Epigenetics, microRNA, and addiction.
paper
Cited
Public
- Authors
- Kenny, Paul J
- Year
- 2014
- Journal
- Dialogues in clinical neuroscience
- PMID
- 25364284
- DOI
- 10.31887/DCNS.2014.16.3/pkenny
- PMCID
- PMC4214176
Drug addiction is characterized by uncontrolled drug consumption and high rates of relapse to drug taking during periods of attempted abstinence. Addiction is now largely considered a disorder of experience-dependent neuroplasticity, driven by remodeling of synapses in reward and motivation relevant brain circuits in response to a history of prolonged drug intake. Alterations in gene expression play a central role in addiction-relevant neuroplasticity, but the mechanisms by which additive drugs remodel brain motivation circuits remains unclear. MicroRNAs (miRNAs) are a class of noncoding RNA that can regulate the expression of large numbers of protein-coding mRNA transcripts by binding to the 3' untranslated region (3' UTR) of target transcripts and blocking their translation into the encoded protein or triggering their destabilization and degradation. Emerging evidence has implicated miRNAs in regulating addiction-relevant neuroplasticity in the brain, and in controlling the motivational properties of cocaine and other drugs of abuse. Here, the role for miRNAs in regulating basic aspects of neuronal function is reviewed. The involvement of miRNAs in controlling the motivational properties of addictive drugs is also summarized. Finally, mechanisms by which miRNAs exert their actions on drug intake, when known, are considered.
No figures extracted from this document.
β Prev
21β28 of 28
| Name | Type |
|---|---|
| acute reinforcing properties of addictive drugs local | phenotype |
| addiction | phenotype |
| Addiction-like state local | phenotype |
| Addiction state local | phenotype |
| adenylyl cyclases local | gene |
| adoptive family members local | cohort |
| AGO2 local | gene |
| Ago2-D2-ablated mice local | cohort |
| Ago.fl/fl mice local | cohort |
| alcohol | phenotype |
| alcohol-dependent rats | cohort |
| alcohol-induced CPP local | phenotype |
| Alcohol Use | phenotype |
| amygdala | anatomy |
| Antisense oligonucleotide against MIR212 local | drug |
| Armitage local | gene |
| arrhythmia local | phenotype |
| ataxia | phenotype |
| Bdnf | gene |
| behavioral responses to cocaine local | phenotype |
| CamKII | drug |
| cAMP | drug |
| cAMP signaling cascade local | drug |
| cannabis use | phenotype |
| Cdk5 | gene |
| cell-specific death local | phenotype |
| cerebellum | anatomy |
| cerebellum degradation local | phenotype |
| cerebral hemorrhage | phenotype |
| CNS | anatomy |
| cocaine | phenotype |
| cocaine intake local | phenotype |
| Cocaine intake local | phenotype |
| cocaine-naive rats local | cohort |
| cocaine self-administration | phenotype |
| Compulsive cocaine intake local | phenotype |
| Compulsive consumption local | phenotype |
| compulsivelike cocaine intake local | phenotype |
| compulsive-like drug-seeking local | phenotype |
| conditioned place preference | phenotype |
| conditioned rewarding effects of cocaine local | phenotype |
| CREB1 | gene |
| CRTC1 local | gene |
| decreased cocaine intake local | phenotype |
| defects in neural development local | phenotype |
| dendritic spine development local | phenotype |
| DICER1 | gene |
| dopamine | drug |
| dorsal striatum | anatomy |
| DRD1 | gene |
| DRD2 | gene |
| DRD3 | gene |
| drug | drug |
| drug dependence | phenotype |
| drug intake | phenotype |
| drug-seeking behavior | phenotype |
| Escalated cocaine intake local | phenotype |
| Escalated intake local | phenotype |
| escalating alcohol intake local | phenotype |
| Escalating cocaine intake local | phenotype |
| escalation of daily cocaine intake local | phenotype |
| extended access rats local | cohort |
| Extended access rats local | cohort |
| families | cohort |
| first-degree family member local | cohort |
| FMR1 | gene |
| FMRP | gene |
| food intake | phenotype |
| Fosb | gene |
| habitual drug seeking local | phenotype |
| habitual drug-seeking local | phenotype |
| HDAC5 | gene |
| HDACs | gene |
| heavy drinking | phenotype |
| Human drug users local | cohort |
| humans | cohort |
| Lenti-MIR212 rats local | cohort |
| let-7d local | drug |
| let-7d local | gene |
| Loss of control over drug consumption local | phenotype |
| MeCP2 | gene |
| medium spiny neurons | anatomy |
| memory | phenotype |
| memory-associated structural and functional plasticity local | phenotype |
| Mesocorticolimbic system | anatomy |
| methamphetamine | drug |
| mice | cohort |
| microRNA | drug |
| miR-124 | drug |
| miR-124a local | drug |
| miR-132 local | gene |
| MIR132 local | gene |
| miR-206 local | drug |
| miR-206 local | variant |
| miR-212 local | drug |
| miR-212 local | gene |
| MIR212 local | gene |
| miR-212/132 cluster local | gene |
| MIR212/132 cluster local | gene |
| miR-212/132 gene cluster local | gene |
| miR-382 local | drug |
| miR-8 local | gene |
| miRNA | drug |
| miRNA-124a local | drug |
| miRNA-124a local | gene |
| miRNAs local | gene |
| motivational properties local | phenotype |
| motivational properties of cocaine local | phenotype |
| Mov10 | gene |
| myocardial infarction | phenotype |
| neurodegeneration | phenotype |
| neuronal differentiation | phenotype |
| neuronal maturation | phenotype |
| neuronal morphology | phenotype |
| neuroplasticity | phenotype |
| nicotine | drug |
| nucleus accumbens | anatomy |
| nucleus accumbens core | anatomy |
| nucleus accumbens shell | anatomy |
| olfactory tubercle | anatomy |
| opiates | drug |
| prefrontal cortex | anatomy |
| psychomotor stimulant effects local | phenotype |
| psychomotor stimulants local | drug |
| punishment-resistant drug seeking local | phenotype |
| punishment-resistant drug-seeking local | phenotype |
| Purkinje cells | anatomy |
| Raf1 | gene |
| Raf1 kinase local | gene |
| rats | cohort |
| rats with extended cocaine access local | cohort |
| rats with restricted cocaine access local | cohort |
| restricted access rats local | cohort |
| Restricted access rats local | cohort |
| Rett syndrome | phenotype |
| Reward circuitries local | anatomy |
| rewarding effects | phenotype |
| rewarding effects of cocaine | phenotype |
| reward system | anatomy |
| RISC local | drug |
| satiating effects local | phenotype |
| sensitivity to rewarding effects local | phenotype |
| somatodendritic compartment local | anatomy |
| spatial learning deficits local | phenotype |
| Spatial learning deficits local | phenotype |
| SPRED1 local | gene |
| striatopallidal neurons | anatomy |
| striatum | anatomy |
| substance abuse | phenotype |
| synapse | anatomy |
| synaptic development and plasticity local | phenotype |
| synaptic function | phenotype |
| Twin cohort | cohort |
| ventral striatum | anatomy |
| wild-type mice | cohort |
| yoked rats local | cohort |
No uploaded files.
Not in any collection.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The genetic epidemiology of substance use disorder: A review. | 2017 | 28938182 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression. | Orr E et al. | β | 2026 | β |
| A Review of Exercise Interventions for Rehabilitation in Drug-Dependent Individuals. | He Q et al. | β | 2025 | β |
| Research progress of DNA methylation on the regulation of substance use disorders and the mechanisms. | Liu Y et al. | β | 2025 | β |
| Unveiling the Complexities of Medications, Substance Abuse, and Plants for Recreational and Narcotic Purposes: An In-Depth Analysis. | Predescu IA et al. | β | 2025 | β |
| How life events may confer vulnerability to addiction: the role of epigenetics. | Liu SX et al. | β | 2024 | β |
| Molecular and Environmental Determinants of Addictive Substances. | Lorek M et al. | β | 2024 | β |
| Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway. | Kumaresan V et al. | β | 2023 | β |
| A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity. | Ortiz GGR et al. | β | 2023 | β |
| MicroRNA-423-5p Mediates Cocaine-Induced Smooth Muscle Cell Contraction by Targeting Cacna2d2. | Dykxhoorn DM et al. | β | 2023 | β |
| Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen. | KoΕosowska K et al. | β | 2023 | β |
| Neurogenetics and Epigenetics of Loneliness. | Bowirrat A et al. | β | 2023 | β |
| The Effects of Transcranial Focused Ultrasound Stimulation of Nucleus Accumbens on Neuronal Gene Expression and Brain Tissue in High Alcohol-Preferring Rats. | Deveci E et al. | β | 2023 | β |
| The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats. | Shao J et al. | β | 2023 | β |
| Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens. | Anderson EM et al. | β | 2022 | β |
| Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens. | Teague CD et al. | β | 2022 | β |
| Orexin Reserve: A Mechanistic Framework for the Role of Orexins (Hypocretins) in Addiction. | James MH et al. | β | 2022 | β |
| Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving. | Xie B et al. | β | 2022 | β |
| Candidate l-methionine target piRNA regulatory networks analysis response to cocaine-conditioned place preference in mice. | Zhang K et al. | β | 2021 | β |
| Epigenetic Mechanisms in Drug Relapse. | Werner CT et al. | β | 2021 | β |
| Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction. | Saad L et al. | β | 2021 | β |
| Evaluation of miRNA as Biomarkers of Emotional Valence in Pigs. | Marsh L et al. | β | 2021 | β |
| HIV-1 Tat and cocaine impact astrocytic energy reservoir influence on miRNA epigenetic regulation. | Doke M et al. | β | 2021 | β |
| Increased Expression of Plasma miRNA-320a and let-7b-5p in Heroin-Dependent Patients and Its Clinical Significance. | Liu H et al. | β | 2021 | β |
| microRNA regulation related to the protective effects of environmental enrichment against cocaine-seeking behavior. | Vannan A et al. | β | 2021 | β |
| Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. | GawliΕska K et al. | β | 2020 | β |
| Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells. | Dash S et al. | β | 2020 | β |
| Epigenetic Mechanisms of Opioid Addiction. | Browne CJ et al. | β | 2020 | β |
| Brain-Derived Extracellular Vesicle microRNA Signatures Associated with In Utero and Postnatal Oxycodone Exposure. | Shahjin F et al. | β | 2019 | β |
| Decreased Level of Blood MicroRNA-133b in Men with Opioid Use Disorder on Methadone Maintenance Therapy. | Hsu CW et al. | β | 2019 | β |
| Genomics and the future of psychopharmacology: MicroRNAs offer novel therapeuticsβ©. | Gurwitz D | β | 2019 | β |
| It is a complex issue: emerging connections between epigenetic regulators in drug addiction. | Anderson EM et al. | β | 2019 | β |
| Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway. | Gao S et al. | β | 2019 | β |
| MicroRNA-137 Drives Epigenetic Reprogramming in the Adult Amygdala and Behavioral Changes after Adolescent Alcohol Exposure. | Kyzar EJ et al. | β | 2019 | β |
| Novel biomarkers to assess in utero effects of maternal opioid use: First steps toward understanding short- and long-term neurodevelopmental sequelae. | Goetzl L et al. | β | 2019 | β |
| Opportunities and challenges in psychopharmacologyβ©. | Schulz P | β | 2019 | β |
| Transgenerational influence of parental morphine exposure on pain perception, anxiety-like behavior and passive avoidance memory among male and female offspring of Wistar rats. | Ahmadian-Moghadam H et al. | β | 2019 | β |
| Vapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus. | Brutman JN et al. | β | 2019 | β |
| Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes. | Cisneros IE et al. | β | 2018 | β |
| Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway. | Zhu W et al. | β | 2018 | β |
| Investigating the genetic profile of dopaminergic neurons in the VTA in response to perinatal nicotine exposure using mRNA-miRNA analyses. | Keller RF et al. | β | 2018 | β |
| MicroRNA cluster miR199a/214 are differentially expressed in female and male rats following nicotine self-administration. | Pittenger ST et al. | β | 2018 | β |
| MicroRNAs regulate synaptic plasticity underlying drug addiction. | Smith ACW et al. | β | 2018 | β |
| MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence. | Cabana-DomΓnguez J et al. | β | 2018 | β |
| DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218. | Torres-BerrΓo A et al. | β | 2017 | β |
| HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. | Taniguchi M et al. | β | 2017 | β |
| MicroRNA Regulation of nAChR Expression and Nicotine-Dependent Behavior in C.Β elegans. | Rauthan M et al. | β | 2017 | β |
| Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. | Sadakierska-Chudy A et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| A Functional 3'UTR Polymorphism (rs2235749) of Prodynorphin Alters microRNA-365 Binding in Ventral Striatonigral Neurons to Influence Novelty Seeking and Positive Reward Traits. | Egervari G et al. | β | 2016 | β |
| FMRP regulates an ethanol-dependent shift in GABA<sub>B</sub>R function and expression with rapid antidepressant properties. | Wolfe SA et al. | β | 2016 | β |
| MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction. | AusiΓ³ J | β | 2016 | β |
| MicroRNAs as regulators of drug abuse and immunity. | Zhang K et al. | β | 2016 | β |
| Turing Revisited: Decoding the microRNA Messages in Brain Extracellular Vesicles for Early Detection of Neurodevelopmental Disorders. | Gillet V et al. | β | 2016 | β |
| Electronic cigarettes: the new face of nicotine delivery and addiction. | Crotty Alexander LE et al. | β | 2015 | β |