Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders.
- Authors
- Lejuez, C W; Magidson, Jessica F; Mitchell, Suzanne H; Sinha, Rajita; Stevens, Michael C; de Wit, Harriet
- Year
- 2010
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 20491733
- DOI
- 10.1111/j.1530-0277.2010.01217.x
- PMCID
- PMC3182265
Alcohol use disorders (AUDs) are a devastating public health problem. The construct of impulsivity is biologically based and heritable, and its various dimensions are relevant for understanding alcohol use. The goal of the current manuscript is to review recent behavioral and biological research examining various dimensions of impulsivity and their relation to AUDs from risk for initial use through dependence and relapse. Moreover, we also highlight key psychological variables including affective processes as they relate to current use and early indications of alcohol problems, as well as psychopathology, violence, and aggression in relation to AUDs. Each section includes a critical summary and we conclude the review with future directions focused on issues relevant to measurement, causality, and intervention. Throughout the review, we attempt to be as specific as possible about the dimensions of impulsivity being referenced, while attempting to draw parallels and highlighting differences as the existing literature allows.
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| Name | Type |
|---|---|
| 13 inbred mouse strains local | cohort |
| Abnormal Cognitive Control local | phenotype |
| abstinent alcohol dependent individuals local | cohort |
| Abstinent former alcohol abusers local | cohort |
| adolescents | cohort |
| Adolescents with AUDs and SUDs (Von Diemen 2008) local | cohort |
| adult female substance users local | cohort |
| adults | cohort |
| Affect dysregulation | phenotype |
| Affective vulnerability local | phenotype |
| affect regulation | phenotype |
| African American adolescents (14-18) local | cohort |
| African American adolescents (Lejuez 2007) local | cohort |
| age at first drink | phenotype |
| age-matched controls local | cohort |
| Age of onset of alcoholism local | phenotype |
| aggression | phenotype |
| aggressiveness | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcohol_dependence | phenotype |
| alcohol dependence status local | phenotype |
| Alcohol dependent men local | cohort |
| Alcohol-induced locomotor activity local | phenotype |
| alcoholism | phenotype |
| Alcohol Problems | phenotype |
| alcohol-related behaviors | phenotype |
| Alcohol-related impairment local | phenotype |
| alcohol-related problems | phenotype |
| alcohol self-administration | phenotype |
| Alcohol urges local | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use initiation | phenotype |
| Alcohol use-related problems local | phenotype |
| alcohol withdrawal | phenotype |
| amygdala | anatomy |
| anterior cingulate cortex | anatomy |
| Antisocial personality characteristics local | phenotype |
| antisocial personality disorder | phenotype |
| Antisocial personality traits local | phenotype |
| anxiety | phenotype |
| ASPD | phenotype |
| at-risk personality characteristics local | phenotype |
| At-risk youth local | cohort |
| attention | phenotype |
| attention deficit hyperactivity disorder | phenotype |
| AUD | phenotype |
| Aversive events local | phenotype |
| axis I disorder | phenotype |
| Bdnf | gene |
| behavioral disinhibition | phenotype |
| behavioral dysregulation | phenotype |
| binge drinking | phenotype |
| biological factors local | phenotype |
| BIS | phenotype |
| borderline personality disorder | phenotype |
| Brain Function Abnormalities local | phenotype |
| cigarettes | phenotype |
| cingulate cortex | anatomy |
| cluster B personality disorder | phenotype |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| college students | cohort |
| conduct disorder | phenotype |
| Consideration of Future Consequences scale local | phenotype |
| Control families | cohort |
| control group | cohort |
| controls | cohort |
| control subjects | cohort |
| Current alcohol abusers local | cohort |
| decision making | phenotype |
| defiant traits local | phenotype |
| delay discounting | phenotype |
| Delayed hypothetical reward discounting local | phenotype |
| detoxified alcohol dependent individuals local | cohort |
| Detoxified alcohol dependent individuals local | cohort |
| Dimensions of impulsivity local | phenotype |
| discounting of gain local | phenotype |
| disinhibition | phenotype |
| Disinhibitory personality traits local | phenotype |
| Disordered Sensitivity to Reinforcement local | phenotype |
| disruptive/antisocial behavior disorders local | phenotype |
| DMT commission errors local | phenotype |
| dorsolateral prefrontal cortex | anatomy |
| DRD2 | gene |
| drinking to cope | phenotype |
| drugs | drug |
| early alcohol use | phenotype |
| Early-onset alcohol dependence local | phenotype |
| Early-onset alcohol dependent individuals local | cohort |
| Early-onset problem drinking local | phenotype |
| Early problem users local | cohort |
| Emotion | phenotype |
| environmental stress | phenotype |
| error processing | phenotype |
| ethanol consumption | phenotype |
| excitement seeking | phenotype |
| Experimental Pharmacological Approaches local | drug |
| extended reward system local | anatomy |
| externalizing disorders | phenotype |
| extraversion | phenotype |
| family history of alcoholism | phenotype |
| forebrain | anatomy |
| frequency of alcohol use | phenotype |
| frontal cortex | anatomy |
| hard-to-resist urges to use drugs local | phenotype |
| harm avoidance | phenotype |
| healthy controls | cohort |
| Heavy social drinkers local | cohort |
| Heavy social drinkers local | phenotype |
| heterogeneous subjects local | cohort |
| High alcohol consumption mice local | cohort |
| high alcohol drinking mice local | cohort |
| high alcohol drinking rats local | cohort |
| High-risk AUD families local | cohort |
| High-risk college sample local | cohort |
| high-risk drinking behaviors local | phenotype |
| high-risk offspring | cohort |
| Hill et al. 2009 study local | cohort |
| Htr2a | gene |
| HTR2A -1438G>A local | variant |
| human alcoholics | phenotype |
| hyperactivity | phenotype |
| ibotenic acid local | drug |
| impaired cognitive control local | phenotype |
| Impulsive Alcohol Use local | phenotype |
| impulsive alcohol use behavior local | phenotype |
| impulsive violent behavior local | phenotype |
| impulsivity | phenotype |
| Impulsivity (personality trait) local | phenotype |
| inattention | phenotype |
| inattention to future rewards local | phenotype |
| inbred strains | cohort |
| insensitivity to punishment | phenotype |
| insula | anatomy |
| Lack of constraint local | phenotype |
| lack of perseverance | phenotype |
| lack of planning | phenotype |
| lack of premeditation | phenotype |
| Late-onset alcohol dependence local | phenotype |
| Late-onset alcohol dependent individuals local | cohort |
| Late onset drinking local | phenotype |
| Late-onset problem drinking local | phenotype |
| lateral prefrontal cortex | anatomy |
| Lighter social drinkers local | cohort |
| Lighter social drinkers local | phenotype |
| Locomotor stimulation local | phenotype |
| low alcohol drinking mice local | cohort |
| low alcohol drinking rats local | cohort |
| male rats | cohort |
| male subjects | cohort |
| medial frontal cortex | anatomy |
| medial temporal brain areas local | anatomy |
| mice | cohort |
| money | drug |
| Monotony avoidance local | phenotype |
| Motor control | phenotype |
| negative affect | phenotype |
| negative reinforcement | phenotype |
| Negative thinking local | phenotype |
| negative urgency | phenotype |
| neuroticism | phenotype |
| non-planning | phenotype |
| Non-planning impulsivity | phenotype |
| non-violent alcohol abusers local | cohort |
| normal controls | cohort |
| Nose poking efficiency local | phenotype |
| novelty seeking | phenotype |
| orbitofrontal cortex | anatomy |
| other drugs | drug |
| P3 amplitude | phenotype |
| parental alcoholism | phenotype |
| Past year drinking frequency local | phenotype |
| Peer pressure | phenotype |
| perseverance local | phenotype |
| personality disorders | phenotype |
| Personality-targeted interventions local | phenotype |
| Petry et al. 2002 study local | cohort |
| positive affect | phenotype |
| Positive and Negative Affect Schedule | phenotype |
| positive reinforcement | phenotype |
| positive urgency | phenotype |
| Post-error behavioral adjustment local | phenotype |
| prefrontal cortex | anatomy |
| premature responding | phenotype |
| PRKCG | gene |
| problematic alcohol use | phenotype |
| Problem drinkers local | cohort |
| Problem drinking onset local | phenotype |
| Problem-drinking parent local | phenotype |
| problem patterns of drinking local | phenotype |
| psychopathology | phenotype |
| putamen | anatomy |
| quantity of alcohol consumed | phenotype |
| quantity of use | phenotype |
| rats | cohort |
| reduced serotonin functioning local | phenotype |
| response control | phenotype |
| response inhibition | phenotype |
| reward-dependent impulsiveness local | phenotype |
| right dorsolateral prefrontal cortex | anatomy |
| risk preference local | phenotype |
| Risk preference local | phenotype |
| risk taking | phenotype |
| risk-taking behavior | phenotype |
| Riskβtaking behaviors local | phenotype |
| rs1800497 | variant |
| self-control | phenotype |
| self-reported impulsivity | phenotype |
| serotonin | drug |
| sex differences | phenotype |
| SLC6A4 | gene |
| social deviance local | phenotype |
| Social drinkers | phenotype |
| Social drinking college students local | cohort |
| Social drinking women local | cohort |
| Stanford Time Perspective Inventory local | phenotype |
| substance use | phenotype |
| superior frontal cortex | anatomy |
| sustained attention | phenotype |
| targeted intervention local | drug |
| temporal cortex | anatomy |
| TPH local | gene |
| TPH intron 7 A218C allele local | variant |
| undergraduates local | cohort |
| Undergraduates local | cohort |
| Undergraduate sample local | cohort |
| UPPS Impulsive Behavior Scale local | phenotype |
| UPPS scales local | phenotype |
| urgency | phenotype |
| Urgency subscale local | phenotype |
| Use frequency local | phenotype |
| ventral striatum | anatomy |
| violence | phenotype |
| violent alcohol abusers local | cohort |
| violent behavior | phenotype |
| wild-type mice | cohort |
| young adults | cohort |
| Youth drinking initiation local | phenotype |
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