Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders.

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Authors: Cho, Seung Bin; Aliev, Fazil; Clark, Shaunna L; Adkins, Amy E; Edenberg, Howard J; Bucholz, Kathleen K; Porjesz, Bernice; Dick, Danielle M
Year: 2017
Journal: Behavior genetics
PMID: 28343281
DOI: 10.1007/s10519-017-9844-4
PMCID: PMC5996973

#	Section	Preview
0	Introduction	Twin studies of the genetic architecture of comorbid psychiatric disorders suggest considerable…
1	Introduction	in genetic analyses (Benke et al. 2014; Derringer et al. 2015; Dick et al. 2008; McGue et al. 2013).…
2	Introduction	In this study, we used GWAS summary statistics to elucidate shared genetic etiology across…
3	Method — Participants and measures	The case-control GWAS subsample was selected from the collaborative study on the genetics of…
4	Method — Participants and measures	were selected from both community-ascertained families and families with alcohol dependent probands,…
5	Method — Participants and measures	counts of AD, ASP, and MD were used as phenotypes for GWAS, and sex was used as a covariate. GWAS…
6	Statistical analysis	We applied LPA to the log of p-values from the GWAS of AD, ASP, and MD symptom counts. LPA is a…
7	Statistical analysis	Although other statistics from association results, such as regression coefficient beta, t…
8	Statistical analysis	In our analyses, we utilized three primary sets of parameters to interpret the results of LPA.…
9	Statistical analysis	We fit LPAs with two to ten classes and examined classifications of SNPs across LPAs with different…
10	Statistical analysis	we used both information criteria and the bootstrap likelihood ratio test (BLRT) (McLachlan and Peel…
11	Statistical analysis	Results of the LPA models were compared to the results from subsets of the data and alternative…
12	Statistical analysis	to examine how the number of clusters and class profiles from non-parametric model compare to the…
13	Results	Table 1 summarizes fit indices and entropy values resulting from the LPA of 2- to 9-class models…
14	Results	Response profiles of classes identified in 2- to 4-class models are summarized in Table 2 and in…
15	Results	and had a profile characterized by relatively low means of class indicators for all three…
16	Results	Patterns of classification, based on most likely class memberships, across LPAs with 2–4 classes…
17	Results	Results from LPA models applied to a subset of SNPs pruned at r2 = 0.1 were very close to the…
18	Results	those from simulated null distributions from varying number of clusters, and the largest difference…
19	Results	cluster mostly remained in the MD cluster of 4-means model. Results of LPA from split-half samples…

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Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders.

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