Ethanol reduces the phase locking of neural activity in human and rodent brain.

paper Cited Public

Authors: Ehlers, Cindy L; Wills, Derek N; Havstad, James
Year: 2012
Journal: Brain research
PMID: 22410292
DOI: 10.1016/j.brainres.2012.02.039
PMCID: PMC3503530

Figure 1

Grand mean values for the phase locking index (PLI) of event-related oscillations (EROs) 60 minutes following placebo/saline administration. MANOVA revealed that the infrequent (target) tone (gray bars), as compared to the frequent (non-target) tone (black bars), produced significant increases in phase locking in all time frequency ranges (delta (1-4 Hz), theta (4-7 Hz), alpha (7-13 Hz), beta (13-30 Hz), and gamma (30-50 Hz)), and in all electrode locations, in humans (n=38, left bars), (FZ= midline frontal cortex, CZ=midline central cortex, PZ=midline parietal cortex) and in rats (n=46, right bars) (FCTX=frontal cortex, DHPC=dorsal hippocampus, AMYG=amygdala).

Figure 2

Grand averages of phase locking index values (PLI) of event–related oscillations (EROs) for 38 young men participating in an ethanol/placebo challenge study. Each graph depicts a time-frequency representation of PLI values in the delta, theta, alpha, beta, and gamma bands following the rare tone in three electrode locations (FZ=midline frontal cortex, CZ=midline central cortex, PZ=midline parietal cortex), at 60 minutes following ethanol or placebo administration. In each graph frequency (Hz) is presented on the Y-axis, time regions of interest on the X-axis (msec) and PLI is presented as color equivalents as indicated on the bar at the bottom of each graph. Ethanol, as compared to placebo produced significant reductions in phase locking at all three electrode sites.

Figure 3

Mean values for the phase locking index (PLI) of event-related oscillations (EROs) 60 minutes following ethanol (black bars) and placebo/saline (white bars) administration for the infrequent (target) tone in the delta (1-4 Hz), theta (4-7 Hz), alpha (7-13 Hz), beta (13-30 Hz), and gamma (30-50 Hz), frequency ranges for the three electrode locations in humans (n=38), in the upper graph (a.), (FZ=midline frontal cortex, CZ=midline central cortex, PZ=midline parietal cortex) and in rats (n=46) in the lower graph (b.) (FCTX= frontal cortex, DHPC=dorsal hippocampus, AMYG=amygdala). Ethanol, as compared to placebo produced significant reductions in phase locking at all three electrode sites in humans and in rats.

Figure 4

Mean values for the phase difference lock index (PDLI) of event-related oscillations (EROs) 60 minutes following ethanol (black bars) and placebo/saline (white bars) administration for the infrequent (target) tone in the delta (1-4 Hz), theta (4-7 Hz), alpha (7-13 Hz), beta (13-30 Hz), and gamma (30-50 Hz), frequency ranges. In humans (n=38), in the upper graph (a.), phase differences were calculated between midline frontal cortex (FZ) and midline parietal cortex (PZ); and in rats (n=46), in the lower graph (b.) phase differences were calculated between frontal cortex (FCTX) and dorsal hippocampus (DHPC), frontal cortex (FCTX) and amygdala (AMYG), and dorsal hippocampus (DHPC) and amygdala (AMYG). Ethanol, as compared to placebo produced significant reductions in phase difference lock index in humans and in rats.

Figure 5

Grand averages of phase locking index values (PLI) of event–related oscillations (EROs) for 46 rats that were administered ethanol and saline (control). Each graph depicts a time-frequency representation of PLI values in the delta, theta, alpha, beta, and gamma bands following the rare tone in three electrode locations (FCTX=frontal cortex, DHPC=dorsal hippocampus, AMYG=amygdala), at 60 minutes following ethanol or saline administration. In each graph frequency (Hz) is presented on the Y-axis, time regions of interest on the X-axis (msec) and PLI is presented as color equivalents as indicated on the bar at the bottom of each graph. Ethanol, as compared to saline, produced significant reductions in phase locking at all three electrode sites.

Figure 6

Individual data points for phase locking index (PLI) of event related oscillations (EROs) at 60 minutes following ethanol administration in human participants. In the upper graph, PLI for the alpha frequency range in parietal cortex (PZ) is plotted on the Y-axis and blood ethanol concentration (BEC g/dL) is plotted on the X-axis. In the lower graph PLI for the beta frequency range in frontal cortex (FZ) is plotted on the Y-axis and total score on the subjective high assessment scale (SHAS) is plotted on the X-axis. Significant correlations were found for PZ Alpha PLI and BEC as well as FZ Beta PLI and total SHAS.

#	Section	Preview
40	4. Experimental procedures — 4.6 ERO, PLI, and PDLI analyses	The EEG amplifier low-pass filters for humans and for animals were set to 35 Hz, but the…
41	4. Experimental procedures — 4.6 ERO, PLI, and PDLI analyses	Rectangular regions of interest (ROIs) were defined within the time-frequency analysis plane by…
42	4. Experimental procedures — 4.7 Statistical analyses	The first set of analyses were aimed at determining, during the placebo/saline condition, whether…
43	4. Experimental procedures — 4.7 Statistical analyses	was conducted with PDLI and PLI values as dependent variables comparing drug condition (ethanol,…

Name	Type
acute alcohol ingestion local	drug
alcohol	phenotype
alcohol dependence	phenotype
alcohol intoxication	phenotype
alcoholism	phenotype
alpha	anatomy
alpha activity	phenotype
alpha band	phenotype
alpha oscillations	phenotype
amygdala	anatomy
animal models	cohort
animals	cohort
anxiolysis	phenotype
ataxia	phenotype
attentional resources local	phenotype
Auditory infrequently presented stimulus local	phenotype
auditory stimuli local	drug
axis I disorder	phenotype
behavioral under-control	phenotype
beta activity	phenotype
beta oscillations	phenotype
blood ethanol concentration	phenotype
Blood ethanol concentration (BEC) local	phenotype
brain	anatomy
Caffeine-free sugar-free soda local	drug
Central executive processes local	phenotype
Cholinergic antagonists local	drug
cognitive and behavioral processes local	phenotype
Cognitive disinhibition local	phenotype
Collaborative Study on the Genetics of Alcoholism (COGA)	cohort
coma	phenotype
Complex motor-learning task local	phenotype
conscious awareness	phenotype
cortex	anatomy
Cortical EEG local	anatomy
Cz	anatomy
death	phenotype
decision-making	phenotype
decreased mentation local	phenotype
delta local	anatomy
delta band	phenotype
delta oscillations	phenotype
disinhibition	phenotype
dorsal hippocampus	anatomy
DSM-III local	phenotype
EEG	phenotype
EEG alpha activity local	phenotype
episodic memory	phenotype
ethanol consumption	phenotype
Ethanol-induced euphoria local	phenotype
euphoria	phenotype
Event-related oscillation	phenotype
Event-related oscillation (ERO) local	phenotype
event-related oscillations	phenotype
Event-Related Oscillations local	anatomy
event-related oscillations (EROs)	phenotype
event-related potential	phenotype
executive functioning	phenotype
FCTX local	anatomy
forehead	anatomy
Frequency bands local	anatomy
Frequently presented stimulus local	phenotype
Frequent non-target tone local	phenotype
frontal cortex	anatomy
Frontal cortical sites local	anatomy
Frontal zone (FZ) local	anatomy
Fz	anatomy
GABAA receptor	drug
GABRA2	gene
Gamma amplitude	phenotype
Gamma frequencies local	phenotype
Gamma frequency local	phenotype
Gamma Frequency local	phenotype
gamma oscillations	phenotype
higher cognitive processing local	phenotype
high frequency oscillations	phenotype
hippocampus	anatomy
human	cohort
Human Central Cortex local	anatomy
Human cohort	cohort
Human Parietal Cortex local	anatomy
humans	cohort
impaired coordination local	phenotype
increased randomness local	phenotype
Interregional phase synchronization local	phenotype
intoxication	phenotype
Intoxication Level local	phenotype
Learned sequences local	phenotype
left earlobe local	anatomy
left lateral infraorbital region local	anatomy
linked ear lobes local	anatomy
locus coeruleus	anatomy
low frequency oscillations local	phenotype
Male humans local	cohort
male participants	cohort
male rats	cohort
Males 18-25 local	cohort
memory	phenotype
mesencephalic reticular local	anatomy
mice	cohort
Motoric disinhibition local	phenotype
muscarinic blockade local	drug
Muscarinic blockade local	drug
N1 local	phenotype
nausea	phenotype
Neuronal phase synchrony local	phenotype
neuronal synchronization (phase locking) local	phenotype
noise local	drug
Non-target Tone local	phenotype
Non-Target Tone local	phenotype
Novel condition local	phenotype
ORP	phenotype
P300 measures	phenotype
Pairwise directional linear index (PDLI) local	phenotype
parietal cortex	anatomy
Parietal zone (PZ) local	anatomy
PDLI local	phenotype
Phase Delay Locking Index (PDLI) local	phenotype
Phase difference lock index local	phenotype
Phase Difference Lock Index local	phenotype
phase difference lock index (PDLI) local	phenotype
phase lag index	anatomy
phase lock index local	phenotype
Phase lock index local	phenotype
phase locking local	phenotype
Phase locking local	phenotype
Phase Locking local	phenotype
Phase locking index local	phenotype
Phase Locking Index local	phenotype
Phase locking index (PLI) local	phenotype
Phase Locking Index (PLI) local	phenotype
Phase locking measures of EROs local	phenotype
Phase locking of EROs local	phenotype
phase synchronization	phenotype
placebo beverage	drug
Placebo/saline local	drug
Pz	anatomy
Rare target tone local	phenotype
rare tone local	drug
Rat cohort local	cohort
Rat Cohort local	cohort
Rat Dorsal Hippocampus local	anatomy
Rat Frontal Cortex local	anatomy
rats	cohort
Rats cohort local	cohort
recognition memory	phenotype
reduction of phase locking local	phenotype
respiratory failure local	phenotype
ROI	anatomy
saline	drug
Sauseng et al., 2007 local	cohort
semantic memory	phenotype
sensory integrative processes local	phenotype
sensory processes local	phenotype
signal detection	phenotype
slurred speech	phenotype
stimulus processing	phenotype
Subjective High Assessment Scale (SHAS)	phenotype
Subjective report of intoxication local	phenotype
subjects	cohort
subjects (n=38) local	cohort
substance use	phenotype
Target Tone local	phenotype
theta band	phenotype
theta oscillations	phenotype
variability in latency local	phenotype
vomiting	phenotype
Wistar rats	cohort
young men	cohort

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In this knowledge base

Title	Year	PMID
Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain.	2014	24819672
Understanding alcohol use disorders with neuroelectrophysiology.	2014	25307587

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Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach.	Correas A et al.	—	2019	→
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication.	Marinkovic K et al.	—	2019	→
Effect of suvorexant on event-related oscillations and EEG sleep in rats exposed to chronic intermittent ethanol vapor and protracted withdrawal.	Sanchez-Alavez M et al.	—	2019	→
Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits.	Alhadeff AL et al.	—	2019	→
Alcohol Activates Scabrous-Notch to Influence Associated Memories.	Petruccelli E et al.	—	2018	→
COMT Inhibition Alters Cue-Evoked Oscillatory Dynamics during Alcohol Drinking in the Rat.	McCane AM et al.	—	2018	→
Effect of Gabapentin on Sleep and Event-Related Oscillations (EROs) in Rats Exposed to Chronic Intermittent Ethanol Vapor and Protracted Withdrawal.	Sanchez-Alavez M et al.	—	2018	→
When the brain changes its mind: Oscillatory dynamics of conflict processing and response switching in a flanker task during alcohol challenge.	Beaton LE et al.	—	2018	→
Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents.	Amodeo LR et al.	—	2017	→
Effects of Age and Acute Moderate Alcohol Administration on Electrophysiological Correlates of Working Memory Maintenance.	Boissoneault J et al.	—	2016	→
Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis.	Sanchez-Alavez M et al.	—	2016	→
Neuropharmacology of altered brain oscillations in schizophrenia.	Koch M et al.	—	2016	→
Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol.	Ehlers CL et al.	—	2015	→
Ultra-slow frequency bands reflecting potential coherence between neocortical brain regions.	Zhang X et al.	—	2015	→
Cholinergic modulation of event-related oscillations (ERO).	Sanchez-Alavez M et al.	—	2014	→
Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain.	Ehlers CL et al.	—	2014	→
Event-related potential responses to the acute and chronic effects of alcohol in adolescent and adult Wistar rats.	Ehlers CL et al.	—	2014	→
Ontogeny and adolescent alcohol exposure in Wistar rats: open field conflict, light/dark box and forced swim test.	Desikan A et al.	—	2014	→
Understanding alcohol use disorders with neuroelectrophysiology.	Rangaswamy M et al.	—	2014	→
Fronto-striatal functional connectivity during response inhibition in alcohol dependence.	Courtney KE et al.	—	2013	→
Peri-adolescent ethanol vapor exposure produces reductions in hippocampal volume that are correlated with deficits in prepulse inhibition of the startle.	Ehlers CL et al.	—	2013	→