Genetic studies of alcohol dependence in the context of the addiction cycle.
paper
Cited
Public
- Authors
- Reilly, Matthew T; Noronha, Antonio; Goldman, David; Koob, George F
- Year
- 2017
- Journal
- Neuropharmacology
- PMID
- 28118990
- DOI
- 10.1016/j.neuropharm.2017.01.017
- PMCID
- PMC6233301
Family, twin and adoption studies demonstrate clearly that alcohol dependence and alcohol use disorders are phenotypically complex and heritable. The heritability of alcohol use disorders is estimated at approximately 50-60% of the total phenotypic variability. Vulnerability to alcohol use disorders can be due to multiple genetic or environmental factors or their interaction which gives rise to extensive and daunting heterogeneity. This heterogeneity makes it a significant challenge in mapping and identifying the specific genes that influence alcohol use disorders. Genetic linkage and (candidate gene) association studies have been used now for decades to map and characterize genomic loci and genes that underlie the genetic vulnerability to alcohol use disorders. These approaches have been moderately successful in identifying several genes that contribute to the complexity of alcohol use disorders. Recently, genome-wide association studies have become one of the major tools for identifying genes for alcohol use disorders by examining correlations between millions of common single-nucleotide polymorphisms with diagnosis status. Genome-wide association studies are just beginning to uncover novel biology; however, the functional significance of results remains a matter of extensive debate and uncertainty. In this review, we present a select group of genome-wide association studies of alcohol dependence, as one example of a way to generate functional hypotheses, within the addiction cycle framework. This analysis may provide novel directions for validating the functional significance of alcohol dependence candidate genes. This article is part of the Special Issue entitled "Alcoholism".
Candidate genes for alcohol dependence characterized into stages of the addiction cycle. This schematic shows the three stages of the addiction cycle: (1): binge-intoxication (blue), (2): withdrawal-negative affect (red) and (3): preoccupation-anticipation (green); also shown are behavioral domains linked to each stage of the cycle: incentive salience, negative emotionality, and executive function, respectively. Candidate functional genes identified by non-GWAS approaches are shown in ovals and colored coded according to the relevant addiction stage the gene is hypothesized to function. GWAS candidates are shown in rectangles color coded according to the relevant addiction stage the gene is hypothesized to function. The general biological function of each gene in the figure is highlighted in black. Non-GWAS functional gene relationships are indicated by overlapping ovals. Hypothesized functional relationships between non-GWAS genes and GWAS candidates are indicated by overlapping ovals and rectangles. GWAS candidates in each stage are grouped according to potential biological functional similarities where possible. Finally, one example of pleiotropy is shown in the preoccupation-anticipation stage. BDNF-COMT functional variants have pleiotropic effects in both the preoccupation-anticipation stage and the withdrawal-negative affect stage. This pleiotropic relationship is shown by dual-color shading of the BDNF-COMT ovals reflecting both addiction stages.
β Prev
81β86 of 86
| Name | Type |
|---|---|
| 1000 Genomes Project | cohort |
| abstinence | phenotype |
| abstinence-induced escalation of alcohol drinking local | phenotype |
| abstinence-related working memory deficits local | phenotype |
| acamprosate | drug |
| acetaldehyde | drug |
| acetylcholine | drug |
| ACF local | drug |
| ACTH | drug |
| addiction | phenotype |
| addiction to drugs and alcohol local | phenotype |
| ADH1B | gene |
| ADH1B Arg48His | variant |
| ADH1C | gene |
| ADH7 | gene |
| adolescents | cohort |
| Adopted-out sons of alcoholics local | cohort |
| Adopted-out sons of non-alcoholics local | cohort |
| Adopted sons of alcoholics local | cohort |
| Adult hippocampus local | anatomy |
| adult offspring of alcohol-dependent probands local | cohort |
| adults | cohort |
| African American | cohort |
| age of onset | phenotype |
| age-related macular degeneration | phenotype |
| aggression | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dehydrogenase | gene |
| alcohol dependence | phenotype |
| Alcohol_dependence | phenotype |
| alcohol dependence factor score local | phenotype |
| Alcohol exposure (nonβdependent) local | phenotype |
| Alcoholic humans local | cohort |
| ALCOHOL_INTAKE local | phenotype |
| alcoholism | phenotype |
| Alcohol metabolizing genes local | gene |
| Alcohol neurotoxicity | phenotype |
| alcohol preference | phenotype |
| ALCOHOL_PREFERRING_RAT local | cohort |
| alcohol relapse | phenotype |
| alcohol-related phenotypes | phenotype |
| alcohol self-administration | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol withdrawal | phenotype |
| alcohol withdrawal induced anxiety local | phenotype |
| alcohol-withdrawal induced anxiety local | phenotype |
| ALCOHOL_WITHDRAWAL_INDUCED_ANXIETY local | phenotype |
| alcohol withdrawal severity local | phenotype |
| ALDH2 | gene |
| American Indians | cohort |
| amygdala | anatomy |
| anhedonia | phenotype |
| ANP local | drug |
| ANP expression local | drug |
| ANP receptor signaling local | drug |
| antalarmin local | drug |
| anterior cingulate cortex | anatomy |
| anti-social personality local | phenotype |
| anxiety | phenotype |
| anxiety responses local | phenotype |
| ASCT1 local | gene |
| Asian | cohort |
| asthma | phenotype |
| attentional control | phenotype |
| AUD | phenotype |
| Australian of European descent local | cohort |
| Australian population | cohort |
| Australian twin community sample local | cohort |
| BAF | drug |
| basolateral amygdala | anatomy |
| Bdnf | gene |
| BDNF Val66Met polymorphism local | variant |
| beta-endorphin | drug |
| binge drinking | phenotype |
| binge drinking mice local | cohort |
| Binge drinking mice local | cohort |
| binge-intoxication local | phenotype |
| binge/intoxication local | phenotype |
| Biological sons of alcoholics adopted by non-related foster families local | cohort |
| bipolar disorder | phenotype |
| brain | anatomy |
| Brain abnormalities characteristic of WKS local | phenotype |
| brain endogenous opioid function local | phenotype |
| cancer | phenotype |
| candidate genes | cohort |
| CARS local | gene |
| catecholamines | drug |
| caudate nucleus | anatomy |
| cerebellar degeneration | phenotype |
| childhood trauma | phenotype |
| children of alcoholics | cohort |
| Chinese | cohort |
| chronic alcoholism | phenotype |
| Clinical diagnosis of alcohol dependence local | phenotype |
| CMTM8 | gene |
| CNS disinhibition | phenotype |
| cocaine | phenotype |
| cocaine relapse risk local | phenotype |
| cocaine self-administration | phenotype |
| Coenzyme A local | drug |
| COGEND | cohort |
| cognition | phenotype |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| common variants | cohort |
| compulsive alcohol consumption local | phenotype |
| compulsive alcohol intake | phenotype |
| compulsive drug and alcohol consumption local | phenotype |
| Compulsive drug and alcohol consumption local | phenotype |
| compulsive drug seeking behavior local | phenotype |
| compulsivity | phenotype |
| COMT | gene |
| corticostriatal pathways local | anatomy |
| Corticostriatal pathways local | anatomy |
| corticotropin-releasing factor | drug |
| cortisol | drug |
| cortisol response | phenotype |
| craving | phenotype |
| CREB1 | gene |
| CREB5 | gene |
| CRF | drug |
| CRH | gene |
| CRHR1 | gene |
| CRHR1 knockout mice | cohort |
| Crhr1 promoter polymorphism local | variant |
| Criterion factor score local | phenotype |
| cue-induced reinstatement | phenotype |
| cysteine | drug |
| cystine | drug |
| DAG1 local | gene |
| deficits in glycine neurotransmission local | phenotype |
| Denmark adoption study local | cohort |
| densely affected families | cohort |
| dependence-induced drinking | phenotype |
| dependent drinking local | phenotype |
| depression | phenotype |
| developmental delay | phenotype |
| diabetes | phenotype |
| discovery sample | cohort |
| disulfiram | drug |
| Dmd | gene |
| dopamine | drug |
| dopaminergic neurons | anatomy |
| dopamine signaling | phenotype |
| dorsal raphe nucleus | anatomy |
| dorsal striatum | anatomy |
| DRD2 | gene |
| DRD4 | gene |
| drinking to avoid emotional or somatic discomfort local | phenotype |
| drug | drug |
| drug dependence | phenotype |
| drug-seeking behavior | phenotype |
| drug taking | phenotype |
| drug withdrawal responses local | phenotype |
| d-serine | drug |
| DSM-IV | phenotype |
| DSM-IV alcohol dependence | phenotype |
| dynorphin | drug |
| dynorphin-ΞΊ opioid local | drug |
| early-onset alcoholism local | phenotype |
| Early-onset alcoholism local | phenotype |
| Emotion | phenotype |
| endocannabinoid system | drug |
| Endocannabinoid system local | anatomy |
| Endophenotypes associated with alcoholism local | phenotype |
| enkephalin | drug |
| epistatic interactions local | variant |
| ethanol consumption | phenotype |
| European American case-control GWAS local | cohort |
| European ancestry | cohort |
| European population | cohort |
| Europeans | cohort |
| excessive alcohol consumption | phenotype |
| EXCESSIVE_ALCOHOL_CONSUMPTION local | phenotype |
| Excessive alcohol-drinking behaviors local | phenotype |
| executive function | phenotype |
| executive functioning | phenotype |
| exfoliation glaucoma | phenotype |
| extended amygdala | anatomy |
| families | cohort |
| Family-based replication study local | cohort |
| Family study of cocaine dependence | cohort |
| fatty acids | drug |
| fenofibrate | drug |
| Finland | cohort |
| Finnish population | cohort |
| first-degree relatives | cohort |
| Fkbp5 | gene |
| fluid intelligence local | phenotype |
| Foroud 2007 cohort local | cohort |
| Frank et al. 2012 GWAS local | cohort |
| GABA | phenotype |
| GABA-B receptor subunit 1 local | gene |
| GATA4 | gene |
| genetic variants | cohort |
| German cohort | cohort |
| German male follow-up sample local | cohort |
| German sample of males local | cohort |
| glutamate | drug |
| glutathione | drug |
| glycine | drug |
| GlyR | drug |
| greater alcohol-cue reactivity local | phenotype |
| greater brain activation during alcohol-cue task local | phenotype |
| greater subjective reinforcement from alcohol consumption local | phenotype |
| GRIN1 | gene |
| GRM5 | gene |
| GWAS | cohort |
| habitual behavior | phenotype |
| Half-siblings raised by alcoholic families local | cohort |
| Half-siblings raised by foster non-alcoholic families local | cohort |
| HapMap | cohort |
| Heaviness of drinking local | phenotype |
| heaviness of drinking factor score local | phenotype |
| high alcohol preference | phenotype |
| hippocampus | anatomy |
| HPA axis local | drug |
| HRAS | gene |
| Htr1a | gene |
| HTR1A variant local | variant |
| HTR2B | gene |
| HTR2B stop codon | variant |
| human alcoholic brain local | cohort |
| Human Alcoholic Brain local | cohort |
| human brain | anatomy |
| Human Genome Project | cohort |
| hyperekplexia-like phenotype local | phenotype |
| Hyperekplexia-like phenotype local | phenotype |
| hypomyelination | phenotype |
| hypothalamicβpituitaryβadrenal axis | anatomy |
| hypothalamus | anatomy |
| impulsivity | phenotype |
| irritability | phenotype |
| Kcnj6 | gene |
| Kcnma1 | gene |
| Koreans | cohort |
| Korsakoff's syndrome | phenotype |
| KRAS | gene |
| l-cysteine | drug |
| leu-enkephalin local | drug |
| leumorphin local | drug |
| limbic brain areas local | anatomy |
| limbic brain regions local | anatomy |
| limbic gray matter volume local | anatomy |
| limbic gray matter volume local | phenotype |
| LIMBIC_REGION local | anatomy |
| limbic regions | anatomy |
| LOC100507053 | gene |
| l-serine | drug |
| MAOB | gene |
| marijuana | phenotype |
| maximum drinks | phenotype |
| Maximum drinks (24h) local | phenotype |
| MBNL2 local | gene |
| mesolimbic dopamine system | drug |
| mice | cohort |
| microcephaly | phenotype |
| missing heritability | phenotype |
| Molecular Genetics of Schizophrenia (MGS2) control sample | cohort |
| mouse brain | anatomy |
| Mpdz | gene |
| msP rat line local | cohort |
| MSX1 local | gene |
| myoclonus-dystonia syndrome local | phenotype |
| N-acetylcysteine | drug |
| naltrexone | drug |
| NAP1 local | drug |
| NAP1L1 local | gene |
| NAP1L2 local | gene |
| NAP1L3 local | gene |
| NAP1L4 local | gene |
| NAP1L5 | gene |
| Native Americans | cohort |
| negative affect | phenotype |
| Negative affective state local | phenotype |
| negative affective state during protracted abstinence local | phenotype |
| negative emotional state local | phenotype |
| negative reinforcement | phenotype |
| NESARC | cohort |
| neurodegeneration | phenotype |
| nicotine | drug |
| NMDA receptor | drug |
| Novel pharmacotherapies local | drug |
| novelty seeking | phenotype |
| NPY | gene |
| NPY variant local | variant |
| nucleus accumbens | anatomy |
| Opioid reward system local | anatomy |
| OPRK1 | cohort |
| OPRK1 variant local | variant |
| OPRM1 | cohort |
| OSBPL5 local | gene |
| oxidative stress | phenotype |
| parietal cortex | anatomy |
| past 12-month frequency local | phenotype |
| Pdyn | gene |
| PECR | gene |
| PHLDA2 local | gene |
| PKNOX2 | gene |
| Pomc | gene |
| poor decision making | phenotype |
| poor executive functioning | phenotype |
| poor inhibitory control | phenotype |
| population-based case-control samples local | cohort |
| population-based epidemiologic studies local | cohort |
| PPAR | gene |
| PPARA | gene |
| PPARG | gene |
| PPARGC1A | gene |
| precuneus | anatomy |
| prefrontal cortex | anatomy |
| preoccupation-anticipation domain local | phenotype |
| propensity to drink in negative emotional states local | phenotype |
| Protracted abstinence from alcohol local | phenotype |
| psychiatric disorders | phenotype |
| Psychiatric Genomics Consortium | cohort |
| psychostimulants | drug |
| RAC1 | gene |
| rare variant | cohort |
| RASL11A local | gene |
| rats | cohort |
| reactive oxygen species | drug |
| Reduced neuroplasticity local | phenotype |
| reinforcement learning | phenotype |
| relapse risk | phenotype |
| replication sample | cohort |
| response inhibition | phenotype |
| reward anticipation | phenotype |
| reward system function local | phenotype |
| rimorphin local | drug |
| rs10224675 local | variant |
| rs10893366 local | variant |
| rs1344694 | variant |
| rs1426153 local | variant |
| rs1693482 | variant |
| rs1789891 | variant |
| rs4770403 local | variant |
| rs6483362 local | variant |
| rs750338 | variant |
| rs7590720 | variant |
| rs9512637 | variant |
| rs9556711 local | variant |
| Rsu1 local | gene |
| RSU1 local | gene |
| SAGE | cohort |
| schizophrenia | phenotype |
| SERINC2 | gene |
| SERINC2 SNPs | variant |
| serotonin | drug |
| severe alcohol use disorder | phenotype |
| SGCA local | gene |
| SGCB local | gene |
| SGCE local | gene |
| SGCG | gene |
| SIGMAR1 local | drug |
| SIGMAR1 local | gene |
| SIGMAR1_ANTAGONISTS local | drug |
| single-nucleotide polymorphism | variant |
| SLC22A18 local | gene |
| Slc7a11 | gene |
| smoking | phenotype |
| SNORA54 local | gene |
| SNP | cohort |
| Social drinkers | phenotype |
| sphingolipids | drug |
| stress | phenotype |
| stress-induced reinstatement | phenotype |
| stress-resilience local | phenotype |
| Stress-resilience local | phenotype |
| stress response | phenotype |
| striatum | anatomy |
| Study of Addiction: Genetics and Environment | cohort |
| substance use | phenotype |
| suicide | phenotype |
| Sweden | cohort |
| Sweden adoption study local | cohort |
| tesaglitazar | drug |
| thiamine | drug |
| thiamine deficiency | drug |
| thiamine pyrophosphate | drug |
| Thiamine signaling local | phenotype |
| Tiihonen 1999 cohort local | cohort |
| TPK1 local | gene |
| TPK1 SNP local | variant |
| trait anxiety | phenotype |
| treatment response | phenotype |
| treatment response to naltrexone local | phenotype |
| Treutlein et al., 2009 local | cohort |
| Treutlein et al. 2009 GWAS | cohort |
| type 1 alcoholism local | phenotype |
| type 2 alcoholism local | phenotype |
| United Kingdom | cohort |
| United States | cohort |
| United States adoption study local | cohort |
| Val158Met | gene |
| ventral striatum | anatomy |
| ventral tegmental area | anatomy |
| Violent criminal offenders local | phenotype |
| Voisey 2011 cohort local | cohort |
| voluntary alcohol consumption | phenotype |
| WAY100635 local | drug |
| Wernicke-Korsakoff syndrome | phenotype |
| Wernicke's encephalopathy | phenotype |
| withdrawal-negative affect addiction cycle local | phenotype |
| withdrawal severity | phenotype |
| working memory | phenotype |
| Ξ²-catenin | drug |
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| A haplotype map of the human genome. Nature 437, 1299β1320.10.1038/nature04226PMC188087116255080 | β | β | β |
| AgrawalA, BierutLJ, 2012 Identifying genetic variation for alcohol dependence. Alcohol Res. 34, 274β281.2313404310.35946/arcr.v34.3.02PMC3662475 | β | β | β |
| AgrawalA, EdenbergHJ, GelernterJ, 2016 Meta-analyses of genome-wide association data hold new promise for addiction genetics. J. Stud. Alcohol Drugs 77, 676β680.2758852210.15288/jsad.2016.77.676PMC5015465 | β | β | β |
| AmenSL, PiacentineLB, AhmadME, LiSJ, MantschJR, RisingerRC, BakerDA, 2011 Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology 36, 871β878.2116046410.1038/npp.2010.226PMC3052624 | β | β | β |
| AntoniFA, HunterEF, LowryPJ, NobleJM, SecklJR, 1992 Atriopeptin: an endogenous corticotropin-release inhibiting hormone. Endocrinology 130, 1753β1755.131124810.1210/endo.130.3.1311248 | β | β | β |
| AryalP, DvirH, ChoeS, SlesingerPA, 2009 A discrete alcohol pocket involved in GIRK channel activation. Nat. Neurosci 12, 988β995.1956160110.1038/nn.2358PMC2717173 | β | β | β |
| AshareRL, ValdezJN, RuparelK, AlbeldaB, HopsonRD, KeefeJR, LougheadJ, LermanC, 2013 Association of abstinence-induced alterations in working memory function and COMT genotype in smokers. Psychopharmacol. (Berl) 230, 653β662.10.1007/s00213-013-3197-3PMC384008923828159 | β | β | β |
| BegumF, GhoshD, TsengGC, FeingoldE, 2012 Comprehensive literature review and statistical considerations for GWAS meta-analysis. Nucleic Acids Res. 40, 3777β3784.2224177610.1093/nar/gkr1255PMC3351172 | β | β | β |
| BeldaX, FuentesS, DaviuN, NadalR, ArmarioA, 2015 Stress-induced sensitization: the hypothalamic-pituitary-adrenal axis and beyond. Stress 18, 269β279.2630010910.3109/10253890.2015.1067678 | β | β | β |
| Ben HamidaS, NeastaJ, LasekAW, KharaziaV, ZouM, CarnicellaS, JanakPH, RonD, 2012 The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. J. Neurosci 32, 15849β15858.2313642410.1523/JNEUROSCI.2846-12.2012PMC3514017 | β | β | β |
| BenzeroukF, GierskiF, GorwoodP, RamozN, StefaniakN, HubschB, KaladjianA, LimosinF, 2013 Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and its implication in executive functions in adult offspring of alcohol-dependent probands. Alcohol 47, 271β274.2358269510.1016/j.alcohol.2013.03.001 | β | β | β |
| BettingerJC, DaviesAG, 2014 The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies. Front. Physiol 5, 346.2524998410.3389/fphys.2014.00346PMC4158801 | β | β | β |
| BevilacquaL, CarliV, SarchiaponeM, GeorgeDK, GoldmanD, RoyA, EnochMA, 2012 Interaction between FKBP5 and childhood trauma and risk of aggressive behavior. Arch. Gen. Psychiatry 69, 62β70.2221379010.1001/archgenpsychiatry.2011.152PMC3437943 | β | β | β |
| BevilacquaL, DolyS, KaprioJ, YuanQ, TikkanenR, PaunioT, ZhouZ, WedenojaJ, MaroteauxL, DiazS, BelmerA, HodgkinsonCA, Dell'ossoL, SuvisaariJ, CoccaroE, RoseRJ, PeltonenL, VirkkunenM, GoldmanD, 2010 A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 468, 1061β1066.2117916210.1038/nature09629PMC3183507 | β | β | β |
| BevilacquaL, GoldmanD, 2013 Genetics of impulsive behaviour. Philos Trans. R Soc. Lond. B Biol. Sci 368 (1615), 20120380.2344046610.1098/rstb.2012.0380PMC3638385 | β | β | β |
| BierutLJ, AgrawalA, BucholzKK, DohenyKF, LaurieC, PughE, FisherS, FoxL, HowellsW, BertelsenS, HinrichsAL, AlmasyL, BreslauN, CulverhouseRC, DickDM, EdenbergHJ, ForoudT, GruczaRA, HatsukamiD, HesselbrockV, JohnsonEO, KramerJ, KruegerRF, KupermanS, LynskeyM, MannK, NeumanRJ, NothenMM, NurnbergerJIJr., PorjeszB, RidingerM, SacconeNL, SacconeSF, SchuckitMA, TischfieldJA, WangJC, RietschelM, GoateAM, RiceJP, 2010 A genome-wide association study of alcohol dependence. Proc. Natl. Acad. Sci. U. S. A. 107, 5082β5087.2020292310.1073/pnas.0911109107PMC2841942 | β | β | β |
| BierutLJ, GoateAM, BreslauN, JohnsonEO, BertelsenS, FoxL, AgrawalA, BucholzKK, GruczaR, HesselbrockV, KramerJ, KupermanS, NurnbergerJ, PorjeszB, SacconeNL, SchuckitM, TischfieldJ, WangJC, ForoudT, RiceJP, EdenbergHJ, 2012 ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Mol. Psychiatry 17, 445β450.2196892810.1038/mp.2011.124PMC3252425 | β | β | β |
| BierutLJ, SacconeNL, RiceJP, GoateA, ForoudT, EdenbergH, AlmasyL, ConneallyPM, CroweR, HesselbrockV, LiTK, NurnbergerJJr., PorjeszB, SchuckitMA, TischfieldJ, BegleiterH, ReichT, 2002 Defining alcohol-related phenotypes in humans. The collaborative study on the genetics of alcoholism. Alcohol Res. Health 26, 208β213.12875049PMC6683836 | β | β | β |
| BlakeDJ, WeirA, NeweySE, DaviesKE, 2002 Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol. Rev 82, 291β329.1191709110.1152/physrev.00028.2001 | β | β | β |
| BlednovYA, BenavidezJM, BlackM, FergusonLB, SchoenhardGL, GoateAM, EdenbergHJ, WetherillL, HesselbrockV, ForoudT, HarrisRA, 2015 Peroxisome proliferator-activated receptors alpha and gamma are linked with alcohol consumption in mice and withdrawal and dependence in humans. Alcohol Clin. Exp. Res 39, 136β145.2551615610.1111/acer.12610PMC4308472 | β | β | β |
| BlednovYA, BergesonSE, WalkerD, FerreiraVM, KuzielWA, HarrisRA, 2005 Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav. Brain Res 165, 110β125.1610569810.1016/j.bbr.2005.06.026PMC3040067 | β | β | β |
| BlednovYA, BlackM, BenavidezJM, StamatakisEE, HarrisRA, 2016 PPAR agonists: II. Fenofibrate and tesaglitazar alter behaviors related to voluntary alcohol consumption. Alcohol Clin. Exp. Res 40, 563β571.2685754110.1111/acer.12972PMC4775356 | β | β | β |
| BlednovYA, StoffelM, ChangSR, HarrisRA, 2001 Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. J. Pharmacol. Exp. Ther 298, 521β530.11454913 | β | β | β |
| BuckKJ, ReillyMT, RogersLM, SzeligaK, GrantK, BrodieMS, 2004 Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination. Alcohol Clin. Exp. Res 28 (2), 211β216.1511292810.1097/01.alc.0000113423.40075.a3 | β | β | β |
| ButterworthRF, 1989 Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. Alcohol Alcohol 24, 271β279.267586010.1093/oxfordjournals.alcalc.a044913 | β | β | β |
| CantorRM, LangeK, SinsheimerJS, 2010 Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am. J. Hum. Genet. 86, 6β22.2007450910.1016/j.ajhg.2009.11.017PMC2801749 | β | β | β |
| CaoLH, YangXL, 2008 Natriuretic peptides and their receptors in the central nervous system. Prog. Neurobiol 84, 234β248.1821545510.1016/j.pneurobio.2007.12.003 | β | β | β |
| ChakravartiA, 1999 Population geneticsβmaking sense out of sequence. Nat. Genet 21, 56β60.991550310.1038/4482 | β | β | β |
| CharbogneP, KiefferBL, BefortK, 2014 15 years of genetic approaches in vivo for addiction research: opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology 76 (Pt B), 204β217.2403591410.1016/j.neuropharm.2013.08.028PMC3858501 | β | β | β |
| ChenAC, ManzN, TangY, RangaswamyM, AlmasyL, KupermanS, NurnbergerJJr., O'ConnorSJ, EdenbergHJ, SchuckitMA, TischfieldJ, ForoudT, BierutLJ, RohrbaughJ, RiceJP, GoateA, HesselbrockV, PorjeszB, 2010 Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcohol Clin. Exp. Res 34, 988β996.2037421610.1111/j.1530-0277.2010.01173.xPMC3248053 | β | β | β |
| ChenG, BuckKJ, 2010 Rostroventral caudate putamen involvement in ethanol withdrawal is influenced by a chromosome 4 locus. Genes Brain Behav 9 (7), 768β776.2060899910.1111/j.1601-183X.2010.00611.xPMC2970669 | β | β | β |
| ChenG, Cuzon CarlsonVC, WangJ, BeckA, HeinzA, RonD, , 2011 Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcohol Clin. Exp. Res 35 (10), 1739β1748.2161542510.1111/j.1530-0277.2011.01520.xPMC3276303 | β | β | β |
| ChenG, ReillyMT, KozellLB, HitzemannR, BuckKJ, 2009 Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice. Alcohol 43 (6), 411β420.1980127110.1016/j.alcohol.2009.05.003PMC2758300 | β | β | β |
| ChenJ, HutchisonKE, CalhounVD, ClausED, TurnerJA, SuiJ, LiuJ, 2015 CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. Hum. Brain Mapp 36, 3007β3019.2593981410.1002/hbm.22824PMC4969622 | β | β | β |
| ChenYC, LuRB, PengGS, WangMF, WangHK, KoHC, ChangYC, LuJJ, LiTK, YinSJ, 1999 Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol Clin. Exp. Res 23, 1853β1860.10630602 | β | β | β |
| ChuK, KoobGF, ColeM, ZorrillaEP, RobertsAJ, 2007 Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacol. Biochem. Behav 86 (4), 813β821.1748224810.1016/j.pbb.2007.03.009PMC2170886 | β | β | β |
| CoffeyDS, 1998 Self-organization, complexity and chaos: the new biology for medicine. Nat. Med 4, 882β885.970123010.1038/nm0898-882 | β | β | β |
| CohenE, FeinnR, AriasA, KranzlerHR, 2007 Alcohol treatment utilization: findings from the national epidemiologic Survey on alcohol and related conditions. Drug Alcohol Depend. 86, 214β221.1691940110.1016/j.drugalcdep.2006.06.008 | β | β | β |
| ComptonWM, DawsonDA, GoldsteinRB, GrantBF, 2013 Crosswalk between DSM-IV dependence and DSM-5 substance use disorders for opioids, cannabis, cocaine and alcohol. Drug Alcohol Depend. 132, 387β390.2364231610.1016/j.drugalcdep.2013.02.036PMC3748225 | β | β | β |
| CottonNS, 1979 The familial incidence of alcoholism: a review. J. Stud. Alcohol 40, 89β116.37694910.15288/jsa.1979.40.89 | β | β | β |
| CoveneyPV, DoughertyER, HighfieldRR, 2016 Big data need big theory too. Philos. Trans. A Math. Phys. Eng. Sci 374.10.1098/rsta.2016.0153PMC505273527698035 | β | β | β |
| CrabbeJC, PhillipsTJ, HarrisRA, ArendsMA, KoobGF, 2006 Alcohol-related genes: contributions from studies with genetically engineered mice. Addict. Biol 11, 195β269.1696175810.1111/j.1369-1600.2006.00038.x | β | β | β |
| CrewsFT, VetrenoRP, 2016 Mechanisms of neuroimmune gene induction in alcoholism. Psychopharmacol. (Berl) 233, 1543β1557.10.1007/s00213-015-3906-1PMC482848425787746 | β | β | β |
| DamsehN, SimoninA, JalasC, PicoraroJA, ShaagA, ChoMT, YaacovB, NeidichJ, Al-AshhabM, JuusolaJ, BaleS, TelegrafiA, RettererK, PappasJG, MoranE, CappellJ, Anyane YeboaK, Abu-LibdehB, HedigerMA, ChungWK, ElpelegO, EdvardsonS, 2015 Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination. J. Med. Genet. 52, 541β547.2604176210.1136/jmedgenet-2015-103104 | β | β | β |
| DavidsonE, CaffarellaJ, VitsevaO, HouYM, KingMP, 2001 Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase. Biol. Chem 382, 399β406.1134788710.1515/BC.2001.049 | β | β | β |
| Dela PenaI, JeonSJ, LeeE, RyuJH, ShinCY, NohM, CheongJH, 2013 Neuronal development genes are key elements mediating the reinforcing effects of methamphetamine, amphetamine, and methylphenidate. Psychopharmacol. (Berl) 230, 399β413.10.1007/s00213-013-3168-823783774 | β | β | β |
| Di Cesare MannelliL, ZanardelliM, MicheliL, GhelardiniC, 2014 PPAR- gamma impairment alters peroxisome functionality in primary astrocyte cell cultures. Biomed. Res. Int 2014, 546453.2472997610.1155/2014/546453PMC3960521 | β | β | β |
| DiasC, FengJ, SunH, ShaoNY, Mazei-RobisonMS, Damez-WernoD, ScobieK, BagotR, LaBonteB, RibeiroE, LiuX, KennedyP, VialouV, FergusonD, PenaC, CalipariES, KooJW, MouzonE, GhoseS, TammingaC, NeveR, ShenL, NestlerEJ, 2014 beta-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature 516, 51β55.2538351810.1038/nature13976PMC4257892 | β | β | β |
| DickinsonD, ElvevagB, 2009 Genes, cognition and brain through a COMT lens. Neuroscience 164, 72β87.1944601210.1016/j.neuroscience.2009.05.014PMC2760675 | β | β | β |
| DopicoAM, BukiyaAN, KuntamallappanavarG, LiuJ, 2016 Modulation of BK channels by ethanol. Int. Rev. Neurobiol 128, 239β279.2723826610.1016/bs.irn.2016.03.019PMC5257281 | β | β | β |
| EdenbergHJ, 2007 The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res. Health 30, 5β13.17718394PMC3860432 | β | β | β |
| EdenbergHJ, ForoudT, 2006 The genetics of alcoholism: identifying specific genes through family studies. Addict. Biol 11, 386β396.1696176610.1111/j.1369-1600.2006.00035.x | β | β | β |
| EdenbergHJ, ForoudT, 2013 Genetics and alcoholism. Nat Rev Gastroenterol Hepatol 10, 487β494.2371231310.1038/nrgastro.2013.86PMC4056340 | β | β | β |
| EdenbergHJ, ForoudT, 2014 Genetics of alcoholism. Handb. Clin. Neurol. 125, 561β571.2530759610.1016/B978-0-444-62619-6.00032-X | β | β | β |
| EdenbergHJ, KollerDL, XueiX, WetherillL, McClintickJN, AlmasyL, BierutLJ, BucholzKK, GoateA, AlievF, DickD, HesselbrockV, HinrichsA, KramerJ, KupermanS, NurnbergerJIJr., RiceJP, SchuckitMA, TaylorR, Todd WebbB, TischfieldJA, PorjeszB, ForoudT, 2010 Genomewide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin. Exp. Res 34, 840β852.2020192410.1111/j.1530-0277.2010.01156.xPMC2884073 | β | β | β |
| EnochMA, 2013 Genetic influences on the development of alcoholism. Curr. Psychiatry Rep 15, 412.2409193610.1007/s11920-013-0412-1PMC4159132 | β | β | β |
| FaisalM, WaseemD, IsmatullahH, TaqiMM, 2014 A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. Comput. Biol. Med 53, 250β257.2517783510.1016/j.compbiomed.2014.07.021 | β | β | β |
| FarrisSP, ArasappanD, Hunicke-SmithS, HarrisRA, MayfieldRD, 2015 Transcriptome organization for chronic alcohol abuse in human brain. Mol. Psychiatry 20, 1438β1447.2545022710.1038/mp.2014.159PMC4452464 | β | β | β |
| FehrC, ShirleyRL, BelknapJK, CrabbeJC, BuckKJ, 2002 Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J. Neurosci 22 (9), 3730β3738.1197884910.1523/JNEUROSCI.22-09-03730.2002PMC6758356 | β | β | β |
| FergusonLB, MostD, BlednovYA, HarrisRA, 2014 PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption. Neuropharmacology 86, 397β407.2503661110.1016/j.neuropharm.2014.06.024PMC4188800 | β | β | β |
| FilbeyFM, ClausED, MorganM, ForesterGR, HutchisonK, 2012 Dopaminergic genes modulate response inhibition in alcohol abusing adults. Addict. Biol 17, 1046β1056.2155449810.1111/j.1369-1600.2011.00328.xPMC11846660 | β | β | β |
| FognaniC, Kilstrup-NielsenC, BerthelsenJ, FerrettiE, ZappavignaV, BlasiF, 2002 Characterization of PREP2, a paralog of PREP1, which defines a novel subfamily of the MEINOX TALE homeodomain transcription factors. Nucleic Acids Res 30, 2043β2051.1197234410.1093/nar/30.9.2043PMC113854 | β | β | β |
| ForoudT, EdenbergHJ, GoateA, RiceJ, FluryL, KollerDL, BierutLJ, ConneallyPM, NurnbergerJI, BucholzKK, LiTK, HesselbrockV, CroweR, SchuckitM, PorjeszB, BegleiterH, ReichT, 2000 Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin. Exp. Res 24, 933β945.10923994 | β | β | β |
| ForoudT, WetherillLF, DickDM, HesselbrockV, NurnbergerJIJr., KramerJ, TischfieldJ, SchuckitM, BierutLJ, XueiX, EdenbergHJ, 2007 Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. Alcohol Clin. Exp. Res. 31, 1773β1779.1785022210.1111/j.1530-0277.2007.00505.x | β | β | β |
| FrankJ, CichonS, TreutleinJ, RidingerM, MattheisenM, HoffmannP, HermsS, WodarzN, SoykaM, ZillP, MaierW, MossnerR, GaebelW, DahmenN, ScherbaumN, SchmalC, SteffensM, LucaeS, IsingM, Muller-MyhsokB, NothenMM, MannK, KieferF, RietschelM, 2012 Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. Addict. Biol 17, 171β180.2200447110.1111/j.1369-1600.2011.00395.xPMC3245349 | β | β | β |
| FrazerKA, BallingerDG, CoxDR, HindsDA, StuveLL, GibbsRA, BelmontJW, BoudreauA, HardenbolP, LealSM, PasternakS, WheelerDA, WillisTD, YuF, YangH, ZengC, GaoY, HuH, HuW, LiC, LinW, LiuS, PanH, TangX, WangJ, WangW, YuJ, ZhangB, ZhangQ, ZhaoH, ZhaoH, ZhouJ, GabrielSB, BarryR, BlumenstielB, CamargoA, DefeliceM, FaggartM, GoyetteM, GuptaS, MooreJ, NguyenH, OnofrioRC, ParkinM, RoyJ, StahlE, WinchesterE, ZiaugraL, AltshulerD, ShenY, YaoZ, HuangW, ChuX, HeY, JinL, LiuY, ShenY, SunW, WangH, WangY, WangY, XiongX, XuL, WayeMM, TsuiSK, XueH, WongJT, GalverLM, FanJB, GundersonK, MurraySS, OliphantAR, CheeMS, MontpetitA, ChagnonF, FerrettiV, LeboeufM, OlivierJF, PhillipsMS, RoumyS, SalleeC, VernerA, HudsonTJ, KwokPY, CaiD, KoboldtDC, MillerRD, PawlikowskaL, Taillon-MillerP, XiaoM, TsuiLC, MakW, SongYQ, TamPK, NakamuraY, KawaguchiT, KitamotoT, MorizonoT, NagashimaA, OhnishiY, SekineA, TanakaT, TsunodaT, DeloukasP, BirdCP, DelgadoM, DermitzakisET, GwilliamR, HuntS, MorrisonJ, PowellD, StrangerBE, WhittakerP, BentleyDR, DalyMJ, de BakkerPI, BarrettJ, ChretienYR, MallerJ, McCarrollS, PattersonN, Pe'erI, PriceA, PurcellS, RichterDJ, SabetiP, SaxenaR, SchaffnerSF, ShamPC, VarillyP, AltshulerD, SteinLD, KrishnanL, SmithAV, Tello-RuizMK, ThorissonGA, ChakravartiA, ChenPE, CutlerDJ, KashukCS, LinS, AbecasisGR, GuanW, LiY, MunroHM, QinZS, ThomasDJ, McVeanG, AutonA, BottoloL, CardinN, EyheramendyS, FreemanC, MarchiniJ, MyersS, SpencerC, StephensM, DonnellyP, CardonLR, ClarkeG, EvansDM, MorrisAP, WeirBS, TsunodaT, MullikinJC, SherryST, FeoloM, SkolA, ZhangH, ZengC, ZhaoH, MatsudaI, FukushimaY, MacerDR, SudaE, RotimiCN, AdebamowoCA, AjayiI, AniagwuT, MarshallPA, NkwodimmahC, RoyalCD, LeppertMF, DixonM, PeifferA, QiuR, KentA, KatoK, NiikawaN, AdewoleIF, KnoppersBM, FosterMW, ClaytonEW, WatkinJ, GibbsRA, BelmontJW, MuznyD, NazarethL, SodergrenE, WeinstockGM, WheelerDA, YakubI, GabrielSB, OnofrioRC, RichterDJ, ZiaugraL, BirrenBW, DalyMJ, AltshulerD, WilsonRK, FultonLL, RogersJ, BurtonJ, CarterNP, CleeCM, GriffithsM, JonesMC, McLayK, PlumbRW, RossMT, SimsSK, WilleyDL, ChenZ, HanH, KangL, GodboutM, WallenburgJC, L'ArchevequeP, BellemareG, SaekiK, WangH, AnD, FuH, LiQ, WangZ, WangR, HoldenAL, BrooksLD, McEwenJE, GuyerMS, WangVO, PetersonJL, ShiM, SpiegelJ, SungLM, ZachariaLF, CollinsFS, KennedyK, JamiesonR, StewartJ, 2007 A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851β861.1794312210.1038/nature06258PMC2689609 | β | β | β |
| GelernterJ, KranzlerHR, ShervaR, AlmasyL, KoestererR, SmithAH, AntonR, PreussUW, RidingerM, RujescuD, WodarzN, ZillP, ZhaoH, FarrerLA, 2014 Genome-wide association study of alcohol dependence: significant findings in African- and European-Americans including novel risk loci. Mol. Psychiatry 19, 41β49.2416640910.1038/mp.2013.145PMC4165335 | β | β | β |
| GhezziA, KrishnanHR, AtkinsonNS, 2014 Susceptibility to ethanol withdrawal seizures is produced by BK channel gene expression. Addict. Biol 19, 332β337.2273458410.1111/j.1369-1600.2012.00465.xPMC4860885 | β | β | β |
| GianoulakisC, DaiX, ThavundayilJ, BrownT, 2005 Levels and circadian rhythmicity of plasma ACTH, cortisol, and beta-endorphin as a function of family history of alcoholism. Psychopharmacol. (Berl) 181, 437β444.10.1007/s00213-005-0129-x16133133 | β | β | β |
| GolanD, LanderES, RossetS, 2014 Measuring missing heritability: inferring the contribution of common variants. Proc. Natl. Acad. Sci. U. S. A. 111, E5272βE5281.2542246310.1073/pnas.1419064111PMC4267399 | β | β | β |
| GoldmanD, OrosziG, DucciF, 2005a The genetics of addictions: uncovering the genes. Nat. Rev. Genet 6, 521β532.1599569610.1038/nrg1635 | β | β | β |
| GoldmanD, OrosziG, O'MalleyS, AntonR, 2005b COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms. J. Stud. Alcohol Suppl 56β64 discussion 33.1622305710.15288/jsas.2005.s15.56 | β | β | β |
| GoodwinDW, 1979 The cause of alcoholism and why it runs in families. Br. J. Addict. Alcohol Other Drugs 74, 161β164.28750810.1111/j.1360-0443.1979.tb02424.x | β | β | β |
| GoodwinDW, 1989 The gene for alcoholism. J. Stud. Alcohol 50, 397β398.277923910.15288/jsa.1989.50.397 | β | β | β |
| GoodwinDW, SchulsingerF, HermansenL, GuzeSB, WinokurG, 1973 Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch. Gen. Psychiatry 28, 238β243.468429010.1001/archpsyc.1973.01750320068011 | β | β | β |
| GoodwinDW, SchulsingerF, KnopJ, MednickS, GuzeSB, 1977 Psychopathology in adopted and nonadopted daughters of alcoholics. Arch. Gen. Psychiatry 34, 1005β1009.90113210.1001/archpsyc.1977.01770210019001 | β | β | β |
| GoodwinDW, SchulsingerF, MollerN, HermansenL, WinokurG, GuzeSB, 1974 Drinking problems in adopted and nonadopted sons of alcoholics. Arch. Gen. Psychiatry 31, 164β169.485143710.1001/archpsyc.1974.01760140022003 | β | β | β |
| GrantBF, GoldsteinRB, SahaTD, ChouSP, JungJ, ZhangH, PickeringRP, RuanWJ, SmithSM, HuangB, HasinDS, 2015 Epidemiology of DSM-5 alcohol use disorder: results from the national epidemiologic Survey on alcohol and related conditions III. JAMA Psychiatry 72, 757β766.2603907010.1001/jamapsychiatry.2015.0584PMC5240584 | β | β | β |
| GrantJD, AgrawalA, BucholzKK, MaddenPA, PergadiaML, NelsonEC, LynskeyMT, ToddRD, TodorovAA, HansellNK, WhitfieldJB, MartinNG, HeathAC, 2009 Alcohol consumption indices of genetic risk for alcohol dependence. Biol. Psychiatry 66, 795β800.1957657410.1016/j.biopsych.2009.05.018PMC3077105 | β | β | β |
| GrepinC, DagninoL, RobitailleL, HaberstrohL, AntaklyT, NemerM, 1994 A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol. Cell Biol 14, 3115β3129.816466710.1128/mcb.14.5.3115PMC358679 | β | β | β |
| GurlingHM, ReveleyMA, MurrayRM, 1984 Increased cerebral ventricular volume in monozygotic twins discordant for alcoholism. Lancet 1, 986β988.614396710.1016/s0140-6736(84)92326-2 | β | β | β |
| HainesJL, HauserMA, SchmidtS, ScottWK, OlsonLM, GallinsP, SpencerKL, KwanSY, NoureddineM, GilbertJR, Schnetz-BoutaudN, AgarwalA, PostelEA, Pericak-VanceMA, 2005 Complement factor H variant increases the risk of age-related macular degeneration. Science 308, 419β421.1576112010.1126/science.1110359 | β | β | β |
| HallerK, RambaldiI, DanielsE, FeatherstoneM, 2004 Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export. J. Biol. Chem 279, 49384β49394.1533992710.1074/jbc.M406046200 | β | β | β |
| HallMA, MooreJH, RitchieMD, 2016 Embracing complex associations in common traits: critical considerations for precision medicine. Trends Genet. 32, 470β484.2739267510.1016/j.tig.2016.06.001 | β | β | β |
| HanssonAC, CippitelliA, SommerWH, FedeliA, BjorkK, SoverchiaL, TerasmaaA, MassiM, HeiligM, CiccocioppoR, 2006 Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proc. Natl. Acad. Sci. U. S. A. 103, 15236β15241.1701582510.1073/pnas.0604419103PMC1622806 | β | β | β |
| HardyPA, ChenW, WilcePA, 1999 Chronic ethanol exposure and withdrawal influence NMDA receptor subunit and splice variant mRNA expression in the rat cerebral cortex. Brain Res. 819, 33β39.1008285810.1016/s0006-8993(98)01340-7 | β | β | β |
| HarperCG, 1988 Brain damage and alcohol abuse: where do we go from here? Br. J. Addict 83, 613β624.290003310.1111/j.1360-0443.1988.tb02586.x | β | β | β |
| HartAB, KranzlerHR, 2015 Alcohol dependence genetics: Lessons learned from Genome-Wide Association Studies (GWAS) and post-GWAS analyses. Alcohol Clin. Exp. Res 39, 1312β1327.2611098110.1111/acer.12792PMC4515198 | β | β | β |
| HawrylyczM, MillerJA, MenonV, FengD, DolbeareT, Guillozet-BongaartsAL, JeggaAG, AronowBJ, LeeCK, BernardA, GlasserMF, DierkerDL, MencheJ, SzaferA, CollmanF, GrangeP, BermanKA, MihalasS, YaoZ, StewartL, BarabasiAL, SchulkinJ, PhillipsJ, NgL, DangC, HaynorDR, JonesA, Van EssenDC, KochC, LeinE, 2015 Canonical genetic signatures of the adult human brain. Nat. Neurosci 18, 1832β1844.2657146010.1038/nn.4171PMC4700510 | β | β | β |
| HeathAC, WhitfieldJB, MartinNG, PergadiaML, GoateAM, LindPA, McEvoyBP, SchrageAJ, GrantJD, ChouYL, ZhuR, HendersAK, MedlandSE, GordonSD, NelsonEC, AgrawalA, NyholtDR, BucholzKK, MaddenPA, MontgomeryGW, 2011 A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. Biol. Psychiatry 70, 513β518.2152978310.1016/j.biopsych.2011.02.028PMC3210694 | β | β | β |
| HermanMA, SidhuH, StoufferDG, KreifeldtM, LeD, Cates-GattoC, , 2015 GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol. Proc. Natl. Acad. Sci. U. S. A. 112 (22), 7091β7096.2596432010.1073/pnas.1416146112PMC4460485 | β | β | β |
| HessCW, RaymondD, Aguiar PdeC, FruchtS, ShribergJ, HeimanGA, KurlanR, KleinC, BressmanSB, OzeliusLJ, Saunders-PullmanR, 2007 Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers. Neurology 68, 522β524.1729691810.1212/01.wnl.0000253188.76092.06 | β | β | β |
| HirschhornJN, 2009 Genomewide association studiesβilluminating biologic pathways. N. Engl. J. Med 360, 1699β1701.1936966110.1056/NEJMp0808934 | β | β | β |
| HonseY, NixonKM, BrowningMD, LeslieSW, 2003 Cell surface expression of NR1 splice variants and NR2 subunits is modified by prenatal ethanol exposure. Neuroscience 122, 689β698.1462291210.1016/s0306-4522(03)00603-1 | β | β | β |
| HrubecZ, OmennGS, 1981 Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin. Exp. Res 5, 207β215.701829910.1111/j.1530-0277.1981.tb04890.x | β | β | β |
| HsuDT, MickeyBJ, LangeneckerSA, HeitzegMM, LoveTM, WangH, KennedySE, PecinaM, ShafirT, HodgkinsonCA, EnochMA, GoldmanD, ZubietaJK, 2012 Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing. J. Neurosci. 32, 3253β3260.2237889610.1523/JNEUROSCI.5533-11.2012PMC3297975 | β | β | β |
| HuangMC, SchwandtML, ChesterJA, KirchhoffAM, KaoCF, LiangT, TapocikJD, RamchandaniVA, GeorgeDT, HodgkinsonCA, GoldmanD, HeiligM, 2014 FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice. Neuropsychopharmacology 39, 2029β2038.2460385510.1038/npp.2014.55PMC4059914 | β | β | β |
| ImotoI, SonodaI, YukiY, InazawaJ, 2001 Identification and characterization of human PKNOX2, a novel homeobox-containing gene. Biochem. Biophys. Res. Commun 287, 270β276.1154928610.1006/bbrc.2001.5578 | β | β | β |
| JoksimovicM, AwatramaniR, 2014 Wnt/beta-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis. J. Mol. Cell Biol 6, 27β33.2428720210.1093/jmcb/mjt043 | β | β | β |
| KalsiG, PrescottCA, KendlerKS, RileyBP, 2009 Unraveling the molecular mechanisms of alcohol dependence. Trends Genet. 25, 49β55.1901056610.1016/j.tig.2008.10.005 | β | β | β |
| KanaiM, TanakaT, OkadaY, 2016 Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set. J. Hum. Genet 61 (10), 861β866.2730598110.1038/jhg.2016.72PMC5090169 | β | β | β |
| KangSJ, RangaswamyM, ManzN, WangJC, WetherillL, HinrichsT, AlmasyL, BrooksA, ChorlianDB, DickD, HesselbrockV, KramerJ, KupermanS, NurnbergerJJr., RiceJ, SchuckitM, TischfieldJ, BierutLJ, EdenbergHJ, GoateA, ForoudT, PorjeszB, 2012 Family-based genomewide association study of frontal theta oscillations identifies potassium channel gene KCNJ6. Genes Brain Behav. 11, 712β719.2255440610.1111/j.1601-183X.2012.00803.xPMC3666338 | β | β | β |
| KarpyakVM, WinhamSJ, PreussUW, ZillP, CunninghamJM, WalkerDL, LewisKA, GeskeJR, ColbyCL, AbulseoudOA, Hall-FlavinDK, LoukianovaLL, SchneeklothTD, FryeMA, BazovI, HeitJA, BakalkinG, MrazekDA, BiernackaJM, 2013 Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. Int. J. Neuropsychopharmacol 16, 975β985.2310146410.1017/S1461145712001137PMC3901318 | β | β | β |
| KendlerKS, 2012 Levels of explanation in psychiatric and substance use disorders: implications for the development of an etiologically based nosology. Mol. Psychiatry 17, 11β21.2167072910.1038/mp.2011.70PMC3215837 | β | β | β |
| KendlerKS, AggenSH, NealeMC, 2013 Evidence for multiple genetic factors underlying DSM-IV criteria for major depression. JAMA Psychiatry 70, 599β607.2374004810.1001/jamapsychiatry.2013.751PMC3800168 | β | β | β |
| KendlerKS, AggenSH, PrescottCA, CrabbeJ, NealeMC, 2012 Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence. Mol. Psychiatry 17, 1306β1315.2210562610.1038/mp.2011.153PMC3371163 | β | β | β |
| KendlerKS, KalsiG, HolmansPA, SandersAR, AggenSH, DickDM, AlievF, ShiJ, LevinsonDF, GejmanPV, 2011 Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcohol Clin. Exp. Res 35, 963β975.2131469410.1111/j.1530-0277.2010.01427.xPMC3083473 | β | β | β |
| KendlerKS, NealeMC, HeathAC, KesslerRC, EavesLJ, 1994 A twin-family study of alcoholism in women. Am. J. Psychiatry 151, 707β715.816631210.1176/ajp.151.5.707 | β | β | β |
| KieferF, WittSH, FrankJ, RichterA, TreutleinJ, LemenagerT, NothenMM, CichonS, BatraA, BernerM, WodarzN, ZimmermannUS, SpanagelR, WiedemannK, SmolkaMN, HeinzA, RietschelM, MannK, 2011 Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. Pharmacogenom. J 11, 368β374.10.1038/tpj.2010.5120585342 | β | β | β |
| KingsmoreSF, LindquistIE, MudgeJ, GesslerDD, BeavisWD, 2008 Genomewide association studies: progress and potential for drug discovery and development. Nat. Rev. Drug Discov 7, 221β230.1827453610.1038/nrd2519PMC2853477 | β | β | β |
| KnappDJ, HarperKM, WhitmanBA, ZimomraZ, BreeseGR, 2016 Stress and withdrawal from chronic ethanol induce selective changes in neuroimmune mRNAs in differing brain sites. Brain Sci. 6.10.3390/brainsci6030025PMC503945427472367 | β | β | β |
| KohtzAS, Aston-JonesG, 2017 Cocaine seeking during initial abstinence is driven by noradrenergic and serotonergic signaling in Hippocampus in a sex-dependent manner. Neuropsychopharmacology 42 (2), 408β418.2751579210.1038/npp.2016.150PMC5399231 | β | β | β |
| KoobGF, VolkowND, 2010 Neurocircuitry of addiction. Neuro psychopharmacology 35, 217β238.10.1038/npp.2009.110PMC280556019710631 | β | β | β |
| KoobGF, VolkowND, 2016 Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry 3, 760β773.2747576910.1016/S2215-0366(16)00104-8PMC6135092 | β | β | β |
| KozellLB, WalterNA, MilnerLC, WickmanK, BuckKJ, 2009 Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. J. Neurosci 29, 11662β11673.1975931310.1523/JNEUROSCI.1413-09.2009PMC2813520 | β | β | β |
| KranzlerHR, EdenbergHJ, 2010 Pharmacogenetics of alcohol and alcohol dependence treatment. Curr. Pharm. Des 16, 2141β2148.2048250910.2174/138161210791516387PMC4142701 | β | β | β |
| KreifeldtM, Cates-GattoC, RobertsAJ, ContetC, 2015 BK Channel beta1 Subunit Contributes to Behavioral Adaptations Elicited by Chronic Intermittent Ethanol Exposure. Alcohol Clin. Exp. Res 39 (12), 2394β2402.2657834510.1111/acer.12911PMC4712106 | β | β | β |
| KreifeldtM, LeD, TreistmanSN, KoobGF, ContetC, 2013 BK channel beta1 and beta4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice. Front. Integr. Neurosci 7, 105.2441600510.3389/fnint.2013.00105PMC3874544 | β | β | β |
| KrishnanHR, SakharkarAJ, TeppenTL, BerkelTD, PandeySC, 2014 The epigenetic landscape of alcoholism. Int. Rev. Neurobiol 115, 75β116.2513154310.1016/B978-0-12-801311-3.00003-2PMC4337828 | β | β | β |
| KumariM, 2001 Differential effects of chronic ethanol treatment on N-methyl-D-aspartate R1 splice variants in fetal cortical neurons. J. Biol. Chem 276, 29764β29771.1138731810.1074/jbc.M100317200 | β | β | β |
| KumarJ, HapidinH, BeeYT, IsmailZ, 2013 Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats. Behav. Brain Funct 9, 43.2427987010.1186/1744-9081-9-43PMC4222772 | β | β | β |
| KupilaJ, KarkkainenO, LaukkanenV, TupalaE, TiihonenJ, StorvikM, 2013 mGluR1/5 receptor densities in the brains of alcoholic subjects: a whole-hemisphere autoradiography study. Psychiatry Res 212, 245β250.2314904310.1016/j.pscychresns.2012.04.003 | β | β | β |
| KwakoLE, MomenanR, LittenRZ, KoobGF, GoldmanD, 2016 Addictions neuroclinical assessment: a neuroscience-based framework for addictive disorders. Biol. Psychiatry 80, 179β189.2677240510.1016/j.biopsych.2015.10.024PMC4870153 | β | β | β |
| LanderES, 1996 The new genomics: global views of biology. Science 274, 536β539.892800810.1126/science.274.5287.536 | β | β | β |
| LeeC, MayfieldRD, HarrisRA, 2014 Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics. Biol. Psychiatry 75 (10), 765β773.2420977810.1016/j.biopsych.2013.08.028PMC3999301 | β | β | β |
| LeeS, SmithGW, ValeW, LeeKF, RivierC, 2001 Mice that lack corticotropin-releasing factor (CRF) receptors type 1 show a blunted ACTH response to acute alcohol despite up-regulated constitutive hypothalamic CRF gene expression. Alcohol Clin. Exp. Res 25, 427β433.11290855 | β | β | β |
| LewohlJM, WilsonWR, MayfieldRD, BrozowskiSJ, MorrisettRA, HarrisRA, 1999 G- protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat. Neurosci 2, 1084β1090.1057048510.1038/16012 | β | β | β |
| LittenRZ, RyanML, FalkDE, ReillyM, FertigJB, KoobGF, 2015 Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment. Alcohol Clin. Exp. Res 39, 579β584.2583301610.1111/acer.12669 | β | β | β |
| LovalloWR, EnochMA, AchesonA, CohoonAJ, SoroccoKH, HodgkinsonCA, VincentAS, GlahnDC, GoldmanD, 2015 Cortisol stress response in men and women modulated differentially by the Mu-opioid receptor gene polymorphism OPRM1 A118G. Neuropsychopharmacology 40, 2546β2554.2588111810.1038/npp.2015.101PMC4569944 | β | β | β |
| MamdaniM, WilliamsonV, McMichaelGO, BlevinsT, AlievF, AdkinsA, HackL, BigdeliT, van der VaartAD, WebBT, BacanuSA, KalsiG, KendlerKS, MilesMF, DickD, RileyBP, DumurC, VladimirovVI, 2015 Integrating mRNA and miRNA weighted gene Co-Expression networks with eQTLs in the nucleus accumbens of subjects with alcohol dependence. PLoS One 10, e0137671.2638126310.1371/journal.pone.0137671PMC4575063 | β | β | β |
| ManolioTA, CollinsFS, CoxNJ, GoldsteinDB, HindorffLA, HunterDJ, McCarthyMI, RamosEM, CardonLR, ChakravartiA, ChoJH, GuttmacherAE, KongA, KruglyakL, MardisE, RotimiCN, SlatkinM, ValleD, WhittemoreAS, BoehnkeM, ClarkAG, EichlerEE, GibsonG, HainesJL, MackayTF, McCarrollSA, VisscherPM, 2009 Finding the missing heritability of complex diseases. Nature 461, 747β753.1981266610.1038/nature08494PMC2831613 | β | β | β |
| MarballiK, GenabaiNK, BlednovYA, HarrisRA, PonomarevI, 2016 Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons. Genes Brain Behav 15, 318β326.2648279810.1111/gbb.12266PMC4785873 | β | β | β |
| MartinPR, PekovichSR, McCoolBA, WhetsellWO, SingletonCK, 1994 Thiamine utilization in the pathogenesis of alcohol-induced brain damage. Alcohol Alcohol Suppl 2, 273β279.8974347 | β | β | β |
| MassieA, BoilleeS, HewettS, KnackstedtL, LewerenzJ, 2015 Main path and byways: non- vesicular glutamate release by system xc(β) as an important modifier of glutamatergic neurotransmission. J. Neurochem 135, 1062β1079.2633693410.1111/jnc.13348PMC4762049 | β | β | β |
| MathiesLD, BlackwellGG, AustinMK, EdwardsAC, RileyBP, DaviesAG, BettingerJC, 2015 SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. Proc. Natl. Acad. Sci. U. S. A. 112, 3032β3037.2571335710.1073/pnas.1413451112PMC4364201 | β | β | β |
| McGueM, 1999 Phenotyping alcoholism. Alcohol Clin. Exp. Res 23, 757β758.1037139210.1111/j.1530-0277.1999.tb04180.x | β | β | β |
| Medrano-FernandezA, BarcoA, 2016 Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders. Mol. Brain 9, 83.2759584310.1186/s13041-016-0263-xPMC5011999 | β | β | β |
| MilnerLC, ShirleyRL, KozellLB, WalterNA, KruseLC, KomiyamaNH, , 2015 Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption. Addict. Biol 20 (1), 143β147.2411840510.1111/adb.12087PMC3997615 | β | β | β |
| MoonatS, SakharkarAJ, ZhangH, PandeySC, 2011 The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism. Addict. Biol 16, 238β250.2118257410.1111/j.1369-1600.2010.00275.xPMC3072812 | β | β | β |
| MorozovaTV, GoldmanD, MackayTF, AnholtRR, 2012 The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. Genome Biol 13, 239.2234870510.1186/gb-2012-13-2-239PMC3334563 | β | β | β |
| Mottagui-TabarS, PrinceJA, WahlestedtC, ZhuG, GoldmanD, HeiligM, 2005 A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. Alcohol Clin. Exp. Res 29, 702β707.1589771310.1097/01.alc.0000164365.04961.b1 | β | β | β |
| MulhollandPJ, ChandlerLJ, 2007 The thorny side of addiction: adaptive plasticity and dendritic spines. ScientificWorldJournal 7, 9β21.10.1100/tsw.2007.247PMC590113617982573 | β | β | β |
| MulliganMK, PonomarevI, HitzemannRJ, BelknapJK, TabakoffB, HarrisRA, CrabbeJC, BlednovYA, GrahameNJ, PhillipsTJ, FinnDA, HoffmanPL, IyerVR, KoobGF, BergesonSE, 2006 Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc. Natl. Acad. Sci. U. S. A. 103, 6368β6373.1661893910.1073/pnas.0510188103PMC1458884 | β | β | β |
| MunozM, Pong-WongR, Canela-XandriO, RawlikK, HaleyCS, TenesaA, 2016 Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank. Nat. Genet 48, 980β983.2742875210.1038/ng.3618PMC5989924 | β | β | β |
| MurrayRM, CliffordC, GurlingHM, TophamA, ClowA, BernadtM, 1983 Current genetic and biological approaches to alcoholism. Psychiatr. Dev 1, 179β192.6675010 | β | β | β |
| N'GouemoP, MoradM, 2014 Alcohol withdrawal is associated with a down-regulation of large- conductance Ca(2)(+)-activated K(+) channels in rat inferior colliculus neurons. Psychopharmacol. (Berl) 231, 2009β2018.10.1007/s00213-013-3346-8PMC398824624241791 | β | β | β |
| OjeladeSA, JiaT, RodanAR, ChenyangT, KadrmasJL, CattrellA, RuggeriB, CharoenP, LemaitreH, BanaschewskiT, BuchelC, BokdeAL, CarvalhoF, ConrodPJ, FlorH, FrouinV, GallinatJ, GaravanH, GowlandPA, HeinzA, IttermannB, LathropM, LubbeS, MartinotJL, PausT, SmolkaMN, SpanagelR, O'ReillyPF, LaitinenJ, VeijolaJM, FengJ, DesrivieresS, JarvelinMR, SchumannG, RothenfluhA, 2015 Rsu1 regulates ethanol consumption in Drosophila and humans. Proc. Natl. Acad. Sci. U. S. A. 112, E4085βE4093.2617029610.1073/pnas.1417222112PMC4522778 | β | β | β |
| PandeySC, UgaleR, ZhangH, TangL, PrakashA, 2008 Brain chromatin remodeling: a novel mechanism of alcoholism. J. Neurosci 28, 3729β3737.1838533110.1523/JNEUROSCI.5731-07.2008PMC6671100 | β | β | β |
| ParkBL, KimJW, CheongHS, KimLH, LeeBC, SeoCH, KangTC, NamYW, KimGB, ShinHD, ChoiIG, 2013 Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. Hum. Genet 132, 657β668.2345609210.1007/s00439-013-1281-8 | β | β | β |
| ParkitnaJR, SikoraM, GoldaS, GolembiowskaK, BystrowskaB, EngblomD, BilbaoA, PrzewlockiR, 2013 Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors. Biol. Psychiatry 73, 263β270.2290216910.1016/j.biopsych.2012.07.019 | β | β | β |
| ParkYJ, LugerK, 2006a Structure and function of nucleosome assembly proteins. Biochem. Cell Biol 84, 549β558.1693682710.1139/o06-088 | β | β | β |
| ParkYJ, LugerK, 2006b The structure of nucleosome assembly protein 1. Proc. Natl. Acad. Sci. U. S. A. 103, 1248β1253.1643221710.1073/pnas.0508002103PMC1345705 | β | β | β |
| PartanenJ, 1972 On the relevance of twin studies. Ann. N. Y. Acad. Sci 197, 114β116.450458410.1111/j.1749-6632.1972.tb28129.x | β | β | β |
| PeallKJ, SmithDJ, KurianMA, WardleM, WaiteAJ, HedderlyT, LinJP, SmithM, WhoneA, PallH, WhiteC, LuxA, JardineP, BajajN, LynchB, KirovG, O'RiordanS, SamuelM, LynchT, KingMD, ChinneryPF, WarnerTT, BlakeDJ, OwenMJ, MorrisHR, 2013 SGCE mutations cause psychiatric disorders: clinical and genetic characterization. Brain 136, 294β303.2336510310.1093/brain/aws308PMC4052887 | β | β | β |
| PeallKJ, WaiteAJ, BlakeDJ, OwenMJ, MorrisHR, 2011 Psychiatric disorders, myoclonus dystonia, and the epsilon-sarcoglycan gene: a systematic review. Mov. Disord 26, 1939β1942.2171399910.1002/mds.23791 | β | β | β |
| PietrzykowskiAZ, FriesenRM, MartinGE, PuigSI, NowakCL, WynnePM, SiegelmannHT, TreistmanSN, 2008 Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron 59, 274β287.1866715510.1016/j.neuron.2008.05.032PMC2714263 | β | β | β |
| PonomarevI, WangS, ZhangL, HarrisRA, MayfieldRD, 2012 Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J. Neurosci 32, 1884β1897.2230282710.1523/JNEUROSCI.3136-11.2012PMC3564514 | β | β | β |
| PrescottCA, KendlerKS, 1999 Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am. J. Psychiatry 156, 34β40.989229510.1176/ajp.156.1.34 | β | β | β |
| PreussUW, WinhamSJ, BiernackaJM, GeskeJR, BakalkinG, KollerG, ZillP, SoykaM, KarpyakVM, 2013 PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort. PLoS One 8, e78688.2422316310.1371/journal.pone.0078688PMC3819371 | β | β | β |
| PritchardJK, CoxNJ, 2002 The allelic architecture of human disease genes: common disease- common variantβ¦or not? Hum. Mol. Genet 11, 2417β2423.1235157710.1093/hmg/11.20.2417 | β | β | β |
| RamosC, MartinezA, RobertB, SorianoE, 2004 Msx1 expression in the adult mouse brain: characterization of populations of beta-galactosidase-positive cells in the hippocampus and fimbria. Neuroscience 127, 893β900.1531290110.1016/j.neuroscience.2004.06.010 | β | β | β |
| RayLA, BarrCS, BlendyJA, OslinD, GoldmanD, AntonRF, 2012 The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin. Exp. Res 36, 385β394.2189572310.1111/j.1530-0277.2011.01633.xPMC3249007 | β | β | β |
| RayLA, SehlM, BujarskiS, HutchisonK, BlaineS, EnochMA, 2013 The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G Γ E effects. Genes Brain Behav 12, 361β369.2347336410.1111/gbb.12032PMC4139150 | β | β | β |
| ReichDE, LanderES, 2001 On the allelic spectrum of human disease. Trends Genet 17, 502β510.1152583310.1016/s0168-9525(01)02410-6 | β | β | β |
| ReichT, EdenbergHJ, GoateA, WilliamsJT, RiceJP, Van EerdeweghP, ForoudT, HesselbrockV, SchuckitMA, BucholzK, PorjeszB, LiTK, ConneallyPM, NurnbergerJIJr., TischfieldJA, CroweRR, CloningerCR, WuW, ShearsS, CarrK, CroseC, WilligC, BegleiterH, 1998 Genome-wide search for genes affecting the risk for alcohol dependence. Am. J. Med. Genet 81, 207β215.9603606 | β | β | β |
| ReillyMT, MilnerLC, ShirleyRL, CrabbeJC, BuckKJ, 2008 5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice. Brain Res 1198, 124β131.1826250610.1016/j.brainres.2008.01.024PMC2322873 | β | β | β |
| Repunte-CanonigoV, ShinW, VendruscoloLF, LefebvreC, van der StapL, KawamuraT, SchlosburgJE, AlvarezM, KoobGF, CalifanoA, SannaPP, 2015 Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks. Genome Biol 16, 68.2588685210.1186/s13059-015-0593-5PMC4410476 | β | β | β |
| Repunte-CanonigoV, van der StapLD, ChenJ, SabinoV, WagnerU, ZorrillaEP, SchumannG, RobertsAJ, SannaPP, 2010 Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake. Brain Res 1339, 1β10.2038850110.1016/j.brainres.2010.03.063PMC2925131 | β | β | β |
| RichiardiJ, AltmannA, MilazzoAC, ChangC, ChakravartyMM, BanaschewskiT, BarkerGJ, BokdeAL, BrombergU, BuchelC, ConrodP, Fauth-BuhlerM, FlorH, FrouinV, GallinatJ, GaravanH, GowlandP, HeinzA, LemaitreH, MannKF, MartinotJL, NeesF, PausT, PausovaZ, RietschelM, RobbinsTW, SmolkaMN, SpanagelR, StrohleA, SchumannG, HawrylyczM, PolineJB, GreiciusMD, 2015 BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. Science 348, 1241β1244.2606884910.1126/science.1255905PMC4829082 | β | β | β |
| RietschelM, TreutleinJ, 2013 The genetics of alcohol dependence. Ann. N. Y. Acad. Sci 1282, 39β70.2317093410.1111/j.1749-6632.2012.06794.x | β | β | β |
| RobisonAJ, NestlerEJ, 2011 Transcriptional and epigenetic mechanisms of addiction. Nat. Rev. Neurosci 12, 623β637.2198919410.1038/nrn3111PMC3272277 | β | β | β |
| RodriguezP, MunroeD, PrawittD, ChuLL, BricE, KimJ, ReidLH, DaviesC, NakagamaH, LoebbertR, WinterpachtA, PetruzziMJ, HigginsMJ, NowakN, EvansG, ShowsT, WeissmanBE, ZabelB, HousmanDE, PelletierJ, 1997 Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. Genomics 44, 253β265.932504610.1006/geno.1997.4868 | β | β | β |
| RuzickaWB, SubburajuS, BenesFM, 2015 Circuit- and diagnosis-specific DNA methylation changes at gamma-aminobutyric acid-related genes in postmortem human Hippocampus in schizophrenia and bipolar disorder. JAMA Psychiatry 72, 541β551.2573842410.1001/jamapsychiatry.2015.49PMC5547581 | β | β | β |
| SabinoV, CottoneP, ZhaoY, IyerMR, SteardoLJr., SteardoL, RiceKC, ContiB, KoobGF, ZorrillaEP, 2009a The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology 34, 1482β1493.1894646710.1038/npp.2008.192PMC2669694 | β | β | β |
| SabinoV, CottoneP, ZhaoY, SteardoL, KoobGF, ZorrillaEP, 2009b Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology 205, 327β335.1944069910.1007/s00213-009-1548-xPMC2748837 | β | β | β |
| SanseauP, AgarwalP, BarnesMR, PastinenT, RichardsJB, CardonLR, MooserV, 2012 Use of genome-wide association studies for drug repositioning. Nat. Biotechnol 30, 317β320.2249127710.1038/nbt.2151 | β | β | β |
| SasabeT, IshiuraS, 2010 Alcoholism and alternative splicing of candidate genes. Int. J. Environ. Res. Public Health 7, 1448β1466.2061703910.3390/ijerph7041448PMC2872348 | β | β | β |
| SavitzJ, HodgkinsonCA, Martin-SoelchC, ShenPH, SzczepanikJ, NugentA, HerscovitchP, GraceAA, GoldmanD, DrevetsWC, 2013 The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. PLoS One 8, e54108.2336564910.1371/journal.pone.0054108PMC3554713 | β | β | β |
| SchuckitMA, GoodwinDA, WinokurG, 1972 A study of alcoholism in half siblings. Am. J. Psychiatry 128, 1132β1136.506083410.1176/ajp.128.9.1132 | β | β | β |
| ShirleyRL, WalterNA, ReillyMT, FehrC, BuckKJ, 2004 Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat. Neurosci 7 (7), 699β700.1520863110.1038/nn1271 | β | β | β |
| SinclairCM, ClevaRM, HoodLE, OliveMF, GassJT, 2012 mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. Pharmacol. Biochem. Behav 101, 329β335.2229681510.1016/j.pbb.2012.01.014PMC3310253 | β | β | β |
| SingletonCK, MartinPR, 2001 Molecular mechanisms of thiamine utilization. Curr. Mol. Med 1,197β207.1189907110.2174/1566524013363870 | β | β | β |
| SmithQR, 2000 Transport of glutamate and other amino acids at the blood-brain barrier. J. Nutr 130, 1016sβ1022s.1073637310.1093/jn/130.4.1016S | β | β | β |
| SnellK, 1984 Enzymes of serine metabolism in normal, developing and neoplastic rat tissues. Adv. Enzyme Regul 22, 325β400.608951410.1016/0065-2571(84)90021-9 | β | β | β |
| SpanagelR, DurstewitzD, HanssonA, HeinzA, KieferF, KohrG, MatthausF, NothenMM, NooriHR, ObermayerK, RietschelM, SchlossP, ScholzH, SchumannG, SmolkaM, SommerW, VengelieneV, WalterH, WurstW, ZimmermannUS, StringerS, SmitsY, DerksEM, 2013 A systems medicine research approach for studying alcohol addiction. Addict. Biol 18, 883β896.2428397810.1111/adb.12109 | β | β | β |
| StopponiS, de GuglielmoG, SomainiL, CippitelliA, CannellaN, KallupiM, UbaldiM, HeiligM, DemopulosG, GaitanarisG, CiccocioppoR, 2013 Activation of PPARgamma by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcohol Clin. Exp. Res 37, 1351β1360.2355062510.1111/acer.12091 | β | β | β |
| StopponiS, SomainiL, CippitelliA, CannellaN, BraconiS, KallupiM, RuggeriB, HeiligM, DemopulosG, GaitanarisG, MassiM, CiccocioppoR, 2011 Activation of nuclear PPARgamma receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. Biol. Psychiatry 69, 642β649.2127696410.1016/j.biopsych.2010.12.010 | β | β | β |
| SutherlandGT, SheedyD, KrilJJ, 2014 Neuropathology of alcoholism. Handb. Clin. Neurol 125, 603β615.2530759910.1016/B978-0-444-62619-6.00035-5 | β | β | β |
| TawaEA, HallSD, LohoffFW, 2016 Overview of the genetics of alcohol use disorder. Alcohol Alcohol 51, 507β514.2744536310.1093/alcalc/agw046PMC5004749 | β | β | β |
| ThomassonHR, EdenbergHJ, CrabbDW, MaiXL, JeromeRE, LiTK, WangSP, LinYT, LuRB, YinSJ, 1991 Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am. J. Hum. Genet 48, 677β681.2014795PMC1682953 | β | β | β |
| ThorleifssonG, MagnussonKP, SulemP, WaltersGB, GudbjartssonDF, StefanssonH, JonssonT, JonasdottirA, JonasdottirA, StefansdottirG, MassonG, HardarsonGA, PeturssonH, ArnarssonA, MotallebipourM, WallermanO, WadeliusC, GulcherJR, ThorsteinsdottirU, KongA, JonassonF, StefanssonK, 2007 Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science 317, 1397β1400.1769025910.1126/science.1146554 | β | β | β |
| TiihonenJ, HallikainenT, LachmanH, SaitoT, VolavkaJ, KauhanenJ, SalonenJT, RyynanenOP, KouluM, KarvonenMK, PohjalainenT, SyvalahtiE, HietalaJ, 1999 Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Mol. Psychiatry 4, 286β289.1039522210.1038/sj.mp.4000509 | β | β | β |
| TikkanenR, TiihonenJ, RautiainenMR, PaunioT, BevilacquaL, PanarskyR, GoldmanD, VirkkunenM, 2015 Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon. Transl. Psychiatry 5, e681.2657522210.1038/tp.2015.170PMC5068763 | β | β | β |
| TippsME, BuckKJ, 2015 GIRK channels: a potential link between learning and addiction. Int. Rev. Neurobiol 123, 239β277.2642298710.1016/bs.irn.2015.05.012 | β | β | β |
| TreutleinJ, CichonS, RidingerM, WodarzN, SoykaM, ZillP, MaierW, MoessnerR, GaebelW, DahmenN, FehrC, ScherbaumN, SteffensM, LudwigKU, FrankJ, WichmannHE, SchreiberS, DraganoN, SommerWH, Leonardi-EssmannF, LourdusamyA, Gebicke-HaerterP, WienkerTF, SullivanPF, NothenMM, KieferF, SpanagelR, MannK, RietschelM, 2009 Genome-wide association study of alcohol dependence. Arch. Gen. Psychiatry 66, 773β784.1958156910.1001/archgenpsychiatry.2009.83PMC4229246 | β | β | β |
| TreutleinJ, KisslingC, FrankJ, WiemannS, DongL, DepnerM, SaamC, LascorzJ, SoykaM, PreussUW, RujescuD, SkowronekMH, RietschelM, SpanagelR, HeinzA, LauchtM, MannK, SchumannG, 2006 Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol. Psychiatry 11, 594β602.1655021310.1038/sj.mp.4001813 | β | β | β |
| TsaiSY, ChuangJY, TsaiMS, WangXF, XiZX, HungJJ, ChangWC, BonciA, SuTP, 2015 Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin- remodeling factors at the nuclear envelope. Proc. Natl. Acad. Sci. U. S. A. 112, E6562βE6570.2655401410.1073/pnas.1518894112PMC4664336 | β | β | β |
| VargaT, CzimmererZ, NagyL, 2011 PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim. Biophys. Acta 1812, 1007β1022.2138248910.1016/j.bbadis.2011.02.014PMC3117990 | β | β | β |
| VedderLC, HallJM, JabrouinKR, SavageLM, 2015 Interactions between chronic ethanol consumption and thiamine deficiency on neural plasticity, spatial memory, and cognitive flexibility. Alcohol Clin. Exp. Res 39, 2143β2153.2641980710.1111/acer.12859PMC4624484 | β | β | β |
| Vogel-CierniaA, WoodMA, 2014 Neuron-specific chromatin remodeling: a missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders. Neuropharmacology 80, 18β27.2414058010.1016/j.neuropharm.2013.10.002PMC3984593 | β | β | β |
| VoiseyJ, SwagellCD, HughesIP, LawfordBR, YoungRM, MorrisCP, 2011 A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study. Behav. Brain Funct 7, 51.2220866110.1186/1744-9081-7-51PMC3268714 | β | β | β |
| WaiteA, TinsleyCL, LockeM, BlakeDJ, 2009 The neurobiology of the dystrophin-associated glycoprotein complex. Ann. Med 41, 344β359.1917242710.1080/07853890802668522 | β | β | β |
| WernickeC, HellmannJ, FinckhU, RommelspacherH, 2010 Chronic ethanol exposure changes dopamine D2 receptor splicing during retinoic acid-induced differentiation of human SH-SY5Y cells. Pharmacol. Rep 62, 649β663.2088500510.1016/s1734-1140(10)70322-4 | β | β | β |
| WhitfieldJB, ZhuG, MaddenPA, NealeMC, HeathAC, MartinNG, 2004 The genetics of alcohol intake and of alcohol dependence. Alcohol Clin. Exp. Res 28, 1153β1160.1531811310.1097/01.alc.0000134221.32773.69 | β | β | β |
| WolenAR, MilesMF, 2012 Identifying gene networks underlying the neurobiology of ethanol and alcoholism. Alcohol Res 34, 306β317.2313404610.35946/arcr.v34.3.05PMC3860407 | β | β | β |
| WronaMZ, WaskiewiczJ, HanQP, HanJ, LiH, DryhurstG, 1997 Putative oxidative metabolites of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline of potential relevance to the addictive and neurodegenerative consequences of ethanol abuse. Alcohol 14, 213β223.916079810.1016/s0741-8329(96)00144-9 | β | β | β |
| WrzosekM, LukaszkiewiczJ, WrzosekM, SerafinP, JakubczykA, KlimkiewiczA, MatsumotoH, BrowerKJ, WojnarM, 2011 Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. Psychiatry Res. 190, 149β151.2162127310.1016/j.psychres.2011.04.027PMC3169703 | β | β | β |
| XueiX, DickD, Flury-WetherillL, TianHJ, AgrawalA, BierutL, GoateA, BucholzK, SchuckitM, NurnbergerJJr., TischfieldJ, KupermanS, PorjeszB, BegleiterH, ForoudT, EdenbergHJ, 2006 Association of the kappa-opioid system with alcohol dependence. Mol. Psychiatry 11, 1016β1024.1692426910.1038/sj.mp.4001882 | β | β | β |
| XuK, SeoD, HodgkinsonC, HuY, GoldmanD, SinhaR, 2013 A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk. Transl. Psychiatry 3, e292.2396292210.1038/tp.2013.62PMC3756290 | β | β | β |
| YamasakiM, YamadaK, FuruyaS, MitomaJ, HirabayashiY, WatanabeM, 2001 3- Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain. J. Neurosci 21, 7691β7704.1156705910.1523/JNEUROSCI.21-19-07691.2001PMC6762884 | β | β | β |
| YouIJ, WrightSR, Garcia-GarciaAL, TapperAR, GardnerPD, KoobGF, David LeonardoE, BohnLM, WeeS, 2016 5-HT1A autoreceptors in the dorsal raphe nucleus convey vulnerability to compulsive cocaine seeking. Neuropsychopharmacology 41, 1210β1222.2632440810.1038/npp.2015.268PMC4793105 | β | β | β |
| ZhouZ, EnochMA, GoldmanD, 2014 Gene expression in the addicted brain. Int. Rev. Neurobiol 116, 251β273.2517247810.1016/B978-0-12-801105-8.00010-2PMC4427035 | β | β | β |
| ZhouZ, ZhuG, HaririAR, EnochMA, ScottD, SinhaR, , 2008 Genetic variation in human NPY expression affects stress response and emotion. Nature 452 (7190), 997β1001.1838567310.1038/nature06858PMC2715959 | β | β | β |
| ZoisE, Vollstadt-KleinS, HoffmannS, ReinhardI, BachP, CharletK, BeckA, TreutleinJ, FrankJ, JordeA, KirschM, DegenhardtF, WalterH, HeinzA, KieferF, 2016 GATA4 variant interaction with brain limbic structure and relapse risk: a voxel-based morphometry study. Eur. Neuropsychopharmacol 26, 1431β1437.2739786510.1016/j.euroneuro.2016.06.011 | β | β | β |
| ZukO, HechterE, SunyaevSR, LanderES, 2012 The mystery of missing heritability: genetic interactions create phantom heritability. Proc. Natl. Acad. Sci. U. S. A. 109, 1193β1198.2222366210.1073/pnas.1119675109PMC3268279 | β | β | β |
| ZukO, SchaffnerSF, SamochaK, DoR, HechterE, KathiresanS, DalyMJ, NealeBM, SunyaevSR, LanderES, 2014 Searching for missing heritability: designing rare variant association studies. Proc. Natl. Acad. Sci. U. S. A. 111, E455βE464.2444355010.1073/pnas.1322563111PMC3910587 | β | β | β |
| ZuoL, GelernterJ, ZhangCK, ZhaoH, LuL, KranzlerHR, MalisonRT, LiCS, WangF, ZhangXY, DengHW, KrystalJH, ZhangF, LuoX, 2012 Genomewide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. Neuropsychopharmacology 37, 557β566.2195643910.1038/npp.2011.229PMC3242317 | β | β | β |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder. | Lee CY et al. | β | 2026 | β |
| Emerging role of N6-methyladenosine (m6A) epitranscriptomic changes in adult anxiety after adolescent alcohol exposure. | Malovic E et al. | β | 2026 | β |
| Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations. | Sahu P et al. | β | 2025 | β |
| Alcohol use in adolescents. | Rubia A et al. | β | 2025 | β |
| Application of Mendelian randomization to explore the genetic association between drinking habits of different beverages and sleep disorder. | Zhang C et al. | β | 2025 | β |
| DRD1 gene is associated with craving changes during withdrawal among patients with alcohol use disorder. | Lin ZY et al. | β | 2025 | β |
| Early signs of cardiovascular abnormalities in patients with alcohol misuse. | Farinelli LA et al. | β | 2025 | β |
| Epigenetic regulation of <i>SYNGAP1</i> in alcohol use disorder in whole blood and saliva. | Edelmann S et al. | β | 2025 | β |
| Genome Variation in Alcohol Use Disorder by Whole-Exome Sequencing. | Liu L et al. | β | 2025 | β |
| High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study. | Schuckit MA et al. | β | 2025 | β |
| Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. | Green NC et al. | β | 2025 | β |
| Investigating the Impact of Long-Term Alcohol Consumption on Serum Chemical Changes: Fourier Transform Infrared Spectroscopy for Human Blood Serum. | Guleken Z et al. | β | 2025 | β |
| Research progress of DNA methylation on the regulation of substance use disorders and the mechanisms. | Liu Y et al. | β | 2025 | β |
| Selectively counteracting cerebellar adaptations to chronic alcohol exposure reduces acute alcohol withdrawal severity in C57BL6/N mice. | McLean NA et al. | β | 2025 | β |
| Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse. | Hakus A et al. | β | 2025 | β |
| Under the Influence: The Epidemic of Excessive Alcohol Use and Its Impact on Heart and Liver Health. | Dhand A et al. | β | 2025 | β |
| DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction? | Ferraguti G et al. | β | 2024 | β |
| Introduction: Approved treatments for alcohol use disorder by regulatory agencies. | Camarini R et al. | β | 2024 | β |
| Addictions, Social Deprivation and Cessation Failure in Head and Neck Squamous Cell Carcinoma Survivors. | Nokovitch L et al. | β | 2023 | β |
| Analysis of the brain transcriptome for substance-associated genes: An update on large-scale genome-wide association studies. | Zhao Y et al. | β | 2023 | β |
| Animal model for high consumption and preference of ethanol and its interplay with high sugar and butter diet, behavior, and neuroimmune system. | Moreira-JΓΊnior RE et al. | β | 2023 | β |
| Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking. | Mulholland PJ et al. | β | 2023 | β |
| DNA Methylation in Alcohol Use Disorder. | Zheng Q et al. | β | 2023 | β |
| Do personality characteristics predict future alcohol problems after considering current demography, substance use, and alcohol response? | Schuckit MA et al. | β | 2023 | β |
| Features of Addiction in Binge-Eating Disorder: Considerations for Screening and Treatment. | Paul A et al. | β | 2023 | β |
| Genetic and Environmental Factors Underlying Parallel Changes in Body Mass Index and Alcohol Consumption: A 36-Year Longitudinal Study of Adult Twins. | Drouard G et al. | β | 2023 | β |
| Identification of Genetic and Genomic Influences on Progressive Ethanol Consumption in Diversity Outbred Mice | Smith M et al. | β | 2023 | β |
| Multi-animal-model study reveals mutations in neural plasticity and nociception genes linked to excessive alcohol drinking. | Muir WM et al. | β | 2023 | β |
| Triple Diagnosis of Attention-Deficit/Hyperactivity Disorder with Coexisting Bipolar and Alcohol Use Disorders: Clinical Aspects and Pharmacological Treatments. | Weiss F et al. | β | 2023 | β |
| AUD Risk, Diagnoses, and Course in a Prospective Study Across Two Generations: Implications for Prevention. | Schuckit MA | β | 2022 | β |
| Effect of Prenatal Opioid Exposure on the Human Placental Methylome. | Borrelli KN et al. | β | 2022 | β |
| Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens. | Anderson EM et al. | β | 2022 | β |
| Paternal alcohol exposure reduces acquisition of operant alcohol self-administration and affects Bdnf DNA methylation in male and female offspring. | Nieto SJ et al. | β | 2022 | β |
| Promoter Specific Methylation of <i>SSTR4</i> is Associated With Alcohol Dependence in Han Chinese Males. | Zhao R et al. | β | 2022 | β |
| The role of alcohol intake in the pharmacogenetics of treatment with clozapine. | Monroy-Jaramillo N et al. | β | 2022 | β |
| Why haven't we solved the addiction crisis? | Blum K et al. | β | 2022 | β |
| Association of <i>PIP4K2A</i> Polymorphisms with Alcohol Use Disorder. | Fedorenko OY et al. | β | 2021 | β |
| Behavioral Profiles of Adolescent Alcohol-Preferring/Non-preferring (P/NP) and High/Low Alcohol-Drinking (HAD/LAD) Rats Are Dependent on Line but Not Sex. | Lundberg S et al. | β | 2021 | β |
| Clinical Neuroscience of Addiction: What Clinical Psychologists Need to Know and Why. | Ray LA et al. | β | 2021 | β |
| Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges. | Schuckit MA et al. | β | 2021 | β |
| Epigenetics of alcohol use disorder-A review of recent advances in DNA methylation profiling. | Longley MJ et al. | β | 2021 | β |
| ERR and dPECR Suggest a Link Between Neuroprotection and the Regulation of Ethanol Consumption Preference. | Velo Escarcena L et al. | β | 2021 | β |
| Psychiatry in the Digital Age: A Blessing or a Curse? | Roth CB et al. | β | 2021 | β |
| Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. | Mazumder AH et al. | β | 2021 | β |
| Reward Deficiency Syndrome (RDS): A Cytoarchitectural Common Neurobiological Trait of All Addictions. | Blum K et al. | β | 2021 | β |
| Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder. | King A et al. | β | 2021 | β |
| The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews. | Boness CL et al. | β | 2021 | β |
| The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle. | Siomek-Gorecka A et al. | β | 2021 | β |
| Viral-Mediated Knockdown of Nucleus Accumbens Shell PAC1 Receptor Promotes Excessive Alcohol Drinking in Alcohol-Preferring Rats. | Minnig MA et al. | β | 2021 | β |
| Addiction by Any Other Name is Still Addiction: Embracing Molecular Neurogenetic/Epigenetic Basis of Reward Deficiency. | Edwards D et al. | β | 2020 | β |
| Alcohol Induced Depression: Clinical, Biological and Genetic Features. | FarrΓ© A et al. | β | 2020 | β |
| A Rationale for Allopregnanolone Treatment of Alcohol Use Disorders: Basic and Clinical Studies. | Morrow AL et al. | β | 2020 | β |
| Epigenetic changes on rat chromosome 4 contribute to disparate alcohol drinking behavior in alcohol-preferring and -nonpreferring rats. | Spence JP et al. | β | 2020 | β |
| Maternal ethanol consumption before paternal fertilization: Stimulation of hypocretin neurogenesis and ethanol intake in zebrafish offspring. | Collier AD et al. | β | 2020 | β |
| Mechanisms of Alcohol Addiction: Bridging Human and Animal Studies. | Kramer J et al. | β | 2020 | β |
| On the path towards personalized medicine: Implications of pharmacogenetic studies of alcohol use disorder medications. | Nieto SJ et al. | β | 2020 | β |
| Pathways to post-traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults. | Subbie-Saenz de Viteri S et al. | β | 2020 | β |
| Sex differences in cognitive performance and alcohol consumption in High Alcohol-Drinking (HAD-1) rats. | Mittal N et al. | β | 2020 | β |
| Spontaneous Early Withdrawal Behaviors after Chronic 24-hour Free-Choice Access to Ethanol. | Hauser SR et al. | β | 2020 | β |
| Spontaneous Ultrasonic Vocalization Transmission in Adult, Male Long-Evans Rats Is Age-Dependent and Sensitive to EtOH Modulation. | Mittal N et al. | β | 2020 | β |
| The Adaptive Behavioral Components (ABC) Model for Planning Longitudinal Behavioral Technology-Based Health Interventions: A Theoretical Framework. | Young SD | β | 2020 | β |
| Addiction resistance to alcohol: What about heavy drinkers who avoid alcohol problems? | Hoffmeister JR et al. | β | 2019 | β |
| A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors. | Bocarsly ME et al. | β | 2019 | β |
| Brain Imaging-Guided Analysis Reveals DNA Methylation Profiles Correlated with Insular Surface Area and Alcohol Use Disorder. | Zhao Y et al. | β | 2019 | β |
| Convergent Evidence From Humans and Drosophila melanogaster Implicates the Transcription Factor MEF2B/Mef2 in Alcohol Sensitivity. | Schmitt RE et al. | β | 2019 | β |
| Early-life risk for domestic violence perpetration: Implications for practice and policy. | Corvo K | β | 2019 | β |
| Genetic determinants of beverage consumption: Implications for nutrition and health. | Cornelis MC | β | 2019 | β |
| Pharmacotherapeutic options for co-morbid depression and alcohol dependence. | Hillemacher T et al. | β | 2019 | β |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | β | 2019 | β |
| Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure. | Nieto SJ et al. | β | 2019 | β |
| "Why did I get that part of you?" Understanding addiction genetics through family history. | Dingel MJ et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| Cross-species molecular dissection across alcohol behavioral domains. | Farris SP et al. | β | 2018 | β |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | β | 2018 | β |
| Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks. | Ben Hamida S et al. | β | 2018 | β |
| Low Vs. High Alcohol: Central Benefits Vs. Detriments. | Tizabi Y et al. | β | 2018 | β |
| A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel. | Schuckit MA et al. | β | 2017 | β |
| Commentary: Perspectives on alcohol-related gene and environment interplay in diverse populations. | Scott MS | β | 2017 | β |
| Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. | Treutlein J et al. | β | 2017 | β |
| Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking. | Ding ZM et al. | β | 2017 | β |
| The future is now: A 2020 view of alcoholism research. | Harris RA et al. | β | 2017 | β |