The genetics of addiction-a translational perspective.
paper
Cited
Public
- Authors
- Agrawal, A; Verweij, K J H; Gillespie, N A; Heath, A C; Lessov-Schlaggar, C N; Martin, N G; Nelson, E C; Slutske, W S; Whitfield, J B; Lynskey, M T
- Year
- 2012
- Journal
- Translational psychiatry
- PMID
- 22806211
- DOI
- 10.1038/tp.2012.54
- PMCID
- PMC3410620
Addictions are serious and common psychiatric disorders, and are among the leading contributors to preventable death. This selective review outlines and highlights the need for a multi-method translational approach to genetic studies of these important conditions, including both licit (alcohol, nicotine) and illicit (cannabis, cocaine, opiates) drug addictions and the behavioral addiction of disordered gambling. First, we review existing knowledge from twin studies that indicates both the substantial heritability of substance-specific addictions and the genetic overlap across addiction to different substances. Next, we discuss the limited number of candidate genes which have shown consistent replication, and the implications of emerging genomewide association findings for the genetic architecture of addictions. Finally, we review the utility of extensions to existing methods such as novel phenotyping, including the use of endophenotypes, biomarkers and neuroimaging outcomes; emerging methods for identifying alternative sources of genetic variation and accompanying statistical methodologies to interpret them; the role of gene-environment interplay; and importantly, the potential role of genetic variation in suggesting new alternatives for treatment of addictions.
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors. | Kallupi M et al. | — | 2026 | → |
| Addiction Susceptibility: Genetic Factors, Personality Traits, and Epigenetic Interactions with the Gut Microbiome. | Borrego-Ruiz A et al. | — | 2025 | → |
| Impulsivity and substance misuse among Turkish people: Serial mediating effect of emotion dysregulation and general anxiety disorder. | Gocet Tekin E et al. | — | 2025 | → |
| The influence of dopamine receptor SNPs on substance use disorder in a Jordanian cohort. | Al-Sanabra O et al. | — | 2025 | → |
| The Structural Validity and Psychometric Properties of the KEY Measure. | Elovainio M et al. | — | 2025 | → |
| A critical review of ethanol effects on neuronal firing: A metabolic perspective. | Popova D et al. | — | 2024 | → |
| Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. | Toikumo S et al. | — | 2024 | → |
| The genetic landscape of substance use disorders. | Gerring ZF et al. | — | 2024 | → |
| The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications. | Bigio B et al. | — | 2024 | → |
| Associations Between E-cigarettes and Subsequent Cocaine Use in Adolescence: An Analysis of the UK Millennium Cohort Study. | Silva CP et al. | — | 2023 | → |
| Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries. | Cassaday HJ et al. | — | 2023 | → |
| Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers. | Borrego-Soto G et al. | — | 2023 | → |
| How has the brain disease model of addiction contributed to tobacco control? | Hall W et al. | — | 2023 | → |
| Prevalence and heritability of alcohol use disorders in 18-year old Swedish twins. | Hildebrand Karlén M et al. | — | 2023 | → |
| Social genetic effects for drug use disorder among spouses. | Salvatore JE et al. | — | 2023 | → |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | — | 2023 | → |
| The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits. | Antón-Galindo E et al. | — | 2023 | → |
| The Stage-Based Model of Addiction-Using <i>Drosophila</i> to Investigate Alcohol and Psychostimulant Responses. | Cummins-Beebee PN et al. | — | 2023 | → |
| Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood. | Deak JD et al. | — | 2022 | → |
| Buprenorphine exposure levels to optimize treatment outcomes in opioid use disorder. | Laffont CM et al. | — | 2022 | → |
| Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence. | Quintanilla ME et al. | — | 2022 | → |
| FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. | Vereczkei A et al. | — | 2022 | → |
| Functional Genomic Analysis of Amphetamine Sensitivity in <i>Drosophila</i>. | Karam CS et al. | — | 2022 | → |
| Individual differences in oxycodone addiction-like behaviors in a large cohort of heterogeneous stock (HS) rats | Kallupi M et al. | — | 2022 | — |
| Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse. | Corongiu S et al. | — | 2022 | → |
| Molecular genetics of cocaine use disorders in humans. | Fernàndez-Castillo N et al. | — | 2022 | → |
| Prevalence of Addictive Behaviors in Medical Students and Their Association With Stress. | Lee J et al. | — | 2022 | → |
| The relationship between social support and Internet addiction among Chinese college freshmen: A mediated moderation model. | Lu X et al. | — | 2022 | → |
| Associations between adolescent cannabis use and young-adult functioning in three longitudinal twin studies. | Schaefer JD et al. | — | 2021 | → |
| Commentary: Addiction, Stigma, and Neurodiversity. | Sussman S | — | 2021 | → |
| Genetics of substance use disorders: a review. | Deak JD et al. | — | 2021 | → |
| Integrating genetic and clinical data to predict impulse control disorders in Parkinson's disease. | Jesús S et al. | — | 2021 | → |
| Molecular genetics of substance use disorders: An umbrella review. | Lopez-Leon S et al. | — | 2021 | → |
| The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. | Carrette LLG et al. | — | 2021 | → |
| Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme. | Hindocha C et al. | — | 2020 | → |
| Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. | Quach BC et al. | — | 2020 | → |
| On the path towards personalized medicine: Implications of pharmacogenetic studies of alcohol use disorder medications. | Nieto SJ et al. | — | 2020 | → |
| Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. | Datta U et al. | — | 2020 | → |
| Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse. | Sanchez-Roige S et al. | — | 2020 | → |
| Discovery of early life stress interacting and sex-specific quantitative trait loci impacting cocaine responsiveness. | Bagley JR et al. | — | 2019 | → |
| Explaining Excessive Weight Gain during Early Recovery from Addiction. | Gottfredson NC et al. | — | 2019 | → |
| Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use. | Allegrini AG et al. | — | 2019 | → |
| <i>OPRM1</i> A118G Polymorphisms and Its Role in Opioid Addiction: Implication on Severity and Treatment Approaches. | Taqi MM et al. | — | 2019 | → |
| Pre- and Post-Immigration Correlates of Alcohol Misuse among Young Adult Recent Latino Immigrants: An Ecodevelopmental Approach. | Levitt E et al. | — | 2019 | → |
| Prevalence of Some Genetic Risk Factors for Nicotine Dependence in Ukraine. | Bashynska V et al. | — | 2019 | → |
| Synaptic Regulation by OPRM1 Variants in Reward Neurocircuitry. | Popova D et al. | — | 2019 | → |
| The psychological and genetic factors of the addictive behaviors (PGA) study. | Kotyuk E et al. | — | 2019 | → |
| Application of Research Domain Criteria to childhood and adolescent impulsive and addictive disorders: Implications for treatment. | Yip SW et al. | — | 2018 | → |
| Behavioral Addictions as Mental Disorders: To Be or Not To Be? | Petry NM et al. | — | 2018 | → |
| Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. | Cannady R et al. | — | 2018 | → |
| Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence. | Lee SH et al. | — | 2018 | → |
| Environmental, genetic and epigenetic contributions to cocaine addiction. | Pierce RC et al. | — | 2018 | → |
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| Genome wide analysis of rare copy number variations in alcohol abuse or dependence. | Rodríguez-López J et al. | — | 2018 | → |
| Human Genetics of Addiction: New Insights and Future Directions. | Hancock DB et al. | — | 2018 | → |
| Review of Neurobiological Influences on Externalizing and Internalizing Pathways to Alcohol Use Disorder. | Hardee JE et al. | — | 2018 | → |
| A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. | Otto JM et al. | — | 2017 | → |
| DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age. | Kozlenkov A et al. | — | 2017 | → |
| Genetic and Environmental Influences on Gambling: A Meta-Analysis of Twin Studies. | Xuan YH et al. | — | 2017 | → |
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| Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations. | Chartier KG et al. | — | 2017 | → |
| Some Good News About Substance Use Disorders. | Worley J | — | 2017 | → |
| A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders. | Munn-Chernoff MA et al. | — | 2016 | → |
| Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement. | Carey CE et al. | — | 2016 | → |
| Causal Role of Alcohol Consumption in an Improved Lipid Profile: The Atherosclerosis Risk in Communities (ARIC) Study. | Vu KN et al. | — | 2016 | → |
| Clinical-genetic model predicts incident impulse control disorders in Parkinson's disease. | Kraemmer J et al. | — | 2016 | → |
| Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study. | Latvala A et al. | — | 2016 | → |
| DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample. | Fudalej S et al. | — | 2016 | → |
| Effect of Adolescent Cigarette Smoking on Adulthood Substance Use and Abuse: The Mediating Role of Educational Attainment. | Strong C et al. | — | 2016 | → |
| Effects of State-Level Tobacco Environment on Cigarette Smoking are Stronger Among Those With Individual-Level Risk Factors. | Shmulewitz D et al. | — | 2016 | → |
| Epidemiology of DSM-5 Drug Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III. | Grant BF et al. | — | 2016 | → |
| Evidence of CNIH3 involvement in opioid dependence. | Nelson EC et al. | — | 2016 | → |
| Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction. | Cadoni C | — | 2016 | → |
| Genetic signatures of heroin addiction. | Chen SJ et al. | — | 2016 | → |
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| KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. | Johnson EO et al. | — | 2016 | → |
| Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics. | Agrawal A et al. | — | 2016 | → |
| Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules. | Wingo T et al. | — | 2016 | → |
| Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. | Otto JM et al. | — | 2016 | → |
| Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. | Johnson JR et al. | — | 2016 | → |
| Smokescreen: a targeted genotyping array for addiction research. | Baurley JW et al. | — | 2016 | → |
| The Addiction-Related Gene Ankk1 is Oppositely Regulated by D1R- and D2R-Like Dopamine Receptors. | Ponce G et al. | — | 2016 | → |
| Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. | Hart AB et al. | — | 2015 | → |
| A review of pharmacogenetic studies of substance-related disorders. | Jones JD et al. | — | 2015 | → |
| Commonalities and Differences Across Substance Use Disorders: Phenomenological and Epidemiological Aspects. | Shmulewitz D et al. | — | 2015 | → |
| COMT Associations with Disordered Gambling and Drinking Measures. | Guillot CR et al. | — | 2015 | → |
| Effects of Interaction Between Dopamine D2 Receptor and Monoamine Oxidase A Genes on Smoking Status in Young Men. | Huang CL et al. | — | 2015 | → |
| Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults. | Long EC et al. | — | 2015 | → |
| Genetic and Environmental Interplay in Adolescent Substance Use Disorders. | Hines LA et al. | — | 2015 | → |
| KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. | Padula AE et al. | — | 2015 | → |
| Latino Immigrants' Biological Parents' Histories of Substance Use Problems in Their Country of Origin Predict Their Pre- and Post-Immigration Alcohol Use Problems. | Blackson TC et al. | — | 2015 | → |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | — | 2015 | → |
| Neural correlates of error monitoring in adolescents prospectively predict initiation of tobacco use. | Anokhin AP et al. | — | 2015 | → |
| Neuroscience of Internet Pornography Addiction: A Review and Update. | Love T et al. | — | 2015 | → |
| The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. | Justinova Z et al. | — | 2015 | → |
| Almost winning: induced MEG theta power in insula and orbitofrontal cortex increases during gambling near-misses and is associated with BOLD signal and gambling severity. | Dymond S et al. | — | 2014 | → |
| Cannabis controversies: how genetics can inform the study of comorbidity. | Agrawal A et al. | — | 2014 | → |
| Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity. | Zhu KJ et al. | — | 2014 | → |
| Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris. | Quan C et al. | — | 2014 | → |
| Crack cocaine users show differences in genotype frequencies of the 3' UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3). | Stolf AR et al. | — | 2014 | → |
| Emerging Adulthood: Developmental Period Facilitative of the Addictions. | Sussman S et al. | — | 2014 | → |
| Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. | Yang C et al. | — | 2014 | → |
| Family-based association analysis of alcohol dependence criteria and severity. | Wetherill L et al. | — | 2014 | → |
| Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders. | Few LR et al. | — | 2014 | → |
| Have the genetics of cannabis involvement gone to pot? | Agrawal A et al. | — | 2014 | → |
| Licit and illicit drug use in cluster headache. | Govare A et al. | — | 2014 | → |
| Medications development for substance-use disorders: contextual influences (dis)incentivizing pharmaceutical-industry positioning. | Janero DR | — | 2014 | → |
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| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | — | 2014 | → |
| The relationship between cannabis outcome expectancies and cannabis refusal self-efficacy in a treatment population. | Connor JP et al. | — | 2014 | → |
| A computational hypothesis for allostasis: delineation of substance dependence, conventional therapies, and alternative treatments. | Levy YZ et al. | — | 2013 | → |
| Are addictions diseases or choices? | Leyton M | — | 2013 | → |
| Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks. | Spanagel R | — | 2013 | → |
| Genetic and pharmacokinetic determinants of response to transdermal nicotine in white, black, and Asian nonsmokers. | Dempsey DA et al. | — | 2013 | → |
| Marijuana: current concepts(†). | Greydanus DE et al. | — | 2013 | → |
| Rab-3 and unc-18 interactions in alcohol sensitivity are distinct from synaptic transmission. | Johnson JR et al. | — | 2013 | → |
| Striatal ups and downs: their roles in vulnerability to addictions in humans. | Leyton M et al. | — | 2013 | → |