The early growth and development study: using the prospective adoption design to examine genotype-environment interplay. 2008.
paper
Cited
Public
- Authors
- Leve, Leslie D; Neiderhiser, Jenae M; Scaramella, Laura V; Reiss, David
- Year
- 2010
- Journal
- Behavior genetics
- PMID
- 20358398
- DOI
- 10.1007/s10519-010-9353-1
- PMCID
- PMC5575997
The Early Growth and Development Study (EGDS) is a prospective adoption design consisting of 360 linked sets of birth parents, adoptive parents, and adopted children followed from 3 months postpartum through child age 7 years and an additional 200 linked sets for whom recruitment is underway. The EGDS brings together the study of genotype–environment correlation and Genotype × Environment (G × E) interaction to inform intervention development by examining mechanisms whereby family processes mediate or moderate the expression of genetic influences. Participants in the EGDS are recruited through domestic adoption agencies located throughout the United States of America. The assessments occur at 6-month intervals until child age 4-½ years and at ages 6 and 7, when the children are in their 1st and 2nd years of formal schooling (kindergarten and first grade). The data collection includes measures of child characteristics, birth and adoptive parent characteristics, adoptive parenting, prenatal exposure to drugs and maternal stress, birth parent and adopted child salivary cortisol reactivity, and DNA from all participants. The preliminary analyses suggest evidence for G×E interaction beginning in infancy. An intervention perspective on future developments in the field of behavioral genetics is described.
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| Name | Type |
|---|---|
| adopted child local | cohort |
| adopted children | cohort |
| Adoption Study Cohort local | cohort |
| adoption triads local | cohort |
| adoptive families local | cohort |
| Adoptive families local | cohort |
| Adoptive family local | cohort |
| adoptive father local | phenotype |
| Adoptive father local | cohort |
| adoptive father anxiety/depression local | phenotype |
| Adoptive fathers local | cohort |
| adoptive mother local | phenotype |
| Adoptive mother local | cohort |
| adoptive mother anxiety/depression local | phenotype |
| Adoptive Mother Anxiety/Depression local | phenotype |
| Adoptive mothers local | cohort |
| adoptive parent local | cohort |
| Adoptive Parent local | cohort |
| adoptive parents | cohort |
| adoptive parents' marital relations local | phenotype |
| adoptive triads local | cohort |
| Adoptive triads local | cohort |
| age | phenotype |
| aggression | phenotype |
| Analog parenting task local | phenotype |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| At-risk children local | cohort |
| attention problems | phenotype |
| birth father local | cohort |
| Birth Father local | cohort |
| birth fathers local | cohort |
| Birth fathers local | cohort |
| birth mother local | cohort |
| birth mother local | phenotype |
| Birth Mother local | cohort |
| birth mother externalizing behavior local | phenotype |
| birth mothers local | cohort |
| Birth mothers local | cohort |
| Birth Mothers local | cohort |
| birth parent drug use local | drug |
| birth parents | cohort |
| Birth Parent Substance Use local | drug |
| CAPI questions local | phenotype |
| child attention to frustration local | phenotype |
| children | cohort |
| Children Exposed to Prenatal Substance Use local | cohort |
| Children Reared in Healthy Postnatal Environments local | cohort |
| children's sociodemographic environments local | phenotype |
| Children with Dual Risks local | cohort |
| child risk local | phenotype |
| child well-being local | phenotype |
| competency local | phenotype |
| conduct disorder | phenotype |
| Contact with adoptive family local | phenotype |
| Contact with birth parent local | phenotype |
| cortisol | drug |
| cortisol response | phenotype |
| Daily behavior local | phenotype |
| decision-making | phenotype |
| depression | phenotype |
| diurnal cortisol patterns local | phenotype |
| diurnal salivary cortisol local | drug |
| domestic adoption placement local | cohort |
| early development local | phenotype |
| Early Growth and Development Study local | cohort |
| early literacy skills local | phenotype |
| Early literacy tasks local | phenotype |
| education | phenotype |
| EGDS local | cohort |
| EGDS adoption triads local | cohort |
| EGDS staff local | cohort |
| eligible nonparticipants local | cohort |
| Emergent literacy local | phenotype |
| executive function | phenotype |
| executive functioning | phenotype |
| Executive function tasks local | phenotype |
| extensive medical surgeries local | phenotype |
| externalizing behavior | phenotype |
| externalizing disorders | phenotype |
| extreme prematurity local | phenotype |
| family processes | phenotype |
| favorable demographic characteristics local | phenotype |
| G×E interaction | phenotype |
| gene-environment interaction | phenotype |
| General well-being local | phenotype |
| genetically influenced behaviors local | phenotype |
| Genetically influenced phenotypic behavior local | phenotype |
| genetic factors | cohort |
| genetic risk for substance use local | phenotype |
| genetic variants | cohort |
| George Washington University local | cohort |
| harsh parenting | phenotype |
| HPA axis functioning local | phenotype |
| income | phenotype |
| Infant Behavior local | phenotype |
| Infants (9-month-old) local | cohort |
| internalizing disorders | phenotype |
| less favorable demographic characteristics local | phenotype |
| major medical conditions local | phenotype |
| maternal prenatal substance use local | drug |
| Mid-Atlantic site local | cohort |
| mood disorders | phenotype |
| noncontingent parenting local | phenotype |
| nonrelative adoptive family local | cohort |
| openness composite local | phenotype |
| openness to experience | phenotype |
| Oregon Social Learning Center local | cohort |
| outcome | phenotype |
| Pacific Northwest site local | cohort |
| parenting | phenotype |
| participants | cohort |
| placement within 3 months postpartum local | cohort |
| Polymorphism | cohort |
| Poorest Adjustment local | phenotype |
| Postnatal Environment (Healthy) local | drug |
| Postnatal Environment (Maladaptive) local | drug |
| postnatal rearing environment local | phenotype |
| Postplacement adjustment local | phenotype |
| Prenatal Substance Use local | drug |
| preventive intervention programs local | drug |
| problem behavior | phenotype |
| Psychosocial adjustment local | phenotype |
| Questionnaires local | phenotype |
| salivary DNA local | drug |
| Satisfaction with the adoption process local | phenotype |
| school performance | phenotype |
| selective placement local | phenotype |
| social competence | phenotype |
| subjective well-being | phenotype |
| substance use | phenotype |
| Substance Use During Pregnancy local | drug |
| Twin cohort | cohort |
| University of California, Davis local | cohort |
| Videotaped interaction tasks local | phenotype |
| Well-Adjusted local | phenotype |
| West/Southwest site local | cohort |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Gene-environment interaction in psychological traits and disorders. | 2011 | 21219196 |
External
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| Parenting in the Context of the Child: Genetic and Social Processes. | Reiss D et al. | — | 2022 | → |
| The intergenerational succession and financialization of Chinese family enterprises: Considering the influence of heirs' growing experience. | Ye S et al. | — | 2022 | → |
| Parental Depression, Overreactive Parenting, and Early Childhood Externalizing Problems: Moderation by Social Support. | Taraban L et al. | — | 2019 | → |
| Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures. | D'Onofrio BM et al. | — | 2016 | → |
| Family environment and attention-deficit/hyperactivity disorder in adopted children: associations with family cohesion and adaptability. | Crea TM et al. | — | 2014 | → |
| Critical need for family-based, quasi-experimental designs in integrating genetic and social science research. | D'Onofrio BM et al. | — | 2013 | → |
| The Early Growth and Development Study: a prospective adoption study from birth through middle childhood. | Leve LD et al. | — | 2013 | → |
| The nature of nurture: disentangling passive genotype-environment correlation from family relationship influences on children's externalizing problems. | Harold GT et al. | — | 2013 | → |
| Using an adoption design to separate genetic, prenatal, and temperament influences on toddler executive function. | Leve LD et al. | — | 2013 | → |
| Familial confounding of the association between maternal smoking during pregnancy and offspring substance use and problems. | D'Onofrio BM et al. | — | 2012 | → |
| Is maternal smoking during pregnancy a causal environmental risk factor for adolescent antisocial behavior? Testing etiological theories and assumptions. | D'Onofrio BM et al. | — | 2012 | → |
| Marital hostility and child sleep problems: direct and indirect associations via hostile parenting. | Rhoades KA et al. | — | 2012 | → |
| Maternal self concept as a provider and cessation of substance use during pregnancy. | Massey SH et al. | — | 2012 | → |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | — | 2011 | → |
| Longitudinal pathways from marital hostility to child anger during toddlerhood: genetic susceptibility and indirect effects via harsh parenting. | Rhoades KA et al. | — | 2011 | → |
| Trajectories of parenting and child negative emotionality during infancy and toddlerhood: a longitudinal analysis. | Lipscomb ST et al. | — | 2011 | → |