Transactions Between Substance Use Intervention, the Oxytocin Receptor (OXTR) Gene, and Peer Substance Use Predicting Youth Alcohol Use.

paper Cited Public

Authors: Cleveland, H Harrington; Griffin, Amanda M; Wolf, Pedro S A; Wiebe, Richard P; Schlomer, Gabriel L; Feinberg, Mark E; Greenberg, Mark T; Spoth, Richard L; Redmond, Cleve; Vandenbergh, David J
Year: 2018
Journal: Prevention science : the official journal of the Society for Prevention Research
PMID: 28150062
DOI: 10.1007/s11121-017-0749-5
PMCID: PMC5696096

#	Section	Preview
0	Peer Selection and Influence and the Role of Genetic Variance	Affiliating with peers who engage in risk behaviors such as substance use increases adolescents’…
1	Peer Selection and Influence and the Role of Genetic Variance	It is important to emphasize that although adolescents may model the behaviors of distant peers and…
2	Peer Selection and Influence and the Role of Genetic Variance	Although findings that link peer affiliations to genetic variation, like all biometric results, do…
3	Substance Misuse Interventions within the PROSPER Project	Given the importance of peer influence for substance use, many preventive interventions are designed…
4	Substance Misuse Interventions within the PROSPER Project	For their school-based program, four communities selected Life Skills Training (Botvin, 2000) and…
5	Candidate Gene Moderation of Intervention Effects	Research adding specific genetic variance to data from preventative intervention studies, including…
6	Candidate Gene Moderation of Intervention Effects	Genetic moderation of intervention effects can also be conditioned by other aspects of the…
7	The Role of Oxytocin in Social Behavior	The foregoing studies involved two commonly examined genetic variants related to dopamine and…
8	The Role of Oxytocin in Social Behavior	and pair bonding to OXTR variation (Walum et al., 2012). Socially relevant characteristics including…
9	The Role of Oxytocin in Social Behavior	It should be noted that although the OXT gene contributes directly to the production of the oxytocin…
10	Current Study	The current study examined whether variability in the OXTR gene moderated associations among (a) the…
11	Current Study	Given that individual differences in affiliations with substance-using peers are heritable…
12	Current Study	(2015) finding that the intervention potentiated the impact of high maternal involvement on alcohol…
13	Current Study	Four hypotheses guided our inquiry: First, OXTR variation will moderate the association between…
14	Methods — Sample and participants	The PROSPER project is an evidence-based intervention program with longitudinal data on 28…
15	Methods — Sample and participants	The gPROSPER sample includes 2,032 youth participating in the larger PROSPER project who provided…
16	Methods — Measures — Control for population stratification (PC1)	When testing for GxE (including G×I), it is important to account for differences in genotype and…
17	Methods — Measures — OXTR Genetic Risk Score	DNA was collected using buccal swabs and genotyped using TaqMan assays on an OpenArray system (Life…
18	Methods — Measures — OXTR Genetic Risk Score	SNP, indicating that rs7632287 could be used as a proxy (R2 = .95;1000 Genomes Project Consortium,…
19	Methods — Measures — Intervention Status	Of the analytic sample, 729 (51.4%) attended and participated in the school intervention, while the…

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In this knowledge base

Title	Year	PMID
Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?".	2018	28735446

External

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Pet ownership is associated with harmful alcohol use among a cohort of people with HIV: a brief research report.	Applebaum JW et al.	—	2023	→
Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review.	Kohlhoff J et al.	—	2022	→
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Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice.	Rodriguez KM et al.	—	2020	→
Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention.	Cleveland HH et al.	—	2018	→
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Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?"	Dick DM	—	2018	→
The Implications of Genetics for Prevention and Intervention Programming.	Musci RJ et al.	—	2018	→