Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
paper
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- Traylor, Matthew; Farrall, Martin; Holliday, Elizabeth G; Sudlow, Cathie; Hopewell, Jemma C; Cheng, Yu-Ching; Fornage, Myriam; Ikram, M Arfan; Malik, Rainer; Bevan, Steve; Thorsteinsdottir, Unnur; Nalls, Mike A; Longstreth, Wt; Wiggins, Kerri L; Yadav, Sunaina; Parati, Eugenio A; Destefano, Anita L; Worrall, Bradford B; Kittner, Steven J; Khan, Muhammad Saleem; Reiner, Alex P; Helgadottir, Anna; Achterberg, Sefanja; Fernandez-Cadenas, Israel; Abboud, Sherine; Schmidt, Reinhold; Walters, Matthew; Chen, Wei-Min; Ringelstein, E Bernd; O'Donnell, Martin; Ho, Weang Kee; Pera, Joanna; Lemmens, Robin; Norrving, Bo; Higgins, Peter; Benn, Marianne; Sale, Michele; KuhlenbΓ€umer, Gregor; Doney, Alexander S F; Vicente, Astrid M; Delavaran, Hossein; Algra, Ale; Davies, Gail; Oliveira, Sofia A; Palmer, Colin N A; Deary, Ian; Schmidt, Helena; Pandolfo, Massimo; Montaner, Joan; Carty, Cara; de Bakker, Paul I W; Kostulas, Konstantinos; Ferro, Jose M; van Zuydam, Natalie R; Valdimarsson, Einar; Nordestgaard, BΓΈrge G; Lindgren, Arne; Thijs, Vincent; Slowik, Agnieszka; Saleheen, Danish; ParΓ©, Guillaume; Berger, Klaus; Thorleifsson, Gudmar; Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2); Hofman, Albert; Mosley, Thomas H; Mitchell, Braxton D; Furie, Karen; Clarke, Robert; Levi, Christopher; Seshadri, Sudha; Gschwendtner, Andreas; Boncoraglio, Giorgio B; Sharma, Pankaj; Bis, Joshua C; Gretarsdottir, Solveig; Psaty, Bruce M; Rothwell, Peter M; Rosand, Jonathan; Meschia, James F; Stefansson, Kari; Dichgans, Martin; Markus, Hugh S; International Stroke Genetics Consortium
- Year
- 2012
- Journal
- The Lancet. Neurology
- PMID
- 23041239
- DOI
- 10.1016/S1474-4422(12)70234-X
- PMCID
- PMC3490334
BACKGROUND: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes. METHODS: We meta-analysed data from 15 ischaemic stroke cohorts with a total of 12β389 individuals with ischaemic stroke and 62β004 controls, all of European ancestry. For the associations reaching genome-wide significance in METASTROKE, we did a further analysis, conditioning on the lead single nucleotide polymorphism in every associated region. Replication of novel suggestive signals was done in 13β347 cases and 29β083 controls. FINDINGS: We verified previous associations for cardioembolic stroke near PITX2 (p=2Β·8Γ10(-16)) and ZFHX3 (p=2Β·28Γ10(-8)), and for large-vessel stroke at a 9p21 locus (p=3Β·32Γ10(-5)) and HDAC9 (p=2Β·03Γ10(-12)). Additionally, we verified that all associations were subtype specific. Conditional analysis in the three regions for which the associations reached genome-wide significance (PITX2, ZFHX3, and HDAC9) indicated that all the signal in each region could be attributed to one risk haplotype. We also identified 12 potentially novel loci at p<5Γ10(-6). However, we were unable to replicate any of these novel associations in the replication cohort. INTERPRETATION: Our results show that, although genetic variants can be detected in patients with ischaemic stroke when compared with controls, all associations we were able to confirm are specific to a stroke subtype. This finding has two implications. First, to maximise success of genetic studies in ischaemic stroke, detailed stroke subtyping is required. Second, different genetic pathophysiological mechanisms seem to be associated with different stroke subtypes. FUNDING: Wellcome Trust, UK Medical Research Council (MRC), Australian National and Medical Health Research Council, National Institutes of Health (NIH) including National Heart, Lung and Blood Institute (NHLBI), the National Institute on Aging (NIA), the National Human Genome Research Institute (NHGRI), and the National Institute of Neurological Disorders and Stroke (NINDS).
Flow diagram of METASTROKE analysesGWAS=genome-wide association study. SNP=single nucleotide polymorphism.
Manhattan plots of βlog10(p) against genomic position for principal analyses(A) All ischaemic stroke. (B) Large-vessel disease. (C) Cardioembolic stroke. (D) Small-vessel disease. Genome-wide meta-analysis association results by genomic position for the four main analyses.
Plots of conditional analysis regions before and after conditioning on lead SNPSNP=single nucleotide polymorphism. Plots of association signals around loci investigated in conditional analyses in subtypes in which they were discovered for the meta-analysed discovery samples. SNPs are coloured on the basis of their correlation (r2) with the labelled top SNP, which has the smallest p value in the region. The fine-scale recombination rates estimated from HapMap data are marked in red, with genes marked below by horizontal blue lines. Arrows on the horizontal blue lines show the direction of transcription, and rectangles are exons. (A,C,E) Regions from discovery meta-analyses. (B,D,F) Same regions as A,C,E after conditioning on the lead SNP from the region.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Acute basal ganglia ischemic stroke: a study on structure-function coupling. | Zhu L et al. | β | 2026 | β |
| A systematic review and meta-analysis assessing the influence of histone deacetylase 6 inhibition on brain infarction and neurological function following acute ischaemic stroke in rodent models. | Ma OB et al. | β | 2026 | β |
| The dynamic nature of genetic risk for schizophrenia within genes regulated by FOXP1 during neurodevelopment. | Ali D et al. | β | 2026 | β |
| Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E-selectin. | Lou T et al. | β | 2025 | β |
| Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis. | Zhang T et al. | β | 2025 | β |
| Association Between Hypoxia-Inducible Factor-1Ξ± and Neurological Diseases: A Bidirectional Two-Sample Mendelian Randomization Analysis. | Liang J et al. | β | 2025 | β |
| Association between Stroke History and Clinical Events in Atrial Fibrillation Patients after Valve Replacement. | Yan X et al. | β | 2025 | β |
| Association of genotypes at single-nucleotide polymorphisms in <i>IL-28B, TGF-Ξ²1</i>, <i>TP53, MTHFR</i> and <i>GSTP1</i> gene and their combinations with ischemic stroke: A case-control study. | Shakoor S et al. | β | 2025 | β |
| Cerebrovascular p16<sup>INK4A</sup> expression induces cerebral small vessel disease-related phenotypes. | Kawatani K et al. | β | 2025 | β |
| Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review. | Kosyakovsky J et al. | β | 2025 | β |
| Evaluating machine learning models for stroke prediction based on clinical variables. | Akinwumi PO et al. | β | 2025 | β |
| Evaluation of Machine Learning and Traditional Statistical Models to Assess the Value of Stroke Genetic Liability for Prediction of Risk of Stroke Within the UK Biobank. | MacCarthy G et al. | β | 2025 | β |
| Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1Ξ± in stroke progression. | Hamadi A et al. | β | 2025 | β |
| Genetic Architecture of Ischemic Stroke: Insights from Genome-Wide Association Studies and Beyond. | Jagodic A et al. | β | 2025 | β |
| Genetic insights into 5-LOX-activating protein: a narrative review of disease associations. | Rataj K et al. | β | 2025 | β |
| HDAC9 Deficiency Upregulates cGMP-dependent Kinase II to Mitigate Neuronal Apoptosis in Ischemic Stroke. | Lin H et al. | β | 2025 | β |
| MetaGeno: a chromosome-wise multi-task genomic framework for ischaemic stroke risk prediction. | Yang Y et al. | β | 2025 | β |
| Recent Advances in Stroke Genetics-Unraveling the Complexity of Cerebral Infarction: A Brief Review. | Yoshimoto T et al. | β | 2025 | β |
| The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence. | Oyovwi MO et al. | β | 2025 | β |
| Using human genomics to validate drug targets for acute ischemic stroke. | Heitsch L et al. | β | 2025 | β |
| A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping. | Dong P et al. | β | 2024 | β |
| Differential ischemic stroke risk linked to novel subtypes of type 2 diabetes: insights from a Mendelian randomization analysis. | Ruan Z et al. | β | 2024 | β |
| Direct targets of MEF2C are enriched for genes associated with schizophrenia and cognitive function and are involved in neuron development and mitochondrial function. | Ali D et al. | β | 2024 | β |
| Genetics of ischemic stroke functional outcome. | Carnwath TP et al. | β | 2024 | β |
| Imputation accuracy across global human populations. | Cahoon JL et al. | β | 2024 | β |
| Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke. | Daghlas I et al. | β | 2024 | β |
| Multi-omics association study of DNA methylation and gene expression levels and diagnoses of cardiovascular diseases in Danish Twins. | Skovgaard AC et al. | β | 2024 | β |
| Obstructive sleep apnea and genotype rs6843082 as a risk factor for cerebrovascular accident. | Yang TC et al. | β | 2024 | β |
| SATB2 organizes the 3D genome architecture of cognition in cortical neurons. | Wahl N et al. | β | 2024 | β |
| Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke. | CΓ‘rcel-MΓ‘rquez J et al. | β | 2024 | β |
| The association between polymorphism of LDL-R gene and ischemic stroke risk in Chinese population: A meta-analysis. | Dai Z et al. | β | 2024 | β |
| Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants. | Granata A | β | 2023 | β |
| Genetics in Ischemic Stroke: Current Perspectives and Future Directions. | Zhang K et al. | β | 2023 | β |
| Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study. | Dofuku S et al. | β | 2023 | β |
| HDAC9 Inhibition as a Novel Treatment for Stroke. | Markus HS | β | 2023 | β |
| Identification and Validation of Active Ingredient in Cerebrotein Hydrolysate-I Based on Pharmacokinetic and Pharmacodynamic Studies. | Guo H et al. | β | 2023 | β |
| Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke. | Qin S et al. | β | 2023 | β |
| Infection with critically ill COVID-19 increases the risk of cardioembolic stroke. | Ma J et al. | β | 2023 | β |
| Integration of Mendelian randomisation and systems biology models to identify novel blood-based biomarkers for stroke. | Islam T et al. | β | 2023 | β |
| Intercellular adhesion molecule 4 and ischemic stroke: a two-sample Mendelian randomization study. | Sun L et al. | β | 2023 | β |
| Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries. | Surakka I et al. | β | 2023 | β |
| Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death. | Sanguigno L et al. | β | 2023 | β |
| The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay. | Cheng S et al. | β | 2023 | β |
| Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis. | Hu X et al. | β | 2022 | β |
| DNA Methylation and Ischemic Stroke Risk: An Epigenome-Wide Association Study. | Cullell N et al. | β | 2022 | β |
| False Utopia of One Unifying Description of the Vulnerable Atherosclerotic Plaque: A Call for Recalibration That Appreciates the Diversity of Mechanisms Leading to Atherosclerotic Disease. | Pasterkamp G et al. | β | 2022 | β |
| Functional Connectivity Changes in Multiple-Frequency Bands in Acute Basal Ganglia Ischemic Stroke Patients: A Machine Learning Approach. | Li J et al. | β | 2022 | β |
| <i>CAMTA1</i> gene affects the ischemia-reperfusion injury by regulating <i>CCND1</i>. | Liu Y et al. | β | 2022 | β |
| Identification of Novel Circulating miRNAs in Patients with Acute Ischemic Stroke. | Aldous EK et al. | β | 2022 | β |
| [Interaction between ischemic stroke risk loci identified by genome-wide association studies and sleep habits]. | Yang RT et al. | β | 2022 | β |
| Multi-omics research strategies in ischemic stroke: A multidimensional perspective. | Li W et al. | β | 2022 | β |
| Nucleosides Associated With Incident Ischemic Stroke in the REGARDS and JHS Cohorts. | Ament Z et al. | β | 2022 | β |
| Population-level variation in enhancer expression identifies disease mechanisms in the human brain. | Dong P et al. | β | 2022 | β |
| Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives. | Debette S et al. | β | 2022 | β |
| The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1. | Ma L et al. | β | 2022 | β |
| The Histone Deacetylase 9 Stroke-Risk Variant Promotes Apoptosis and Inflammation in a Human iPSC-Derived Smooth Muscle Cells Model. | Granata A et al. | β | 2022 | β |
| Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project. | Hu Y et al. | β | 2022 | β |
| Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population. | Yang X et al. | β | 2021 | β |
| Benefits of Cohort Studies in a Consortia-Dominated Landscape. | Zenebe-Gete S et al. | β | 2021 | β |
| Causal effect of atrial fibrillation/flutter on chronic kidney disease: A bidirectional two-sample Mendelian randomization study. | Yoshikawa M et al. | β | 2021 | β |
| Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients With Cardiometabolic Disease. | Marston NA et al. | β | 2021 | β |
| EDNRA Gene rs1878406 Polymorphism is Associated With Susceptibility to Large Artery Atherosclerotic Stroke. | Wei W et al. | β | 2021 | β |
| Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons. | Cosgrove D et al. | β | 2021 | β |
| Genetic and Genomic Epidemiology of Stroke in People of African Ancestry. | Prapiadou S et al. | β | 2021 | β |
| Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies. | Armstrong ND et al. | β | 2021 | β |
| GWAS-linked hot loci predict short-term functional outcome and recurrence of ischemic stroke in Chinese population. | Zhu R et al. | β | 2021 | β |
| <i>DGAT2-MOGAT2</i> SNPs and Gene-Environment Interactions on Serum Lipid Profiles and the Risk of Ischemic Stroke. | Zhou YG et al. | β | 2021 | β |
| IMCC: A Novel Quantitative Approach Revealing Variation of Global Modular Map and Local Inter-Module Coordination Among Differential Drug's Targeted Cerebral Ischemic Networks. | Wang P et al. | β | 2021 | β |
| Infarct Recurrence in Intracranial Atherosclerosis: Results from the MyRIAD Study. | Romano JG et al. | β | 2021 | β |
| Interactive Effects of a Combination of the HDAC3 and HDAC9 Genes with Diabetes Mellitus on the Risk of Ischemic Stroke. | Chiou HY et al. | β | 2021 | β |
| Ischemic Stroke and Sleep: The Linking Genetic Factors. | Korostovtseva L | β | 2021 | β |
| Mendelian Randomization Studies in Stroke: Exploration of Risk Factors and Drug Targets With Human Genetic Data. | Georgakis MK et al. | β | 2021 | β |
| Microbiome and ischemic stroke: A systematic review. | Lee YT et al. | β | 2021 | β |
| Migraine and Stroke: In Search of Shared Pathways, Mechanisms, and Risk Factors. | Hassan M et al. | β | 2021 | β |
| Network Protein Interaction in the Link between Stroke and Periodontitis Interplay: A Pilot Bioinformatic Analysis. | Leira Y et al. | β | 2021 | β |
| Obesity-related genetic determinants of stroke. | Gago-Dominguez M et al. | β | 2021 | β |
| Predictive Performance of a Polygenic Risk Score for Incident Ischemic Stroke in a Healthy Older Population. | Neumann JT et al. | β | 2021 | β |
| Quis Custodiet Ipsos Custodes (Who Controls the Controllers)? Two Decades of Studies on HDAC9. | Brancolini C et al. | β | 2021 | β |
| Residual Recurrence Risk of Ischemic Cerebrovascular Events: Elements and Implications. | Li J et al. | β | 2021 | β |
| SATB2-LEMD2 interaction links nuclear shape plasticity to regulation of cognition-related genes. | Feurle P et al. | β | 2021 | β |
| SLC17A3 rs9379800 and Ischemic Stroke Susceptibility at the Northern Region of Malaysia. | Ching SC et al. | β | 2021 | β |
| SNP rs2043211 (p.C10X) in CARD8 Is Associated with Large-Artery Atherosclerosis Stroke in a Chinese Population. | Gu J et al. | β | 2021 | β |
| Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics. | Cheng S et al. | β | 2021 | β |
| Zfhx3 Transcription Factor Represses the Expression of <i>SCN5A</i> Gene and Decreases Sodium Current Density (I<sub>Na</sub>). | Rubio-AlarcΓ³n M et al. | β | 2021 | β |
| Additional common loci associated with stroke and obesity identified using pleiotropic analytical approach. | Wang L et al. | β | 2020 | β |
| Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function. | Flynn M et al. | β | 2020 | β |
| Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific. | Dykstra-Aiello C et al. | β | 2020 | β |
| Angiogenesis-Related Genes in Endothelial Progenitor Cells May Be Involved in Sickle Cell Stroke. | Ito MT et al. | β | 2020 | β |
| Association between ALDH2 rs671 polymorphism and risk of ischemic stroke: A protocol for systematic review and meta analysis. | Jiang Y et al. | β | 2020 | β |
| Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke. | Ye D et al. | β | 2020 | β |
| Association of genetic polymorphisms in chromosome 9p21 with risk of ischemic stroke. | Han X et al. | β | 2020 | β |
| Atherosclerotic Aortic Calcification-Associated Polymorphism in HDAC9 and Associations with Mortality, Cardiovascular Disease, and Kidney Disease. | ΓrnlΓΆv J et al. | β | 2020 | β |
| DNA methylation of AHCY may increase the risk of ischemic stroke. | Zhao L et al. | β | 2020 | β |
| Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. | Souilhol C et al. | β | 2020 | β |
| Family history and polygenic risk of cardiovascular disease: Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy. | Timmerman N et al. | β | 2020 | β |
| Functional Genetic Variation in the 3'-UTRNTRK2 is Associated with Risk of Ischemic Stroke. | Shi J et al. | β | 2020 | β |
| Genetic Etiology Shared by Multiple Sclerosis and Ischemic Stroke. | Tian Z et al. | β | 2020 | β |
| Genetic variation contributes to gene expression response in ischemic stroke: an eQTL study. | Amini H et al. | β | 2020 | β |
| Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. | Keene KL et al. | β | 2020 | β |
| Integrate Molecular Phenome and Polygenic Interaction to Detect the Genetic Risk of Ischemic Stroke. | Li X et al. | β | 2020 | β |
| Ischemic Stroke and Genetic Variants: In Search of Association with Severity and Recurrence in a Brazilian Population. | da Silva CF et al. | β | 2020 | β |
| Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke. | Montaner J et al. | β | 2020 | β |
| Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms. | Stanzione R et al. | β | 2020 | β |
| Personalized warfarin treatment based on the PITX2 single nucleotide polymorphism rs6843082. | Liu T et al. | β | 2020 | β |
| SERPINA1 gene expression in whole blood links the rs6647 variant G allele to an increased risk of large artery atherosclerotic stroke. | Liu Q et al. | β | 2020 | β |
| Stroke and Alzheimer's Disease: A Mendelian Randomization Study. | Wang T et al. | β | 2020 | β |
| The ACTB Variants and Alcohol Drinking Confer Joint Effect to Ischemic Stroke in Chinese Han Population. | Yang S et al. | β | 2020 | β |
| Translational Genomics in Neurocritical Care: a Review. | Myserlis P et al. | β | 2020 | β |
| Adherence to the Mediterranean diet and risk of stroke and stroke subtypes. | Chen GC et al. | β | 2019 | β |
| Aldehyde dehydrogenase-2 as a therapeutic target. | Kimura M et al. | β | 2019 | β |
| Associations among Genetic Variants and Intracranial Aneurysm in a Chinese Population. | Li B et al. | β | 2019 | β |
| Biologic roles of the ABH and Lewis histo-blood group antigens part II: thrombosis, cardiovascular disease and metabolism. | Stowell SR et al. | β | 2019 | β |
| Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review. | Torres-Aguila NP et al. | β | 2019 | β |
| Detection of Putative Functional Single Nucleotide Polymorphisms in Blood Pressure Loci and Validation of Association Between Single Nucleotide Polymorphism in WBP1L and Hypertension in the Chinese Han Population. | Zhang H et al. | β | 2019 | β |
| Family history and polygenic risk of cardiovascular disease: independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy | Timmerman N et al. | β | 2019 | β |
| Genes encoding SATB2-interacting proteins in adult cerebral cortex contribute to human cognitive ability. | Cera I et al. | β | 2019 | β |
| Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults. | Gan W et al. | β | 2019 | β |
| Genetics of Vascular Cognitive Impairment. | Markus HS et al. | β | 2019 | β |
| Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke. | Wu Y et al. | β | 2019 | β |
| Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis. | Chen JX et al. | β | 2019 | β |
| Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke. | Abraham G et al. | β | 2019 | β |
| HDAC9 Polymorphism Alters Blood Gene Expression in Patients with Large Vessel Atherosclerotic Stroke. | Shroff N et al. | β | 2019 | β |
| HDAC9 Polymorphisms Predict Susceptibility, Severity, and Short-Term Outcome of Large Artery Atherosclerotic Stroke in Chinese Population. | Wang M et al. | β | 2019 | β |
| Intermodule Coupling Analysis of Huang-Lian-Jie-Du Decoction on Stroke. | Wang P et al. | β | 2019 | β |
| Monogenic, Polygenic, and MicroRNA Markers for Ischemic Stroke. | Chen W et al. | β | 2019 | β |
| Noncardioembolic Stroke in Patients with Atrial Fibrillation. | Katsi V et al. | β | 2019 | β |
| Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study. | Valdes-Marquez E et al. | β | 2019 | β |
| Ring Finger Protein 213 Variant and Plaque Characteristics, Vascular Remodeling, and Hemodynamics in Patients With Intracranial Atherosclerotic Stroke: A High-Resolution Magnetic Resonance Imaging and Hemodynamic Study. | Choi EH et al. | β | 2019 | β |
| Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach. | Polivka J et al. | β | 2019 | β |
| Role of cigarette smoking in the development of ischemic stroke and its subtypes: a Mendelian randomization study. | Qian Y et al. | β | 2019 | β |
| Subtype Specificity of Genetic Loci Associated With Stroke in 16β664 Cases and 32β792 Controls. | Traylor M et al. | β | 2019 | β |
| Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit. | Wzorek J et al. | β | 2018 | β |
| Association of the matrix metalloproteinase-3 polymorphisms rs679620 and rs3025058 with ischemic stroke risk: a meta-analysis. | Zhang QW | β | 2018 | β |
| Breakpoint mapping and haplotype analysis of translocation t(1;12)(q43;q21.1) in two apparently independent families with vascular phenotypes. | Luukkonen TM et al. | β | 2018 | β |
| Canadian stroke best practice recommendations: Secondary prevention of stroke, sixth edition practice guidelines, update 2017. | Wein T et al. | β | 2018 | β |
| Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke. | Crawford KM et al. | β | 2018 | β |
| DNA Methylation in Stroke. Update of Latest Advances. | Krupinski J et al. | β | 2018 | β |
| Downregulation of the Vitamin D Receptor Regulated Gene Set in the Hippocampus After MDMA Treatment. | Petschner P et al. | β | 2018 | β |
| Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment. | Whitton L et al. | β | 2018 | β |
| Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke. | Cole JW et al. | β | 2018 | β |
| Genetic susceptibility to cerebrovascular disease: A systematic review. | Griessenauer CJ et al. | β | 2018 | β |
| Genetic variants in ALDH2 predict risk of ischemic stroke in a Chinese population. | Cheng X et al. | β | 2018 | β |
| Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. | Finucane HK et al. | β | 2018 | β |
| Hypertension genomics and cardiovascular prevention. | Ng FL et al. | β | 2018 | β |
| Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. | Yamada Y et al. | β | 2018 | β |
| Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke. | Stepanyan A et al. | β | 2018 | β |
| Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study. | Duan L et al. | β | 2018 | β |
| Partial loss of function of colony-stimulating factor 1 receptor in a patient with white matter abnormalities. | Konno T et al. | β | 2018 | β |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | β | 2018 | β |
| Pure mechanistic analysis of additive neuroprotective effects between baicalin and jasminoidin in ischemic stroke mice. | Wang PQ et al. | β | 2018 | β |
| Risk Factors, Regional Disparity and Trends of Ischemic Stroke Etiologic Subtypes. | Tian DY et al. | β | 2018 | β |
| Shared Biological Pathways Between Alzheimer's Disease and Ischemic Stroke. | Cui P et al. | β | 2018 | β |
| Shared Gene Expression Between Multiple Sclerosis and Ischemic Stroke. | Li H et al. | β | 2018 | β |
| Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke. | Xiong X et al. | β | 2018 | β |
| Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack. | Brookes RL et al. | β | 2018 | β |
| Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence. | Buchtele N et al. | β | 2018 | β |
| The combined effects of cardiovascular disease related SNPs on ischemic stroke. | Xu K et al. | β | 2018 | β |
| Traditional and Genetic Risk Score and Stroke Risk Prediction in Korea. | Jung KJ et al. | β | 2018 | β |
| Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization. | Haitjema S et al. | β | 2017 | β |
| Adiponectin Gene Polymorphism and Ischemic Stroke Subtypes in a Chinese Population. | Li S et al. | β | 2017 | β |
| Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities. | Owolabi M et al. | β | 2017 | β |
| A genome-wide association study links small-vessel ischemic stroke to autophagy. | Lee TH et al. | β | 2017 | β |
| Alpha-1 antitrypsin dysfunction and large artery stroke. | Meschia JF | β | 2017 | β |
| A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study. | Hauer AJ et al. | β | 2017 | β |
| Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. | Telomeres Mendelian Randomization Collaboration et al. | β | 2017 | β |
| Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms. | Lubitz SA et al. | β | 2017 | β |
| Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. | Dale CE et al. | β | 2017 | β |
| Classical rather than genetic risk factors account for high cardiovascular disease prevalence in Lithuania: A cross-sectional population study. | BurokienΔ N et al. | β | 2017 | β |
| Common coding variant in <i>SERPINA1</i> increases the risk for large artery stroke. | Malik R et al. | β | 2017 | β |
| [Complex assessment of the contribution of genetic factors to the risk of ischemic stroke]. | Korchagin VI et al. | β | 2017 | β |
| Design and rationale for examining neuroimaging genetics in ischemic stroke: The MRI-GENIE study. | Giese AK et al. | β | 2017 | β |
| Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques - Tampere Vascular Study. | Sulkava M et al. | β | 2017 | β |
| Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. | Nakatochi M et al. | β | 2017 | β |
| Genetic polymorphisms in the <i>ALDH2</i> gene and the risk of ischemic stroke in a Chinese han population. | Sun S et al. | β | 2017 | β |
| Genetic predisposition to ischaemic stroke by <i>RAGE</i> and <i>HMGB1</i> gene variants in Chinese Han population. | Li Y et al. | β | 2017 | β |
| Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. | Hachiya T et al. | β | 2017 | β |
| Genetic Risk Prediction of Atrial Fibrillation. | Lubitz SA et al. | β | 2017 | β |
| Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study. | Traylor M et al. | β | 2017 | β |
| Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. | Phuah CL et al. | β | 2017 | β |
| Genetic variation associated with cardiovascular risk in autoimmune diseases. | Perrotti PP et al. | β | 2017 | β |
| Genetic variation at 16q24.2 is associated with small vessel stroke. | Traylor M et al. | β | 2017 | β |
| GISCOME - Genetics of Ischaemic Stroke Functional Outcome network: A protocol for an international multicentre genetic association study. | Maguire JM et al. | β | 2017 | β |
| Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. | Benjamin EJ et al. | β | 2017 | β |
| High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors. | Di Narzo AF et al. | β | 2017 | β |
| Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies. | Yamada Y et al. | β | 2017 | β |
| Joinville stroke biobank: study protocol and first year's results. | Ferreira LE et al. | β | 2017 | β |
| Lack of association between the <i>APLNR</i> variant rs9943582 with ischemic stroke in the Chinese Han GeneID population. | Wang P et al. | β | 2017 | β |
| Pharmacogenetic Associations of Ξ²1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes). | Magvanjav O et al. | β | 2017 | β |
| Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling. | Harston GW et al. | β | 2017 | β |
| Stroke in Women: Risk Factors and Clinical Biomarkers. | Mirzaei H | β | 2017 | β |
| The association between HDAC9 gene polymorphisms and stroke risk in the Chinese population: A meta-analysis. | Zhou X et al. | β | 2017 | β |
| The Importance of Conducting Stroke Genomics Research in African Ancestry Populations. | Xu H et al. | β | 2017 | β |
| The research on association of copy number variation in chromosome 9p21 region with atherothrombotic stroke in the Han Chinese population. | Liu H et al. | β | 2017 | β |
| Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study. | Larsson SC et al. | β | 2017 | β |
| ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population. | Yu J et al. | β | 2017 | β |
| Aldehyde dehydrogenase 2 polymorphism as a protective factor for intracranial vascular stenosis in ischemic stroke in Han Chinese. | Qu Y et al. | β | 2016 | β |
| Analysis of Association between MAP2K4 Gene Polymorphism rs3826392 and IL-1b Serum Level in Southern Chinese Han Ischemic Stroke Patients. | Gu L et al. | β | 2016 | β |
| [Analysis of FOXO1A and FOXO3A Gene Allele Association with Human Longevity]. | Erdman VV et al. | β | 2016 | β |
| A Polymorphism in RNF213 Is a Susceptibility Gene for Intracranial Atherosclerosis. | Bang OY et al. | β | 2016 | β |
| Are Genetic Tests for Atherosclerosis Ready for Routine Clinical Use? | Paynter NP et al. | β | 2016 | β |
| Association Between the Gene Polymorphisms of HDAC9 and the Risk of Atherosclerosis and Ischemic Stroke. | Qingxu G et al. | β | 2016 | β |
| Associations between exhaust and non-exhaust particulate matter and stroke incidence by stroke subtype in South London. | Crichton S et al. | β | 2016 | β |
| Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. | SeppΓ€lΓ€ I et al. | β | 2016 | β |
| Association study of C-reactive protein associated gene HNF1A with ischemic stroke in Chinese population. | Shi H et al. | β | 2016 | β |
| Blood and CSF biomarkers in brain subcortical ischemic vascular disease: Involved pathways and clinical applicability. | Vilar-Bergua A et al. | β | 2016 | β |
| Brain microangiopathy and macroangiopathy share common risk factors and biomarkers. | Bang OY et al. | β | 2016 | β |
| Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. | Keenan T et al. | β | 2016 | β |
| Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study. | van der Laan SW et al. | β | 2016 | β |
| Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease. | Ihara M et al. | β | 2016 | β |
| Epidemiology of cardiovascular disease: recent novel outlooks on risk factors and clinical approaches. | Niiranen TJ et al. | β | 2016 | β |
| Epidemiology of Ischemic Stroke. | Favate AS et al. | β | 2016 | β |
| Exome array analysis of ischaemic stroke: results from a southern Swedish study. | SΓΆderholm M et al. | β | 2016 | β |
| Family History and Risk of Recurrent Stroke. | Chung JW et al. | β | 2016 | β |
| From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. | Nurnberg ST et al. | β | 2016 | β |
| Genetic analysis of emerging risk factors in coronary artery disease. | van Iperen EP et al. | β | 2016 | β |
| Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke. | Traylor M et al. | β | 2016 | β |
| Genetic factors in cerebral small vessel disease and their impact on stroke and dementia. | Haffner C et al. | β | 2016 | β |
| Genetic Risk Factors for Ischemic and Hemorrhagic Stroke. | Chauhan G et al. | β | 2016 | β |
| Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. | Hinds DA et al. | β | 2016 | β |
| Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. | Cheng YC et al. | β | 2016 | β |
| Genomics of Atrial Fibrillation. | Gutierrez A et al. | β | 2016 | β |
| HDAC9, TWIST1 and FERD3L gene expression in asymptomatic stable and unstable carotid plaques. | Ferronato S et al. | β | 2016 | β |
| HDAC9 Variant Rs2107595 Modifies Susceptibility to Coronary Artery Disease and the Severity of Coronary Atherosclerosis in a Chinese Han Population. | Wang XB et al. | β | 2016 | β |
| Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. | Writing Group Members et al. | β | 2016 | β |
| Heritability and Genome-Wide Association Analyses of Intracranial Carotid Artery Calcification: The Rotterdam Study. | Adams HH et al. | β | 2016 | β |
| Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype. | Pasterkamp G et al. | β | 2016 | β |
| Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. | Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium et al. | β | 2016 | β |
| Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study. | Lee TH et al. | β | 2016 | β |
| Imaging markers of cerebrovascular pathologies: Pathophysiology, clinical presentation, and risk factors. | Raman MR et al. | β | 2016 | β |
| Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. | Malik R et al. | β | 2016 | β |
| Polygenic risk of ischemic stroke is associated with cognitive ability. | Harris SE et al. | β | 2016 | β |
| Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population. | Han Z et al. | β | 2016 | β |
| Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients. | Wu H et al. | β | 2016 | β |
| Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease. | Traylor M et al. | β | 2016 | β |
| Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. | Williams SR et al. | β | 2016 | β |
| Stroke injury, cognitive impairment and vascular dementia. | Kalaria RN et al. | β | 2016 | β |
| The association between vascular endothelial growth factor gene polymorphisms and stroke: a meta-analysis. | Wu T et al. | β | 2016 | β |
| The Geographic Distribution of Genetic Risk as Compared to Social Risk for Chronic Diseases in the United States. | Rehkopf DH et al. | β | 2016 | β |
| Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol. | Cotlarciuc I et al. | β | 2016 | β |
| Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. | Surendran P et al. | β | 2016 | β |
| Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke. | Carrera C et al. | β | 2016 | β |
| A genetic risk score for hypertension associates with the risk of ischemic stroke in a Swedish case-control study. | Fava C et al. | β | 2015 | β |
| A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. | Hirokawa M et al. | β | 2015 | β |
| An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes. | MuiΓ±o E et al. | β | 2015 | β |
| Association Between TRAF6 Gene Polymorphisms and Susceptibility of Ischemic Stroke in Southern Chinese Han Population. | Su L et al. | β | 2015 | β |
| Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study. | Yamada Y et al. | β | 2015 | β |
| Association of GWAS-supported loci rs2107595 in HDAC9 gene with ischemic stroke in southern Han Chinese. | Su L et al. | β | 2015 | β |
| Association of GWAS-Supported Variants rs2200733 and rs6843082 on Chromosome 4q25 with Ischemic Stroke in the Southern Chinese Han Population. | Su L et al. | β | 2015 | β |
| Association of <i>TOMM40</i> and <i>SLC22A4</i> polymorphisms with ischemic stroke. | Yamase Y et al. | β | 2015 | β |
| Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association. | Musunuru K et al. | β | 2015 | β |
| Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. | Interleukin 1 Genetics Consortium | β | 2015 | β |
| Cardiovascular risk factors for acute stroke: Risk profiles in the different subtypes of ischemic stroke. | Arboix A | β | 2015 | β |
| Changes of resting cerebral activities in subacute ischemic stroke patients. | Wu P et al. | β | 2015 | β |
| Chronic obstructive pulmonary disease and cerebrovascular disease: A comprehensive review. | Lahousse L et al. | β | 2015 | β |
| Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. | RannikmΓ€e K et al. | β | 2015 | β |
| Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. | Debette S et al. | β | 2015 | β |
| Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes. | Smith JA et al. | β | 2015 | β |
| Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. | Azghandi S et al. | β | 2015 | β |
| Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex. | Traylor M et al. | β | 2015 | β |
| Drug resistance and secondary treatment of ischaemic stroke: The genetic component of the response to acetylsalicylic acid and clopidogrel. | Gallego-Fabrega C et al. | β | 2015 | β |
| Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. | Lopez LM et al. | β | 2015 | β |
| Genetic Architecture of Lacunar Stroke. | Traylor M et al. | β | 2015 | β |
| Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke. | Hanscombe KB et al. | β | 2015 | β |
| Genetic overlap between diagnostic subtypes of ischemic stroke. | Holliday EG et al. | β | 2015 | β |
| Genetic risk factors and Mendelian randomization in cardiovascular disease. | Swerdlow DI et al. | β | 2015 | β |
| Genetics of cerebral small vessel disease. | Choi JC | β | 2015 | β |
| Genetics of ischaemic stroke in young adults. | Terni E et al. | β | 2015 | β |
| Genome-wide association studies of late-onset cardiovascular disease. | Smith JG et al. | β | 2015 | β |
| Heart disease and stroke statistics--2015 update: a report from the American Heart Association. | Mozaffarian D et al. | β | 2015 | β |
| Homogeneous case subgroups increase power in genetic association studies. | Traylor M et al. | β | 2015 | β |
| Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury. | Du R et al. | β | 2015 | β |
| Interactions among Candidate Genes Selected by Meta-Analyses Resulting in Higher Risk of Ischemic Stroke in a Chinese Population. | Luo M et al. | β | 2015 | β |
| Ischemic Stroke: From Next Generation Sequencing and GWAS to Community Genomics? | Black M et al. | β | 2015 | β |
| Linking genes to neurological clinical practice: the genomic basis for neurorehabilitation. | Goldberg A et al. | β | 2015 | β |
| Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk. | Harriott AM et al. | β | 2015 | β |
| Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. | Carty CL et al. | β | 2015 | β |
| Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. | Verhaaren BF et al. | β | 2015 | β |
| No Additional Prognostic Value of Genetic Information in the Prediction of Vascular Events after Cerebral Ischemia of Arterial Origin: The PROMISe Study. | Achterberg S et al. | β | 2015 | β |
| Overview of genetic research in anorexia nervosa: The past, the present and the future. | Brandys MK et al. | β | 2015 | β |
| PPARΞ³ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke. | Bazina A et al. | β | 2015 | β |
| Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. | Auer PL et al. | β | 2015 | β |
| Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage. | Battey TW et al. | β | 2015 | β |
| Shared genetic aetiology of coronary artery disease and atherosclerotic stroke - 2015. | Kessler T et al. | β | 2015 | β |
| Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. | Malik R et al. | β | 2015 | β |
| The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey). | Helgeland Γ et al. | β | 2015 | β |
| The myth of the "vulnerable plaque": transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment. | Arbab-Zadeh A et al. | β | 2015 | β |
| Tumor necrosis factor beta NcoI polymorphism (rs909253) is associated with inflammatory and metabolic markers in acute ischemic stroke. | de Sousa Parreira J et al. | β | 2015 | β |
| Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study. | van der Laan SW et al. | β | 2015 | β |
| Variants on Chromosome 9p21 Confer Risks of Noncardioembolic Cerebral Infarction and Carotid Plaque in the Chinese Han Population. | Lu Z et al. | β | 2015 | β |
| Aging and cardiovascular diseases: the role of gene-diet interactions. | Corella D et al. | β | 2014 | β |
| A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. | Traylor M et al. | β | 2014 | β |
| A quantitative assessment of the association between 1425G/A polymorphism in PRKCH and risk of stroke. | Sun L et al. | β | 2014 | β |
| Are ALOX5AP gene SNPs a risk or protective factor for stroke? | Papapostolou A et al. | β | 2014 | β |
| Association between 9p21 genomic markers and ischemic stroke risk: evidence based on 21 studies. | Ni X et al. | β | 2014 | β |
| Association of the ASCO classification with the executive function subscores of the Montreal cognitive assessment in patients with postischemic stroke. | Washida K et al. | β | 2014 | β |
| Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. | Bis JC et al. | β | 2014 | β |
| BRG1 variant rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates expression of pre-mRNA-splicing factor SFRS3. | Xiong X et al. | β | 2014 | β |
| Cardiovascular twist to the rapidly evolving apolipoprotein L1 story. | Farrall M | β | 2014 | β |
| Chromosome 16q22 variants in a region associated with cardiovascular phenotypes correlate with ZFHX3 expression in a transcript-specific manner. | Martin RI et al. | β | 2014 | β |
| Correlation between the single nucleotide polymorphisms of the human phosphodiesterase 4D gene and the risk of cerebral infarction in the Uygur and Han ethnic groups of Xinjiang, China. | Ma J et al. | β | 2014 | β |
| Current concepts and clinical applications of stroke genetics. | Falcone GJ et al. | β | 2014 | β |
| Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. | Bailey EL et al. | β | 2014 | β |
| Effect of genetic variants associated with plasma homocysteine levels on stroke risk. | Cotlarciuc I et al. | β | 2014 | β |
| Epigenetic memory: the Lamarckian brain. | Fischer A | β | 2014 | β |
| Evaluation of cryptogenic stroke with advanced diagnostic techniques. | Bang OY et al. | β | 2014 | β |
| Exploring the genetic basis of stroke. Spanish stroke genetics consortium. | Giralt-Steinhauer E et al. | β | 2014 | β |
| Gene polymorphism of rs556621 but Not rs11984041 is associated with the risk of large artery atherosclerotic stroke in a Xinjiang Uyghur population. | Liu J et al. | β | 2014 | β |
| Genetic insights into cardiometabolic risk factors. | Whitfield JB | β | 2014 | β |
| Genetics of ischemic stroke in young adults. | Cheng YC et al. | β | 2014 | β |
| Genome-wide association studies in neurology. | Tan MS et al. | β | 2014 | β |
| Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. | Foroud T et al. | β | 2014 | β |
| Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke. | Williams SR et al. | β | 2014 | β |
| Genomics of post-prandial lipidomic phenotypes in the Genetics of Lipid lowering Drugs and Diet Network (GOLDN) study. | Irvin MR et al. | β | 2014 | β |
| Global DNA methylation of ischemic stroke subtypes. | Soriano-TΓ‘rraga C et al. | β | 2014 | β |
| Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. | Meschia JF et al. | β | 2014 | β |
| HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. | Kim DS et al. | β | 2014 | β |
| Heart disease and stroke statistics--2014 update: a report from the American Heart Association. | Go AS et al. | β | 2014 | β |
| Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. | Sinner MF et al. | β | 2014 | β |
| Is sodium valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case-control study. | Dregan A et al. | β | 2014 | β |
| Mechanisms and treatment of ischaemic stroke--insights from genetic associations. | Markus HS et al. | β | 2014 | β |
| Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. | Kilarski LL et al. | β | 2014 | β |
| Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. | Malik R et al. | β | 2014 | β |
| Pathophysiology and risk factors of cervical artery dissection: what have we learnt from large hospital-based cohorts? | Debette S | β | 2014 | β |
| Polygenic overlap between kidney function and large artery atherosclerotic stroke. | Holliday EG et al. | β | 2014 | β |
| Polymorphisms of ECE1 may contribute to susceptibility to ischemic stroke in Han Chinese of Northern China. | Sui R et al. | β | 2014 | β |
| Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. | Ibrahim-Verbaas CA et al. | β | 2014 | β |
| 'Prognostic -Omic Clusters' (POCs): a novel approach to health and disease. | Jayasinghe S | β | 2014 | β |
| Rare variants and cardiovascular disease. | Wain LV | β | 2014 | β |
| Risk factors and their impact on carotid intima-media thickness in young and middle-aged ischemic stroke patients and controls: the Norwegian Stroke in the Young Study. | Fromm A et al. | β | 2014 | β |
| Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. | Dichgans M et al. | β | 2014 | β |
| Stroke genetics: a review and update. | Lindgren A | β | 2014 | β |
| The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: a Mendelian randomization study. | Leong A et al. | β | 2014 | β |
| The single nucleotide polymorphism rs2208454 confers an increased risk for ischemic stroke: a case-control study. | Luo M et al. | β | 2014 | β |
| [Update on the genetics of stroke]. | LΓ³pez FernΓ‘ndez JC et al. | β | 2014 | β |
| Variant rs1906591 on chromosome 4q25 confers increased risk of cardioembolic stroke in Chinese patients. | Luo M et al. | β | 2014 | β |
| Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke. | LΓΆvkvist H et al. | β | 2014 | β |
| 17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status. | Adib-Samii P et al. | β | 2013 | β |
| Advances in stroke: genetics 2012. | Meschia JF et al. | β | 2013 | β |
| ALDH2, a novel protector against stroke? | Sun A et al. | β | 2013 | β |
| Clinical neurogenetics: stroke. | Rost NS | β | 2013 | β |
| Coagulation factorΒ XIII Tyr204Phe gene variant and the risk of ischemic stroke. | Landau MB et al. | β | 2013 | β |
| Detailed analysis of gene polymorphisms associated with ischemic stroke in South Asians. | Yadav S et al. | β | 2013 | β |
| Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis. | Markus HS et al. | β | 2013 | β |
| Genetic profiles in ischaemic stroke. | Bevan S et al. | β | 2013 | β |
| Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association. | Ganesh SK et al. | β | 2013 | β |
| Genetics of ischaemic stroke. | Sharma P et al. | β | 2013 | β |
| [Genetics of ischemic stroke]. | Gschwendtner A et al. | β | 2013 | β |
| Genome-wide analysis of blood pressure variability and ischemic stroke. | Yadav S et al. | β | 2013 | β |
| Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke. | Liao YC et al. | β | 2013 | β |
| Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis. | Cao YY et al. | β | 2013 | β |
| Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes. | Traylor M et al. | β | 2013 | β |
| WellcomeTrust genome-wide association study of ischemic stroke. | Markus HS | β | 2013 | β |
| Next frontiers in the genetic epidemiology of Alzheimer's disease. | Ikram MA et al. | β | 2012 | β |