Transactions Between Substance Use Intervention, the Oxytocin Receptor (OXTR) Gene, and Peer Substance Use Predicting Youth Alcohol Use.

paper Cited Public

Authors: Cleveland, H Harrington; Griffin, Amanda M; Wolf, Pedro S A; Wiebe, Richard P; Schlomer, Gabriel L; Feinberg, Mark E; Greenberg, Mark T; Spoth, Richard L; Redmond, Cleve; Vandenbergh, David J
Year: 2018
Journal: Prevention science : the official journal of the Society for Prevention Research
PMID: 28150062
DOI: 10.1007/s11121-017-0749-5
PMCID: PMC5696096

#	Section	Preview
20	Methods — Measures — Peer Substance Use	Social network modeling of peer substance use in these data is detailed elsewhere (Osgood, Ragan et…
21	Methods — Measures — Alcohol Use	Alcohol use by the 9th grade was assessed using three aggregated “Yes” (1) or “No” (0)…
22	Methods — Statistical Analysis	To address the clustered structure of the data (i.e., children nested within schools), we fit a…
23	Results — Preliminary Results	Three sets of preliminary analyses were conducted to examine possible sources of bias in the data.…
24	Results — Preliminary Results	equilibrium (p-values > 0.05), consistent with accurate genotyping. In addition, the SNPs were not…
25	Results — Primary Analysis	To examine Hypothesis 1 analyses were conducted to determine the moderating role of OXTR risk on the…
26	Results — Primary Analysis	in the intervention condition. Figure 2 shows that affiliations with substance-using friends were…
27	Results — Primary Analysis	A series of three models predicting 9th-Grade Alcohol Use were conducted to examine Hypotheses 2…
28	Results — Primary Analysis	The effects of the three-way interaction were probed using a series of conditional main effects…
29	Results — Primary Analysis	Figure 3 presents the associations between peer substance use and adolescent alcohol use in the…
30	Results — Primary Analysis	the intervention condition. The divergence can be accounted for by lower alcohol use among…
31	Results — Primary Analysis	In addition, we considered whether the primary results held up when controlling for participation in…
32	Results — Primary Analysis	Key findings from these results are that: (1) low OXTR risk youth associate with low substance-using…
33	Discussion	The purpose of this study was to investigate whether OXTR variation moderated intervention effects…
34	Discussion	In contrast to this clear result, analyses addressing the possible role of OXTR variation on the…
35	Discussion	That affiliation with substance-using friends is similarly linked to individual adolescents’…
36	Discussion	Framed differently, findings also contribute to our understanding of just what OXTR variation itself…
37	Discussion — Limitations and Future Directions	The current study uses a cGxE framework to examine the effect of the interactive relationship among…
38	Discussion — Limitations and Future Directions	into whom is being affected by interventions and why. Other approaches offer advantages as well.…
39	Discussion — Limitations and Future Directions	The current analyses predict alcohol use, but not volume or frequency. We chose this measure because…

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In this knowledge base

Title	Year	PMID
Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?".	2018	28735446

External

Title	Authors	Journal	Year	Link
Pet ownership is associated with harmful alcohol use among a cohort of people with HIV: a brief research report.	Applebaum JW et al.	—	2023	→
Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review.	Kohlhoff J et al.	—	2022	→
Alcohol and oxytocin: Scrutinizing the relationship.	Ryabinin AE et al.	—	2021	→
A systematic review of gene-by-intervention studies of alcohol and other substance use.	Neale ZE et al.	—	2021	→
Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice.	Rodriguez KM et al.	—	2020	→
Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention.	Cleveland HH et al.	—	2018	→
A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.	Kim J et al.	—	2018	→
Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?"	Dick DM	—	2018	→
The Implications of Genetics for Prevention and Intervention Programming.	Musci RJ et al.	—	2018	→