Contributions of studies on alcohol use disorders to understanding cerebellar function.

paper Cited Public

Authors: Zahr, Natalie M; Pitel, Anne-Lise; Chanraud, Sandra; Sullivan, Edith V
Year: 2010
Journal: Neuropsychology review
PMID: 20809198
DOI: 10.1007/s11065-010-9141-y
PMCID: PMC2998898

#	Section	Preview
20	Brain Structure/Function Relationships in Alcohol Use Disorders	Part B of the Trail Making Test, which assesses visual search, working memory, and cognitive…
21	Conclusion	This overview proposes the guiding hypothesis that disruption of frontocerebellar circuitry is one…
22	Conclusion	activity may also be a source of maintenance of addictive behavior, given the roles of the…

Name	Type
abstinence	phenotype
addiction	phenotype
alcohol	phenotype
alcohol abuse	phenotype
alcohol dependence	phenotype
alcoholics with a history of thiamine deficiency local	cohort
alcoholics with exceptionally high levels of alcohol consumption local	cohort
Alcoholics with Wernicke-Korsakoff syndrome local	cohort
alcoholism	phenotype
anterior cingulate cortex	anatomy
Anterior lobe local	anatomy
ataxia	phenotype
auditory-verbal-learning test performance local	phenotype
axial diffusivity	phenotype
axonal deletion local	phenotype
axonal integrity	phenotype
axonal (Wallerian) degeneration local	phenotype
basal ganglia	anatomy
Bilateral extrastriate cortices local	anatomy
Body sway	phenotype
Brain Volume Deficits local	phenotype
brain white matter	anatomy
Central pontine myelinolysis	phenotype
Central pontine sites local	anatomy
cerebellar cortex	anatomy
cerebellar hemisphere	anatomy
cerebellar region	anatomy
Cerebellar systems local	anatomy
cerebellar vermis	anatomy
Cerebellar white matter volume reduction local	phenotype
cerebellum	anatomy
cerebral hemispheres	anatomy
Cho	drug
choline	drug
Chronic Alcohol Dependent Subjects local	cohort
chronic alcoholism	phenotype
cognition	phenotype
cognitive flexibility	phenotype
controls	cohort
Corticocerebellar fiber systems local	anatomy
Corticopontine pathway local	anatomy
CPM	phenotype
Curtailed Longevity local	phenotype
demyelination	phenotype
denial	phenotype
Diffusion Tensor Imaging local	phenotype
dorsolateral prefrontal cortex	anatomy
dorsomedial prefrontal cortex	anatomy
excessive alcohol consumption	phenotype
Executive deficits local	phenotype
executive functioning	phenotype
Fluency local	phenotype
fractional anisotropy	phenotype
frontal cortex	anatomy
Frontal fiber bundles local	anatomy
frontal lobe white matter local	anatomy
frontocerebellar circuitry	anatomy
Frontocerebellar network local	anatomy
granular layer	anatomy
gray matter	anatomy
human alcoholic subjects local	cohort
implicit learning local	phenotype
increase in water content of frontal lobe white matter local	phenotype
individuals that relapsed local	cohort
Inferior fiber bundles local	anatomy
infratentorial tissue local	anatomy
lateral prefrontal cortex	anatomy
Left extrastriate cortex local	anatomy
left prefrontal cortex	anatomy
Letter-number sequencing local	phenotype
Maximum daily alcohol consumption local	drug
mean diffusivity	phenotype
microscopic white matter lesions local	phenotype
Microstructural degradation local	phenotype
midbrain	anatomy
molecular layer	anatomy
motor coordination	phenotype
motor cortex	anatomy
myelin integrity local	phenotype
Myelin Integrity local	phenotype
NAA	drug
N-acetylaspartate	drug
neuronal integrity	phenotype
Nonverbal fluency local	phenotype
pallidum	anatomy
parietal cortex	anatomy
patients that relapsed within 3 weeks of detoxification local	cohort
pons	anatomy
Pontine relaxation times local	phenotype
Poor performance on tasks local	phenotype
Posterior fiber bundles local	anatomy
posterior inferior vermis local	anatomy
postural instability local	phenotype
precuneus	anatomy
prefrontal cortex	anatomy
procedural learning	phenotype
Quadriplegia local	phenotype
radial diffusivity	phenotype
Recently detoxified alcoholics local	cohort
reduction in white matter volume local	phenotype
relapse	phenotype
Right superior cerebellum local	anatomy
Stroop task	phenotype
Structural MRI local	phenotype
Superior fiber bundles local	anatomy
superior frontal cortex	anatomy
tCr	drug
thalamus	anatomy
thiamine	drug
thiamine deficiency	drug
those that remained abstinent local	cohort
Trail Making Test Part B local	phenotype
truncal tremor local	phenotype
uncomplicated alcoholics	phenotype
verbal fluency	phenotype
Vermal white matter local	anatomy
Vermal white matter loss local	phenotype
Visual search local	phenotype
Visuospatial deficits	phenotype
visuospatial learning and memory performance local	phenotype
Wernicke-Korsakoff syndrome	phenotype
white matter	anatomy
white matter disruption local	phenotype
White matter impairment local	phenotype
white matter shrinkage local	phenotype
White matter volume shrinkage local	phenotype
Wisconsin Card Sorting test local	phenotype
working memory	phenotype

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In this knowledge base

Title	Year	PMID
Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks.	2021	34601489
Understanding alcohol use disorders with neuroelectrophysiology.	2014	25307587

External

Title	Authors	Journal	Year	Link
Assessment of Postural Stability in Semi-Open Prisoners: A Pilot Study.	Błażkiewicz M et al.	—	2025	→
Compensation patterns and altered functional connectivity in alcohol use disorder with and without Korsakoff's syndrome.	Morand A et al.	—	2024	→
Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.	Guo J et al.	—	2024	→
Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.	Maggioni E et al.	—	2023	→
Coordination and Cognition in Pure Nutritional Wernicke's Encephalopathy with Cerebellar Degeneration after COVID-19 Infection: A Unique Case Report.	Arts NJM et al.	—	2023	→
Alcohol and the Brain.	Nutt D et al.	—	2021	→
Altered Cerebro-Cerebellar Dynamic Functional Connectivity in Alcohol Use Disorder: a Resting-State fMRI Study.	Abdallah M et al.	—	2021	→
Contribution of sleep disturbances to the heterogeneity of cognitive and brain alterations in alcohol use disorder.	Laniepce A et al.	—	2021	→
Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks.	Lim Y et al.	—	2021	→
Frontocerebellar gray matter plasticity in alcohol use disorder linked to abstinence.	Muller AM et al.	—	2021	→
Alcohol use disorders and the brain.	Rao R et al.	—	2020	→
Cerebellar Morphometry and Cognition in the Context of Chronic Alcohol Consumption and Cigarette Smoking.	Cardenas VA et al.	—	2020	→
A Pivotal Role for Thiamine Deficiency in the Expression of Neuroinflammation Markers in Models of Alcohol-Related Brain Damage.	Toledo Nunes P et al.	—	2019	→
Cerebellar Hypermetabolism in Alcohol Use Disorder: Compensatory Mechanism or Maladaptive Plasticity?	Ritz L et al.	—	2019	→
Effects of drinking on late-life brain and cognition.	Topiwala A et al.	—	2018	→
Frontal lobe executive dysfunction and cerebral perfusion study in alcohol dependence syndrome.	Khanna P et al.	—	2017	→
Movement Disorders in Non-Wilsonian Hepatic Cirrhotic Patients: The Subgroup Analysis of Various Phenotypes and Associated Risk Factors.	Methawasin K et al.	—	2016	→
Volumetric Differences in Cerebellar Lobes in Individuals from Multiplex Alcohol Dependence Families and Controls: Their Relationship to Externalizing and Internalizing Disorders and Working Memory.	Hill SY et al.	—	2016	→
Alcohol-related brain damage in older people.	Rao R et al.	—	2015	→
Ethanol intake-induced apoptosis in glial cells and axonal disorders in the cerebellar white matter of UChA rats (voluntary ethanol consumers).	Martinez M et al.	—	2015	→
FDG-PET Contributions to the Pathophysiology of Memory Impairment.	Segobin S et al.	—	2015	→
Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex--Recent Advances.	Valenzuela CF et al.	—	2015	→
Thalamic abnormalities are a cardinal feature of alcohol-related brain dysfunction.	Pitel AL et al.	—	2015	→
Alcohol and the sleeping brain.	Colrain IM et al.	—	2014	→
[Alcohol induced cognitive deficits].	Weiss E et al.	—	2014	→
Assessment of motor and process skills in daily life activities of treated substance addicts.	Rojo-Mota G et al.	—	2014	→
Chronic alcohol consumption and its effect on nodes of frontocerebellar and limbic circuitry: comparison of effects in France and the United States.	Le Berre AP et al.	—	2014	→
Cognitive functioning in older adults with early, late, and very late onset alcohol dependence.	Kist N et al.	—	2014	→
Compensatory recruitment of neural resources in chronic alcoholism.	Chanraud S et al.	—	2014	→
Effects of ethanol on immune response in the brain: region-specific changes in adolescent versus adult mice.	Kane CJ et al.	—	2014	→
Understanding alcohol use disorders with neuroelectrophysiology.	Rangaswamy M et al.	—	2014	→
Altered resting-state connectivity in adolescent cannabis users.	Orr C et al.	—	2013	→
Modulation of limbic-cerebellar functional connectivity enables alcoholics to recognize who is who.	Pitel AL et al.	—	2013	→
Function and dysfunction of prefrontal brain circuitry in alcoholic Korsakoff's syndrome.	Oscar-Berman M	—	2012	→
Neuroanatomy and neuropathology associated with Korsakoff's syndrome.	Kril JJ et al.	—	2012	→
The cerebellum as a target for estrogen action.	Hedges VL et al.	—	2012	→
Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF.	Hill SY et al.	—	2011	→
Clinical and pathological features of alcohol-related brain damage.	Zahr NM et al.	—	2011	→
Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain.	Zahr NM et al.	—	2011	→