Impact of binge drinking during college on resting state functional connectivity.
paper
Primary
Public
- Authors
- Tong, Tien T; Vaidya, Jatin G; Kramer, John R; Kuperman, Samuel; Langbehn, Douglas R; O'Leary, Daniel S
- Year
- 2021
- Journal
- Drug and alcohol dependence
- PMID
- 34388578
- DOI
- 10.1016/j.drugalcdep.2021.108935
- PMCID
- PMC8464531
AIM: The current study examined the longitudinal effects of standard binge drinking (4+/5+ drinks for females/males in 2 hours) and extreme binge drinking (8+/10+ drinks for females/males in 2 hours) on resting-state functional connectivity. METHOD: 119 college students (61 males) were recruited in groups of distinct bingeing patterns at baseline: non-bingeing controls, standard and extreme bingers. Resting-state scans were first obtained when participants were freshmen/sophomores and again approximately two years later. Associations between longitudinal bingeing (reported during this two-year gap) and network connectivity were examined. Network connectivity was calculated by aggregating all edges affiliated with the same network (an edge is a functional connection between two brain regions). The relationship between longitudinal bingeing and connectivity edges was also studied using connectome-based predictive modeling (CPM). RESULTS: Greater standard bingeing was negatively associated with change in connectivity between Default Mode Network and Ventral Attention Network (DMN-VAN; False Discovery Rate corrected), controlling for initial binge groups, longitudinal network changes, motions, scanner, SES, sex, and age. The correlations between change in DMN-VAN connectivity and change in cognitive performance (Stroop, Digit Span, Letter Fluency, and Trail Making) were also tested, but the results were not significant. Lastly, CPM failed to identify a generalizable predictive model of longitudinal bingeing from change in connectivity edges. CONCLUSIONS: Binge drinking is associated with abnormality in networks implicated in attention and self-focused processes, which, in turn, have been implicated in rumination, craving, and relapse. More extensive alterations in functional connectivity might be observed with heavier or longer binge drinking pattern.
Significant result of the network-level analysis. A) Seeds of the Default Mode Network (DMN, orange) and Ventral Attention Network (VAN, black). B) Association between the predicted change in DMN-VAN connectivity (Time 2 minus Time 1) and log-transformed longitudinal standard bingeing.
Results of the consistency analysis. Edges with change in connectivity strength (Time 2 minus Time 1) that demonstrated significant (puncorrected<.0001) and consistent A) positive and B) negative associations with longitudinal standard bingeing, and consistent C) positive and D) negative associations with longitudinal extreme bingeing. Only important seeds with degree ≥ 30 are depicted (a range of degree threshold was examined, the degree threshold of 30 was chosen due to its high interpretability). Degree is the total number of edges linked to a seed. Seed size is proportional to their degree. Left/right hemisphere is on the left/right, respectively.
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