Neurocognitive correlates of white matter quality in adolescent substance users.
paper
Cited
Public
- Authors
- Bava, Sunita; Jacobus, Joanna; Mahmood, Omar; Yang, Tony T; Tapert, Susan F
- Year
- 2010
- Journal
- Brain and cognition
- PMID
- 19932550
- DOI
- 10.1016/j.bandc.2009.10.012
- PMCID
- PMC2832074
BACKGROUND: Progressive myelination during adolescence implicates an increased vulnerability to neurotoxic substances and enduring neurocognitive consequences. This study examined the cognitive manifestations of altered white matter microstructure in chronic marijuana and alcohol-using (MJ+ALC) adolescents. METHODS: Thirty-six MJ+ALC adolescents (ages 16-19) and 36 demographically similar controls were evaluated with diffusion tensor imaging (Bava et al., 2009) and neurocognitive tests. Regions of group difference in fractional anisotropy (FA) and mean diffusivity (MD) were analyzed in relation to cognitive performance. RESULTS: In users, lower FA in temporal areas related to poorer performance on attention, working memory, and speeded processing tasks. Among regions where users had higher FA than controls, occipital FA was positively associated with working memory and complex visuomotor sequencing, whereas FA in anterior regions was negatively associated with verbal memory performance. CONCLUSIONS: Findings suggest differential influences of white matter development on cognition in MJ+ALC using adolescents than in non-using peers. Neuroadaptation may reflect additive and subtractive responses to substance use that are complicated by competing maturational processes.
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| Name | Type |
|---|---|
| addiction | phenotype |
| Adolescent chronic marijuana users local | cohort |
| Adolescent marijuana and alcohol users local | cohort |
| Adolescent MJ+ALC users local | cohort |
| adolescents | cohort |
| adolescent substance use | phenotype |
| Adult MJ+ALC users local | cohort |
| Age-matched controls local | cohort |
| ALC | drug |
| alcohol | phenotype |
| Alcohol Use Disorder | phenotype |
| amygdala | anatomy |
| Anisotropic white matter differences local | phenotype |
| anterior limb of the internal capsule local | anatomy |
| Anterior limb of the internal capsule local | anatomy |
| anxiety | phenotype |
| arcuate portion of the right superior longitudinal fasciculus local | anatomy |
| arcuate portion of the SLF local | anatomy |
| attention | phenotype |
| Attenuated frontal response during spatial working memory local | phenotype |
| atypical activation local | phenotype |
| basal ganglia | anatomy |
| Bava et al., 2009 local | cohort |
| Beck Depression Inventory | phenotype |
| bilateral crus cerebri local | anatomy |
| bipolar I disorder | phenotype |
| cerebellum | anatomy |
| Child Behavior Checklist | drug |
| Chronic health conditions | phenotype |
| chronic marijuana use | phenotype |
| cingulate cortex | anatomy |
| Clinically abnormal brain anatomy local | phenotype |
| cognition | phenotype |
| cognitive and behavioral alterations local | phenotype |
| complex attention local | phenotype |
| complex sequencing local | phenotype |
| complex sequencing performance local | phenotype |
| Contextual verbal memory local | phenotype |
| control group | cohort |
| controls | cohort |
| corpus callosum | anatomy |
| Corpus callosum isthmus local | anatomy |
| cortical and white matter volume loss local | phenotype |
| Crus cerebri local | anatomy |
| cuneus region of the occipital lobe local | anatomy |
| CVLT-II List A Trial 1 local | phenotype |
| CVLT-II List A Trial 1 score local | phenotype |
| decreased FA local | phenotype |
| decreased gray matter density local | phenotype |
| Deficits in attention local | phenotype |
| Deficits in memory retrieval local | phenotype |
| Deficits in visuospatial functioning local | phenotype |
| delta9-THC local | drug |
| depression | phenotype |
| digit span backward | phenotype |
| Digit Span total scaled score local | phenotype |
| Digit Symbol total scaled score local | phenotype |
| D-KEFS TMT Switching local | phenotype |
| D-KEFS TMT Switching performance local | phenotype |
| DSM-IV | phenotype |
| externalizing disorders | phenotype |
| FA | phenotype |
| FA cluster local | anatomy |
| Fagerstrom Test for Nicotine Dependence score local | phenotype |
| FA in right ILF local | phenotype |
| First trial verbal list learning local | phenotype |
| fractional anisotropy | phenotype |
| fractional anisotropy (FA) | phenotype |
| frontal cortex | anatomy |
| Head trauma with loss of consciousness >2 minutes local | phenotype |
| heavy drinking | phenotype |
| hippocampus | anatomy |
| illicit drugs | phenotype |
| Illicit drug use during pregnancy local | phenotype |
| improved performance local | phenotype |
| increased FA local | phenotype |
| increased metabolism local | phenotype |
| Inferior frontal areas local | anatomy |
| inferior frontal region local | anatomy |
| Inferior frontal region local | anatomy |
| inferior longitudinal fasciculus | anatomy |
| internal capsule | anatomy |
| internalizing disorders | phenotype |
| learning and memory | phenotype |
| learning disabilities | phenotype |
| Left-handedness | phenotype |
| left ILF local | anatomy |
| left occipital-frontal region local | anatomy |
| left postcentral sensory gyrus local | anatomy |
| left SLF local | anatomy |
| left superior longitudinal fasciculus local | anatomy |
| Left superior longitudinal fasciculus local | anatomy |
| left temporo-thalamic tract local | anatomy |
| Lifetime cigarettes smoked local | phenotype |
| Lifetime other drug use instances local | phenotype |
| lingual gyrus | anatomy |
| Logical Memory II delayed recall local | phenotype |
| lower WAIS-III Digit Symbol performance local | phenotype |
| marijuana | phenotype |
| Marijuana + Alcohol local | drug |
| Marijuana+Alcohol use local | drug |
| marijuana use disorder | phenotype |
| Maternal drinking (>7 drinks/week or >4 drinks/day) local | phenotype |
| MD | phenotype |
| MD cluster local | anatomy |
| MD in ILF local | anatomy |
| MD in occipital-lingual region local | anatomy |
| mean diffusivity | phenotype |
| medication | drug |
| mental retardation | phenotype |
| MJ local | drug |
| MJ+ALC group local | cohort |
| MJ+ALC teens local | cohort |
| MJ+ALC youths local | cohort |
| mood disorders | phenotype |
| Morphological changes local | phenotype |
| MRI contraindications | phenotype |
| negative consequences | phenotype |
| neuroadaptation | phenotype |
| Neurobehavioral functioning local | phenotype |
| Neurobiological vulnerabilities local | phenotype |
| neurocognitive decrements local | phenotype |
| Neurocognitive deficits | phenotype |
| Neurocognitive vulnerabilities local | phenotype |
| neurological disorders | phenotype |
| Neuromaturation local | phenotype |
| neuropsychological deficits | phenotype |
| Neuropsychological domains local | phenotype |
| neuropsychological test performance | phenotype |
| nicotine | drug |
| nicotine dependence | phenotype |
| Non-fluency in English local | phenotype |
| Non-using peers local | cohort |
| occipital brain regions local | anatomy |
| Occipital-cuneus local | anatomy |
| occipital-cuneus region local | anatomy |
| Occipital gyri local | anatomy |
| other drug use | phenotype |
| over-the-counter medications local | drug |
| parental history of SUD local | phenotype |
| Parental history of SUD local | phenotype |
| Parental SUD | phenotype |
| parietal cortex | anatomy |
| participants | cohort |
| PASAT 2-second trial local | phenotype |
| poorer performance | phenotype |
| postcentral gyrus | anatomy |
| prefrontal cortex | anatomy |
| prefrontal white matter | anatomy |
| Premature birth (<33 weeks gestation) local | phenotype |
| Premature myelination local | phenotype |
| premorbid intellectual functioning local | phenotype |
| Premorbid IQ | phenotype |
| psychosis | phenotype |
| reduced neurocognitive functioning local | phenotype |
| right anterior limb of the internal capsule local | anatomy |
| Right anterior limb of the internal capsule local | anatomy |
| right ILF local | anatomy |
| Right ILF local | anatomy |
| right inferior frontal local | anatomy |
| right inferior longitudinal fasciculus local | anatomy |
| right occipital-cuneus local | anatomy |
| Right occipital region local | anatomy |
| right superior temporal gyrus | anatomy |
| sex | phenotype |
| speeded processing local | phenotype |
| Speeded processing local | phenotype |
| Spielberger State Trait Anxiety Inventory local | phenotype |
| splenium | anatomy |
| striatum | anatomy |
| structural abnormalities | anatomy |
| substance use | phenotype |
| SUD | phenotype |
| superior longitudinal fasciculus | anatomy |
| Superior medial local | anatomy |
| superior temporal gyrus | anatomy |
| teens | cohort |
| temporal brain areas local | anatomy |
| temporal lobe | anatomy |
| temporal region | anatomy |
| thalamus | anatomy |
| Tonsil local | anatomy |
| users | cohort |
| users local | phenotype |
| verbal learning and memory local | phenotype |
| Verbal learning and memory local | phenotype |
| verbal memory | phenotype |
| verbal retention local | phenotype |
| Visuomotor processing local | phenotype |
| visuomotor sequencing local | phenotype |
| Visuomotor switching performance local | phenotype |
| Visuospatial functioning local | phenotype |
| WAIS-III Digit Span total scaled score local | phenotype |
| WAIS-III Digit Symbol local | phenotype |
| WAIS-III Digit Symbol total scaled score local | phenotype |
| white matter | anatomy |
| White matter development local | anatomy |
| withdrawal | phenotype |
| WMS-III Logical Memory delayed recall local | phenotype |
| WMS-III Logical Memory II delayed recall local | phenotype |
| working memory | phenotype |
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