable implementations of key functions, such as logistic regression, linkage disequilibrium estimation, and genomic distance evaluation. In addition, GWAS and population-genetic data now frequently contain genotype likelihoods, phase information, and/or multiallelic variants, none of which can be represented by PLINK 1's primary data format. FINDINGS: To address these issues, we are developing a second-generation codebase for PLINK. The first major release from this codebase, PLINK 1.9, introduces extensive use of bit-level parallelism, [Formula: see text]-time/constant-space Hardy-Weinberg equilibrium and Fisher's exact tests, and many other algorithmic improvements. In combination, these changes accelerate most operations by 1-4 orders of magnitude, and allow the program to handle datasets too large to fit in RAM. We have also developed an extension to the data format which adds low-overhead support for genotype likelihoods, phase, multiallelic variants, and reference vs. alternate alleles, which is the basis of our planned second release (PLINK 2.0). CONCLUSIONS: The second-generation versions of PLINK will offer dramatic improvements in performance and compatibility. For the first time, users without access to high-end computing resources can perform several essential analyses of the feature-rich and very large genetic datasets coming into use.
Computation pattern for our 2 Γ 3 Fisherβs exact test implementation. This is a plot of the set of alternative 2 Γ 3 contigency tables explicitly considered by our algorithm when testing the table with 65, 136, 324 in the top row and 81, 172, 314 in the bottom row. Letting β denote the relative likelihood of observing the tested table under the null hypothesis, the set of tables with null hypothesis relative likelihoods between 2β53β and β has an ellipsoidal annulus shape, with area scaling as O(n) as the problem size increases; while the set of tables with relative likelihood greater than 2β53lmax (where lmax is the maximal single-table relative likelihood) has an elliptical shape, also with O(n) area. Summing the relative likelihoods in the first set, and then dividing that number by the sum of the relative likelihoods in the second set, yields the desired p-value to 10+ digit accuracy in O(n) time. In addition, we exploit the fact that a βrowβ of 2 Γ 3 table likelihoods sums to a single 2 Γ 2 table likelihood; this lets us essentially skip the top and bottom of the annulus, as well as all but a single row of the central ellipse.
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| Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease. | Miller SJ et al. | β | 2026 | β |
| Investigating genetic differentiation between brackish and fresh water collections of the arboviral vector Aedes aegypti. | Balcazar D et al. | β | 2026 | β |
| Ischaemic heart disease is the factor associated with severe COVID-19 in the urban population of Uzbekistan: a singleβcenter retrospective study. | Ibadullaeva N et al. | β | 2026 | β |
| Isolation and divergence of Greater Earless Lizards (Phrynosomatidae: Cophosaurus) in western North America support multiple diversification processes and a complex demographic history. | Blair C et al. | β | 2026 | β |
| Isotopic and genetic evidence of partial mycoheterotrophy in leafy variants of Cremastra aphylla, a predominantly leafless orchid. | Suetsugu K et al. | β | 2026 | β |
| Ivermectin reduces withdrawal-induced alcohol intake in rats: Association with CeA GABAergic enhancement and P2rx4 genetic liability. | Campo P et al. | β | 2026 | β |
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| Kinship estimation bias carries over to heritability estimation bias using variance components. | Hou Z et al. | β | 2026 | β |
| Knowledge-graph embeddings for osteoarthritis candidate prediction. | Wang Z et al. | β | 2026 | β |
| Large-Scale Facial Image Analysis and GWAS Unravel the Genetic Architecture of Facial Morphological Aging. | Shin JG et al. | β | 2026 | β |
| Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease. | Wu C et al. | β | 2026 | β |
| Leaping between branches: Hybridisation and the tangled evolutionary history of true lemurs. | Mercuri G et al. | β | 2026 | β |
| Leveraging ancestral recombination graphs for scalable mixed-model analysis of complex traits. | Zhu J et al. | β | 2026 | β |
| Leveraging Knowledge of Traditional Italian Maize Landrace Diversity to Identify Signals of Local Adaptation. | Lezzi A et al. | β | 2026 | β |
| Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity's influence on breast cancer risk. | Power GM et al. | β | 2026 | β |
| LiMA: Robust inference of molecular mediation from summary statistics. | Lepik K et al. | β | 2026 | β |
| Linking the plasma proteome to genetics in individuals from continental Africa provides insights into type 2 diabetes pathogenesis. | Soremekun O et al. | β | 2026 | β |
| Lizards on a sky archipelago: Genomic approaches to the evolution of the mountain genus Iberolacerta. | Talavera A et al. | β | 2026 | β |
| Longitudinal study on the association between salty food preference and obesity prevalence. | Bae JH et al. | β | 2026 | β |
| <i>CMTM8</i> variants influence BNT162b2 COVID-19 vaccination response by regulating granulocytic/polymorphonuclear myeloid-derived suppressor cell activity. | Testori A et al. | β | 2026 | β |
| m6AConquer: a consistently quantified and orthogonally validated database for the N6-methyladenosine (m6A) epitranscriptome. | Zhao X et al. | β | 2026 | β |
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| May obesity increase the risk of lymphoma? Insights from genetic evidence. | Liu J et al. | β | 2026 | β |
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| Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities. | Kim MS et al. | β | 2026 | β |
| Mining 2 key candidate genes for pork tenderness in large White pigs based on GWAS, colocalization analysis, SMR and TWAS. | Yu J et al. | β | 2026 | β |
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| A Reassessment of the Genomic Ancestry of the World's Largest Captive Baboon Colony. | Mercuri G et al. | β | 2025 | β |
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| Association between polygenic risk and survival in breast cancer patients. | Kurant DE et al. | β | 2025 | β |
| Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study. | Leffa DT et al. | β | 2025 | β |
| Association of Genetic Predisposition to Inflammation With Cancer-Related Cognitive Impairment and Fatigue in Women Who Received Chemotherapy for Nonmetastatic Breast Cancer. | Olowofela AS et al. | β | 2025 | β |
| Association of Germline Single Nucleotide Polymorphisms in Steroid Hormone Metabolism Pathway With Androgen Deprivation Therapy Prognosis of Prostate Cancer in Chinese Population. | Shi R et al. | β | 2025 | β |
| Association of Hypertension With Telomere Length, Considering Non-Genetic and Genetic Factors, in Middle-Aged Koreans. | Baek Y et al. | β | 2025 | β |
| Associations between genetic variations of HLA and IGHV, vaccination schedule, and COVID-19 vaccine immunogenicity. | Ke L et al. | β | 2025 | β |
| Associations Between Polygenic Risk for Alzheimer's Disease and Grey Matter Volume Are Dependent on APOE, Pathological and Diagnostic Status. | Nocella V et al. | β | 2025 | β |
| Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry. | Wang L et al. | β | 2025 | β |
| A tandem repeat atlas for the genome of inbred mouse strains: A genetic variation resource. | Ren W et al. | β | 2025 | β |
| A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk. | Zhao T et al. | β | 2025 | β |
| A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population. | Hu J et al. | β | 2025 | β |
| Autosomal dominant primary hyperparathyroidism in the Keeshond dog breed is strongly associated with a missense variant in sirtuin-6. | Wade CM et al. | β | 2025 | β |
| Baboons at a Crossroads: Hybridisation Events and Genomic Links of Central Mozambique's Baboons With Papio Neighbors. | Caldon M et al. | β | 2025 | β |
| Beyond black and white: dissecting the genetic basis of skin depigmentation in Nellore cattle. | Campos MAF et al. | β | 2025 | β |
| Beyond Genetic Indicators: How Reproductive Mode and Hybridisation Challenge Freshwater Mussel Conservation. | Faust E et al. | β | 2025 | β |
| BIGH3 is a mediator of TGFΞ²-Induced collagen formation in fibrosis and pancreatic cancer and a potential therapeutic target. | Willumsen N et al. | β | 2025 | β |
| Binge drinking trajectories across adolescence and early adulthood: Associations with genetic influences for dual-systems impulsive personality traits, alcohol consumption, and alcohol use disorder. | Miller AP et al. | β | 2025 | β |
| Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries. | Khani M et al. | β | 2025 | β |
| Bioinformatic insights into five Chinese population substructures inferred from the East Asian-specific AISNP panel. | Chen J et al. | β | 2025 | β |
| Blood-based DNA methylation profiles in major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders. | David FS et al. | β | 2025 | β |
| Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases. | Wang JH et al. | β | 2025 | β |
| Boost or Bust? The Impact of Supplementation on Functional Genetic Diversity and Selective Processes in Tasmanian Devils. | Schraven AL et al. | β | 2025 | β |
| Breeding Selection for U.S. Siberian Huskies Has Altered Genes Regulating Metabolism, Endurance, Development, Body Conformation, Immune Function, and Behavior. | Huson HJ et al. | β | 2025 | β |
| Breeding values and index creation for health and behavior traits in Labrador Retriever guide dogs. | Thorsrud JA et al. | β | 2025 | β |
| Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage. | Light-Maka I et al. | β | 2025 | β |
| Bronze and Iron Age genomes reveal the integration of diverse ancestries in the Tarim Basin. | Zhang F et al. | β | 2025 | β |
| BTS: a scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across >1000s of omics datasets. | Kuksa PP et al. | β | 2025 | β |
| Can Polygenic Risk Scores for Metabolic Syndrome Contribute to Long-Term Syndrome Development in First-Episode Psychosis Patients? A Naturalistic 21-Year Follow-Up Study. | Cuesta MJ et al. | β | 2025 | β |
| CATT haplotype of the FKBP5 gene and dissociative phenomenology. | Moser S et al. | β | 2025 | β |
| Causal associations between cognitive impairments and retinal diseases: A two-sample Mendelian randomization study. | Shi Q et al. | β | 2025 | β |
| Causal relationship between 179 plasma lipids and intracranial aneurysm: A 2-sample Mendelian randomization study. | Ding L et al. | β | 2025 | β |
| Cell-free DNA as a potential alternative to genomic DNA in genetic studies. | Zeng J et al. | β | 2025 | β |
| Cell-weighted polygenic risk scores are associated with Ξ²-amyloid and tau biomarkers in Alzheimer's disease. | Kumar A et al. | β | 2025 | β |
| Characterisation of the Historic Demographic Decline of the British European Polecat Population. | Shaw R et al. | β | 2025 | β |
| Chromosome-scale assemblies of flowering dogwood cultivars enable identification of candidate genes regulating anthocyanin biosynthesis in leaves and bracts. | Hamm TP et al. | β | 2025 | β |
| Claudin and Rab proteins are key molecular components involved in coccidiosis resistance in Portuguese Merino sheep. | Varela-MartΓnez E et al. | β | 2025 | β |
| Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank. | Xu W et al. | β | 2025 | β |
| Clinical Utility of Plasma GFAP and NEFL as Biomarkers for Dementia in the Community. | Li HY et al. | β | 2025 | β |
| Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study. | GΓΌler M et al. | β | 2025 | β |
| Coexistence in Sympatry With Gene Flow Before Speciation Has Completed. | Schluter D et al. | β | 2025 | β |
| Cognition before and after psychosis onset: A naturalistic study of change, heterogeneity, and prognosis. | Lee M et al. | β | 2025 | β |
| Collapsing landmasses and secondary contacts: introgression and the evolution of adaptive diversity in Caucasian rock lizards. | Tarkhnishvili D et al. | β | 2025 | β |
| Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain Ξ²-Amyloid Deposition: Beyond <i>APOE</i>. | Ramanan VK et al. | β | 2025 | β |
| Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution. | Baya NA et al. | β | 2025 | β |
| Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis. | Kulecka M et al. | β | 2025 | β |
| Combining population genomics, larval dispersal modelling and graph theory to reveal connectivity patterns of the black-lipped pearl oyster in French Polynesia. | Gradel A et al. | β | 2025 | β |
| Common and rare genetic variants explain distinct diagnostic variance in pediatric attention deficit hyperactivity disorder. | Arnett AB et al. | β | 2025 | β |
| Common genetic variants modify disease risk and clinical presentation in monogenic diabetes. | Murray Leech J et al. | β | 2025 | β |
| Common genetic variation influencing the human lung imaging phenotypes. | Zhu M et al. | β | 2025 | β |
| COMPADRE: Combined pedigree-aware distant relatedness estimation for improved pedigree reconstruction. | Evans GF et al. | β | 2025 | β |
| Comparative analysis of Chloroplast genomes in 48 samples from 5 species and 2 varieties of AgropyronΒ Gaertn. (Poaceae, Triticeae). | Zheng L et al. | β | 2025 | β |
| Comparative genome-wide analysis of <i>Ovis aries</i> in Saudi Arabia highlighting inbreeding and genetic isolation of the Najdi sheep breed. | Aldawish AK et al. | β | 2025 | β |
| Comparative genomic analysis of QTL for resistance to Aphanomyces euteiches between pea, lentil, faba bean, and the model species Medicago truncatula. | LeprΓ©vost T et al. | β | 2025 | β |
| Comparison between SNP array and imputed data to estimate population structure and ROH hotspots in horse breeds. | Chessari G et al. | β | 2025 | β |
| Comparison of associations suggests mainly distinct pools of genetic risk factors contribute to cisplatin-induced hearing loss and hearing difficulty in the general population. | Shahbazi M et al. | β | 2025 | β |
| Complex genetic effects linked to plasma protein abundance in the UK Biobank. | Sigurdsson AI et al. | β | 2025 | β |
| Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease. | Gupta AK et al. | β | 2025 | β |
| Comprehensive detection of structural variations in long and short reads dataset of French cattle. | Naji MM et al. | β | 2025 | β |
| Comprehensive genomic and phenotypic analyses reveal the genetic basis of fruit quality in litchi. | Yan Q et al. | β | 2025 | β |
| Comprehensive Multi-omics Analysis of Regulatory Variants for Body Weight in Cattle. | Niu ηηΎ€η Q et al. | β | 2025 | β |
| Computationally efficient whole-genome quantile regression at biobank scale. | Wang F et al. | β | 2025 | β |
| Conservation Arks: Genomic Erosion and Inbreeding in an Abundant Island Population of Koalas. | Gates K et al. | β | 2025 | β |
| Consistent asymmetry in DNA damage artefacts across target regions in exome sequencing data. | Medina TD et al. | β | 2025 | β |
| Constructing genotype and phenotype network helps reveal disease heritability and phenome-wide association studies. | Cao X et al. | β | 2025 | β |
| Contribution of Polygenic Scores to Progression Independent of Relapse Activity in Multiple Sclerosis. | Clarelli F et al. | β | 2025 | β |
| Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation. | Zhang R et al. | β | 2025 | β |
| Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites. | Ebrahimi E et al. | β | 2025 | β |
| Data Resource Profile: Genomic data in multiple British birth cohorts (1946-2001)-linkage with health, social, and environmental data from birth to old age. | Shireby G et al. | β | 2025 | β |
| Deciphering gene-smoking interactions in age-related macular degeneration through cross-biobank genomic integration. | Guo J et al. | β | 2025 | β |
| Deciphering the genetic basis of nodule number through integrative analysis of host genotype and endophytes. | Zeng R et al. | β | 2025 | β |
| Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression. | Ouellet-Morin I et al. | β | 2025 | β |
| Decoding the beef cattle genome through whole-genome sequencing reveals the genetic basis of carcass and meat quality traits. | Nanaie HA et al. | β | 2025 | β |
| Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs. | Litman A et al. | β | 2025 | β |
| Detecting latent interaction effects when analyzing binary traits. | Zhang Z et al. | β | 2025 | β |
| Development and application of an updated haplotype reference panel for association analysis of spontaneous sex reversal in XX rainbow trout. | Liu S et al. | β | 2025 | β |
| Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis. | McMenamin KJ et al. | β | 2025 | β |
| Development of a cost-effective, multifunctional SNP panel and analysis workflow for Wolf monitoring in Finland. | Harmoinen J et al. | β | 2025 | β |
| Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms. | Freudenberg-Hua Y et al. | β | 2025 | β |
| Differential Performance of Polygenic Score for Coronary Artery Disease Based on Coronary Artery Calcium Between Men Living With and Without HIV. | Wojcik G et al. | β | 2025 | β |
| Differentiating the demographic histories and local adaptations of middle-altitude Qiang and Tibetan people. | Sun Q et al. | β | 2025 | β |
| Discovery of obesity genes through cross-ancestry analysis. | Banerjee D et al. | β | 2025 | β |
| Disease clusters and their genetic determinants following a diagnosis of depression: analyses based on a novel three-dimensional disease network approach. | Hou C et al. | β | 2025 | β |
| Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging. | Farinas A et al. | β | 2025 | β |
| Dissecting the genetic basis of response to salmonid alphavirus in Atlantic salmon. | Manousi D et al. | β | 2025 | β |
| Distinct glial functions are associated with Alzheimer's disease based on cell-type- and pathway-specific polygenic risk score analysis. | Pratt T et al. | β | 2025 | β |
| Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR. | Shadrin AA et al. | β | 2025 | β |
| Divergent and stabilizing selection shape the phenotypic space of Arabidopsis thaliana. | Przybylska MS et al. | β | 2025 | β |
| Diversification and differentiation of Stipa species shed light on the regional evolutionary history of the eastern Eurasian steppe. | Yan D et al. | β | 2025 | β |
| Do Common Genetic Factors Underlie Comorbidity Between Migraine and Major Depressive Disorder in Youth? | Merikangas AK et al. | β | 2025 | β |
| Dynamic human admixture histories over the pastΒ ~1300 years at the northern Himalayan frontier. | Bandyopadhyay E et al. | β | 2025 | β |
| Dynamic screening initiation using 16 plasma protein biomarkers with polygenic risk and PLCOm2012: a precision prevention framework for lung cancer. | Wang R et al. | β | 2025 | β |
| Dysregulation of miR-335-5p, miR-30d-5p, and miR-744-5p in extracellular vesicles from first-episode psychosis patients: Implications for biomarker discovery. | Xavier G et al. | β | 2025 | β |
| Effect of PCSK9 Inhibition With Alirocumab in Patients With Probable Familial Hypercholesterolemia or Type III Hyperlipoproteinemia: Results From the ODYSSEY OUTCOMES Trial. | Geba GP et al. | β | 2025 | β |
| Effects of using deep learning to predict the geographic origin of barley genebank accessions on genome-environment association studies. | Chang CW et al. | β | 2025 | β |
| Efficient candidate drug target discovery through proteogenomics in a Scottish cohort. | Kuliesius J et al. | β | 2025 | β |
| Electrophysiological resting-state signatures link polygenic scores to general intelligence. | Engler R et al. | β | 2025 | β |
| Elucidating the genetic basis of earlobe color in Qingyuan partridge chickens through genomics and metabolomics. | Liu X et al. | β | 2025 | β |
| Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study. | Sun F et al. | β | 2025 | β |
| Enhanced genetic fine mapping accuracy with Bayesian Linear Regression models in diverse genetic architectures. | Shrestha M et al. | β | 2025 | β |
| Enhanced Risk Prediction for Coronary Heart Disease by Leveraging Polygenic Risk Score and Clinical Risk Score in European Hypertensive Adults. | Shen S et al. | β | 2025 | β |
| Ensemble AnalySis with Interpretable Genomic Prediction (EasiGP): Computational tool for interpreting ensembles of genomic prediction models. | Tomura S et al. | β | 2025 | β |
| Epigenetic Potential and Dispersal Propensity in a Free-Living Songbird: A Spatial and Temporal Approach. | Jimeno B et al. | β | 2025 | β |
| Estimating allele frequencies, ancestry proportions and genotype likelihoods in the presence of mapping bias. | GΓΌnther T et al. | β | 2025 | β |
| Estimating the Effective Population Size Across Space and Time in the Critically Endangered Western Chimpanzee in Guinea-Bissau: Challenges and Implications for Conservation Management. | da Silva MJF et al. | β | 2025 | β |
| Estimation of Genetic Parameters for Carcass and Meat Quality Traits Using Genomic Information in Yorkshire Pigs. | Zheng Y et al. | β | 2025 | β |
| European and African ancestry-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites. | Yang C et al. | β | 2025 | β |
| Evaluating Kinship Estimation Methods for Reduced-Representation SNP Data in Non-model Species. | McMaster ES et al. | β | 2025 | β |
| Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications. | Dias JA et al. | β | 2025 | β |
| Evaluating the roles of drift and selection in trait loss along an elevational gradient. | Buysse SF et al. | β | 2025 | β |
| Evaluation of genetic diversity and population structure of wheat core collection using SNP and KASP markers for major agronomic traits. | Wang X et al. | β | 2025 | β |
| Evolution of population structure in a commercial European hybrid dent maize breeding program and consequences on genetic diversity. | Kadoumi R et al. | β | 2025 | β |
| Examining polygenic scores for depression, depressive symptoms from childhood to adolescence, and adolescent substance use in a diverse sample: The moderating impact of a family-centered intervention. | Elam KK et al. | β | 2025 | β |
| EXGEP: a framework for predicting genotype-by-environment interactions using ensembles of explainable machine-learning models. | Yu T et al. | β | 2025 | β |
| Exploration of hanging coffin customs and the bo people in China through comparative genomics. | Zhou H et al. | β | 2025 | β |
| Exploring depression treatment response by using polygenic risk scoring across diverse populations. | Lapinska S et al. | β | 2025 | β |
| Exploring genetic diversity and population structure of Myanmar indigenous chickens using double digest restriction site-associated DNA sequencing. | Mon SLY et al. | β | 2025 | β |
| Exploring Genetic Heterogeneity in Type 2 Diabetes Subtypes. | Timasheva Y et al. | β | 2025 | β |
| Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions. | Darlay R et al. | β | 2025 | β |
| Exploring skeletal disorders in cattle and sheep: a WGS-based framework for diagnosis and classification. | Jacinto J et al. | β | 2025 | β |
| Exploring the causal relationship between vitamin D levels and deficiency with the risk of cataract: A Mendelian Randomisation study. | Hashimi M et al. | β | 2025 | β |
| Exploring the genetic architecture of multiple long-term conditions using a genome-wide association study in the UK Biobank population. | Nair ATN et al. | β | 2025 | β |
| Exploring the Genetic Underpinnings of Diffusion Tensor Image Analysis Along the Perivascular Space: A Genome-Wide Correlation Study and Implications for Brain Health. | Wu J et al. | β | 2025 | β |
| Exploring the polygenic landscape of wool traits in Turkish merinos through multi-locus GWAS approaches: Karacabey Merino. | Yaman Y et al. | β | 2025 | β |
| Exploring transcriptomic and genomic differences between susceptible and resistant fetal pigs to maternal PRRSV infection at late gestation. | Ko H et al. | β | 2025 | β |
| Fair positive unlabeled learning for predicting undiagnosed Alzheimer's disease in diverse electronic health records. | Tran T et al. | β | 2025 | β |
| Female lineages and changing kinship patterns in Neolithic ΓatalhΓΆyΓΌk. | YΓΌncΓΌ E et al. | β | 2025 | β |
| Fine-scale assessment of ROH patterns and genomic inbreeding in diverse horse breeds using two SNP array densities. | Moghbeli Damane M et al. | β | 2025 | β |
| First insights into microbial changes within an Inflammatory Bowel Disease Family Cohort study. | Rausch P et al. | β | 2025 | β |
| First interspecific multi-parent advanced generation inter-cross (MAGIC) population in <i>Capsicum</i> peppers: development, phenotypic evaluation, genomic analysis, and prospects. | Ortega-Albero N et al. | β | 2025 | β |
| Fitness benefits of genetic rescue despite chromosomal differences in an endangered pocket mouse. | Wilder AP et al. | β | 2025 | β |
| Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, <i>Zostera marina</i>. | Nolan CT et al. | β | 2025 | β |
| From individuals to ancestries: Towards attributing trait variation to haplotypes. | Yang Y et al. | β | 2025 | β |
| From Mind to Liver: Exploring the Causal Relationship Between Anxiety Disorders and Non-Alcoholic Fatty Liver Disease Through Mendelian Randomization and UK Biobank Validation. | Song H et al. | β | 2025 | β |
| Functional analysis of the FGF2 gene in horn development in sheep and identification of key regulatory variants. | Liu F et al. | β | 2025 | β |
| Functionally enriched human polymorphisms associate to species in the chronic wound microbiome. | Gabrilska RA et al. | β | 2025 | β |
| Functional Role of Single-Nucleotide Polymorphisms on IFNG and IFNGR1 in Humans with Cardiovascular Disease. | Mehta M et al. | β | 2025 | β |
| Genealogical Analysis of Replicate Flower Colour Hybrid Zones in Antirrhinum. | Pal A et al. | β | 2025 | β |
| Gene-Diet Interaction Analysis in UK Biobank Identified Genetic Loci That Modify the Association Between Fish Oil Supplementation and the Incidence of Dementia. | Lu Y et al. | β | 2025 | β |
| Gene-environment-brain topology reveals clinical subtypes of depression in UK Biobank. | Tassi E et al. | β | 2025 | β |
| Genetically Estimated Ancestry and the Risk of Pre-Eclampsia: A Multiethnic Case-Control Study. | Conti-Ramsden F et al. | β | 2025 | β |
| Genetic analyses of eight complex diseases using predicted continuous representations of disease. | Chen R et al. | β | 2025 | β |
| Genetic Analysis of Apple Autumn Canopy Senescence in a Nordic Climate. | Skytte Af SΓ€tra J | β | 2025 | β |
| Genetic Ancestry, Intrinsic Tumor Subtypes, and Breast Cancer Survival in Latin American Women. | Alves da Quinta D et al. | β | 2025 | β |
| Genetic and Landscape Connectivity of Blacklegged Ticks During Range Expansion in Select States of the Midwestern USA. | Dong DY et al. | β | 2025 | β |
| Genetic and molecular landscape of comorbidities in people living with HIV. | Botey-Bataller J et al. | β | 2025 | β |
| Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups. | Markelova EE et al. | β | 2025 | β |
| Genetic and polygenic contributions to familial hypercholesterolemia in Thailand: Implications for diagnosis and lipid management. | Pasookhush P et al. | β | 2025 | β |
| Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats. | TonnelΓ© H et al. | β | 2025 | β |
| Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry. | Wang J et al. | β | 2025 | β |
| Genetic association analyses of cognitive performance across multi-ancestry older adults: Application of Tobit models. | Wu X et al. | β | 2025 | β |
| Genetic crossroads of cardiovascular disease and its comorbidities: toward holistic therapeutic strategies. | Mishra BH et al. | β | 2025 | β |
| Genetic diversity analysis and multi-fingerprint map construction of Naematelia aurantialba germplasm resources. | Zeng Y et al. | β | 2025 | β |
| Genetic diversity and population structure of Jabal Akhdar goats revealed by genome-wide single nucleotide polymorphism markers. | Al-Yarubi OA et al. | β | 2025 | β |
| Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis. | Tchuisseu-Kwangoua LA et al. | β | 2025 | β |
| Genetic effects on migration behavior contribute to increasing spatial differentiation at trait-associated loci in Estonia. | Kuznetsov IA et al. | β | 2025 | β |
| Genetic Factors of Elite Wrestling Status: A Multi-Ethnic Comparative Study. | Kozuma A et al. | β | 2025 | β |
| Genetic influences for distinct impulsivity domains are differentially associated with early substance use initiation: Results from the ABCD Study. | Kinstler E et al. | β | 2025 | β |
| Genetic Insights into Head-to-Body Ratios Via Deep Learning-Based Image Segmentation and Implications for Common Diseases. | Shi W et al. | β | 2025 | β |
| Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults. | Shi Y et al. | β | 2025 | β |
| Genetic Overlap Between DSM-IV Major Depressive Disorder and Suicidal Behaviors: Evidence from Polygenic Risk Scores in Young Adult Twins. | Gillespie NA et al. | β | 2025 | β |
| Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study. | Skelton M et al. | β | 2025 | β |
| Genetic parameters and genomic prediction of egg production traits in ducks. | Han C et al. | β | 2025 | β |
| Genetic polymorphisms associated with metabolic dysfunction-associated steatotic liver disease and cardiometabolic risk susceptibility in the Chinese Han population. | Dai M et al. | β | 2025 | β |
| Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study. | Sutoh Y et al. | β | 2025 | β |
| Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study. | Choi M et al. | β | 2025 | β |
| Genetic risk for alcohol use disorder in relation to individual symptom criteria: Do polygenic indices provide unique information for understanding severity and heterogeneity? | Sarles YM et al. | β | 2025 | β |
| Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging. | Petrican R et al. | β | 2025 | β |
| Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis. | Pukaj A et al. | β | 2025 | β |
| Genetics and context for precision health in Greater Boston. | Koyama S et al. | β | 2025 | β |
| Genetic stability in the lower Yangtze River basin from Song to Qing Dynasty. | He H et al. | β | 2025 | β |
| Genetic susceptibility and validation of angiographic patterns in Takayasu arteritis. | Casares-Marfil D et al. | β | 2025 | β |
| Genetic testing predicts appearance but not behavior in dogs. | Lord KA et al. | β | 2025 | β |
| Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity. | Wang X et al. | β | 2025 | β |
| Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease. | Kim D et al. | β | 2025 | β |
| Genetic Variants Affect Distinct Metabolic Pathways in Pediatric Multisystem Inflammatory Syndrome and Severe COVID-19. | Urbanski AH et al. | β | 2025 | β |
| Genetic variants associated with chronic postsurgical pain: evidence from the China Surgery and Anaesthesia Cohort study. | Song J et al. | β | 2025 | β |
| Genetic variants linked to statin-associated Type 2 diabetes mellitus: Findings from the UK Biobank and the All of Us Research Program. | Park YA et al. | β | 2025 | β |
| Genetic variation in recalcitrant repetitive regions of the <i>Drosophila melanogaster</i> genome. | Shukla HG et al. | β | 2025 | β |
| Genome landscape and genetic architecture of recombination in domestic goats (Capra hircus). | Etourneau A et al. | β | 2025 | β |
| Genome of the extinct Gotland cattle breed. | Johnsson M et al. | β | 2025 | β |
| Genome-resolved tracking of <i>Penicillium commune</i> in a bakery facility highlights long-term environmental persistence. | Fagerlund A et al. | β | 2025 | β |
| Genome Selection for Fleece Traits in Inner Mongolia Cashmere Goats Based on GWAS Prior Marker Information. | Yao H et al. | β | 2025 | β |
| Genome-wide analyses reveal intricate genetic mechanisms underlying egg production efficiency in chickens. | Tan L et al. | β | 2025 | β |
| Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health. | Jawinski P et al. | β | 2025 | β |
| Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome. | Aslam MM et al. | β | 2025 | β |
| Genome-wide association and fine-mapping analyses identify novel candidate genes affecting serum cortisol levels using imputed whole-genome sequencing data in pigs. | Kim TH et al. | β | 2025 | β |
| Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets. | Ricci A et al. | β | 2025 | β |
| Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants. | FΓΆrster F et al. | β | 2025 | β |
| Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome. | Fan KH et al. | β | 2025 | β |
| Genome-Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study. | Deng WQ et al. | β | 2025 | β |
| Genome-wide association study analysis of single nucleotide variants in <i>L. infantum</i> associated with IL-6 inflammatory response in visceral leishmaniasis. | da Silva AM et al. | β | 2025 | β |
| Genome-Wide Association Study and Candidate Gene Identification for Girth Traits in Rubber Tree. | Li W et al. | β | 2025 | β |
| Genome-Wide Association Study and Meta-Analysis Uncovers Key Candidate Genes for Body Weight Traits in Chickens. | Wen J et al. | β | 2025 | β |
| Genome-wide association study and polygenic risk prediction of hypothyroidism. | Rand SA et al. | β | 2025 | β |
| Genome-Wide Association Study and RNA-Seq Analysis Uncover Candidate Genes Controlling Growth Traits in Red Tilapia (<i>Oreochromis</i> spp.) Under Hyperosmotic Stress. | Jiang B et al. | β | 2025 | β |
| Genome-wide association study for Kleiber ratio and growth efficiency traits in Lori-Bakhtiari sheep. | Navoshki F et al. | β | 2025 | β |
| Genome-Wide Association Study for Milk Protein Content in Romanian Dual-Purpose Cattle. | Bratu DG et al. | β | 2025 | β |
| Genome-wide association study identifies candidate SNP markers and genes associated with low nitrogen tolerance in <i>Brassica napus</i>. | Chen J et al. | β | 2025 | β |
| Genome-wide association study identifies <i>ABCG1</i> as a susceptibility locus for tick-borne encephalitis. | Gampawar PG et al. | β | 2025 | β |
| Genome-wide association study identifies novel candidate genes linked to acute and chronic thermal stress resilience in olive flounder (Paralichthys olivaceus). | Hanchapola HACR et al. | β | 2025 | β |
| Genome-wide association study identifies novel genes for plant architecture and yield traits in cassava (<i>Manihot esculenta</i> Crantz). | Olayinka AF et al. | β | 2025 | β |
| Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study. | Shinoda G et al. | β | 2025 | β |
| Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program. | Raghavan S et al. | β | 2025 | β |
| Genome-Wide Association Study of Immune Indices in Yaks. | Yu D et al. | β | 2025 | β |
| Genome-Wide Association Study of Morphological Defects in Nellore Cattle Using a Binary Trait Framework. | Campos MAF et al. | β | 2025 | β |
| Genome-Wide Association Study of Osteoporosis Risk in Korean Pre-Menopausal Women: The Korean Genome and Epidemiology Study. | Kim SK et al. | β | 2025 | β |
| Genome-wide association study of pulpal and apical diseases. | Salminen A et al. | β | 2025 | β |
| Genome-wide association study of the taste and hedonic ratings of the low-calorie sweetener acesulfame potassium. | Kan M et al. | β | 2025 | β |
| Genome-wide association study on dairy goat milk production traits using three models. | Huang Z et al. | β | 2025 | β |
| Genome-wide association study reveals novel loci associated with body size and carcass yields in Shaoxing ducks. | Xu W et al. | β | 2025 | β |
| Genome-wide association study uncovers the genetic loci for yield-related traits in waxy rice. | Fei Y et al. | β | 2025 | β |
| Genome wide association study unveils the genetic basis of Orobanche crenata resistance in pea. | Wohor OZ et al. | β | 2025 | β |
| Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure. | Shraim R et al. | β | 2025 | β |
| Genomic analyses support locally derived crown-of-thorns seastar outbreaks in the Pacific. | Leiva C et al. | β | 2025 | β |
| Genomic analysis highlights the conservation significance of Torenia concolor (Linderniaceae) from the periphery of its distribution range. | Isagi Y et al. | β | 2025 | β |
| Genomic Analysis of Adaptability and Genetic Structure of Jabal Akhdar Goats: Evidence of Positive Selection in an Indigenous Omani Breed. | Mohammad Z et al. | β | 2025 | β |
| Genomic Analysis of Latvian Brown Old Type and Latvian Blue Local Dairy Cattle Breeds Using SNP Data. | Jonkus D et al. | β | 2025 | β |
| Genomic Analysis of Reproductive Trait Divergence in Duroc and Yorkshire Pigs: A Comparison of Mixed Models and Selective Sweep Detection. | Chen C et al. | β | 2025 | β |
| Genomic Analysis of the Natural Variation of Fatty Acid Composition in Seed Oils of <i>Camelina sativa</i>. | Decker S et al. | β | 2025 | β |
| Genomic and phenotypic delimitation of species in a temperate aquatic biodiversity hotspot. | MacGuigan DJ et al. | β | 2025 | β |
| Genomic Basis and Climate Change Vulnerability of Migration Timing in Atlantic Salmon (<i>Salmo salar</i>). | Beck SV et al. | β | 2025 | β |
| Genomic characterisation of endangered Landim pigs reveals distinctive features and immune-related selection. | Teixeira F et al. | β | 2025 | β |
| Genomic Characterization of Peruvian Creole Goats: Insights into Population Structure and Runs of Homozygosity. | Corredor FA et al. | β | 2025 | β |
| Genomic data define species delimitation in Liberica coffee with implications for crop development and conservation. | Davis AP et al. | β | 2025 | β |
| Genomic data from the extinct California brown bear suggests a source population for reintroduction to California. | Wooldridge TB et al. | β | 2025 | β |
| Genomic Data Reveal Multiple Introduction Sources and Limited Post-Colonization Gene Flow in Southeast Michigan Invasive Red Swamp Crayfish (<i>ProcambarusΒ clarkii</i>). | Adams NE et al. | β | 2025 | β |
| Genomic diversity and selection signatures in Asian Zebu Cattle: insights into adaptation and genetic erosion. | Mavunga TK et al. | β | 2025 | β |
| Genomic diversity and structure of prehistoric alpine individuals from the Tyrolean Iceman's territory. | Croze M et al. | β | 2025 | β |
| Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits. | Wang J et al. | β | 2025 | β |
| Genomic epidemiology of <i>Histoplasma</i> in Africa. | Mapengo RE et al. | β | 2025 | β |
| Genomic evidence of positive selection highlights functional divergence associated with environmental resilience in central and West African indigenous cattle. | Bitew MK et al. | β | 2025 | β |
| Genomic exploration of durable wheat rust resistance by integrating data from multiple worldwide populations. | Joukhadar R et al. | β | 2025 | β |
| Genomic formation of lower Yellow River populations in the Han dynasty. | Ji Z et al. | β | 2025 | β |
| Genomic insights into the convergent evolution of desert adaptation in camels and antelopes. | Zhou J et al. | β | 2025 | β |
| Genomic insights into the demographic history and local adaptation of wild boars across Eurasia. | Wang Z et al. | β | 2025 | β |
| Genomic insights into the population structure and genetic diversity of Ugandan indigenous cattle. | Okwasiimire R et al. | β | 2025 | β |
| Genomic insights into the reticulate evolution of viviparous Phrynocephalus lizards on the Qinghai-Tibetan Plateau. | Guo X et al. | β | 2025 | β |
| Genomic insights into Yanbian cattle: Breed-specific selective sweeps identified by whole-genome sequencing. | Baek J et al. | β | 2025 | β |
| Genomic insights on the history and selection trajectories of the Comune di Sicilia goat. | Floridia V et al. | β | 2025 | β |
| Genomic Landscape of High-Altitude Adaptation in East African Mountain Honey Bees (<i>Apis mellifera</i>). | Mazzoni M et al. | β | 2025 | β |
| Genomic landscape of the Great Steppe: Genetic variants in healthy Kazakh individuals. | Serikzhan A et al. | β | 2025 | β |
| Genomic resequencing reveals genetic diversity, population structure, and core collection of durian germplasm. | Zhong Y et al. | β | 2025 | β |
| Genomic Scan for Runs of Homozygosity and Identification of Candidate Genes Under Domestication in Fengjing Pigs. | Ni L et al. | β | 2025 | β |
| Genomic Signatures in Maned Three-Toed Sloths From Ancient to Recent Environmental Changes in Brazil's Threatened Atlantic Forest. | Arantes LS et al. | β | 2025 | β |
| Genomic Signatures of Adaptive Evolution in <i>Taenioides</i> sp. During Northward Invasion. | Huang K et al. | β | 2025 | β |
| Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes. | Ma W et al. | β | 2025 | β |
| Geographically proximate rare species exhibit strong population divergence while maintaining intraspecific genetic diversity in Homoranthus (Myrtaceae). | McMaster ES et al. | β | 2025 | β |
| ο»ΏGlobal population genomics redefines domestication and clinical diversity in the <i>Aspergillus flavus-oryzae</i> complex. | Pfliegler WP et al. | β | 2025 | β |
| Global Stress Responses Identify the Functionally Divergent Regulators Required for <i>Candida auris</i> Commensalism and Pathogenicity. | Xu C et al. | β | 2025 | β |
| GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate Ξ²-cell mitochondrial remodelling and function. | Austin G et al. | β | 2025 | β |
| Glycaemic responses to metformin monotherapy by SNP clusters in patients with type 2 diabetes. | Sheu WH et al. | β | 2025 | β |
| GmSop20 Functions as a Key Coordinator of the Oil-To-Protein Ratio in Soybean Seeds. | Zheng H et al. | β | 2025 | β |
| Gone With the Wind: Exploring a Vanished Rock Dove, <i>Columba livia</i>, Hybrid Zone in the Sahara Desert. | HernΓ‘ndez-Alonso G et al. | β | 2025 | β |
| Graph-based pangenomes and pan-phenome provide a cornerstone for eggplant biology and breeding. | Gaccione L et al. | β | 2025 | β |
| Greater value add from electronic health records than polygenic risk scores for predicting myocardial infarction in machine learning. | Isgut M et al. | β | 2025 | β |
| Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale. | Shafieinouri M et al. | β | 2025 | β |
| Gut fungi are associated with human genetic variation and disease risk. | Van Syoc EP et al. | β | 2025 | β |
| GWAS Reveals Key Candidate Genes Associated with Milk-Production in Saanen Goats. | Li F et al. | β | 2025 | β |
| Haploinsufficiency of GRHL2 is associated with orofacial clefting in humans. | Curtis SW et al. | β | 2025 | β |
| Health effects of loss of function variants in gene targets for Alzheimer's disease prevention. | Ma Y et al. | β | 2025 | β |
| High-density genome-wide association study points out major candidate genes for resistance to infectious pancreatic necrosis in rainbow trout. | D'Ambrosio J et al. | β | 2025 | β |
| Higher levels of plasma phosphatidylcholine (17:0_18:1) raise the risk of developing Parkinson's disease. | Su D et al. | β | 2025 | β |
| High Imputation Accuracy Can Be Achieved Using a Small Reference Panel in a Natural Population With Low Genetic Diversity. | Tan HZ et al. | β | 2025 | β |
| Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease. | Rothhaar P et al. | β | 2025 | β |
| High-quality bonds: <i>serine acetyltransferase 2</i> gene revealed by GWAS is associated with grain protein content in spring durum wheat. | Ermolaev A et al. | β | 2025 | β |
| HiLand Resource: A Comprehensive Database of Highland Human Populations. | Zhang εΌ δΌζ° W et al. | β | 2025 | β |
| History of speciation inferred from genomic analysis of a species complex of north temperate fishes. | Taylor EB et al. | β | 2025 | β |
| HLA-B Serine 116 Confers Protection Against Severe COVID-19 in a Cohort From Rio de Janeiro, Brazil. | Pereira MADS et al. | β | 2025 | β |
| Hospital-treated infectious diseases and the risk of epilepsy in older age. | Zhuang Q et al. | β | 2025 | β |
| How accurate is genomic prediction across wild populations? | Aase K et al. | β | 2025 | β |
| Human Population Genetic History and Evolutionary Dynamics on the Eastern Tibetan Plateau. | He G et al. | β | 2025 | β |
| Humpback whale genomes reflect the increased efficiency of commercial whaling. | Furni F et al. | β | 2025 | β |
| Identification of a Novel Haplotype Associated with Roan Coat Color in American Quarter Horses. | Everts RE et al. | β | 2025 | β |
| Identification of a Novel <i>CLPX</i> Variant in a Mixed-Breed Dog with Anemia and Spinocerebellar Ataxia. | de Cecco BS et al. | β | 2025 | β |
| Identification of clinically meaningful, overlapping obstructive respiratory disease subtypes via data-driven approaches in a primary care population. | Pikoula M et al. | β | 2025 | β |
| Identification of functional non-coding variants associated with orofacial cleft. | Kumari P et al. | β | 2025 | β |
| Identification of genetic variants associated with ear length in drop-eared dogs. | Rudolph TE et al. | β | 2025 | β |
| Identification of MAPK10 as a Candidate Gene for High Milk Production in Water Buffaloes Through a Genome-Wide Association Study. | Li W et al. | β | 2025 | β |
| Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity. | Chou WH et al. | β | 2025 | β |
| Identification of potential therapeutic targets for problematic alcohol use using multi-omics data. | Lee DJ et al. | β | 2025 | β |
| Identifying Alzheimer's disease-related pathways based on whole-genome sequencing data. | Wang Y et al. | β | 2025 | β |
| Identifying sepsis susceptibility genes in post-surgical patients using an artificial intelligence approach. | Vaquerizo-Villar F et al. | β | 2025 | β |
| Identifying the Genetic Ancestry of the Pediatric Obesity-Related Asthma Variant (rs6494395) at Rps27l. | Yang D et al. | β | 2025 | β |
| Identity by descent and local ancestry mapping of HCV spontaneous clearance in populations of diverse ancestries. | Yu Z et al. | β | 2025 | β |
| Immune and metabolic disturbance as a function of genetic risk and phase of illness in major depression. | Howard DM et al. | β | 2025 | β |
| Immunogenomic diversity of triple-negative breast cancers in obese and non-obese black and white women. | Hossain F et al. | β | 2025 | β |
| Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care. | Ntritsos G et al. | β | 2025 | β |
| Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk. | Lu Z et al. | β | 2025 | β |
| Improvement of polygenic modeling of blood pressure traits using lifestyle information in the UK Biobank. | Tiezzi F et al. | β | 2025 | β |
| Improving accuracy in genome-wide association studies: a two-step approach for handling below limit of detection biomarker measurements. | Deng YA et al. | β | 2025 | β |
| Imputation disparities driven by recent selection and their impact on disease risk estimation in East and Southeast Asian populations. | Li D et al. | β | 2025 | β |
| Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years. | Bougiouri K et al. | β | 2025 | β |
| Inbreeding patterns and genetic diversity under selection in Teha sheep. | Wang S et al. | β | 2025 | β |
| Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE. | Dong Z et al. | β | 2025 | β |
| Inferring Domestic Goat Demographic History Through Ancient Genome Imputation. | Erven JAM et al. | β | 2025 | β |
| Insights into pedigree- and genome-based inbreeding patterns in Martina Franca donkey breed. | Landi V et al. | β | 2025 | β |
| Integrated genetic and geographic ancestry prediction via large-scale genomic data and machine learning. | Chen J et al. | β | 2025 | β |
| Integrated genomic and transcriptomic analysis identifies novel candidate genes affecting carcass backfat thickness in pigs. | Liu Q et al. | β | 2025 | β |
| Integrated Multi-Omics Analysis and Cross-Model Validation Reveal Mitochondrial Signatures in Alzheimer's Disease. | Xu X et al. | β | 2025 | β |
| Integrating eQTL and genome-wide association studies to uncover additive and dominant regulatory circuits in pig uterine capacity. | Xu Z et al. | β | 2025 | β |
| Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping. | Xiang R et al. | β | 2025 | β |
| Integrating gene expression data via weighted multiple kernel ridge regression improved accuracy of genomic prediction. | Wang X et al. | β | 2025 | β |
| Integrative analysis identifies novel proteins associated with chronic kidney disease in participants with abnormal glucose metabolism. | Li N et al. | β | 2025 | β |
| Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes. | Du Y et al. | β | 2025 | β |
| Integrative Machine Learning Approaches for Identifying Loci Associated with Anthracnose Resistance in Strawberry. | Jang YJ et al. | β | 2025 | β |
| Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction. | Venkatesh R et al. | β | 2025 | β |
| Interaction between coffee consumption and polygenic risk score in relation to diabetes: insights from the Maastricht study. | Rao Y et al. | β | 2025 | β |
| Interaction of early life stress and NADβ+β/SIRT1 pathway genetic risk promotes depression. | Torok D et al. | β | 2025 | β |
| Interplay between large low-recombining regions and pseudo-overdominance in a plant genome. | Salson M et al. | β | 2025 | β |
| Interpreting SNP heritability in admixed populations. | Huang J et al. | β | 2025 | β |
| Investigating the demographic history of Sindhi population inhabited in West Coast India. | Kumar L et al. | β | 2025 | β |
| Investigating the genetic imprint of long body length, high lean meat rate, high fertility and long gestation period in Danish Landrace pigs. | Chen J et al. | β | 2025 | β |
| Investigating the interplay between prematurity and genetic variation in the context of rare developmental disorders. | Wootton O et al. | β | 2025 | β |
| Investigating the Relationship Between Maternal Smoking During Pregnancy and Offspring Handedness: Extending the Proxy Gene-by-Environment Mendelian Randomization Study Design to Include Polygenic Risk Scores. | Crick DCP et al. | β | 2025 | β |
| Investigation of the role of the LC3 conjugation system in autophagy for human reward system reactivity. | Treutlein J et al. | β | 2025 | β |
| Key genomic regions identified through selection signatures distinguish cattle breeds reared in Sardinia Island. | Fabbri MC et al. | β | 2025 | β |
| Kinship Decouple and Phenotype Selection (KDPS): a tool for phenotype-aware decoupling of related subjects. | Gu W et al. | β | 2025 | β |
| Large-scale copy number variant analysis in genes linked to ParkinsonΒ΄s disease. | Landoulsi Z et al. | β | 2025 | β |
| Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People. | He G et al. | β | 2025 | β |
| Lessons learned: Recommendations for reproducible paleogenomic data analyses. | Souilmi Y et al. | β | 2025 | β |
| Leveraging global genetics resources to enhance polygenic prediction across ancestrally diverse populations. | Pain O | β | 2025 | β |
| Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations. | Zhou G et al. | β | 2025 | β |
| Light Exposure at Night and Cardiovascular Disease Incidence. | Windred DP et al. | β | 2025 | β |
| Limited population structure but signals of recent selection in introduced African Fig Fly (Zaprionus indianus) in North America. | Erickson PA et al. | β | 2025 | β |
| Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism. | Kong Y et al. | β | 2025 | β |
| Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism. | SorlΓ JV et al. | β | 2025 | β |
| Lithobiomes Heterogeneity and Geographic Distance Shape the Landscape Genomics Within Brazilian Mountain Systems. | Cabrini M et al. | β | 2025 | β |
| Local Climate Adaptation in Chinese Indigenous Pig Genomes. | Liu Y et al. | β | 2025 | β |
| Longitudinal study reveals plasma glycans associations with prediabetes/type 2 diabetes in KORA study. | Niu J et al. | β | 2025 | β |
| Long-read structural variant discovery and targeted short read genotyping enables population scale characterization of structural variation in rhesus macaques. | Ray K et al. | β | 2025 | β |
| Long shared haplotypes identify the southern Urals as a primary source for the 10th-century Hungarians. | Gyuris B et al. | β | 2025 | β |
| Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease. | Weerakkody TN et al. | β | 2025 | β |
| Low-call-rate SNPs and presence-absence variation identified in the rice pan-genome can improve genomic prediction of rice gene bank accessions. | Krusenbaum L et al. | β | 2025 | β |
| LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome. | Maloney MT et al. | β | 2025 | β |
| <i>FST</i> Polymorphisms Associate with Musculoskeletal Traits and Modulate Exercise Response Differentially by Sex and Modality in Northern Han Chinese Adults. | Cao W et al. | β | 2025 | β |
| Machine learning-based penetrance of genetic variants. | Forrest IS et al. | β | 2025 | β |
| Machine Learning-Based Prediction for Stroke Patient Classification using Polygenic Risk Scores. | Piazzi M et al. | β | 2025 | β |
| Machine Learning-Based Prediction of Gout Using Polygenic Risk Scores and Clinical Variables: A Korean Cohort Study. | Kwak DH et al. | β | 2025 | β |
| Machine learning in Alzheimer's disease genetics. | Bracher-Smith M et al. | β | 2025 | β |
| Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease. | AlbarrΓ‘n-JuΓ‘rez J et al. | β | 2025 | β |
| Mapping genes for resilient dairy cows by means of across-breed genome-wide association analysis. | KeΓler F et al. | β | 2025 | β |
| Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development. | Zhu JD et al. | β | 2025 | β |
| Mapping rare protein-coding variants on multi-organ imaging traits. | Fan Y et al. | β | 2025 | β |
| Mapping Species Birth Across the Recombination Landscapes of Marine Snails. | Giles EC et al. | β | 2025 | β |
| Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus | Zhang Y et al. | β | 2025 | β |
| Maternal gut microbiome during early pregnancy predicts preterm birth. | Miao Z et al. | β | 2025 | β |
| Maternal parity modifies the association of birthweight polygenic score with fetal growth. | Wijesiriwardhana P et al. | β | 2025 | β |
| Maternal Smoking During Pregnancy Interacts With Genetic Factors to Increase Risk for Low Birth Weight but Not Harmful Offspring Smoking Behaviors in Europeans. | Romero Villela PN et al. | β | 2025 | β |
| Mating system of free-ranging domestic dogs and its consequences for dog evolution. | Car C et al. | β | 2025 | β |
| Mediational effects of reading-related intermediate phenotypes from polygenic scores to reading skills. | Remon A et al. | β | 2025 | β |
| Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition. | Liu Y et al. | β | 2025 | β |
| Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk. | Yates T et al. | β | 2025 | β |
| Mendelian randomization revealed a one-way causal association between increased Isovalerylcarnitine (C5) levels and the risk of idiopathic pulmonary fibrosis. | He J et al. | β | 2025 | β |
| Mendelian Randomization Reveals Unidirectional Links Between Amyloid-Ξ² and Tau in Alzheimer's Disease. | Kim JP et al. | β | 2025 | β |
| Mendelian Randomization Studies of Myopia: Choosing the Right Summary Statistics. | Nguyen TN et al. | β | 2025 | β |
| Metabolic variation reflects dietary exposure in a multi-ethnic Asian population. | Low DY et al. | β | 2025 | β |
| Metal Transporter Gene <i>SLC39A8</i> Polymorphism rs13107325 and Dietary Manganese Intake Are Associated with Measures of Cardiovascular Disease Risk in a UK Biobank Population Cohort. | Sigdel R et al. | β | 2025 | β |
| Mitochondrial haplogroup M contributes to asthma risk in the Kuwaiti population. | Dashti M et al. | β | 2025 | β |
| Mitochondrial variation in Taiwan Biobank reveals ancestry structure and trait associations. | Chou TH et al. | β | 2025 | β |
| ML-MAGES enables multivariate genetic association analyses with genes and effect size shrinkage. | Liu X et al. | β | 2025 | β |
| Modeling the genomic architecture of adiposity and anthropometrics across the lifespan. | Arehart CH et al. | β | 2025 | β |
| MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality. | van der Graaf A et al. | β | 2025 | β |
| MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer's disease model. | Jiao HS et al. | β | 2025 | β |
| Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. | Johnson EC et al. | β | 2025 | β |
| Multi-ancestry genome-wide association analyses of polycystic ovary syndrome. | Zhao H et al. | β | 2025 | β |
| Multi-ancestry genome-wide association meta-analysis identifies candidate genes for computed tomography-based carcass composition traits in pigs. | Han H et al. | β | 2025 | β |
| Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. | Rajabli F et al. | β | 2025 | β |
| Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations. | Greene CA et al. | β | 2025 | β |
| Multi-centric origins and gene flow shape the diversity of Ξ²-thalassemia mutations in Southern East Asia. | Zhang Q et al. | β | 2025 | β |
| Multi-Genome-Wide association studies provide new insights into the genetic architecture of Varroa resistance in honeybees. | Davoodi P et al. | β | 2025 | β |
| Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes. | Carletti M et al. | β | 2025 | β |
| Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores. | O'Neill N et al. | β | 2025 | β |
| Multi-omics analysis indicates an association between TAPBP and prostate cancer. | Wang X et al. | β | 2025 | β |
| Multi-parental cross design-based QTL mapping approach elucidates fruit firmness and softening genetic control in European pears (Pyrus communis). | Grignaffini F et al. | β | 2025 | β |
| Multiple genomic ancestries in the broom hare mark the complex biogeographic history of hares in the Iberian Peninsula. | Souto J et al. | β | 2025 | β |
| Multispectral imaging and automated analysis for quantifying grain quality to reveal known and potential novel alleles affecting grain traits in wheat. | Dai J et al. | β | 2025 | β |
| Multivariate Effects of SNPs on Environmental Streptococcal Mastitis Evaluated With an NGS-Based Association Study Using Targeted Resequencing in the Bovine MHC Region. | Nagata F et al. | β | 2025 | β |
| Museomics and Salvaged Feathers Piece Together the Evolutionary History and Conservation Genomics of the Elusive, Critically Endangered Night Parrot (Pezoporus occidentalis). | Yeap HL et al. | β | 2025 | β |
| Museum Genomics Reveals Temporal Genetic Stasis and Global Genetic Diversity in Arabidopsis thaliana. | Lopez L et al. | β | 2025 | β |
| Mycoheterotrophic continuum in rhizoctonia associations: genetic divergence and carbon acquisition variation among Odontochilus orchids. | Suetsugu K et al. | β | 2025 | β |
| Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence. | Stammen C et al. | β | 2025 | β |
| Neurobeachin (NBEA) is a novel gene associated with GLP-1 receptor agonist associated weight loss. | Mariam-Smith A et al. | β | 2025 | β |
| Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders. | Federmann LM et al. | β | 2025 | β |
| Neurogenomic and behavioral principles shape freezing dynamics and synergistic performance in Drosophila melanogaster. | Sato DX et al. | β | 2025 | β |
| New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping. | Lu C et al. | β | 2025 | β |
| Night shift work and lung cancer risk: a prospective cohort study with mediator analysis from the UK Biobank. | Zheng X et al. | β | 2025 | β |
| N-lactoyl amino acids are potential biomarkers for insulin resistance and diabetic complications. | Naja K et al. | β | 2025 | β |
| No causal links between estradiol and female's brain and mental health using Mendelian randomization. | Oppenheimer H et al. | β | 2025 | β |
| Non-Random Mortality in an Experimental Oyster Restoration. | Truskey S et al. | β | 2025 | β |
| Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors. | Logue MW et al. | β | 2025 | β |
| Novel Genetic Variants Associated with Diabetic Neuropathy Risk in Type 2 Diabetes: A Whole-Exome Sequencing Approach. | HajdΓΊ N et al. | β | 2025 | β |
| Novel genetic variants associated with stable isotope-based vitamin B<sub>12</sub> bioavailability measurements in healthy Indian adults. | Sivadas A et al. | β | 2025 | β |
| Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease. | Phillips JM et al. | β | 2025 | β |
| Novel polygenic risk score associates with diverticulitis in a multi-institutional, ancestrally diverse cohort. | Neylan CJ et al. | β | 2025 | β |
| Optimization of Genomic Breeding Value Estimation Model for Abdominal Fat Traits Based on Machine Learning. | Chen H et al. | β | 2025 | β |
| OsLB2.2 negatively regulates rice disease resistance at seedling stage in rice. | Ma T et al. | β | 2025 | β |
| Out-of-Anatolia: Cultural and genetic interactions during the Neolithic expansion in the Aegean. | Koptekin D et al. | β | 2025 | β |
| Parallel evolution of salinity tolerance in <i>Arabidopsis thaliana</i> accessions from Cape Verde Islands. | MartΓnez Rivas FJ et al. | β | 2025 | β |
| Pastrami: a fast and efficient algorithm for fine-scale genetic ancestry inference. | Conley AB et al. | β | 2025 | β |
| Pathway insights and predictive modeling for type 2 diabetes using polygenic risk scores. | Liao WL et al. | β | 2025 | β |
| Patrilineages of ethnolinguistically diverse populations reveal multifactorial influences on Chinese paternal population stratification. | Yang T et al. | β | 2025 | β |
| Pervasive and recurrent hybridization prevents inbreeding in Europe's most threatened seabird. | Izquierdo-ArΓ nega G et al. | β | 2025 | β |
| PGSFusion streamlines polygenic score construction and epidemiological applications in biobank-scale cohorts. | Yang S et al. | β | 2025 | β |
| Pharmacogenomic and Clinical Predictors of Deferasirox Response in Transfusion-Dependent Thalassemia Identified Using Whole-Genome Sequencing. | Yampayon K et al. | β | 2025 | β |
| Phenotypic, genetic, and population structure analysis offer insights into the genetic architecture of root shape in <i>Beta vulgaris</i>. | Vega A et al. | β | 2025 | β |
| Phenotypic, transcriptomic, and genomic analyses reveal the spatiotemporal patterns and associated genes of coarse hair density in goats. | Zhang JP et al. | β | 2025 | β |
| Phylogeographic and Genomic Insights Unveil the Evolutionary History and Post-Glacial Recolonization Routes of the Palmate Newt (<i>Lissotriton helveticus</i>) Into Europe. | Burriel-Carranza B et al. | β | 2025 | β |
| Physical Activity and Favorable Adiposity Genetic Liability Reduce the Risk of Hypertension Among High Body Mass Individuals. | Hezekiah C et al. | β | 2025 | β |
| Pinus radiata genome reveals a downward demographic trajectory and opportunities for genomics-assisted breeding. | Sturrock S et al. | β | 2025 | β |
| Polygenic and developmental profiles of autism differ by age at diagnosis. | Zhang X et al. | β | 2025 | β |
| Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study. | Kasela S et al. | β | 2025 | β |
| Polygenic Risk, Agent Orange Exposure, and Lymphoid Neoplasms in the Veterans Affairs Million Veteran Program. | Teng X et al. | β | 2025 | β |
| Polygenic Risk for Substance Use Disorders as Predictors of Substance Use Initiation Among African American Youth. | Sosnowski DW et al. | β | 2025 | β |
| Polygenic risks and cardiovascular treatment effects in severe mental illness. | Yao K et al. | β | 2025 | β |
| Polygenic Risk Score as a Predictor of Bone Fracture or Osteoporosis in Prostate Cancer Patients Receiving Androgen Deprivation Therapy. | Liu YQ et al. | β | 2025 | β |
| Polygenic risk score as a tool to predict gestational weight gain and gestational diabetes among pregnant women in Taiwan. | Liao WL et al. | β | 2025 | β |
| Polygenic Risk Score for Coronary Artery Disease Across the Spectrum of Atherosclerotic Disease. | Zimerman A et al. | β | 2025 | β |
| Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. | Huang YC et al. | β | 2025 | β |
| Polygenic risk score for type 2 diabetes shows context-dependent effects across populations. | Guo B et al. | β | 2025 | β |
| Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids. | Chun MY et al. | β | 2025 | β |
| Polygenic risk scores for prostate cancer: Comparative evaluations in UK and Australian cohorts. | Tanha HM et al. | β | 2025 | β |
| Polygenic risk scores improve stroke risk stratification in Chinese adults: Validation from the Chinese multi-provincial cohort study. | Wang Z et al. | β | 2025 | β |
| Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population. | Lin WD et al. | β | 2025 | β |
| Polygenic risk scores of rheumatoid arthritis associated with seropositivity and bone erosions in a Taiwanese population. | Wu TS et al. | β | 2025 | β |
| Polygenic Score for Body Mass Index Is Associated with Weight Loss and Lipid Outcomes After Metabolic and Bariatric Surgery. | Aldegheri L et al. | β | 2025 | β |
| Polygenic scores for depression are associated with indices of neighborhood adversity. | Feurer C et al. | β | 2025 | β |
| Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change. | Xu Y et al. | β | 2025 | β |
| Population Genomic Insights Into Recent Nutria (<i>Myocastor coypus</i>) Invasion Dynamics. | Ahrens KD et al. | β | 2025 | β |
| Population Genomics and Genetic Diversity of <i>Prosopis cineraria</i> in the United Arab Emirates: Insights for Conservation in Arid Ecosystems. | Gkanogiannis A et al. | β | 2025 | β |
| Population-genomics reveals a dual ancestry of grizzly bears. | de Jong MJ et al. | β | 2025 | β |
| Population genomics traces zebra mussel invasions along the expanding western North American front in Minnesota, USA to their source waters. | McCartney MA et al. | β | 2025 | β |
| Population homogeneity with unequal exploitation and recruitment contribution within the 2700 km geographic distribution of the commercial hairy crab Romaleon setosum (Decapoda: Cancridae) in Chile. | Tubin-Arenas B et al. | β | 2025 | β |
| Population Patterns and Dynamics of <i>Ilisha elongata</i> (Clupeiformes: Pristigasteridae) Revealed by Target Enrichment Data. | Wang Q et al. | β | 2025 | β |
| Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health. | Zhao Y et al. | β | 2025 | β |
| Population-specific polygenic risk scores for people of Han Chinese ancestry. | Chen HH et al. | β | 2025 | β |
| Population structure and inter-species admixture within a likely extinct yet formerly widespread Hawaiian honeycreeper. | Przelomska NAS et al. | β | 2025 | β |
| Positive Selection in Aggression-Linked Genes and Their Protein Interaction Networks. | Awadi A et al. | β | 2025 | β |
| Precipitation legacy effects on soil microbiota facilitate adaptive drought responses in plants. | Ginnan NA et al. | β | 2025 | β |
| Predicting adolescent disordered eating and behaviours: exploring environmental moderators of polygenic risk. | Curtis M et al. | β | 2025 | β |
| Predicting suicidality in people living with HIV in Uganda: a machine learning approach. | Mutema AB et al. | β | 2025 | β |
| Predictive performance for alcohol use disorder of polygenic scores based on the general addiction risk factor and problematic alcohol use. | PΓ©rez-GutiΓ©rrez AM et al. | β | 2025 | β |
| Prematurity and genetic liability for autism spectrum disorder. | Zhang Y et al. | β | 2025 | β |
| Prioritized SNP Selection from Whole-Genome Sequencing Improves Genomic Prediction Accuracy in Sturgeons Using Linear and Machine Learning Models. | Song H et al. | β | 2025 | β |
| Privacy-hardened and hallucination-resistant synthetic data generation with logic-solvers. | Burgess MA et al. | β | 2025 | β |
| Protein Catabolites as Blood-Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project. | Harrison BR et al. | β | 2025 | β |
| Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease. | Caro I et al. | β | 2025 | β |
| PSVRP: a pig structural variant reference panel for complex trait genomics and precision breeding. | Li X et al. | β | 2025 | β |
| Quantifying APOL1, Human Leukocyte Antigen, and Other Genetic Contributions to Unexplained Kidney Failure. | Sadeghi-Alavijeh O et al. | β | 2025 | β |
| Quantile-specific confounding: correction for subtle population stratification via quantile regression. | Wang C et al. | β | 2025 | β |
| RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood. | Navarro-Delgado EI et al. | β | 2025 | β |
| Range extension and re-assessment of <i>Eugenia stirpiflora</i> (O.Berg) Krug & Urb., an endemic Myrtaceae to the Virgin Islands. | BΓ‘rrios S et al. | β | 2025 | β |
| Rapid adaptation to a globally introduced virulent pathogen in a keystone species. | Cassin-Sackett L et al. | β | 2025 | β |
| Rapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemic. | Metheringham CL et al. | β | 2025 | β |
| Rare genetic variants and severe COVID-19 in previously healthy admixed Latin American adults. | Rocha GD et al. | β | 2025 | β |
| Rare phenotypes of white coat color in Simmental calves: genetic causes of syndromic forms of albinism and depigmentation. | Jacinto JGP et al. | β | 2025 | β |
| Rare-Variant Genome-Wide Association and Polygenic Score Assessment of Vitamin D Status in a Middle Eastern Population. | Hendi NN et al. | β | 2025 | β |
| Real-World Utility of GWAS-Based Diabetes Mellitus Panel Testing. | Jeong IH et al. | β | 2025 | β |
| Recent Adaptation in a Threatened Salmonid Revealed by Museum Genomics. | Sharo AG et al. | β | 2025 | β |
| Recurrent Hybridisations During Diversification of One Rhododendron Species Complex. | Wang J et al. | β | 2025 | β |
| Relationship between metabolic syndrome and overactive bladder: insights from the NHANES and Mendelian randomization study. | Liu Z et al. | β | 2025 | β |
| Remarkable heterogeneity revealed in the genetic architecture of resistance to a key bacterial pathogen in two commercial rainbow trout populations. | Pouil S et al. | β | 2025 | β |
| Revisiting the dispersal history of walnut by analyzing the ancient DNA of walnut remains in Xinjiang, China. | Zhang B et al. | β | 2025 | β |
| Revisiting the Trans-Ancestry Genetic Correlation of Refractive Error. | Clark R et al. | β | 2025 | β |
| Rice cycles between drought and well-watered-adapted phenotypes by changing lateral root formation. | Bochmann H et al. | β | 2025 | β |
| Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk. | Hu J et al. | β | 2025 | β |
| Saving the locals: a conservation genomics approach to the endangered Spanish Toothcarp, Aphanius iberus (Valenciennes, 1846). | Estarellas M et al. | β | 2025 | β |
| Screening a new European hake (Merluccius merluccius) chromosome-level genome assembly suggests an XX/XY sex-determining system driven by the SRY-box transcription factor 3 (sox3). | MartΓnez P et al. | β | 2025 | β |
| SDFA: a standardized decomposition format and toolkit for efficient analysis of structural variants in large-scale population genomic studies. | Peng W et al. | β | 2025 | β |
| Selection Signature Analysis of Whole-Genome Sequences to Identify Genome Differences Between Selected and Unselected Holstein Cattle. | Cai J et al. | β | 2025 | β |
| Selection Signatures in the Genome of Dzhalgin Merino Sheep Breed. | Krivoruchko A et al. | β | 2025 | β |
| Sequencing Analysis Demonstrates That a Complex Genetic Architecture Contributes to Risk for Spina Bifida. | Strain M et al. | β | 2025 | β |
| Severe obesity as an oligogenic condition: evidence from 1714 adults seeking treatment in the UK National Health Service. | Almansoori S et al. | β | 2025 | β |
| Sex-Linked Differentiation in Commercially Exploited Fishes: Rethinking Population Structure in Dynamic Marine Environments. | Gardiner CEC et al. | β | 2025 | β |
| Sex-Specific Polygenic Risk Scores and Replication in a Model-Free Analysis of Schizophrenia Data. | Ott A et al. | β | 2025 | β |
| Sex-stratified genome-wide association meta-analysis of major depressive disorder. | Thomas JT et al. | β | 2025 | β |
| Signatures of selective sweeps in continuous-space populations. | Chotai M et al. | β | 2025 | β |
| Single- and multiple-locus model genome-wide association study for growth traits in Dongliao black pigs. | Sun K et al. | β | 2025 | β |
| Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue. | Chen ZJ et al. | β | 2025 | β |
| Single-variant genome-wide association study and regional heritability mapping of protein efficiency and performance traits in Large White pigs. | Ewaoluwagbemiga EO et al. | β | 2025 | β |
| Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits. | Wilson EP et al. | β | 2025 | β |
| SLC45A4 is a pain gene encoding a neuronal polyamine transporter. | Middleton SJ et al. | β | 2025 | β |
| Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components. | Omdahl AR et al. | β | 2025 | β |
| Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies. | Stamp J et al. | β | 2025 | β |
| Sparse polygenic risk score inference with the spike-and-slab LASSO. | Song J et al. | β | 2025 | β |
| Statistical construction of calibrated prediction intervals for polygenic score-based phenotype prediction. | Xu C et al. | β | 2025 | β |
| Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers. | Blechter B et al. | β | 2025 | β |
| STREAM-PRS: a multi-tool pipeline for streamlining polygenic risk score computation. | Becelaere S et al. | β | 2025 | β |
| Strong Association Between MiRNA Gene Variants and Type 2 Diabetes Mellitus in a Caucasian Population. | Manthou E et al. | β | 2025 | β |
| Strong Bottlenecks Constrain Adaptive Coevolution in a Host-Parasite Metapopulation. | Angst P et al. | β | 2025 | β |
| Structural and deleterious burdens and their effects on yield traits in foxtail millet domestication. | Du M et al. | β | 2025 | β |
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| Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS. | Wang FL et al. | β | 2025 | β |
| Temporal Genomics Reveal a Century of Genomic Diversity Shifts Across a Biodiversity Hotspot Avian Assemblage. | Manthey JD et al. | β | 2025 | β |
| Testing the Mother's Curse Hypothesis in Human Mitochondrial Genome Evolution. | Yuan R et al. | β | 2025 | β |
| That's So Last Season: Unraveling the Genomic Consequences of Fur Farming in Arctic Foxes (Vulpes lagopus). | Cockerill CA et al. | β | 2025 | β |
| The association between parental BMI and offspring adiposity: A genetically informed analysis of trios. | Wright L et al. | β | 2025 | β |
| The association of a polygenic lifespan score with the risk of common age-related diseases and mortality. | Tynkkynen NP et al. | β | 2025 | β |
| The BioSUD Biobank as a genomic resource for substance use disorders in Italy. | Ribatti RM et al. | β | 2025 | β |
| The brief resilience scale: a genome-wide association study in the UK Biobank. | Cornelis MC et al. | β | 2025 | β |
| The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection. | Brown AC et al. | β | 2025 | β |
| The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians. | Lin C et al. | β | 2025 | β |
| The Causal Mechanism Between the Dipeptidyl Peptidase-4, Heart Failure, and Other Cardiovascular Diseases: A Mendelian Randomization and Mediation Study. | Chen CK et al. | β | 2025 | β |
| The chronODE framework for modelling multi-omic time series with ordinary differential equations and machine learning. | Borsari B et al. | β | 2025 | β |
| The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CΓDIGO): building local capacity in genomics and bioinformatics. | MariΓ±o-RamΓrez L et al. | β | 2025 | β |
| The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities. | Arruda AL et al. | β | 2025 | β |
| The First Whole Genome Sequence and Methylation Profile of <i>Gerronema lapidescens</i> QL01. | Qiao Y et al. | β | 2025 | β |
| The genetic architecture of cervical length is shared with spontaneous preterm birth risk. | Wolf HM et al. | β | 2025 | β |
| The genetic architecture of HIV-1 virulence. | Blanquart F et al. | β | 2025 | β |
| The Genetic Associations Between Kidney Stones, Obesity, Type 2 Diabetes, and Hypertension. | Zhou LT et al. | β | 2025 | β |
| The genetic basis of chloride exclusion in grapevines. | Sharma S et al. | β | 2025 | β |
| The genetic diversity and population structure of native horse breeds in Xinjiang, China. | Tang C et al. | β | 2025 | β |
| The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression. | Wang X et al. | β | 2025 | β |
| The genetic lottery goes to school: Better schools compensate for the effects of students' genetic differences. | Cheesman R et al. | β | 2025 | β |
| The Genomic Basis of the Svalbard Reindeer's Adaptation to an Extreme Arctic Environment. | Dussex N et al. | β | 2025 | β |
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| The Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer Mice. | Howell EK et al. | β | 2025 | β |
| The gut microbiome associated with LGI1-antibody encephalitis. | Gilbert E et al. | β | 2025 | β |
| The Health for Life in Singapore (HELIOS) Study: delivering precision medicine research for Asian populations. | Wang X et al. | β | 2025 | β |
| The Historical Biogeography of Divergence in the Relict Cypress <i>Chamaecyparis obtusa</i>, and the Implications for Conservation and Management in East Asia. | Aihara T et al. | β | 2025 | β |
| The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle. | Prabakaran AD et al. | β | 2025 | β |
| The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis. | Durumutla HB et al. | β | 2025 | β |
| The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa. | Reynolds AW et al. | β | 2025 | β |
| The interplay among space, environment, and gene flow drives genetic differentiation in endemic Baja California Agave sobria subspecies. | Klimova A et al. | β | 2025 | β |
| The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men. | Oskarsdottir H et al. | β | 2025 | β |
| The interplay of recombination landscape and a transposable element in European populations of Chironomus riparius. | Pettrich LC et al. | β | 2025 | β |
| The <i>SELENOP</i> Polymorphism rs7579 Predicts Hepatic Steatosis in Females With Insulin Resistance in the General Population. | Yamamoto R et al. | β | 2025 | β |
| The Mediterranean Habitat of the Nile Soft-Shelled Turtle (<i>Trionyx triunguis</i>): Genomic and Reproductive Insights into an Endangered Population. | Gaspar A et al. | β | 2025 | β |
| The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development. | Girdhar K et al. | β | 2025 | β |
| The Peripheral Epigenome Predicts White Matter Volume Contingent on Developmental Stage: An ECHO Study. | Hanson T et al. | β | 2025 | β |
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| Three distinct genetic lineages of Trichonephila clavata based on mitochondrial COI and genome-wide SNPs on the Korean Peninsula. | Kim G et al. | β | 2025 | β |
| Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women. | Ho PJ et al. | β | 2025 | β |
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| Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy. | Ma Z et al. | β | 2025 | β |
| Transcriptome-wide Mendelian randomization exploring dynamic CD4+ T cell gene expression in colorectal cancer development. | Deslandes B et al. | β | 2025 | β |
| Trans-eQTLs Can Be Used to Identify Tissue-Specific Gene Regulatory Networks. | Nikpay M | β | 2025 | β |
| Transferability of polygenic risk scores for metabolic and cardiovascular traits in an underrepresented population. | Pasookhush P et al. | β | 2025 | β |
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| Two genes, one culprit - a functional candidate validation of a SPATA7 deletion in dogs with day blindness/retinal degeneration. | Murgiano L et al. | β | 2025 | β |
| Uncovering genetic mechanisms associated with harmful use of alcohol in admixed Latin Americans. | Amaral EHB et al. | β | 2025 | β |
| Uncovering the architecture of production-driven introgression in Cinisara cattle breed. | Floridia V et al. | β | 2025 | β |
| Uncovering the Genetic Structure of the Sekler Population in Transylvania Through Genome-Wide Autosomal Data. | SzabΓ³ A et al. | β | 2025 | β |
| Uniformity of body weight in growing pigs is persistent during growth but affected by sow- and litter-related factors. | Hooyberghs K et al. | β | 2025 | β |
| Unraveling the Genetic Legacy: Comparative Analysis of YucatΓ‘n Black Hairless Pig and Worldwide Indigenous Breeds. | Lara-Castillo JB et al. | β | 2025 | β |
| Unravelling the genetic architecture of inflammatory bowel disease multiplex families with rare and common variant polygenic risk scores. | Jans DS et al. | β | 2025 | β |
| Unravelling the genetic landscape of Channa argus in Shandong Province: Insights into population differentiation, adaptation and conservation from whole-genome resequencing. | An L et al. | β | 2025 | β |
| Using the ancestral recombination graph to study the history of rare variants in founder populations. | Mejia-Garcia A et al. | β | 2025 | β |
| Utility of blood DNA methylation and immune cell-type estimates to identify clinically relevant links between immunity and health conditions in a large cohort. | Herrera-Rivero M et al. | β | 2025 | β |
| Validating a remote saliva collection tool for genomic analyses in free ranging dogs. | Cimarelli G et al. | β | 2025 | β |
| Validation of a genome-wide polygenic score for body mass index in South Asians. | Menon R et al. | β | 2025 | β |
| Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk. | Carlson JC et al. | β | 2025 | β |
| Variational autoencoder-based model improves polygenic prediction in blood cell traits. | Li X et al. | β | 2025 | β |
| Variation in APOE Ξ΅4 Prevalence and Associations With Dementia-Related Outcomes by European Descent Among White Americans. | Perales-Puchalt J et al. | β | 2025 | β |
| Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI. | Curtis D | β | 2025 | β |
| Whole-exome sequencing identifies 5 novel genes associated with carpal tunnel syndrome. | Wang ZY et al. | β | 2025 | β |
| Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women. | Nierenberg JL et al. | β | 2025 | β |
| Whole Exome Sequencing Study Uncovers Novel Candidate Genes and Protein-Coding Variants for Cataract. | Chaar DL et al. | β | 2025 | β |
| Whole-Genome Data to Investigate Recent and Historical Dog Introgression Patterns in Italian Wolves. | Battilani D et al. | β | 2025 | β |
| Whole-genome sequences provide insights into the formation and adaptation of human populations in the Himalayas. | Arciero E et al. | β | 2025 | β |
| Whole-genome sequencing and variants data of 304 indigenous goats from Southwest China. | Zhang J et al. | β | 2025 | β |
| Whole-genome sequencing GWAS reveals bovine genomic effects on enteric methane emissions in beef cattle. | Arikawa LM et al. | β | 2025 | β |
| Whole genome sequencing in adolescent idiopathic scoliosis cohort implicates multiple biological pathways. | Tuncay IO et al. | β | 2025 | β |
| Whole-Genome Sequencing in Galicia Reveals Male-Biased Pre-Islamic North African Ancestry, Subtle Population Structure, and Microgeographic Patterns of Disease Risk. | Pardo-Seco J et al. | β | 2025 | β |
| Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene. | Sonehara K et al. | β | 2025 | β |
| X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome. | Step K et al. | β | 2025 | β |
| X-LDR: an atlas of linkage disequilibrium across species. | Zhu TN et al. | β | 2025 | β |