Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.
paper
Cited
Public
- Authors
- Lichtenstein, Paul; Yip, Benjamin H; Bjรถrk, Camilla; Pawitan, Yudi; Cannon, Tyrone D; Sullivan, Patrick F; Hultman, Christina M
- Year
- 2009
- Journal
- Lancet (London, England)
- PMID
- 19150704
- DOI
- 10.1016/S0140-6736(09)60072-6
- PMCID
- PMC3879718
BACKGROUND: Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry. We aimed to assess genetic and environmental contributions to liability for schizophrenia, bipolar disorder, and their comorbidity. METHODS: We linked the multi-generation register, which contains information about all children and their parents in Sweden, and the hospital discharge register, which includes all public psychiatric inpatient admissions in Sweden. We identified 9 009 202 unique individuals in more than 2 million nuclear families between 1973 and 2004. Risks for schizophrenia, bipolar disorder, and their comorbidity were assessed for biological and adoptive parents, offspring, full-siblings and half-siblings of probands with one of the diseases. We used a multivariate generalised linear mixed model for analysis of genetic and environmental contributions to liability for schizophrenia, bipolar disorder, and the comorbidity. FINDINGS: First-degree relatives of probands with either schizophrenia (n=35 985) or bipolar disorder (n=40 487) were at increased risk of these disorders. Half-siblings had a significantly increased risk (schizophrenia: relative risk [RR] 3.6, 95% CI 2.3-5.5 for maternal half-siblings, and 2.7, 1.9-3.8 for paternal half-siblings; bipolar disorder: 4.5, 2.7-7.4 for maternal half-siblings, and 2.4, 1.4-4.1 for paternal half-siblings), but substantially lower than that of the full-siblings (schizophrenia: 9.0, 8.5-11.6; bipolar disorder: 7.9, 7.1-8.8). When relatives of probands with bipolar disorder were analysed, increased risks for schizophrenia existed for all relationships, including adopted children to biological parents with bipolar disorder. Heritability for schizophrenia and bipolar disorder was 64% and 59%, respectively. Shared environmental effects were small but substantial (schizophrenia: 4.5%, 4.4%-7.4%; bipolar disorder: 3.4%, 2.3%-6.2%) for both disorders. The comorbidity between disorders was mainly (63%) due to additive genetic effects common to both disorders. INTERPRETATION: Similar to molecular genetic studies, we showed evidence that schizophrenia and bipolar disorder partly share a common genetic cause. These results challenge the current nosological dichotomy between schizophrenia and bipolar disorder, and are consistent with a reappraisal of these disorders as distinct diagnostic entities.
Amount of variance accounted for by genetic, shared environmental and nonshared environmental influences for schizophrenia and bipolar disorder.Note: Red denotes genetic influences and blue shared and nonshared environmental influences. Solid red: Genetic variance for disorder (schizophrenia/bipolar disorder) that is shared with the other disorder. Hatched red: Genetic variance for disorder (schizophrenia/bipolar disorder) that is not shared with the other disorder.
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| The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia. | Misiak B et al. | โ | 2023 | โ |
| The Genetic Side of the Mood: A Scientometric Review of the Genetic Basis of Mood Disorders. | Bonacina G et al. | โ | 2023 | โ |
| The Manic Idea Creator? A Review and Meta-Analysis of the Relationship between Bipolar Disorder and Creative Cognitive Potential. | Forthmann B et al. | โ | 2023 | โ |
| The molecular cytoarchitecture of the adult mouse brain. | Langlieb J et al. | โ | 2023 | โ |
| The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research. | Nakamura T et al. | โ | 2023 | โ |
| "To fast or not to fast?" Ramadan and religiosity through the eyes of people with bipolar disorder: an exploratory study. | Mejri I et al. | โ | 2023 | โ |
| Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders. | Ye J et al. | โ | 2023 | โ |
| Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study. | Hilland E et al. | โ | 2022 | โ |
| A Comparative Multimodal Meta-analysis of Anisotropy and Volume Abnormalities in White Matter in People Suffering From Bipolar Disorder or Schizophrenia. | Zhao G et al. | โ | 2022 | โ |
| A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies. | Shao Z et al. | โ | 2022 | โ |
| A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy. | Athanasiadis G et al. | โ | 2022 | โ |
| Age-dependent effects of schizophrenia genetic risk on cortical thickness and cortical surface area: Evaluating evidence for neurodevelopmental and neurodegenerative models of schizophrenia. | Kuo SS et al. | โ | 2022 | โ |
| A Nation-Wide Swedish Cohort Study on Early Maternal Age at First Childbirth and Risk for Offspring Deaths, Accidents, and Suicide Attempts. | Sujan AC et al. | โ | 2022 | โ |
| A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study. | Schulte EC et al. | โ | 2022 | โ |
| A Possible White Matter Compensating Mechanism in the Brain of Relatives of People Affected by Psychosis Inferred from Repeated Long-Term DTI Scans. | Caspi Y | โ | 2022 | โ |
| Association between genetic and socioenvironmental risk for schizophrenia during upbringing in a UK longitudinal cohort. | Newbury JB et al. | โ | 2022 | โ |
| Association of Etiological Factors for Hypomanic Symptoms, Bipolar Disorder, and Other Severe Mental Illnesses. | Hosang GM et al. | โ | 2022 | โ |
| Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence. | Kuhns L et al. | โ | 2022 | โ |
| A systematic review and meta-analysis of structural and functional brain alterations in individuals with genetic and clinical high-risk for psychosis and bipolar disorder. | Luna LP et al. | โ | 2022 | โ |
| Brain-wide versus genome-wide vulnerability biomarkers for severe mental illnesses. | Kochunov P et al. | โ | 2022 | โ |
| Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the US. | Dalby M et al. | โ | 2022 | โ |
| Circulating hsa-let-7e-5p and hsa-miR-125a-5p as Possible Biomarkers in the Diagnosis of Major Depression and Bipolar Disorders. | Gecys D et al. | โ | 2022 | โ |
| Correlations between peripheral levels of inflammatory mediators and frontolimbic structures in bipolar disorder: an exploratory analysis. | Mohite S et al. | โ | 2022 | โ |
| Cumulative sociodemographic disadvantage partially mediates associations between childhood trauma and schizotypy. | Tonini E et al. | โ | 2022 | โ |
| Deep learning-based integration of genetics with registry data for stratification of schizophrenia and depression. | Allesรธe RL et al. | โ | 2022 | โ |
| Development of the Korea-Polyenvironmental Risk Score for Psychosis. | Jeon EJ et al. | โ | 2022 | โ |
| Diagnosis stability and outcome of psychotic episodes in a Romanian group of children and adolescents. | Rad F et al. | โ | 2022 | โ |
| Diagnostic classification of schizophrenia and bipolar disorder by using dynamic functional connectivity: An fNIRS study. | Eken A et al. | โ | 2022 | โ |
| Different Frequency of Heschl's Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders. | Takahashi T et al. | โ | 2022 | โ |
| Disrupted <i>Cacna1c</i> gene expression perturbs spontaneous Ca<sup>2+</sup> activity causing abnormal brain development and increased anxiety. | Smedler E et al. | โ | 2022 | โ |
| Dissecting the association between psychiatric disorders and neurological proteins: a genetic correlation and two-sample bidirectional Mendelian randomization study. | Huang H et al. | โ | 2022 | โ |
| Distinctively lower DISC1 mRNA levels in patients with schizophrenia, especially in those with higher positive, negative, and depressive symptoms. | Chen YM et al. | โ | 2022 | โ |
| dsMTL: a computational framework for privacy-preserving, distributed multi-task machine learning. | Cao H et al. | โ | 2022 | โ |
| Dynamic and Static Cognitive Deficits in Schizophrenia and Bipolar Disorder After the First Episode. | Zanelli J et al. | โ | 2022 | โ |
| Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition. | San-Martin R et al. | โ | 2022 | โ |
| Effects of psychosis-associated genetic markers on brain volumetry: a systematic review of replicated findings and an independent validation. | Vouga Ribeiro N et al. | โ | 2022 | โ |
| Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder. | Hesam-Shariati S et al. | โ | 2022 | โ |
| Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels. | Toyama M et al. | โ | 2022 | โ |
| Exosomes in schizophrenia: Pathophysiological mechanisms, biomarkers, and therapeutic targets. | Wang Y et al. | โ | 2022 | โ |
| Eye Movement Patterns Can Distinguish Schizophrenia From the Major Affective Disorders and Healthy Control Subjects. | St Clair D et al. | โ | 2022 | โ |
| Family History of Psychiatric Disorders as a Risk Factor for Maternal Postpartum Depression: A Systematic Review and Meta-analysis. | Zacher Kjeldsen MM et al. | โ | 2022 | โ |
| Family history of psychiatric disorders as a risk factor for maternal postpartum depression: a systematic review protocol. | Kjeldsen MZ et al. | โ | 2022 | โ |
| Gene expression changes following chronic antipsychotic exposure in single cells from mouse striatum. | Abrantes A et al. | โ | 2022 | โ |
| Genetic analysis of the ZNF804A gene in Mexican patients with schizophrenia, schizoaffective disorder and bipolar disorder. | Mรผnch-Anguiano L et al. | โ | 2022 | โ |
| Genetic and functional analyses implicate microRNA 499A in bipolar disorder development. | Tielke A et al. | โ | 2022 | โ |
| Genetic Polymorphisms in miR-137 and Its Target Genes, TCF4 and CACNA1C, Contribute to the Risk of Bipolar Disorder: A Preliminary Case-Control Study and Bioinformatics Analysis. | Mokhtari MA et al. | โ | 2022 | โ |
| Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci. | Wistrรถm ED et al. | โ | 2022 | โ |
| Genome-wide association studies-supported rs12966547 variant of the long noncoding RNA LOC105372125 is significantly associated with susceptibility to schizophrenia and bipolar disorder in Han Chinese women. | Zhao Z et al. | โ | 2022 | โ |
| Genome-wide DNA methylation in an animal model and human studies of schizophrenia: a protocol for a meta-analysis. | Magwai T et al. | โ | 2022 | โ |
| Glutamatergic dysfunction in Schizophrenia. | Kruse AO et al. | โ | 2022 | โ |
| Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. | Wang C et al. | โ | 2022 | โ |
| Influence of pre-treatment structural brain measures on effects of action-based cognitive remediation on executive function in partially or fully remitted patients with bipolar disorder. | Mogensen MB et al. | โ | 2022 | โ |
| Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. | de Zwarte SMC et al. | โ | 2022 | โ |
| Interactive effects of polygenic risk and cognitive subtype on brain morphology in schizophrenia spectrum and bipolar disorders. | Quidรฉ Y et al. | โ | 2022 | โ |
| In utero exposure to antipsychotic medication and psychiatric outcomes in the offspring. | Momen NC et al. | โ | 2022 | โ |
| Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11. | Gregersen M et al. | โ | 2022 | โ |
| Minor physical anomalies in bipolar disorder in comparison to healthy controls and schizophrenia: A systematic review and meta-analysis. | Bora E | โ | 2022 | โ |
| Neural Correlates of the Risk for Schizophrenia and Bipolar Disorder: A Meta-analysis of Structural and Functional Neuroimaging Studies. | Cattarinussi G et al. | โ | 2022 | โ |
| Neurocognitive Artificial Neural Network Models Are Superior to Linear Models at Accounting for Dimensional Psychopathology. | Haywood D et al. | โ | 2022 | โ |
| Neurocognitive heterogeneity in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study - VIA 7. | Hemager N et al. | โ | 2022 | โ |
| Novel disease associations with schizophrenia genetic risk revealed in ~400,000 UK Biobank participants. | Zhang R et al. | โ | 2022 | โ |
| NRG1 knockdown rescues PV interneuron GABAergic maturation deficits and schizophrenia behaviors in fetal growth restriction mice. | Dong J et al. | โ | 2022 | โ |
| Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review. | Murillo-Garcรญa N et al. | โ | 2022 | โ |
| Oxidative stress parameters and antioxidants in adults with unipolar or bipolar depression versus healthy controls: Systematic review and meta-analysis. | Jimรฉnez-Fernรกndez S et al. | โ | 2022 | โ |
| Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System. | Bigdeli TB et al. | โ | 2022 | โ |
| Peripheral lymphocyte signaling pathway deficiencies predict treatment response in first-onset drug-naรฏve schizophrenia. | Lago SG et al. | โ | 2022 | โ |
| Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples. | Machlitt-Northen S et al. | โ | 2022 | โ |
| Preliminary studies on apparent mendelian psychotic disorders in consanguineous families. | Kanwal A et al. | โ | 2022 | โ |
| Reprint of: Elemental dysregulation in psychotic spectrum disorders: A review and research synthesis. | Zaks N et al. | โ | 2022 | โ |
| Research Review: A guide to computing and implementing polygenic scores in developmental research. | Allegrini AG et al. | โ | 2022 | โ |
| Schizophrenia. | Jauhar S et al. | โ | 2022 | โ |
| Schizophrenia and Bipolar Polygenic Risk Scores in Relation to Intracranial Volume. | de Zwarte SMC et al. | โ | 2022 | โ |
| Serotonin transporter functional polymorphisms potentially increase risk of schizophrenia separately and as a haplotype. | Ghamari R et al. | โ | 2022 | โ |
| Shared Genetics and Causality Between Decaffeinated Coffee Consumption and Neuropsychiatric Diseases: A Large-Scale Genome-Wide Cross-Trait Analysis and Mendelian Randomization Analysis. | Yin B et al. | โ | 2022 | โ |
| Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study. | El Nagar Z et al. | โ | 2022 | โ |
| Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders. | Xu M et al. | โ | 2022 | โ |
| Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders. | Akingbuwa WA et al. | โ | 2022 | โ |
| The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1. | Haddad Derafshi B et al. | โ | 2022 | โ |
| The colors of our brain: an integrated approach for dimensionality reduction and explainability in fMRI through color coding (i-ECO). | Tarchi L et al. | โ | 2022 | โ |
| The genetics of bipolar disorder with obesity and type 2 diabetes. | Miola A et al. | โ | 2022 | โ |
| The impact of educational attainment, intelligence and intellectual disability on schizophrenia: a Swedish population-based register and genetic study. | Song J et al. | โ | 2022 | โ |
| The mood disorder spectrum vs. schizophrenia decision tree: EDIPHAS research into the childhood and adolescence of 205 patients. | Lรฉger M et al. | โ | 2022 | โ |
| The P-factor and its genomic and neural equivalents: an integrated perspective. | Sprooten E et al. | โ | 2022 | โ |
| The SFT2D2 gene is associated with the autoimmune pathology of schizophrenia in a Chinese population. | Liu D et al. | โ | 2022 | โ |
| Third-generation genome sequencing implicates medium-sized structural variants in chronic schizophrenia. | Lee CC et al. | โ | 2022 | โ |
| Transmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum. | Wu Y et al. | โ | 2022 | โ |
| Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum. | Watson D et al. | โ | 2022 | โ |
| A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics. | Lu H et al. | โ | 2021 | โ |
| Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function. | Li Q et al. | โ | 2021 | โ |
| Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates. | Page NF et al. | โ | 2021 | โ |
| Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man. | Hime GR et al. | โ | 2021 | โ |
| A nationwide population-based longitudinal study mapping psychiatric disorders during lifetime in siblings to patients with bipolar disorder. | Vedel Kessing L et al. | โ | 2021 | โ |
| ANK3 Gene Polymorphism Rs10994336 Influences Executive Functions by Modulating Methylation in Patients With Bipolar Disorder. | Tang L et al. | โ | 2021 | โ |
| "Apples and pears are similar, but still different things." Bipolar disorder and schizophrenia- discrete disorders or just dimensions ? | Grunze H et al. | โ | 2021 | โ |
| A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia. | Mahmood T et al. | โ | 2021 | โ |
| A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone. | North HF et al. | โ | 2021 | โ |
| Association Between REELIN Gene Polymorphisms (rs7341475 and rs262355) and Risk of Schizophrenia: an Updated Meta-analysis. | Marzan S et al. | โ | 2021 | โ |
| Association between schizotypal personality traits and emotional instability: mediation and moderation analysis among Chinese college students. | Liu J et al. | โ | 2021 | โ |
| Attractin Participates in Schizophrenia by Affecting Testosterone Levels. | Li N et al. | โ | 2021 | โ |
| Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions. | Hwang M et al. | โ | 2021 | โ |
| Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia. | Cobia D et al. | โ | 2021 | โ |
| Benefits and harms of Risperidone and Paliperidone for treatment of patients with schizophrenia or bipolar disorder: a meta-analysis involving individual participant data and clinical study reports. | Hodkinson A et al. | โ | 2021 | โ |
| Bullying victimization and stress sensitivity in help-seeking youth: findings from an experience sampling study. | Rauschenberg C et al. | โ | 2021 | โ |
| Combined cortisol and melatonin measurements with detailed parameter analysis can assess the circadian rhythms in bipolar disorder patients. | Fang L et al. | โ | 2021 | โ |
| Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics. | Zhang Y et al. | โ | 2021 | โ |
| Detecting local genetic correlations with scan statistics. | Guo H et al. | โ | 2021 | โ |
| Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes. | Priol AC et al. | โ | 2021 | โ |
| Disorganization of Oscillatory Activity in Animal Models of Schizophrenia. | Speers LJ et al. | โ | 2021 | โ |
| DNA Methylation and Schizophrenia: Current Literature and Future Perspective. | Magwai T et al. | โ | 2021 | โ |
| Do the Transmissible Liability Index (TLI) and Adolescent Cannabis Use Predict Paranoid and Schizotypal Symptoms at Young Adulthood? | Sharma P et al. | โ | 2021 | โ |
| Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study. | Ajnakina O et al. | โ | 2021 | โ |
| Elemental dysregulation in psychotic spectrum disorders: A review and research synthesis. | Zaks N et al. | โ | 2021 | โ |
| Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions. | Robinson N et al. | โ | 2021 | โ |
| Estimating Aggregate Environmental Risk Score in Psychiatry: The Exposome Score for Schizophrenia. | Pries LK et al. | โ | 2021 | โ |
| Familial Aggregation of CKD and Heritability of Kidney Biomarkers in the General Population: The Lifelines Cohort Study. | Zhang J et al. | โ | 2021 | โ |
| Familial Aggregation of Head and Neck Cancer in Taiwan. | Padua PF et al. | โ | 2021 | โ |
| Familial co-aggregation of schizophrenia and eating disorders in Sweden and Denmark. | Zhang R et al. | โ | 2021 | โ |
| Familial Psychosis Associated With a Missense Mutation at <i>MACF1</i> Gene Combined With the Rare Duplications DUP3p26.3 and DUP16q23.3, Affecting the <i>CNTN6</i> and <i>CDH13</i> Genes. | Pol-Fuster J et al. | โ | 2021 | โ |
| Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample. | Kendler KS et al. | โ | 2021 | โ |
| For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder. | Yegin Z et al. | โ | 2021 | โ |
| Functional patient-derived cellular models for neuropsychiatric drug discovery. | Lago SG et al. | โ | 2021 | โ |
| Gene-Environment Interactions in Schizophrenia: A Literature Review. | Wahbeh MH et al. | โ | 2021 | โ |
| Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multisite Study of Multiplex Pedigrees. | Knowles EEM et al. | โ | 2021 | โ |
| Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function. | Rathje M et al. | โ | 2021 | โ |
| Genomic perspectives on the circadian clock hypothesis of psychiatric disorders. | von Schantz M et al. | โ | 2021 | โ |
| Genomic prediction using low-coverage portable Nanopore sequencing. | Lamb HJ et al. | โ | 2021 | โ |
| Global Scientific Outputs of Schizophrenia Publications From 1975 to 2020: a Bibliometric Analysis. | Kiraz S et al. | โ | 2021 | โ |
| Heart rate variability is associated with disease severity in psychosis spectrum disorders. | Benjamin BR et al. | โ | 2021 | โ |
| Hidden Role of Gut Microbiome Dysbiosis in Schizophrenia: Antipsychotics or Psychobiotics as Therapeutics? | Munawar N et al. | โ | 2021 | โ |
| Identification of a Risk Locus at 7p22.3 for Schizophrenia and Bipolar Disorder in East Asian Populations. | Li W et al. | โ | 2021 | โ |
| Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis. | Tamouza R et al. | โ | 2021 | โ |
| Inherited L1 Retrotransposon Insertions Associated With Risk for Schizophrenia and Bipolar Disorder. | Reiner BC et al. | โ | 2021 | โ |
| Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. | Jia X et al. | โ | 2021 | โ |
| MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population. | Liu X et al. | โ | 2021 | โ |
| Meta-analysis of sample-level dbGaP data reveals novel shared genetic link between body height and Crohn's disease. | Di Narzo A et al. | โ | 2021 | โ |
| MicroRNAs in the Onset of Schizophrenia. | Thomas KT et al. | โ | 2021 | โ |
| Neuropsychiatric Genetics of Psychosis in the Mexican Population: A Genome-Wide Association Study Protocol for Schizophrenia, Schizoaffective, and Bipolar Disorder Patients and Controls. | Camarena B et al. | โ | 2021 | โ |
| Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain. | Hua J et al. | โ | 2021 | โ |
| Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. | Rรธdevand L et al. | โ | 2021 | โ |
| Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals. | Kember RL et al. | โ | 2021 | โ |
| Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. | Takeuchi H et al. | โ | 2021 | โ |
| Polygenic risk scores across the extended psychosis spectrum. | Smigielski L et al. | โ | 2021 | โ |
| Polymorphisms in MicroRNA Genes Associated with Schizophrenia Susceptibility but Not with Effectiveness of MECT. | Zhang D et al. | โ | 2021 | โ |
| Postpartum psychiatric readmissions: A nationwide study in women with and without epilepsy. | Isseroff D et al. | โ | 2021 | โ |
| Precursors of self-reported subclinical hypomania in adolescence: A longitudinal general population study. | Nielsen LG et al. | โ | 2021 | โ |
| Protocol for a pharmacogenomic study on individualised antipsychotic drug treatment for patients with schizophrenia. | Su Y et al. | โ | 2021 | โ |
| Psychiatric symptoms and syndromes transcending diagnostic boundaries in Indian multiplex families: The cohort of ADBS study. | Sreeraj VS et al. | โ | 2021 | โ |
| Psychotic-Like Experiences in Adolescence Occurring in Combination or Isolation: Associations with Schizophrenia Risk Factors. | Cardno AG et al. | โ | 2021 | โ |
| Rare germline variants in individuals diagnosed with schizophrenia within multiplex families. | Li S et al. | โ | 2021 | โ |
| Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study. | Briley PM et al. | โ | 2021 | โ |
| Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review. | Baselmans BML et al. | โ | 2021 | โ |
| Role of rTMS in the treatment of cognitive impairments in Bipolar Disorder and Schizophrenia: a review of Randomized Controlled Trials. | Sciortino D et al. | โ | 2021 | โ |
| Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults. | Bartsch U et al. | โ | 2021 | โ |
| Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder. | Joo SW et al. | โ | 2021 | โ |
| Shared genetic architecture across psychiatric disorders. | Grotzinger AD | โ | 2021 | โ |
| Structural neuroimaging phenotypes of a novel multi-gene risk score in youth bipolar disorder. | Cazes J et al. | โ | 2021 | โ |
| The conserved ASTN2/BRINP1 locus at 9q33.1-33.2 is associated with major psychiatric disorders in a large pedigree from Southern Spain. | Pol-Fuster J et al. | โ | 2021 | โ |
| The effect of antipsychotics on the cognitive performance of individuals with psychotic disorders: Network meta-analyses of randomized controlled trials. | Baldez DP et al. | โ | 2021 | โ |
| The interaction of ASAH1 and NGF gene involving in neurotrophin signaling pathway contributes to schizophrenia susceptibility and psychopathology. | Su Y et al. | โ | 2021 | โ |
| The state of the science in psychiatric genomics. | Sullivan PF et al. | โ | 2021 | โ |
| Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders. | Puglisi-Allegra S et al. | โ | 2021 | โ |
| Treatment of Symptom Clusters in Schizophrenia, Bipolar Disorder and Major Depressive Disorder With the Dopamine D3/D2 Preferring Partial Agonist Cariprazine. | Batinic B et al. | โ | 2021 | โ |
| Using iPSC Models to Understand the Role of Estrogen in Neuron-Glia Interactions in Schizophrenia and Bipolar Disorder. | Reis de Assis D et al. | โ | 2021 | โ |
| Weak Association Between the Glutamate Decarboxylase 1 Gene (GAD1) and Schizophrenia in Han Chinese Population. | Zhang L et al. | โ | 2021 | โ |
| 22q11.2 deletion syndrome and schizophrenia. | Qin X et al. | โ | 2020 | โ |
| Aberrant structural covariance networks in youth at high familial risk for mood disorder. | Heinze K et al. | โ | 2020 | โ |
| A critical narrative analysis of psychiatrists' engagement with psychosis as a contentious area. | O'Donoghue T et al. | โ | 2020 | โ |
| Adaptive Fisher method detects dense and sparse signals in association analysis of SNV sets. | Cai X et al. | โ | 2020 | โ |
| Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review. | Johnsen LK et al. | โ | 2020 | โ |
| Alterations of Cognition and Cerebral Ventricle Volume in Manic and Euthymic Pediatric Bipolar Disorder. | Kuang L et al. | โ | 2020 | โ |
| An atlas of genetic correlations between psychiatric disorders and human blood plasma proteome. | Cheng S et al. | โ | 2020 | โ |
| A neuroimaging biomarker for striatal dysfunction in schizophrenia. | Li A et al. | โ | 2020 | โ |
| An Extended Swedish National Adoption Study of Bipolar Disorder Illness and Cross-Generational Familial Association With Schizophrenia and Major Depression. | Kendler KS et al. | โ | 2020 | โ |
| A selective inference approach for false discovery rate control using multiomics covariates yields insights into disease risk. | Yurko R et al. | โ | 2020 | โ |
| Assessment Causality in Associations Between Serum Uric Acid and Risk of Schizophrenia: A Two-Sample Bidirectional Mendelian Randomization Study. | Luo Q et al. | โ | 2020 | โ |
| Association of <i>DTNBP1</i> With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population. | Yang Y et al. | โ | 2020 | โ |
| Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls. | Lyngstad SH et al. | โ | 2020 | โ |
| Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features. | Parker DA et al. | โ | 2020 | โ |
| Beyond the Mind-Serum Trace Element Levels in Schizophrenic Patients: A Systematic Review. | Baj J et al. | โ | 2020 | โ |
| Characterization of genome-wide association study data reveals spatiotemporal heterogeneity of mental disorders. | Dai Y et al. | โ | 2020 | โ |
| Childhood social isolation and psychotic experiences in young adulthood: a community based study. | Bennett JC et al. | โ | 2020 | โ |
| Common gray and white matter abnormalities in schizophrenia and bipolar disorder. | Lee DK et al. | โ | 2020 | โ |
| Comparison of cognitive dysfunction between schizophrenia and bipolar disorder patients: A meta-analysis of comparative studies. | Li W et al. | โ | 2020 | โ |
| Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome. | Courtois E et al. | โ | 2020 | โ |
| Cross-Disorder Analysis of Brain Structural Abnormalities in Six Major Psychiatric Disorders: A Secondary Analysis of Mega- and Meta-analytical Findings From the ENIGMA Consortium. | Opel N et al. | โ | 2020 | โ |
| Dissecting the molecular biology of schizophrenia: A call for emphasising genetic and phenotypic heterogeneity: commentary on Torrey and Yolken (this issue). | Schwab SG | โ | 2020 | โ |
| Effects of Lithium Combined with Second-Generation Antipsychotics for the Treatment of Manic Episodes in Patients with Bipolar Disorder: A Naturalistic Study in China. | Liu Y et al. | โ | 2020 | โ |
| Epidemiological Studies of Prenatal and Childhood Infection and Schizophrenia. | Karlsson H et al. | โ | 2020 | โ |
| Evaluating the Impact of Nonrandom Mating: Psychiatric Outcomes Among the Offspring of Pairs Diagnosed With Schizophrenia and Bipolar Disorder. | Nordsletten AE et al. | โ | 2020 | โ |
| Genetic polymorphisms of PIP5K2A and course of schizophrenia. | Poltavskaya EG et al. | โ | 2020 | โ |
| Genetic Risk Assessment in Psychiatry. | Peay HL | โ | 2020 | โ |
| Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. | Smeland OB et al. | โ | 2020 | โ |
| Genomic Variation, Evolvability, and the Paradox of Mental Illness. | Gualtieri CT | โ | 2020 | โ |
| Glutamate in schizophrenia: Neurodevelopmental perspectives and drug development. | Egerton A et al. | โ | 2020 | โ |
| Identificacion of MRI-based psychosis subtypes: Replication and refinement. | Planchuelo-Gรณmez ร et al. | โ | 2020 | โ |
| Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia. | Halvorsen M et al. | โ | 2020 | โ |
| Interaction of reelin and stress on immobility in the forced swim test but not dopamine-mediated locomotor hyperactivity or prepulse inhibition disruption: Relevance to psychotic and mood disorders. | Notaras MJ et al. | โ | 2020 | โ |
| Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. | Powell SK et al. | โ | 2020 | โ |
| In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia. | Koszลa O et al. | โ | 2020 | โ |
| LINE-1 hypomethylation is associated with poor risperidone response in a first episode of psychosis cohort. | Marques DF et al. | โ | 2020 | โ |
| Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. | Steen NE et al. | โ | 2020 | โ |
| Methods and Challenges for Assessing Heterogeneity. | Feczko E et al. | โ | 2020 | โ |
| Mitochondrial function parameters as a tool for tailored drug treatment of an individual with psychosis: a proof of concept study. | Bar-Yosef T et al. | โ | 2020 | โ |
| Multiple rare inherited variants in a four generation schizophrenia family offer leads for complex mode of disease inheritance. | John J et al. | โ | 2020 | โ |
| Network analysis of mood symptoms in adolescents with or at high risk for bipolar disorder. | Weintraub MJ et al. | โ | 2020 | โ |
| No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia. | Yao Y et al. | โ | 2020 | โ |
| Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior. | Yoshino Y et al. | โ | 2020 | โ |
| Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients. | Li M et al. | โ | 2020 | โ |
| On the diagnostic and neurobiological origins of bipolar disorder. | Charney AW et al. | โ | 2020 | โ |
| Personality traits across the psychosis spectrum: A Hierarchical Taxonomy of Psychopathology conceptualization of clinical symptomatology. | Longenecker JM et al. | โ | 2020 | โ |
| Phosphoinositide-3-kinase regulatory subunit 1 gene polymorphisms are associated with schizophrenia and bipolar disorder in the Han Chinese population. | Huang J et al. | โ | 2020 | โ |
| Plasma Metabolite Profiles in First Episode Psychosis: Exploring Symptoms Heterogeneity/Severity in Schizophrenia and Bipolar Disorder Cohorts. | Joaquim HPG et al. | โ | 2020 | โ |
| Pluripotential Risk and Clinical Staging: Theoretical Considerations and Preliminary Data From a Transdiagnostic Risk Identification Approach. | Hartmann JA et al. | โ | 2020 | โ |
| Polygenic analysis suggests the involvement of calcium signaling in executive function in schizophrenia patients. | Kirchner SK et al. | โ | 2020 | โ |
| Polygenic risk scores: from research tools to clinical instruments. | Lewis CM et al. | โ | 2020 | โ |
| Polygenic Risk Scores Shed Light on the Relationship between Schizophrenia and Cognitive Functioning: Review and Meta-Analysis. | Mallet J et al. | โ | 2020 | โ |
| Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls. | Engen MJ et al. | โ | 2020 | โ |
| Precision psychiatry with immunological and cognitive biomarkers: a multi-domain prediction for the diagnosis of bipolar disorder or schizophrenia using machine learning. | Fernandes BS et al. | โ | 2020 | โ |
| Real-world digital implementation of the Psychosis Polyrisk Score (PPS): A pilot feasibility study. | Oliver D et al. | โ | 2020 | โ |
| Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology. | Waszczuk MA et al. | โ | 2020 | โ |
| Reduced density of oligodendrocytes and oligodendrocyte clusters in the caudate nucleus in major psychiatric illnesses. | Vostrikov VM et al. | โ | 2020 | โ |
| Reporting trigger factors for (hypo)manic episodes in bipolar disorder: association with personality and prognosis. | Smedler E et al. | โ | 2020 | โ |
| Risk of Stroke in Patients With Atrial Fibrillation Is Associated With Stroke in Siblings: A Nationwide Study. | Berntsson J et al. | โ | 2020 | โ |
| Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights. | Zamanpoor M | โ | 2020 | โ |
| Schizophrenia in ICD-11: Comparison of ICD-10 and DSM-5. | Valle R | โ | 2020 | โ |
| Sex-Dependent Aggregation of Tinnitus in Swedish Families. | Trpchevska N et al. | โ | 2020 | โ |
| Specificity and Continuity of Schizophrenia and Bipolar Disorder: Relation to Biomarkers. | Yamada Y et al. | โ | 2020 | โ |
| Structural abnormality in schizophrenia versus bipolar disorder: A whole brain cortical thickness, surface area, volume and gyrification analyses. | Madre M et al. | โ | 2020 | โ |
| The connection between microbiome and schizophrenia. | Golofast B et al. | โ | 2020 | โ |
| The Effectiveness of Mental Health Rehabilitation Services: A Systematic Review and Narrative Synthesis. | Dalton-Locke C et al. | โ | 2020 | โ |
| The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine. | Yang Z et al. | โ | 2020 | โ |
| The Gut Microbiome in Bipolar Disorder and Pharmacotherapy Management. | Flowers SA et al. | โ | 2020 | โ |
| The Maudsley environmental risk score for psychosis. | Vassos E et al. | โ | 2020 | โ |
| The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology. | Smeland OB et al. | โ | 2020 | โ |
| The predictive performance of the bipolarity index in a Dutch epidemiological sample manuscript. | Ter Meulen WG et al. | โ | 2020 | โ |
| The role of altered brain structural connectivity in resilience, vulnerability, and disease expression to schizophrenia. | Wei Q et al. | โ | 2020 | โ |
| Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder. | Kathuria A et al. | โ | 2020 | โ |
| Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action. | Manchia M et al. | โ | 2020 | โ |
| Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks. | Bareลกiฤ A et al. | โ | 2020 | โ |
| Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum. | Kotov R et al. | โ | 2020 | โ |
| Whole-exome sequencing of 81 individuals from 27 multiply affected bipolar disorder families. | Forstner AJ et al. | โ | 2020 | โ |
| Wnt receptor gene <i>FZD1</i> was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort. | Liu X et al. | โ | 2020 | โ |
| 120th Anniversary of the Kraepelinian Dichotomy of Psychiatric Disorders. | Rybakowski JK | โ | 2019 | โ |
| A 12-month prospective study on the time to hospitalization and clinical management of a cohort of bipolar type I and schizoaffective bipolar patients. | Murru A et al. | โ | 2019 | โ |
| Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder. | Van Voorhis AC et al. | โ | 2019 | โ |
| A Case-Control Study of ABCB1, ABCB6, and ABCG1 Polymorphisms and Schizophrenia in a Han Chinese Population. | Ma G et al. | โ | 2019 | โ |
| A framework for linking resting-state chronnectome/genome features in schizophrenia: A pilot study. | Rashid B et al. | โ | 2019 | โ |
| A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. | Schork AJ et al. | โ | 2019 | โ |
| A longitudinal approach to biological psychiatric research: The PsyCourse study. | Budde M et al. | โ | 2019 | โ |
| Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia. | Kumar A et al. | โ | 2019 | โ |
| Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients. | Liu Y et al. | โ | 2019 | โ |
| Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk. | Tang Y et al. | โ | 2019 | โ |
| Altered voxel-wise gray matter structural brain networks in schizophrenia: Association with brain genetic expression pattern. | Liu F et al. | โ | 2019 | โ |
| Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia. | Banerjee N et al. | โ | 2019 | โ |
| A population-based heritability estimate of bipolar disorder - In a Swedish twin sample. | Johansson V et al. | โ | 2019 | โ |
| Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study. | Luo Q et al. | โ | 2019 | โ |
| Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. | Bai D et al. | โ | 2019 | โ |
| Association of Genetic Polymorphisms with Age at Onset in Han Chinese Patients with Bipolar Disorder. | Hu SH et al. | โ | 2019 | โ |
| A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder. | Dezhina Z et al. | โ | 2019 | โ |
| BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy. | Doherty C et al. | โ | 2019 | โ |
| Bipolar disorder and 1513A>C P2RX7 polymorphism frequency. | Gubert C et al. | โ | 2019 | โ |
| [Breakthrough in understanding the molecular causes of psychiatric disorders]. | Nรถthen MM et al. | โ | 2019 | โ |
| CACNA1C polymorphism and brain cortical structure in bipolar disorder | Smedler E et al. | โ | 2019 | โ |
| Clinical phenotype and genetic risk factors for bipolar disorder with binge eating: an update. | Cuellar-Barboza AB et al. | โ | 2019 | โ |
| Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder. | Yang Y et al. | โ | 2019 | โ |
| Comorbid disorders as moderators of response to family interventions among adolescents with bipolar disorder. | Weintraub MJ et al. | โ | 2019 | โ |
| Cortico-limbic connectivity as a possible biomarker for bipolar disorder: where are we now? | Vai B et al. | โ | 2019 | โ |
| Cytochrome P450 2C19 Poor Metabolizer Phenotype in Treatment Resistant Depression: Treatment and Diagnostic Implications. | Veldic M et al. | โ | 2019 | โ |
| Decreased need for sleep as an endophenotype of bipolar disorder: an actigraphy study. | Sebela A et al. | โ | 2019 | โ |
| DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits. | Jiang L et al. | โ | 2019 | โ |
| Determining population stratification and subgroup effects in association studies of rare genetic variants for nicotine dependence. | Hsieh AR et al. | โ | 2019 | โ |
| Diagnostic Issues of Depressive Disorders from Kraepelinian Dualism to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. | Park SC et al. | โ | 2019 | โ |
| Discussion on Brain Structure and Function in Schizophrenia by Multimodal Magnetic Resonance Imaging. | Zhi X et al. | โ | 2019 | โ |
| Effective connectivity within a triple network brain system discriminates schizophrenia spectrum disorders from psychotic bipolar disorder at the single-subject level. | Palaniyappan L et al. | โ | 2019 | โ |
| Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms. | Greenwood TA et al. | โ | 2019 | โ |
| Enriching Human Interactome with Functional Mutations to Detect High-Impact Network Modules Underlying Complex Diseases. | Cui H et al. | โ | 2019 | โ |
| Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark. | Khan A et al. | โ | 2019 | โ |
| Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches. | Fรถcking M et al. | โ | 2019 | โ |
| eQTLs Weighted Genetic Correlation Analysis Detected Brain Region Differences in Genetic Correlations for Complex Psychiatric Disorders. | Wen Y et al. | โ | 2019 | โ |
| Evidence for intact stimulus-specific neural adaptation for visual objects in schizophrenia and bipolar disorder: An ERP study. | Wynn JK et al. | โ | 2019 | โ |
| Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes. | Ganesh S et al. | โ | 2019 | โ |
| Familial abnormalities of endocannabinoid signaling in schizophrenia. | Koethe D et al. | โ | 2019 | โ |
| Functional connectomics of affective and psychotic pathology. | Baker JT et al. | โ | 2019 | โ |
| Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia. | Liu CM et al. | โ | 2019 | โ |
| Genetic correlations of polygenic disease traits: from theory to practice. | van Rheenen W et al. | โ | 2019 | โ |
| Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. | Drange OK et al. | โ | 2019 | โ |
| Genome-wide association study identifies 30 loci associated with bipolar disorder. | Stahl EA et al. | โ | 2019 | โ |
| Glutamatergic function in a genetic high-risk group for psychosis: A proton magnetic resonance spectroscopy study in individuals with 22q11.2 deletion. | Rogdaki M et al. | โ | 2019 | โ |
| Handwriting movements for assessment of motor symptoms in schizophrenia spectrum disorders and bipolar disorder. | Crespo Y et al. | โ | 2019 | โ |
| Identifying cognitive subgroups in bipolar disorder: A cluster analysis. | Lima F et al. | โ | 2019 | โ |
| Imaging Genetics Towards a Refined Diagnosis of Schizophrenia. | Jiang W et al. | โ | 2019 | โ |
| Interrogating the Evolutionary Paradox of Schizophrenia: A Novel Framework and Evidence Supporting Recent Negative Selection of Schizophrenia Risk Alleles. | Liu C et al. | โ | 2019 | โ |
| Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study. | Kalman JL et al. | โ | 2019 | โ |
| JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. | Openshaw RL et al. | โ | 2019 | โ |
| Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia. | Bergen SE et al. | โ | 2019 | โ |
| Machine learning identifies unaffected first-degree relatives with functional network patterns and cognitive impairment similar to those of schizophrenia patients. | Jing R et al. | โ | 2019 | โ |
| Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders. | Kim Y et al. | โ | 2019 | โ |
| Neuropsychological Functioning and Temperament Traits in a Czech Sample of Children and Adolescents at Familial Risk of Bipolar Disorder. | Goetz M et al. | โ | 2019 | โ |
| Personality and the Expression of Symptomatology in Schizophrenia and Bipolar Disorder. | Uroลกeviฤ S et al. | โ | 2019 | โ |
| Polygenic risk for schizophrenia and associated brain structural changes: A systematic review. | van der Merwe C et al. | โ | 2019 | โ |
| Polygenic risk score increases schizophrenia liability through cognition-relevant pathways. | Toulopoulou T et al. | โ | 2019 | โ |
| Polygenic Risk Scores for Psychiatric Disorders Reveal Novel Clues About the Genetics of Disordered Gambling. | Piasecki TM et al. | โ | 2019 | โ |
| Prediction of Onset of Substance-Induced Psychotic Disorder and Its Progression to Schizophrenia in a Swedish National Sample. | Kendler KS et al. | โ | 2019 | โ |
| Premorbid adjustment trajectories in schizophrenia and bipolar disorder: A transdiagnostic cluster analysis. | Chan CC et al. | โ | 2019 | โ |
| Preventing discrimination based on psychiatric risk biomarkers. | Brannan C et al. | โ | 2019 | โ |
| Psychological interventions for people with psychotic experiences: protocol for a systematic review and meta-analysis. | Soneson E et al. | โ | 2019 | โ |
| Psychopathology and personality factors in first-degree relatives of patients with schizophrenia. | Verma N et al. | โ | 2019 | โ |
| Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes. | Oliver D et al. | โ | 2019 | โ |
| Rare Variants in Tissue Inhibitor of Metalloproteinase 2 as a Risk Factor for Schizophrenia: Evidence From Familial and Cohort Analysis. | John J et al. | โ | 2019 | โ |
| Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. | Aas M et al. | โ | 2019 | โ |
| Right care, first time: a highly personalised and measurement-based care model to manage youth mental health. | Hickie IB et al. | โ | 2019 | โ |
| Roles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorder. | Caliskan M et al. | โ | 2019 | โ |
| Rs7219 Regulates the Expression of GRB2 by Affecting miR-1288-Mediated Inhibition and Contributes to the Risk of Schizophrenia in the Chinese Han Population. | Yang J et al. | โ | 2019 | โ |
| Running in the Family? Structural Brain Abnormalities and IQ in Offspring, Siblings, Parents, and Co-twins of Patients with Schizophrenia. | de Zwarte SMC et al. | โ | 2019 | โ |
| Shared psychotic disorder in children and young people: a systematic review. | Vigo L et al. | โ | 2019 | โ |
| Slower and Less Variable Binocular Rivalry Rates in Patients With Bipolar Disorder, OCD, Major Depression, and Schizophrenia. | Ye X et al. | โ | 2019 | โ |
| SNP Variation of <i>RELN</i> Gene and Schizophrenia in a Chinese Population: A Hospital-Based Case-Control Study. | Luo X et al. | โ | 2019 | โ |
| Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study. | Christiani CJ et al. | โ | 2019 | โ |
| Testing the expanded continuum hypothesis of schizophrenia and bipolar disorder. Neural and psychological evidence for shared and distinct mechanisms. | Sorella S et al. | โ | 2019 | โ |
| The Amygdala in Schizophrenia and Bipolar Disorder: A Synthesis of Structural MRI, Diffusion Tensor Imaging, and Resting-State Functional Connectivity Findings. | Ho NF et al. | โ | 2019 | โ |
| The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder. | de Zwarte SMC et al. | โ | 2019 | โ |
| The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges. | Smeland OB et al. | โ | 2019 | โ |
| The Finnish psychiatric birth cohort consortium (PSYCOHORTS) - content, plans and perspectives. | Filatova S et al. | โ | 2019 | โ |
| The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders. | Comes AL et al. | โ | 2019 | โ |
| The genomics of major psychiatric disorders in a large pedigree from Northern Sweden. | Szatkiewicz J et al. | โ | 2019 | โ |
| The Microbiota-Gut-Brain Axis. | Cryan JF et al. | โ | 2019 | โ |
| Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature. | Kovรกcs Z et al. | โ | 2019 | โ |
| The schizophrenia and bipolar twin study in Sweden (STAR). | Johansson V et al. | โ | 2019 | โ |
| The subcellular localization of bHLH transcription factor TCF4 is mediated by multiple nuclear localization and nuclear export signals. | Greb-Markiewicz B et al. | โ | 2019 | โ |
| Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study. | Quattrone D et al. | โ | 2019 | โ |
| Transdiagnostic dimensions of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). | Reininghaus U et al. | โ | 2019 | โ |
| Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review. | Prata DP et al. | โ | 2019 | โ |
| Variance Components Models for Analysis of Big Family Data of Health Outcomes in the Lifelines Cohort Study. | Demetrashvili N et al. | โ | 2019 | โ |
| A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci. | Leonenko G et al. | โ | 2018 | โ |
| A genome-wide association study of early gamma-band response in a schizophrenia case-control sample. | Konte B et al. | โ | 2018 | โ |
| All for One and One for All: Mental Disorders in One Dimension. | Caspi A et al. | โ | 2018 | โ |
| A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. | Li W et al. | โ | 2018 | โ |
| Analysis of Gene Expression Variance in Schizophrenia Using Structural Equation Modeling. | Igolkina AA et al. | โ | 2018 | โ |
| Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder. | Reinbold CS et al. | โ | 2018 | โ |
| Ankyrins: Roles in synaptic biology and pathology. | Smith KR et al. | โ | 2018 | โ |
| Anti-Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease. | Peter I et al. | โ | 2018 | โ |
| A polygenic p factor for major psychiatric disorders. | Selzam S et al. | โ | 2018 | โ |
| Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. | de Jong S et al. | โ | 2018 | โ |
| Are we failing clinical trials? A case for strong aggregate outcomes. | Joyce DW et al. | โ | 2018 | โ |
| Assessing the evidence for shared genetic risks across psychiatric disorders and traits. | Martin J et al. | โ | 2018 | โ |
| Assessment of Cognition and Personality as Potential Endophenotypes in the Western Australian Family Study of Schizophrenia. | McCarthy NS et al. | โ | 2018 | โ |
| Assessment of Neurocognitive Functions in 7-Year-Old Children at Familial High Risk for Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7. | Hemager N et al. | โ | 2018 | โ |
| Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population. | Yang Y et al. | โ | 2018 | โ |
| Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder. | Allardyce J et al. | โ | 2018 | โ |
| Association of CACNA1C with bipolar disorder among the Pakistani population. | Khalid M et al. | โ | 2018 | โ |
| Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder. | Markota M et al. | โ | 2018 | โ |
| Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition. | Ranlund S et al. | โ | 2018 | โ |
| Bipolar disorders. | Vieta E et al. | โ | 2018 | โ |
| Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. | McElroy SL et al. | โ | 2018 | โ |
| Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells. | Hoffmann A et al. | โ | 2018 | โ |
| Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study. | Cheng CM et al. | โ | 2018 | โ |
| Cognition and community functioning in schizophrenia: The nature of the relationship. | Kuo SS et al. | โ | 2018 | โ |
| Common mental disorder including psychotic experiences: Trailblazing a new recovery pathway within the Improving Access to Psychological Therapies programme in England. | Perez J et al. | โ | 2018 | โ |
| Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population. | Ren H et al. | โ | 2018 | โ |
| Convergence of placenta biology and genetic risk for schizophrenia. | Ursini G et al. | โ | 2018 | โ |
| Coproducing healthcare service improvement for people with common mental health disorders including psychotic experiences: a study protocol of a multiperspective qualitative study. | Georgiadis A et al. | โ | 2018 | โ |
| Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility. | Kimura H et al. | โ | 2018 | โ |
| Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations. | Mรธrch-Johnsen L et al. | โ | 2018 | โ |
| Differential effect of disease-associated ST8SIA2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls. | Fullerton JM et al. | โ | 2018 | โ |
| Dimensional assessment of schizotypal, psychotic, and other psychiatric traits in children and their parents: development and validation of the Childhood Oxford-Liverpool Inventory of Feelings and Experiences on a representative US sample. | Evans DW et al. | โ | 2018 | โ |
| Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. | Viswanath B et al. | โ | 2018 | โ |
| Dissecting the catatonia phenotype in psychotic and mood disorders on the basis of familial-genetic factors. | Peralta V et al. | โ | 2018 | โ |
| DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder. | Sugawara H et al. | โ | 2018 | โ |
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| Increased MRI-based cortical grey/white-matter contrast in sensory and motor regions in schizophrenia and bipolar disorder. | Jรธrgensen KN et al. | โ | 2016 | โ |
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| No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population. | Liu Y et al. | โ | 2016 | โ |
| No association between ZNF804A rs1344706 and schizophrenia in a case-control study of Han Chinese. | Wang J et al. | โ | 2016 | โ |
| No progressive brain changes during a 1-year follow-up of patients with first-episode psychosis. | Haukvik UK et al. | โ | 2016 | โ |
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| The -141C Ins/Del and Taq1A polymorphism in the dopamine D2 receptor gene may confer susceptibility to schizophrenia in Asian populations. | Wang Y et al. | โ | 2016 | โ |
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