Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology.
- Authors
- Corral-FrΓas, N S; Nikolova, Y S; Michalski, L J; Baranger, D A A; Hariri, A R; Bogdan, R
- Year
- 2015
- Journal
- Psychological medicine
- PMID
- 25853627
- DOI
- 10.1017/S0033291715000525
- PMCID
- PMC4700837
BACKGROUND: Early life stress (ELS) is consistently associated with increased risk for subsequent psychopathology. Individual differences in neural response to reward may confer vulnerability to stress-related psychopathology. Using data from the ongoing Duke Neurogenetics Study, the present study examined whether reward-related ventral striatum (VS) reactivity moderates the relationship between retrospectively reported ELS and anhedonic symptomatology. We further assessed whether individual differences in reward-related VS reactivity were associated with other depressive symptoms and problematic alcohol use via stress-related anhedonic symptoms and substance use-associated coping. METHOD: Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) was collected while participants (n = 906) completed a card-guessing task, which robustly elicits VS reactivity. ELS, anhedonic symptoms, other depressive symptoms, coping behavior, and alcohol use behavior were assessed with self-report questionnaires. Linear regressions were run to examine whether VS reactivity moderated the relationship between ELS and anhedonic symptoms. Structural equation models examined whether this moderation was indirectly associated with other depression symptoms and problematic alcohol use through its association with anhedonia. RESULTS: Analyses of data from 820 participants passing quality control procedures revealed that the VS Γ ELS interaction was associated with anhedonic symptoms (p = 0.011). Moreover, structural equation models indirectly linked this interaction to non-anhedonic depression symptoms and problematic alcohol use through anhedonic symptoms and substance-related coping. CONCLUSIONS: These findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS. Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.
Structural equation models examining the indirect effect of early life stress and left ventral striatum reactivity to reward on (a) non-anhedonic depressive symptoms, and (b) problematic alcohol use through anhedonic symptoms and substance-related coping.
(a) Statistical parametric map illustrating bilateral ventral striatum (VS) activation clusters for the contrast βpositive reward > negative lossβ overlaid onto a canonical structural brain image Montreal Neurological Institute coordinates and statistics (p < 0.05, family-wise error whole-brain corrected and β₯10 contiguous voxels): left hemisphere: x = β12, y = 8, z= β10, t = 13.59, p < 0.001; right hemisphere: x = 12, y = 10, z = β8, t = 12.63, p < 0.001. (b) Left VS reactivity moderates the relationship between early life adversity anhedonic symptoms (Left VS: ΞR2 = 0.0045, b = β0.7552, F1,789 = 6.35, p = 0.0119). Data plotted are raw values. Lines represent participants with low VS reactivity (light grey; β1 s.d.), medium VS reactivity (grey; average), and high VS reactivity (black; +1 s.d.). Shaded area represent JohnsonβNeyman area of significance. (CTQ score >41.56).
Early life stress-related anhedonia is dependent on left ventral striatum (VS) reactivity to reward and is associated with other depressive symptoms. (a) Structural equation model examining the indirect effect early life stress and left VS reactivity to reward on other depression symptoms via the mediating effects of anhedonia (* p < 0.05, *** p < 0.001).(b) Indirect effect of early life stress on depression via anhedonia as a function of VS reactivity. Middle line indicates effect size parameter estimate, curved lines reflect the bounds of the 95% confidence interval (CI) (the regions in which the 95% CI does not cross 0 are considered to be the values at which the indirect effect is significant).
Early life stress-related anhedonia is dependent on ventral striatum (VS) reactivity to reward and is associated with problematic alcohol use. (a) Structural equation model examining the indirect effect childhood adversity and left VS reactivity to reward on problematic alcohol use via the mediating effects of anhedonia and substance-related coping (* p < 0.05, *** p < 0.001). Paths are marked with unstandardized coefficients. (b) Indirect effect of early life adversity on problematic alcohol use via anhedonia and substance use-related coping as a function of VS reactivity. Middle line indicates effect size parameter estimate, curved lines reflect the bounds of the 95% confidence interval (CI) (the regions in which the 95% CI does not cross 0 are considered to be the values at which the indirect effect is significant).
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Adolescents' ventral striatal reward neural activity moderates the association between lifetime trauma exposure and lower depression after 6 months. | Eckstrand KL et al. | β | 2026 | β |
| Associations between polygenic risk for anhedonia and functional brain activity during reward processing. | SchΓ€fer N et al. | β | 2026 | β |
| Brain network localization of anhedonia. | Liu C et al. | β | 2026 | β |
| How childhood adversity affects components of decision making. | Smith KE et al. | β | 2025 | β |
| Investigating Neural Reward Sensitivity in the School Grade Incentive Delay Task and Its Relation to Academic Buoyancy. | Vel Tromp MJB et al. | β | 2025 | β |
| Major Depression in Comorbidity with Substance use Disorders: Patients' Features and Clinical-Neurobiological Rationale of Antidepressant Treatments. | De Filippis S et al. | β | 2025 | β |
| Neural Response to Reward and Loss Following Basic Combat Training. | Freeman C et al. | β | 2025 | β |
| Value-Directed Remembering: A Dual-Process Perspective. | Li Q et al. | β | 2025 | β |
| Anhedonia mediates the relationships between childhood trauma and symptom severity of PTSD and depression, but not of social anxiety. | Haim-Nachum S et al. | β | 2024 | β |
| Computational Modeling Differentiates Learning Rate From Reward Sensitivity Deficits Produced by Early-Life Adversity in a Rodent Touchscreen Probabilistic Reward Task. | Kangas BD et al. | β | 2024 | β |
| Interpersonal Trauma Effects on Adolescent Depression: The Moderating Role of Neurophysiological Responses to Positive Interpersonal Images. | Long Y et al. | β | 2024 | β |
| Neighborhood Resources Associated With Psychological Trajectories and Neural Reactivity to Reward After Trauma. | Webb EK et al. | β | 2024 | β |
| Neural and immune interactions linking early life stress and anhedonia. | Phillips RD | β | 2024 | β |
| Neurobiology and systems biology of stress resilience. | Kalisch R et al. | β | 2024 | β |
| Neurocognitive risk phenotyping to predict mood symptoms in adolescence. | Kaiser RH et al. | β | 2024 | β |
| Sleep disturbance and social reward processing as characteristics linking minority victimization and suicidal ideation in youth. | Seah THS et al. | β | 2024 | β |
| Amygdala and nucleus accumbens activation during reward anticipation moderates the association between life stressor frequency and depressive symptoms. | Fassett-Carman AN et al. | β | 2023 | β |
| Associations between parental conflict and social and monetary reward responsiveness in adolescents with clinical depression. | Hill KE et al. | β | 2023 | β |
| Differences in parent and youth perceived neighborhood threat on nucleus accumbens-frontoparietal network resting state connectivity and alcohol sipping in children enrolled in the ABCD study. | Harris JC et al. | β | 2023 | β |
| Functional neuroimaging of resilience to trauma: convergent evidence and challenges for future research. | Norbury A et al. | β | 2023 | β |
| Splitting the reward: Differences in inflammatory marker associations with neural connectivity between reward anticipation and reward outcome in adolescents at high risk for depression. | Rengasamy M et al. | β | 2023 | β |
| The interplay of childhood maltreatment and maternal depression in relation to the reward positivity in youth. | Suor JH et al. | β | 2023 | β |
| Transdiagnostic phenomena of psychopathology in the context of the RDoC: protocol of a multimodal cross-sectional study. | Meiering MS et al. | β | 2023 | β |
| Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study. | Hendrikse CJ et al. | β | 2022 | β |
| Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry. | Zhan B et al. | β | 2022 | β |
| Developmental Trajectories of Anhedonia in Preclinical Models. | Birnie MT et al. | β | 2022 | β |
| Discontinuation of hormonal contraception due to changes in mood and decreases in sexual desire: the role of adverse childhood experiences. | Novick AM et al. | β | 2022 | β |
| Emerging ecophenotype: reward anticipation is linked to high-risk behaviours after sexual abuse. | Pechtel P et al. | β | 2022 | β |
| Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies. | Duque-Quintero M et al. | β | 2022 | β |
| Environmental Contributions to Anhedonia. | Harkness KL et al. | β | 2022 | β |
| In young women, a link between childhood abuse and subliminal processing of aversive cues is moderated by impulsivity. | Regier PS et al. | β | 2022 | β |
| Loss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers. | Li G et al. | β | 2022 | β |
| Medial Prefrontal Cortex Activity to Reward Outcome Moderates the Association Between Victimization Due to Sexual Orientation and Depression in Youth. | Eckstrand KL et al. | β | 2022 | β |
| Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping. | Feng C et al. | β | 2022 | β |
| Physical and social anhedonia in female adolescents: A factor analysis of self-report measures. | Yang X et al. | β | 2022 | β |
| Phytoestrogen genistein modulates neuron-microglia signaling in a mouse model of chronic social defeat stress. | Fujikawa R et al. | β | 2022 | β |
| Trauma Cue-Elicited Alcohol Craving as a Function of Adult Versus Childhood-Onset Interpersonal Traumatic Events in Young Adult Drinkers. | Bing-Canar H et al. | β | 2022 | β |
| Trauma Disrupts Reinforcement Learning in Rats-A Novel Animal Model of Chronic Stress Exposure. | Bielawski T et al. | β | 2022 | β |
| [Anhedonia in depression: neurobiological and genetic aspects]. | Kibitov AO et al. | β | 2021 | β |
| Cortisol reactivity to stress predicts behavioral responsivity to reward moderation by sex, depression, and anhedonia. | Cunningham S et al. | β | 2021 | β |
| Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings. | Oswald LM et al. | β | 2021 | β |
| Impact of Early Life Stress on Reward Circuit Function and Regulation. | Hanson JL et al. | β | 2021 | β |
| Learning it the hard way - how enjoying life and positive appraisal buffer the negative effects of stressors on mental health in the COVID-19 pandemic. | Daniels A et al. | β | 2021 | β |
| Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence. | MΓ©ndez Leal AS et al. | β | 2021 | β |
| The Developmental Origins of Opioid Use Disorder and Its Comorbidities. | Levis SC et al. | β | 2021 | β |
| The longitudinal stability of fMRI activation during reward processing in adolescents and young adults. | Baranger DAA et al. | β | 2021 | β |
| Trauma Affects Prospective Relationships Between Reward-Related Ventral Striatal and Amygdala Activation and 1-Year Future Hypo/Mania Trajectories. | Eckstrand KL et al. | β | 2021 | β |
| Trauma-related dysfunction in the fronto-striatal reward circuit. | Sambuco N et al. | β | 2021 | β |
| An affective neuroscience model of boosting resilience in adults. | Tabibnia G | β | 2020 | β |
| A role for the <i>CD38</i> rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans. | Lee MR et al. | β | 2020 | β |
| Developmental trajectories to reduced activation of positive valence systems: A review of biological and environmental contributions. | Kujawa A et al. | β | 2020 | β |
| Early life stress and development: potential mechanisms for adverse outcomes. | Smith KE et al. | β | 2020 | β |
| Levers and barriers to success in the use of translational neuroscience for the prevention and treatment of mental health and promotion of well-being across the lifespan. | Horn SR et al. | β | 2020 | β |
| Offensive Behavior, Striatal Glutamate Metabolites, and Limbic-Hypothalamic-Pituitary-Adrenal Responses to Stress in Chronic Anxiety. | Ullmann E et al. | β | 2020 | β |
| Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance. | Birnie MT et al. | β | 2020 | β |
| Reward-Related Brain Activity Prospectively Predicts Increases in Alcohol Use in Adolescents. | Swartz JR et al. | β | 2020 | β |
| Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence. | Goldstein BL et al. | β | 2020 | β |
| The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience. | al'Absi M | β | 2020 | β |
| Trait impulsivity and acute stress interact to influence choice and decision speed during multi-stage decision-making. | Raio CM et al. | β | 2020 | β |
| Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review. | Destoop M et al. | β | 2019 | β |
| A Transdiagnostic Perspective on Social Anhedonia. | Barkus E et al. | β | 2019 | β |
| Blunted neural response to appetitive images prospectively predicts symptoms of depression, and not anxiety, during the transition to university. | Sandre A et al. | β | 2019 | β |
| Blunted Social Reward Responsiveness Moderates the Effect of Lifetime Social Stress Exposure on Depressive Symptoms. | Pegg S et al. | β | 2019 | β |
| Prefrontal Executive Control Rescues Risk for Anxiety Associated with High Threat and Low Reward Brain Function. | Scult MA et al. | β | 2019 | β |
| Transdiagnostic psychiatry: a systematic review. | Fusar-Poli P et al. | β | 2019 | β |
| Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults. | Eckstrand KL et al. | β | 2019 | β |
| Brain mechanisms mediating effects of stress on reward sensitivity. | Ironside M et al. | β | 2018 | β |
| Early life adversity and health-risk behaviors: proposed psychological and neural mechanisms. | Duffy KA et al. | β | 2018 | β |
| Heightened connectivity between the ventral striatum and medial prefrontal cortex as a biomarker for stress-related psychopathology: understanding interactive effects of early and more recent stress. | Hanson JL et al. | β | 2018 | β |
| Past-year relational victimization is associated with a blunted neural response to rewards in emerging adults. | Ethridge P et al. | β | 2018 | β |
| The effects of early life stress on reward processing. | Novick AM et al. | β | 2018 | β |
| Ventral Striatal Function Interacts With Positive and Negative Life Events to Predict Concurrent Youth Depressive Symptoms. | Luking KR et al. | β | 2018 | β |
| Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry - the contribution of functional brain imaging. | McCrory EJ et al. | β | 2017 | β |
| Child Trauma Exposure and Psychopathology: Mechanisms of Risk and Resilience. | McLaughlin KA et al. | β | 2017 | β |
| Depressive symptom domains and alcohol use severity among Hispanic emerging adults: Examining moderating effects of gender. | Cano MΓ et al. | β | 2017 | β |
| Further support for association between GWAS variant for positive emotion and reward systems. | Lancaster TM et al. | β | 2017 | β |
| How the brain connects in response to acute stress: A review at the human brain systems level. | van Oort J et al. | β | 2017 | β |
| Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction. | Watt MJ et al. | β | 2017 | β |
| Like mother like daughter: putamen activation as a mechanism underlying intergenerational risk for depression. | Colich NL et al. | β | 2017 | β |
| Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia. | Eisenstein SA et al. | β | 2017 | β |
| Reward functioning in posttraumatic stress and substance use disorders. | Vujanovic AA et al. | β | 2017 | β |
| Reward-Related Ventral Striatum Activity Buffers against the Experience of Depressive Symptoms Associated with Sleep Disturbances. | Avinun R et al. | β | 2017 | β |
| Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood. | Carey CE et al. | β | 2017 | β |
| Stress and Decision Making: Effects on Valuation, Learning, and Risk-taking. | Porcelli AJ et al. | β | 2017 | β |
| Toward understanding the impact of trauma on the early developing human brain. | Thomason ME et al. | β | 2017 | β |
| A Neural Mechanism of Preference Shifting Under Zero Price Condition. | Votinov M et al. | β | 2016 | β |
| Behavioral and self-reported sensitivity to reward are linked to stress-related differences in positive affect. | Corral-FrΓas NS et al. | β | 2016 | β |
| COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. | Corral-FrΓas NS et al. | β | 2016 | β |
| Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis. | Zhang B et al. | β | 2016 | β |
| Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse. | Dennison MJ et al. | β | 2016 | β |
| PER1 rs3027172 Genotype Interacts with Early Life Stress to Predict Problematic Alcohol Use, but Not Reward-Related Ventral Striatum Activity. | Baranger DA et al. | β | 2016 | β |
| Emotional and cognitive dysregulation in schizophrenia and depression: understanding common and distinct behavioral and neural mechanisms. | Anticevic A et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |