AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future.

paper Cited Public

Authors: Bowers, M Scott; Chen, Billy T; Bonci, Antonello
Year: 2010
Journal: Neuron
PMID: 20624588
DOI: 10.1016/j.neuron.2010.06.004
PMCID: PMC2904302

#	Section	Preview
20	2. Psychostimulant-induced synaptic plasticity — 2.1 Cocaine-induced synaptic plasticity: VTA	al., 2009) offer another promising tool in which drug-induced alterations in synaptic function can…
21	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	NAcb AMPAR activation is implicated in many cocaine-seeking behaviors (Conrad et al., 2008; Cornish…
22	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	Passive cocaine exposure can alter NAcb AMPAR function, but on a different time course than in the…
23	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	et al., 1995) and in biochemical experiments (Boudreau et al., 2007). However, after a longer…
24	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	Unlike the effects of non-contingent infusions of cocaine, the effects of voluntary cocaine…
25	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	et al., 2008). The increase in GluA2-lacking AMPAR appears to play an important role in facilitating…
26	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	Cocaine self-administration can also alter regulation of glutamate release in the NAcb. Decreased…
27	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	Thus, protracted abstinence from cocaine self-administration can induce at least two separate…
28	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	A recent study shows that cocaine-induced potentiation of glutamatergic transmission in the NAcb…
29	2. Psychostimulant-induced synaptic plasticity — 2.2 Cocaine-induced synaptic plasticity: NAcb	drug-related cues while de-emphasizing all other non-drug stimuli or cues. This is hypothesized to…
30	3. Second messenger pathways that can modulate AMPAR function	A number of studies has shown that signaling through the cAMP response element binding protein…
31	3. Second messenger pathways that can modulate AMPAR function	Increased CREB phosphorylation appears to regulate cocaine reinforcement, as NAcb CREB…
32	3. Second messenger pathways that can modulate AMPAR function	Another downstream CREB target, ΔFosB, is also quite interesting, in part due to a unique,…
33	3. Second messenger pathways that can modulate AMPAR function	Analysis of postmortem midbrain (Tang et al., 2003) and NAcb (Hemby et al., 2005) tissue collected…
34	3. Second messenger pathways that can modulate AMPAR function	Psychostimulants can also interact with AMPAR plasticity in more complex ways. The capacity of…
35	3. Second messenger pathways that can modulate AMPAR function	Although CREB is predominantly thought of in relation to PKA-mediated signaling, extracellular…
36	3. Second messenger pathways that can modulate AMPAR function	Synaptic strengthening can be accompanied by neurite outgrowth, spine splitting, and synaptogenesis.…
37	3. Second messenger pathways that can modulate AMPAR function	novel environment (Lu et al., 2002), and heightened reactivity to novel situations has been used as…
38	3. Second messenger pathways that can modulate AMPAR function	There are several molecular changes that emerge during abstinence from psychostimulant exposure that…
39	3. Second messenger pathways that can modulate AMPAR function	Horger et al., 1999; Lu et al., 2004a) can reversibly modulate behavior and synaptic plasticity (Pu…

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In this knowledge base

Title	Year	PMID
The genetic epidemiology of substance use disorder: A review.	2017	28938182
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling.	2011	21338877

External

Title	Authors	Journal	Year	Link
An emerging role for synaptic Zn<sup>2+</sup> in substance use disorders.	Solis O et al.	—	2026	→
AMPA/kainate receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving.	Huerta Sanchez LL et al.	—	2025	→
AMPA receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving	Sanchez LLH et al.	—	2025	—
Synaptic Plasticity Linked to Ionotropic Glutamate Receptors After Nicotine Exposure.	Kazmi A et al.	—	2025	→
AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal.	Bai X et al.	—	2023	→
Autophosphorylation of αCaMKII regulates alcohol consumption by controlling sedative effects of alcohol and alcohol-induced loss of excitatory synapses.	Cały A et al.	—	2023	→
[Brain iron deposition increases in the bilateral substantia nigra of patients with medication-overuse headache: a quantitative susceptibility mapping analysis].	Li X et al.	—	2023	→
The excitatory transmission from basolateral nuclues of amygdala to nucleus accumbens shell regulates propofol self-administration through AMPA receptors.	Dong Z et al.	—	2023	→
Domain-selective BET inhibition attenuates transcriptional and behavioral responses to cocaine.	Singh MB et al.	—	2022	→
Synaptic plasticity in two cell types of central amygdala for regulation of emotion and pain.	Ge J et al.	—	2022	→
Cocaine-seeking behaviour is differentially expressed in male and female mice exposed to maternal separation and is associated with alterations in AMPA receptors subunits in the medial prefrontal cortex.	Castro-Zavala A et al.	—	2021	→
Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression.	Nguyen ATM et al.	—	2021	→
Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease.	Chen APF et al.	—	2021	→
Maternal separation increases cocaine intake through a mechanism involving plasticity in glutamate signalling.	Castro-Zavala A et al.	—	2021	→
Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap?	Hersey M et al.	—	2021	→
GluA1 in central amygdala increases pain but inhibits opioid withdrawal-induced aversion.	Cai YQ et al.	—	2020	→
GluA1 in Central Amygdala Promotes Opioid Use and Reverses Inhibitory Effect of Pain.	Hou YY et al.	—	2020	→
Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory.	Gao SQ et al.	—	2020	→
One Is Not Enough: Understanding and Modeling Polysubstance Use.	Crummy EA et al.	—	2020	→
Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission.	Nudmamud-Thanoi S et al.	—	2020	→
Sex differences in the vulnerability to cocaine's addictive effects after early-life stress in mice.	Castro-Zavala A et al.	—	2020	→
Ultrasound stress compromises the correlates of emotional-like states and brain AMPAR expression in mice: effects of antioxidant and anti-inflammatory herbal treatment.	Costa-Nunes JP et al.	—	2020	→
Brain activity of anandamide: a rewarding bliss?	Scherma M et al.	—	2019	→
Prenatal ethanol exposure increases risk of psychostimulant addiction.	Wang R et al.	—	2019	→
Targeting redox regulation to treat substance use disorder using N‐acetylcysteine	Womersley JS et al.	—	2019	→
Activation of Protein Kinase G After Repeated Cocaine Administration Is Necessary for the Phosphorylation of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor GluA1 at Serine 831 in the Rat Nucleus Accumbens.	Yang JH et al.	—	2018	→
Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior.	Whitaker LR et al.	—	2018	→
Chronic voluntary oral methamphetamine induces deficits in spatial learning and hippocampal protein kinase Mzeta with enhanced astrogliosis and cyclooxygenase-2 levels.	Avila JA et al.	—	2018	→
Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications.	Caprioli D et al.	—	2018	→
Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell.	Ebner SR et al.	—	2018	→
Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis.	Iamjan SA et al.	—	2018	→
Modulation of salience network intranetwork resting state functional connectivity in women with chronic migraine.	Androulakis XM et al.	—	2018	→
Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling.	Hearing M et al.	—	2018	→
Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression.	Sepulveda-Orengo MT et al.	—	2018	→
The role of caveolin-1 in morphine-induced structural plasticity in primary cultured mouse cerebral cortical neurons.	Cui W et al.	—	2018	→
Autophosphorylation of alpha isoform of calcium/calmodulin-dependent kinase II regulates alcohol addiction-related behaviors.	Mijakowska Z et al.	—	2017	→
Heroin-piracetam mixture: Suggested mechanisms of action and risks of misinterpretation for drug users.	Cappelletti S et al.	—	2017	→
Increased BDNF may not be associated with cognitive impairment in heroin-dependent patients.	Luan X et al.	—	2017	→
Matrix Metalloproteinase-9 and Synaptic Plasticity in the Central Amygdala in Control of Alcohol-Seeking Behavior.	Stefaniuk M et al.	—	2017	→
Mechanistic Resolution Required to Mediate Operant Learned Behaviors: Insights from Neuronal Ensemble-Specific Inactivation.	Warren BL et al.	—	2017	→
Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core.	Marron Fernandez de Velasco E et al.	—	2017	→
The genetic epidemiology of substance use disorder: A review.	Prom-Wormley EC et al.	—	2017	→
Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons.	Jedynak J et al.	—	2016	→
Differential Control of Cocaine Self-Administration by GABAergic and Glutamatergic CB1 Cannabinoid Receptors.	Martín-García E et al.	—	2016	→
Disrupting GluA2 phosphorylation potentiates reinstatement of cocaine seeking.	Briand LA et al.	—	2016	→
Dopamine Replacement Therapy, Learning and Reward Prediction in Parkinson's Disease: Implications for Rehabilitation.	Ferrazzoli D et al.	—	2016	→
eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.	Placzek AN et al.	—	2016	→
Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats.	Poland RS et al.	—	2016	→
Increased expression of proenkephalin and prodynorphin mRNAs in the nucleus accumbens of compulsive methamphetamine taking rats.	Cadet JL et al.	—	2016	→
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.	Huang W et al.	—	2016	→
Assembly of AMPA receptors: mechanisms and regulation.	Gan Q et al.	—	2015	→
Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice.	Mereu M et al.	—	2015	→
Gambling disorder and its relationship with substance use disorders: implications for nosological revisions and treatment.	Grant JE et al.	—	2015	→
GIRK Channel Plasticity and Implications for Drug Addiction.	Marron Fernandez de Velasco E et al.	—	2015	→
Nucleus accumbens AMPA receptor involvement in cocaine-conditioned place preference under different dietary conditions in rats.	Zheng D et al.	—	2015	→
Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala.	Hou YY et al.	—	2015	→
Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits.	Hussain S et al.	—	2015	→
Psychostimulants affect dopamine transmission through both dopamine transporter-dependent and independent mechanisms.	Dela Peña I et al.	—	2015	→
Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms.	Fuccillo MV et al.	—	2015	→
The Brain on Drugs: From Reward to Addiction.	Volkow ND et al.	—	2015	→
The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option.	Siniscalchi A et al.	—	2015	→
Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction.	Cruz FC et al.	—	2015	→
Addiction science: Uncovering neurobiological complexity.	Volkow ND et al.	—	2014	→
CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking.	Williams CL et al.	—	2014	→
Dopamine D₁-D₂ receptor heteromer regulates signaling cascades involved in addiction: potential relevance to adolescent drug susceptibility.	Perreault ML et al.	—	2014	→
Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone.	Leggio GM et al.	—	2014	→
Glial modulators as potential treatments of psychostimulant abuse.	Beardsley PM et al.	—	2014	→
Implication of NMDA receptors in behavioural sensitization to psychostimulants: a short review.	Landa L et al.	—	2014	→
Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors.	Hauser KF et al.	—	2014	→
Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms.	Jayanthi S et al.	—	2014	→
Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors.	Braren SH et al.	—	2014	→
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Neurocircuitry of drug reward.	Ikemoto S et al.	—	2014	→
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Activation of protein kinase C is required for AMPA receptor GluR1 phosphorylation at serine 845 in the dorsal striatum following repeated cocaine administration.	Oh JH et al.	—	2013	→
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.	Farrell MS et al.	—	2013	→
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Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement.	Cannady R et al.	—	2013	→
Episodic memories and their relevance for psychoactive drug use and addiction.	Müller CP	—	2013	→
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Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.	Kempadoo KA et al.	—	2013	→
Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats.	Vélez-Hernández ME et al.	—	2013	→
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Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum.	Cerovic M et al.	—	2013	→
New technologies for examining the role of neuronal ensembles in drug addiction and fear.	Cruz FC et al.	—	2013	→
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Routes, destinations and delays: recent advances in AMPA receptor trafficking.	Henley JM et al.	—	2011	→
Striatal signal transduction and drug addiction.	Philibin SD et al.	—	2011	→
The emerging link between autoimmune disorders and neuropsychiatric disease.	Kayser MS et al.	—	2011	→
The role of NMDA and AMPA/Kainate receptors in the consolidation of catalepsy sensitization.	Riedinger K et al.	—	2011	→
The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders.	Winstanley CA	—	2011	→