The contribution of parental alcohol use disorders and other psychiatric illness to the risk of alcohol use disorders in the offspring.
paper
Cited
Public
- Authors
- Sørensen, Holger J; Manzardo, Ann M; Knop, Joachim; Penick, Elizabeth C; Madarasz, Wendy; Nickel, Elizabeth J; Becker, Ulrik; Mortensen, Erik L
- Year
- 2011
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 21676003
- DOI
- 10.1111/j.1530-0277.2011.01467.x
- PMCID
- PMC3653408
BACKGROUND: Few population-based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD). METHODS: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status. RESULTS: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members. CONCLUSIONS: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.
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| Name | Type |
|---|---|
| Adopted daughters local | cohort |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| alcoholism | phenotype |
| Alcohol-related diagnosis local | phenotype |
| Alcohol Use Disorder | phenotype |
| Alcohol use disorders (AUD) local | phenotype |
| anxiety | phenotype |
| assortative mating | phenotype |
| attention deficit hyperactivity disorder | phenotype |
| AUD | phenotype |
| behavioral disorders | phenotype |
| Biological mothers local | cohort |
| Biological parents | cohort |
| both parents AUD | phenotype |
| both parents with Alcohol Use Disorder local | phenotype |
| cohort members | cohort |
| Cohort offspring local | cohort |
| conduct disorder | phenotype |
| Copenhagen Metropolit Study local | cohort |
| Copenhagen Perinatal Cohort local | cohort |
| Danish adoption studies local | cohort |
| Danish Central Psychiatric Register local | cohort |
| Danish Cohort Study (Osler et al., 2006) local | cohort |
| Danish National Hospital Register local | cohort |
| Danish Psychiatric Central Register local | cohort |
| Danish women local | cohort |
| Denmark cohort | cohort |
| depression | phenotype |
| Deprived circumstances during childhood local | phenotype |
| Deprived Social Circumstances During Childhood local | phenotype |
| families | cohort |
| family history of alcoholism | phenotype |
| Family study (Lieb et al., 2002) local | cohort |
| fathers | cohort |
| Goodwin adoption studies local | cohort |
| hospital admissions (parental OPD) local | phenotype |
| Large family study (Nurnberger et al., 2004) local | cohort |
| maternal OPD local | phenotype |
| Maternal OPD local | phenotype |
| Maternal Other Psychiatric Disorder local | phenotype |
| Maternal Other Psychiatric Disorders local | phenotype |
| maternal psychiatric hospitalisation (OPD) local | phenotype |
| Mater University Study of Pregnancy (MUSP) local | cohort |
| men | cohort |
| mood disorders | phenotype |
| mother AUD | phenotype |
| mothers | cohort |
| offspring | cohort |
| Offspring alcoholism local | phenotype |
| Offspring Alcohol Use Disorder local | phenotype |
| offspring gender local | phenotype |
| Offspring gender local | phenotype |
| Offspring of fathers local | cohort |
| Offspring of mothers local | cohort |
| Offspring OPD local | phenotype |
| Other Psychiatric Disorder local | phenotype |
| Other psychiatric disorder (OPD) local | phenotype |
| other psychiatric disorders | phenotype |
| Outpatient alcohol clinic local | cohort |
| parental alcoholism | phenotype |
| Parental loss local | phenotype |
| Parental mental disorders local | phenotype |
| parental OPD local | phenotype |
| Parental OPD local | phenotype |
| parental other psychiatric disorder local | phenotype |
| parental social status local | phenotype |
| Parental social status local | phenotype |
| Parental Social Status local | phenotype |
| parents | cohort |
| paternal alcoholism | phenotype |
| paternal alcohol use disorder | phenotype |
| paternal OPD local | phenotype |
| Paternal OPD local | phenotype |
| Paternal Other Psychiatric Disorder local | phenotype |
| Paternal Other Psychiatric Disorders local | phenotype |
| prenatal alcohol exposure | phenotype |
| sex | phenotype |
| substance abuse | phenotype |
| Twin cohort | cohort |
| WINALCO database local | cohort |
| WINALCO-database local | cohort |
| women | cohort |
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