Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.
paper
Cited
Public
- Authors
- Kuleshov, Maxim V; Jones, Matthew R; Rouillard, Andrew D; Fernandez, Nicolas F; Duan, Qiaonan; Wang, Zichen; Koplev, Simon; Jenkins, Sherry L; Jagodnik, Kathleen M; Lachmann, Alexander; McDermott, Michael G; Monteiro, Caroline D; Gundersen, Gregory W; Ma'ayan, Avi
- Year
- 2016
- Journal
- Nucleic acids research
- PMID
- 27141961
- DOI
- 10.1093/nar/gkw377
- PMCID
- PMC4987924
Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr.
Benchmarking different enrichment analysis methods. (A) Deviation of the cumulative distribution from uniform of the scaled ranks of TFs derived from different enrichment analysis methods; (B) Comparison between crisp and fuzzy version of the proportion test. The ranking distribution of randomly ordered ChEA terms is plotted in gray dashed line. The area under the curve (AUC) is indicated in the legend as a measure of the degree of deviation from uniform.
Statistics of Enrichr. (A) Histogram of gene lists submitted per user. (B) Histogram of uploaded list lengths. (C) Histogram of appearance of genes in uploaded list. (D) Histogram of annotated gene set sizes within Enrichr.
Comparing Enrichr resources with MSigDB and GO-Elite. (A) Venn diagram summarizing the various resources processed and served by Enrichr, MSigDB and GO-Elite. (B) Venn diagram to compare the number of processed gene sets of genetic and chemical perturbations curated from publications in Enrichr and MSigDB.
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| Bioinformatics Analysis Reveals the Oncogenic Role and Therapeutic Potential of lncRNA SNHG25 in Colon Adenocarcinoma. | Hao R et al. | β | 2025 | β |
| Bioinformatics and experimental validation of ferroptosis-related genes in steroid-induced osteonecrosis of the femoral head. | Guo MG et al. | β | 2025 | β |
| Bioinformatics and system biology approach to discover the common pathogenetic processes between COVID-19 and chronic hepatitis B. | Ma X et al. | β | 2025 | β |
| Biomarker discovery for early breast cancer diagnosis using machine learning on transcriptomic data for biosensor development. | Mayoral-PeΓ±a K et al. | β | 2025 | β |
| Biomaterial-mediated Cell Atlas: an insight from single-cell and spatial transcriptomics. | Yang X et al. | β | 2025 | β |
| BrainGeneBot: a framework for variant prioritization and generative pretrained transformer-informed interpretation across polygenic risk score studies. | Qu G et al. | β | 2025 | β |
| Brain lateralization for perceiving direction of motion is reversed in Williams syndrome and related to BUD23. | Mills DL et al. | β | 2025 | β |
| Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U. | Alidadiani S et al. | β | 2025 | β |
| Brain transcriptomic signatures for mood disorders and suicide phenotypes: an anterior insula and subgenual ACC network postmortem study. | Arasappan D et al. | β | 2025 | β |
| BRD4 and MYB inhibition overcomes venetoclax resistance in EVI1-rearranged acute myeloid leukemia. | Zang W et al. | β | 2025 | β |
| Bronchial epithelial cell-derived extracellular vesicles drive inflammasome activation and <i>NTHi</i> infection in COPD. | Bateman G et al. | β | 2025 | β |
| Bulk and Single-Cell Transcriptomes Reveal Exhausted Signature in Prognosis of Hepatocellular Carcinoma. | Chun R et al. | β | 2025 | β |
| Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis. | Li N et al. | β | 2025 | β |
| CD81<sup>+</sup> senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis. | Fu L et al. | β | 2025 | β |
| Cell-type-directed network-correcting combination therapy for Alzheimer's disease. | Li Y et al. | β | 2025 | β |
| Cell Type-Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function. | de Klerk JA et al. | β | 2025 | β |
| Cell type-specific in vivo proteomes with a multicopy mutant methionyl tRNA synthetase mouse line. | Alvarez-Pardo R et al. | β | 2025 | β |
| Cellular and molecular characterisation of the peripheral immune environment in migraine. | O'Brien JA et al. | β | 2025 | β |
| CEP76 impairment at the centrosome-cilium interface contributes to a spectrum of ciliopathies. | Khan K et al. | β | 2025 | β |
| Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease. | Vromen EM et al. | β | 2025 | β |
| Challenges and Advantages of Using Spatially Resolved Lipidomics to Assess the Pathological State of Human Lung Tissue. | Calvo I et al. | β | 2025 | β |
| Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl<sub>2</sub>. | Barton A et al. | β | 2025 | β |
| Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome. | Clough CA et al. | β | 2025 | β |
| Characterization of Mast2 kinase defines structural features, regulation, and substrates. | Lemke MC et al. | β | 2025 | β |
| Characterizing CSF inflammatory proteomics in pediatric post-hemorrhagic hydrocephalus and Anti-NMDAR encephalitis. | Broudy T et al. | β | 2025 | β |
| Characterizing Stroke Clots Using Single-Cell Sequencing. | Renedo D et al. | β | 2025 | β |
| Chromatin and transcriptional dynamics underlying the immune-modulatory effects of vitamin D<sub>3</sub> in vivo. | RybiΕski M et al. | β | 2025 | β |
| Chromatin remodeling restrains oncogenic functions in prostate cancer. | Rosti V et al. | β | 2025 | β |
| Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration. | Rademacher K et al. | β | 2025 | β |
| Chronic ISG15 Exposure Accelerates CD8+ T-cell Dysfunction while Increasing PD-1 Blockade Sensitivity in Oral Squamous Cell Carcinoma. | Chen YL et al. | β | 2025 | β |
| Circulating MicroRNA Biomarkers for Chronic Pain and Acupuncture Response: An Exploratory High-Dimensional Small-Sample Study. | Kang IH et al. | β | 2025 | β |
| Circulating microRNAs as biomarkers for ischemic heart disease: a systematic review and gene set enrichment analysis. | Alcibahy Y et al. | β | 2025 | β |
| CKS2 is overexpressed in high-grade and recurrent meningiomas and functions as an oncogene via the CKS2/miR-26a/miR-101 axis. | Sharma A et al. | β | 2025 | β |
| CluVar: clustering of variants using autoencoder for inferring cancer subclones from single cell RNA sequencing data. | Kim CW et al. | β | 2025 | β |
| Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2β+βand TN breast cancer types. | Zakir M et al. | β | 2025 | β |
| Coiled-coil-helix-coiled-coil-helix Domain Containing 1 Promotes Hepatocellular Carcinoma Progression by RegulatingΒ Transforming Growth Factor Beta Receptor 1 in the Tumor Immune Microenvironment. | Chenzhou X et al. | β | 2025 | β |
| Colonic inflammation modulates the intestinal circadian landscape. | Butler TD et al. | β | 2025 | β |
| Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice. | Boeck M et al. | β | 2025 | β |
| Combining network toxicology, machine learning and molecular docking to explore the mechanism of bisphenol A-induced Asthma. | Xian D et al. | β | 2025 | β |
| Commonalities and differences in gene expression patterns in major depressive disorder and chronic spontaneous urticaria: implications for comorbidity. | Jiang Y et al. | β | 2025 | β |
| Comparative effects of standardized Centella asiatica extract (ECa 233) and its active compound mixture on proteomics and mitochondrial function. | Boondam Y et al. | β | 2025 | β |
| Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer's, Parkinson's, and Huntington's Diseases. | Alharbi LI et al. | β | 2025 | β |
| Comparative toxicity of tire wear particle leachates: Zinc as a key toxicant affecting development and motility in zebrafish larvae. | Kim B et al. | β | 2025 | β |
| Comparative Transcriptomic Profiling in Patients Affected by Duchenne and Becker Muscular Dystrophies: A Focus on ECM Genes Dysregulation. | Rizzo B et al. | β | 2025 | β |
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| Complete loss of PAX4 causes transient neonatal diabetes in humans. | Russ-Silsby J et al. | β | 2025 | β |
| Comprehensive analysis of the BID gene to uncover the role of novel alternative splicing isoforms in colon adenocarcinoma: a systematic review of literature and bioinformatics analysis. | Zangooie A et al. | β | 2025 | β |
| Comprehensive and In-Depth Molecular and Pathway Studies of the Hippocampus in Alzheimer's Disease. | Tayani Pour F et al. | β | 2025 | β |
| Comprehensive bioinformatics analysis of omics data to reveal molecular mechanisms and biomarkers in multiple cancers. | Mia M et al. | β | 2025 | β |
| Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease. | Gupta AK et al. | β | 2025 | β |
| Comprehensive map of the regulatory network triggered by MET exon 14 skipping reveals important involvement of the RAS-ERK signaling pathway. | Truong MJ et al. | β | 2025 | β |
| Comprehensive Meta-Analysis of Differentially Expressed Proteins in Cerebrospinal Fluid Associated with Multiple Sclerosis. | Sakiz E et al. | β | 2025 | β |
| Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia. | Hossen MA et al. | β | 2025 | β |
| Constitutive expression of the transcriptional co-activator IΞΊBΞΆ promotes melanoma growth and immunotherapy resistance. | Kolb A et al. | β | 2025 | β |
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| Convergent Genetic Architecture in Concurrent Anorectal Malformations and Hypospadias: The <i>ESRRA-STARD8</i> Axis as a Key Regulator of Urogenital Development. | Goswami C et al. | β | 2025 | β |
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| CORESH: a gene signature-based search engine for public gene expression datasets. | Sukhov V et al. | β | 2025 | β |
| Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver. | Dagdeviren S et al. | β | 2025 | β |
| Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets. | Veronese-Paniagua DA et al. | β | 2025 | β |
| CrebA regulation of secretory capacity: genome-wide transcription profiling coupled with in vivo DNA binding studies. | Jackson DJ et al. | β | 2025 | β |
| c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT. | BakΔ±rdΓΆΔen D et al. | β | 2025 | β |
| Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation. | Yuan S et al. | β | 2025 | β |
| Cross-species blood transcriptional correlates of BCG-mediated protection against tuberculosis include innate and adaptive immune processes. | Bridges K et al. | β | 2025 | β |
| Cross-tissue enrichment patterns reveal functional clustering in normal human tissues from GTEx. | P S A et al. | β | 2025 | β |
| Current insight into HIV-1 persistence from single-cell transcriptome profiling in acutely treated cohorts of infection. | Iyer LR et al. | β | 2025 | β |
| CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Matrix Metalloproteinase-7 and Calcifying Extracellular Vesicle Release. | Krohn JB et al. | β | 2025 | β |
| Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability. | Wang X et al. | β | 2025 | β |
| Darling (v2.0): Mining disease-related databases for the detection of biomedical entity associations. | Baltoumas FA et al. | β | 2025 | β |
| Database analysis reveals endophilin A expression as a marker of metastasis and prognosis in breast cancer. | Mehta V et al. | β | 2025 | β |
| Data-driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes. | Nourbakhsh M et al. | β | 2025 | β |
| Data-Driven Extraction of Human Kinase-Substrate Relationships From Omics Datasets. | Maier BD et al. | β | 2025 | β |
| DBI Mediates the Progression of Ankylosing Spondylitis by Regulating CD56<sup>dim</sup> NK Cells Cytotoxicity Function. | Zhao R et al. | β | 2025 | β |
| DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress. | Shawky AMA et al. | β | 2025 | β |
| Deciphering mechanisms leading to preterm birth through post-GWAS integration of multi-omics data. | Bhattacharjee E et al. | β | 2025 | β |
| Decoding Bromodomain and Extra-Terminal Domain Protein-Mediated Epigenetic Mechanisms in Human Uterine Fibroids. | Yang Q et al. | β | 2025 | β |
| Decoding cross-talk between Mpox and HIV: insights from transcriptomics and network-based analyses. | Mishra SK et al. | β | 2025 | β |
| Decoding the germline genetic architecture of prostate cancer at a single cell resolution. | Wang C et al. | β | 2025 | β |
| Decoding the interplay between COVID-19 and diabetic nephropathy through bioinformatics and systems biology techniques. | Chen X et al. | β | 2025 | β |
| Decoding the transcriptome from bulk RNA of infection-naΓ―ve versus imprinted patients with SARS-CoV-2 Omicron B.1.1.529. | Sonnleitner ST et al. | β | 2025 | β |
| Deconvolution of molecular mechanisms in di-n-butyl phthalate/mono-n-butyl phthalate induced diabetic kidney disease by integrated machine learning and molecular docking. | Chen W et al. | β | 2025 | β |
| Deep inflations maintain surfactant function and alveolar fluid balance in lungs with reduced surfactant protein B levels during mechanical ventilation. | LΓΆwe M et al. | β | 2025 | β |
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| Design, Synthesis, and Integrated In Silico-In Vitro Evaluation of Triazole-Linked Benz/Imidazole-2-Thione/Selone Derivatives as Selective CDK1 Inhibitors for Breast Cancer Therapy. | Abdulkareem AE et al. | β | 2025 | β |
| Detection of viral contamination in cell lines using ViralCellDetector. | Shankar R et al. | β | 2025 | β |
| Determination of Critical Genes and Key Regulatorys in Colorectal Cancer with Meta- and Network Analysis of Microarray Datasets. | Fatehi R et al. | β | 2025 | β |
| Developmental low-dose bisphenol A exposure leads to extensive transcriptome female masculinization and male feminization later in life. | Lind T et al. | β | 2025 | β |
| Development of a Human Preclinical Platform for the Identification of Neuroprotective Compounds. | GonzΓ‘lez RG et al. | β | 2025 | β |
| Differential activity of transcription factors and neuronal effectors during the development of pikeperch brain. | SymonovΓ‘ R et al. | β | 2025 | β |
| Differential DNA methylation in infants with IgE- and non-IgE-mediated cow's milk allergy and its association with acquired tolerance. | LΓ³pez-GΓ³mez R et al. | β | 2025 | β |
| Differential effects of fetal bovine serum and human platelet lysate on mesenchymal stromal cell-mediated support of hematopoietic stem/progenitor cells: a functional and transcriptomic analysis. | Carreira MC et al. | β | 2025 | β |
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| Direct and bisulfite-free 5-methylcytosine and 5-hydroxymethylcytosine sequencing at single-cell resolution with scTAPS and scCAPSβ+β. | Chen X et al. | β | 2025 | β |
| Discovering anticancer drug target combinations via network-informed signaling-based approach. | Yavuz BR et al. | β | 2025 | β |
| Discovering bioactive pharmaceuticals from natural products for type 2 diabetes mellitus using network pharmacology, molecular docking, and molecular dynamics. | Rahmani B et al. | β | 2025 | β |
| Discovery of a potent C<sub>20</sub>-oxime pachysandra alkaloid analogue promising for treatment of hepatocellular carcinoma. | Zhao CL et al. | β | 2025 | β |
| Discovery of placental microRNAs associated with maternal insulin sensitivity during pregnancy. | Majid S et al. | β | 2025 | β |
| Dissecting immune cell-specific genetics in migraine: a multi-omics framework for target discovery and therapeutic prioritization. | Hong Y et al. | β | 2025 | β |
| Dissecting infant leukemia developmental origins with a hemogenic gastruloid model. | Ragusa D et al. | β | 2025 | β |
| Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19. | Wolday D et al. | β | 2025 | β |
| Distinct responses to non-autonomous UPR<sup>ER</sup> mediated by glutamatergic and octopaminergic neurons. | Coakley AJ et al. | β | 2025 | β |
| Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. | Shin JH et al. | β | 2025 | β |
| Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas. | Cheung JF et al. | β | 2025 | β |
| Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis. | Zheng C et al. | β | 2025 | β |
| Divergence between neural and retinal lineage specification during human brain development by signal transduction. | Nam KH et al. | β | 2025 | β |
| DNA methylation-based epigenetic clocks highlight immune-driven aging acceleration in COVID-19 across diverse populations. | Gupta MK et al. | β | 2025 | β |
| DNA methylation patterns associated with prior tuberculosis infection in people with HIV. | Baluku JB et al. | β | 2025 | β |
| DNA methylation regulates TREM1 expression to modulate immune responses and drive progression in colorectal neuroendocrine neoplasm as a potential therapeutic target. | Guo H et al. | β | 2025 | β |
| Double-positive T cells form heterotypic clusters with circulating tumor cells to foster cancer metastasis. | Scholten D et al. | β | 2025 | β |
| Dual RNA isolation from blood: an optimized protocol for host and bacterial RNA purification for dual RNA-sequencing analysis in whole blood sepsis samples. | Joubert IA et al. | β | 2025 | β |
| Dual Roles of Signal Transducer and Activator of Transcription 1 (STAT1) in Cancer: Expression Patterns, Prognostic Significance, and Immune Associations Across Multiple Tumor Types. | Kamal E et al. | β | 2025 | β |
| Dynamic allelic expression in mouse mammary glands across the adult developmental cycle. | Hanin G et al. | β | 2025 | β |
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| Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization. | Yabaji SM et al. | β | 2025 | β |
| Dysregulated Expression of Canonical and Non-Canonical Glycolytic Enzyme Isoforms in Peripheral Blood from Subjects with Alcohol Use Disorder and from Individuals with Acute Alcohol Consumption. | Rojas-Pirela M et al. | β | 2025 | β |
| Early <i>in vivo</i> target genes in human immune cells highlight vitamin D's role in antioxidant defense. | Tripathi T et al. | β | 2025 | β |
| Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. | Denk D et al. | β | 2025 | β |
| Effects of ageing and exercise training on cerebrovascular vasomotor reactivity, depressive behaviour and the hippocampal transcriptome. | Scheuermann B et al. | β | 2025 | β |
| Efficient gene set analysis for DNA methylation addressing probe dependency and bias. | Xu Z et al. | β | 2025 | β |
| Elevated <i>MMP9</i> Expression-A Potential In Vitro Biomarker for COMPopathies. | Dietmar HF et al. | β | 2025 | β |
| Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds. | Dura M et al. | β | 2025 | β |
| Engineering biomimetic bone marrow niche with gene modified mesenchymal stromal cells for ex vivo culture of human hematopoietic stem and progenitor cells. | Suresh S et al. | β | 2025 | β |
| Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications. | Trautmann CL et al. | β | 2025 | β |
| Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA. | Cingaram PKR et al. | β | 2025 | β |
| EnrichKit: a multi-omics tool for livestock research. | Liu L et al. | β | 2025 | β |
| Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome. | Wu CC et al. | β | 2025 | β |
| Enrichment of Immune Cell-Derived Extracellular Vesicles From Plasma Using 35 and 70Β nm Size-Exclusion Chromatography Columns of Different Sizes. | Potakowskyj I et al. | β | 2025 | β |
| Epigenetic alterations in obstructive sleep Apnea: a pooled analysis of DNA methylation profiles in humans and animal models. | Engal E et al. | β | 2025 | β |
| Epigenetic and transcriptional programming of murine eosinophils in the esophagus. | Felton JM et al. | β | 2025 | β |
| Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer's disease App<sup>NL-G-F</sup> knock-in mouse model. | Okhovat M et al. | β | 2025 | β |
| Epigenetic control of metabolic identity across cell types. | Pacheco MP et al. | β | 2025 | β |
| Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis. | Blanc RS et al. | β | 2025 | β |
| Epigenetic landscape of hormone-independent sexual dimorphism and characterization of canine XIST. | Oh SJ et al. | β | 2025 | β |
| Epigenetic mechanisms linking atherosclerosis to ischemic stroke: insights from DNA methylation and transcriptome integration. | Ding B et al. | β | 2025 | β |
| Epigenetic reprogramming drives endothelial dysfunction via neuropilin-1 in pulmonary hypertension. | Ochoa MT et al. | β | 2025 | β |
| Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons. | Cuvertino S et al. | β | 2025 | β |
| Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment. | Kiss M et al. | β | 2025 | β |
| EpInflammAge: Epigenetic-Inflammatory Clock for Disease-Associated Biological Aging Based on Deep Learning. | Kalyakulina A et al. | β | 2025 | β |
| Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-Ξ³ in <i>ex vivo</i> skin cultures. | KΓΌhtreiber H et al. | β | 2025 | β |
| Epistasis regulates genetic control of cardiac hypertrophy. | Wang Q et al. | β | 2025 | β |
| Epitranscriptomics Regulation of CD70, CD80, and TIGIT in Cancer Immunity. | Rigopoulos CP et al. | β | 2025 | β |
| ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L. | Feng W et al. | β | 2025 | β |
| ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA. | Soderholm A et al. | β | 2025 | β |
| Escape genes from X-chromosome inactivation: new insights into candidate genes for intellectual disability in females. | de Oliveira LA et al. | β | 2025 | β |
| Estimating progression of Alzheimer's disease with extracellular vesicle-related multi-omics risk models. | Zhang X et al. | β | 2025 | β |
| Evaluating impacts of the trichloroethylene metabolite <i>S</i>-(1,2-dichlorovyinyl)-L-cysteine on transcriptomic responses and cytokine release in a macrophage model: implications for pregnancy outcomes. | Benjamin A et al. | β | 2025 | β |
| Evaluation of circulating microRNAs in plasma from horses with non-strangulating intestinal infarction and idiopathic peritonitis. | Toft K et al. | β | 2025 | β |
| Evaluation of Exosome-derived Small RNAs as Potential Biomarkers for Pancreatic Ductal Adenocarcinoma Using Next-generation Sequencing. | Kim H et al. | β | 2025 | β |
| Evaluation of Metaplastic Triple-Negative Breast Cancer Extracellular Matrix Structure and Protein Composition. | Savoie JJ et al. | β | 2025 | β |
| Evolutionary dynamics of predicted G-quadruplexes in human and other great apes. | Mohanty SK et al. | β | 2025 | β |
| Evolution is in the details: Regulatory differences in modern human and Neanderthal. | Barker HR et al. | β | 2025 | β |
| Excess prenatal folic acid supplementation alters cortical DNA methylation and gene expression networks. | Haghani V et al. | β | 2025 | β |
| Exclusive functional signatures for gene annotation with vast OpenOrd layout. | Buzanov G et al. | β | 2025 | β |
| EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers. | Maric M et al. | β | 2025 | β |
| Exosomal MicroRNAs as Epigenetic Biomarkers for Endometriosis: A Systematic Review and Bioinformatics Analysis. | Santos CMAM et al. | β | 2025 | β |
| Exploration of M2 macrophage-related biomarkers and a candidate drug for glioblastoma using high-dimensional weighted gene co-expression network analysis. | Feng S et al. | β | 2025 | β |
| Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening. | Ma Z et al. | β | 2025 | β |
| Exploring gene expression heterogeneity in burn wounds through machine learning models: <i>in silico</i> analyses-experimental research. | Khosravani H et al. | β | 2025 | β |
| Exploring molecular links between obesity and osteoporosis: insights from in-silico analysis and mannose supplementation. | James R et al. | β | 2025 | β |
| Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients. | Peng W et al. | β | 2025 | β |
| Exploring Therapeutic Targets and Drugs for Recurrent Spontaneous Abortion by M1 Macrophage Exosome Sequencing Analysis: A Bioinformatic and Vitro Study. | Tang C et al. | β | 2025 | β |
| Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O<sub>2</sub> =2β―%) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O<sub>2</sub> β₯ 21β―%) in HTR-8/SVneo cells. | Stein FH et al. | β | 2025 | β |
| Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models. | Robert J et al. | β | 2025 | β |
| FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch. | Patel R et al. | β | 2025 | β |
| Fibroblast growth factor signaling induces a chondrocyte-like state of peripheral nerve fibroblast during aging. | Stefanovska D et al. | β | 2025 | β |
| Filaggrin<sup>High</sup> melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures. | Jinesh GG et al. | β | 2025 | β |
| FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective. | Lu H et al. | β | 2025 | β |
| Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects. | Walsh RM et al. | β | 2025 | β |
| From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells. | Sonninen TM et al. | β | 2025 | β |
| Fucoxanthin ameliorates PM<sub>2.5</sub>-mediated skin cell inflammation and senescence. | Fernando PDSM et al. | β | 2025 | β |
| Functional characterization of dysregulated LncRNAs in BRCA and CESC highlights their role in cancer prognosis. | Sharma M et al. | β | 2025 | β |
| Functional dynamics between resident transcriptionally active microbes (TAMs) and host genes underlie Dengue severity. | Kumari P et al. | β | 2025 | β |
| GASTON-Mix: a unified model of spatial gradients and domains using spatial mixture-of-experts. | Chitra U et al. | β | 2025 | β |
| GATA2 mutation is associated with immune dysfunction and increased Mycobacterium haemophilum susceptibility in immunocompromised individuals. | Gupta A et al. | β | 2025 | β |
| GeDi: simplifying gene set distances for enhanced omics interpretation in R/Bioconductor. | Nedwed AS et al. | β | 2025 | β |
| GeneAgent: self-verification language agent for gene-set analysis using domain databases. | Wang Z et al. | β | 2025 | β |
| Gene co-expression patterns shared between chemobrain and neurodegenerative disease models in rodents. | Zare MS et al. | β | 2025 | β |
| Gene Expression-Based Inference of Metabolic Signatures Reveals Distinct Molecular Profiles in Right- and Left-Sided Colon Cancer. | ErtuΔrul I et al. | β | 2025 | β |
| GeneRAIN: multifaceted representation of genes via deep learning of gene expression networks. | Su Z et al. | β | 2025 | β |
| Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets. | Vijay V et al. | β | 2025 | β |
| Generation of a Compendium of Transcription Factor Cascades and Identification of Potential Therapeutic Targets Using Graph Machine Learning. | Sivarajkumar S et al. | β | 2025 | β |
| Gene-set enrichment analysis and visualization on the web using EnrichmentMap:RNASeq. | Franz M et al. | β | 2025 | β |
| Genetic influence of the brain on epigenetic age acceleration: evidence of a large-scale genetic correlation study. | Li C et al. | β | 2025 | β |
| Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach. | Dasgupta S et al. | β | 2025 | β |
| Genetic Pleiotropy and Causal Pathways Linking Glycemic Traits to Asthma: An Integrated Proteogenomic Investigation. | Chen L et al. | β | 2025 | β |
| Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism. | Zhou D et al. | β | 2025 | β |
| Genetic variants in the vitamin D pathway genes are predictors of the risk of diabetic kidney disease in Central Asian Kazakhstani cohort with type 2 diabetes. | Taurbekova B et al. | β | 2025 | β |
| Genome-annotated bivariate analysis of shared heritability in autoimmune hepatitis with psychiatric comorbidity. | Liu L et al. | β | 2025 | β |
| Genome-Based Mexican Diet Bioactives Target Molecular Pathways in HBV, HCV, and MASLD: A Bioinformatic Approach for Liver Disease Prevention. | Leal-Mercado L et al. | β | 2025 | β |
| Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies Pathways for Host-Directed Therapeutic Targeting. | Russell CD et al. | β | 2025 | β |
| Genome-wide discovery of multiple sclerosis genetic risk variant allelic regulatory activity. | Granitto M et al. | β | 2025 | β |
| Genomic insights into the convergent evolution of desert adaptation in camels and antelopes. | Zhou J et al. | β | 2025 | β |
| Genomic rare variant mechanisms for congenital cardiac laterality defect: A digenic model approach. | Rai A et al. | β | 2025 | β |
| Gestational and Lactation Exposure to Perfluorohexanoic Acid Results in Sex-Specific Changes in the Cerebellum in Mice. | Plunk EC et al. | β | 2025 | β |
| Glucose-activated JMJD1A drives visceral adipogenesis via Ξ±-ketoglutarate-dependent chromatin remodeling. | Yang C et al. | β | 2025 | β |
| Glycans on non-structural protein 1 prevent premature T-cell mediated dengue virus clearance. | Idris F et al. | β | 2025 | β |
| GOREA: Unbiased Interpretation of Functional Enrichment. | Lee H et al. | β | 2025 | β |
| GraphAge: Unleashing the power of graph neural network to decode epigenetic aging. | Ahmed SS et al. | β | 2025 | β |
| Gut-larynx axis and its contribution to laryngeal immunity. | An R et al. | β | 2025 | β |
| Gut microbiota and tuberculosis. | Liu Y et al. | β | 2025 | β |
| Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem. | Coleon A et al. | β | 2025 | β |
| Harnessing cell cycle intervention and evading P-glycoprotein efflux: natural product-inspired C2-aminophenyl chromones as dual modulators against multidrug-resistant cancer. | Chang YH et al. | β | 2025 | β |
| Harnessing Distinct Tissue-Resident Immune Niches via S100A9/TLR4 Improves Ketone, Lipid, and Glucose Metabolism. | Lucibello G et al. | β | 2025 | β |
| Harnessing plasma transcriptomics for non-invasive cancer biomarker identification: a comprehensive review. | Mohamed NMHN et al. | β | 2025 | β |
| Harnessing Single-Cell RNA-Seq for Computational Drug Repurposing in Cancer Immunotherapy. | Cheng OJ et al. | β | 2025 | β |
| Health-enhancing physical activity induce beneficial skeletal muscle mitochondrial adaptations in individuals with rheumatoid arthritis. | Shorter E et al. | β | 2025 | β |
| Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency. | Ladd B et al. | β | 2025 | β |
| Heterogeneous expression of immunotherapy response markers in non-small cell lung cancer with hyperactive NRF2 pathway: PD-L1 and beyond. | Almeida-Lima K et al. | β | 2025 | β |
| High-Frequency Irreversible Electroporation Alters Proteomic Profiles and Tropism of Small Tumor-Derived Extracellular Vesicles to Promote Immune Cell Infiltration. | Murphy KR et al. | β | 2025 | β |
| High Temperature Promoted the Accumulation of Citrus Yellow Mosaic Virus in Citrus sinensis via Weakening the Immune Function of the CsWRKY76-CsPR4A Modules. | Tian XB et al. | β | 2025 | β |
| High-Throughput Proteomics in Lymphangioleiomyomatosis: Premelanosome Protein as a Diagnostic Biomarker, Construction of a Diagnosis Score, and Evidence of Neutrophil Involvement. | Diesler R et al. | β | 2025 | β |
| Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response. | Jain K et al. | β | 2025 | β |
| Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome. | Castro-MuΓ±oz LJ et al. | β | 2025 | β |
| HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes. | Bernardo E et al. | β | 2025 | β |
| HPV as a Molecular Hacker: Computational Exploration of HPV-Driven Changes in Host Regulatory Networks. | Chetta M et al. | β | 2025 | β |
| Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity. | Sayeed K et al. | β | 2025 | β |
| Human cytomegalovirus long non-coding RNA counteracts nuclear cGAS to facilitate immune evasion. | Lee S et al. | β | 2025 | β |
| Human endothelial cells promote a human neural stem cell type B phenotype via Notch signaling. | Gutierrez B et al. | β | 2025 | β |
| Hypoxia Affects Stem Cell Fate in Patient-Derived Ileum Enteroids in a HIF-1Ξ±-Dependent Manner. | Uckeley ZM et al. | β | 2025 | β |
| iDDN: determining trans-omics network structure and rewiring with integrative differential dependency networks. | Wang Y et al. | β | 2025 | β |
| Idebenone Mitigates Traumatic-Brain-Injury-Triggered Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways While Increasing Microglial Genes. | Hwang H et al. | β | 2025 | β |
| Identification and validation of diagnostic markers and drugs for pediatric bronchopulmonary dysplasia based on integrating bioinformatics and molecular docking analysis. | Guo R et al. | β | 2025 | β |
| Identification and validation of mitochondrial ferroptosis and immune microenvironment-related hub biomarkers in liver cirrhosis by integrated bioinformatics analysis. | Deng P et al. | β | 2025 | β |
| Identification and Validation of Oxidative Stress-Related Diagnostic Marker Genes and Immune Landscape in Ulcerative Interstitial Cystitis by Integrating Bioinformatics and Machine Learning. | Fu C et al. | β | 2025 | β |
| Identification of Ageing-related Hub Genes in Humans, Mouse and Rat Based on Bioinformatics Analysis. | Chaurasiya M et al. | β | 2025 | β |
| Identification of Anticancer Targets in Ovarian Cancer Using Genomic Drug Sensitivity Data. | Son Y et al. | β | 2025 | β |
| Identification of a PAK6-Mediated MDM2/p21 Axis That Modulates Survival and Cell Cycle Control of Drug-Resistant Stem/Progenitor Cells in Chronic Myeloid Leukemia. | Wu A et al. | β | 2025 | β |
| Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis. | Xin X et al. | β | 2025 | β |
| Identification of biomarkers related to neutrophil extracellular traps and potential therapeutic drugs for rheumatoid arthritis using computational analysis. | Sheng L et al. | β | 2025 | β |
| Identification of Diagnostic Biomarkers and Therapeutic Targets in Sepsis-Associated ARDS via Combining Bioinformatics with Machine Learning Analysis. | Liu T et al. | β | 2025 | β |
| Identification of differentially expressed genes and associated immune cell types in South African gallbladder cancer patients. | Devar J et al. | β | 2025 | β |
| Identification of Drug Repurposing Candidates for Coxsackievirus B3 Infection in iPSC-Derived Brain-like Endothelial Cells. | Wood JF et al. | β | 2025 | β |
| Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens. | Aguado-Alvaro LP et al. | β | 2025 | β |
| Identification of Epigenetic Regulatory Networks of Gene Methylation-miRNA-Transcription Factor Feed-Forward Loops in Basal-like Breast Cancer. | Okano LM et al. | β | 2025 | β |
| Identification of key proteins and pathways in myocardial infarction using machine learning approaches. | Liu C et al. | β | 2025 | β |
| Identification of <i>CXCL8, IL1A</i>, and <i>IL1B</i> as Hub Genes of Therapeutic Resistance in Glioblastoma Multiforme <i>via</i> Bioinformatics Analysis. | Lee S et al. | β | 2025 | β |
| Identification of mitochondria-related hub genes and immune associations in acute myocardial infarction: A bioinformatic analysis. | Xu X et al. | β | 2025 | β |
| Identification of novel gene expression patterns and pathways involved in PARP-1 inhibitor resistance. | Khan Z et al. | β | 2025 | β |
| Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach. | Youn S et al. | β | 2025 | β |
| Identification of shared key genes in Rheumatoid Arthritis and COVID-19 and their relevance as diagnostic biomarkers and with immune infiltration: New insights from bioinformatics analysis. | Lan WY et al. | β | 2025 | β |
| Identification of shared pathogenetic mechanisms between endometriosis and RSA based on comprehensive bioinformatics analysis. | Sheng J et al. | β | 2025 | β |
| Identification of SLC7A1 as a potential therapeutic target for high-grade meningioma. | Song L et al. | β | 2025 | β |
| Identifying causal genes for prostatitis through drug-targeted Mendelian randomization. | Yan K et al. | β | 2025 | β |
| Identifying conserved metastatic pathways across cancers through integrated transcriptomic and network analysis. | Sanjaya A et al. | β | 2025 | β |
| Identifying Immunomodulatory Subpopulations of Adipose Stromal Vascular Fraction and Stem/Stromal Cells Through Single-Cell Transcriptomics and Bulk Proteomics. | Parsons AM et al. | β | 2025 | β |
| Identifying regulators of aged fibroblast activation in 3D tissue models. | Liu H et al. | β | 2025 | β |
| IFNΞ³ and TNFΞ± optimize salivary gland mesenchymal stromal cells: an alternative to marrow- and adipose-MSCs for radiation xerostomia. | Larsen MC et al. | β | 2025 | β |
| IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation. | Sharma G et al. | β | 2025 | β |
| IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes. | Bao L et al. | β | 2025 | β |
| IL-4, IL-15, and Type I Interferon Orchestrate the Shaping of the Heterogeneity of Virtual Memory CD8 T Cells. | Park HJ et al. | β | 2025 | β |
| Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing. | Tampere M et al. | β | 2025 | β |
| Imidacloprid exposure in rats induces cardiac inflammatory response through activating TLR4/NF-ΞΊB/NLRP3 and JAK/STAT signaling pathways: focus on the berberine-loaded nanoliposomes. | Alkharashi L et al. | β | 2025 | β |
| Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism. | Hu X et al. | β | 2025 | β |
| InCURA: integrative gene clustering based on transcription factor binding sites. | Rinck L et al. | β | 2025 | β |
| In-Depth Cell-Type-Specific Proteome Landscape of the Brain from Human Amyloid-Ξ² Overexpression Mouse Model. | Ryu T et al. | β | 2025 | β |
| Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation. | Barros D et al. | β | 2025 | β |
| Inhibition of Aspartate Ξ²-Hydroxylase Enhances Anti-Tumor Immunity. | Johari SD et al. | β | 2025 | β |
| Inhibition of DOCK1 suppresses Notch signalling pathway and impairs leukaemogenesis. | Lin ME et al. | β | 2025 | β |
| Inhibition of PI3K/AKT/mTOR signaling enhances autophagy in HL-60 acute myeloid leukemia cells: An integrative bioinformatic and in vitro study. | Malekan M et al. | β | 2025 | β |
| In Silico Analysis of Post-COVID-19 Condition (PCC) Associated SNP rs9367106 Predicts the Molecular Basis of Abnormalities in the Lungs and Brain Functions. | Maiti AK | β | 2025 | β |
| Integrated ATAC-seq and RNA-seq analysis identifies Grid2 and Reln as potential regulatory genes in migraine pathophysiology. | Wang F et al. | β | 2025 | β |
| Integrated Bioinformatics and Experimental Analysis Revealed Crosstalk Between IL-6, Autophagy, Ubiquitination, and Key miRNAs in Female Infertility: Insights from Ovarian Endometriosis and Polycystic Ovary Syndrome. | Nahdi S et al. | β | 2025 | β |
| Integrated Bioinformatics Identifies NLRP3 Inflammasome Hub Genes and Therapeutic Targets in Schizophrenia. | Ma J et al. | β | 2025 | β |
| Integrated Gene and Isoform-Level Transcriptomic Analysis of Adverse Childhood Experiences in the Human Prefrontal Cortex. | NΓΊΓ±ez-RΓos DL et al. | β | 2025 | β |
| Integrated Genomic and GEO Data Analysis Reveals Therapeutic Targets for Rosacea. | Deng X et al. | β | 2025 | β |
| Integrated <i>in-silico</i> approach to explore the therapeutic potential of RNAs and druggable polyphenols to mine alternative breast cancer therapeutic strategies targeting cancer hallmarks. | Chakraborty S et al. | β | 2025 | β |
| Integrated multi-omics analysis reveals necroptosis-related biomarker BIRC3 for early diagnosis and therapeutic targeting in preeclampsia. | Lin Q et al. | β | 2025 | β |
| Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation. | Traxler P et al. | β | 2025 | β |
| Integrating brain imaging features and genomic profiles for the subtyping of major depression. | Yin L et al. | β | 2025 | β |
| Integrating imaging and omics for enhanced subtyping of mild cognitive impairment associated with Alzheimer's disease. | Afxenti S et al. | β | 2025 | β |
| Integrative Bioinformatic Approach for microRNA Interactome Networks in Human Papillomavirus-16 Infection. | DoΔan B | β | 2025 | β |
| Integrative GWAS and RNA-Seq analysis for target identification and virtual drug screening in colorectal cancer. | Liu Q et al. | β | 2025 | β |
| Integrative Metabolomics, Pharmacoinformatics and Experimental Studies Reveal the Neuroprotective Potential of <i>Caulerpa racemosa</i> Metabolites Against Alzheimer's Disease. | Handayani N et al. | β | 2025 | β |
| Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction. | Venkatesh R et al. | β | 2025 | β |
| Integrative neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder. | Dias HD et al. | β | 2025 | β |
| Integrative single-cell and spatial transcriptome analysis reveals the functions of TREM2<sup>high</sup> macrophages and infarct border dynamics post-myocardial infarction. | Xiong T et al. | β | 2025 | β |
| Integrative Transcriptomic and Perturbagen Analyses Reveal Sex-Specific Molecular Signatures Across Glioma Subtypes. | Rami Reddy MVSR et al. | β | 2025 | β |
| Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development. | Edupuganti RR et al. | β | 2025 | β |
| Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage. | Barrington J et al. | β | 2025 | β |
| Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice. | Ciampi C et al. | β | 2025 | β |
| Investigating the Molecular Impact of GGMSC on Redox and Metabolic Pathways in Pancreatic Cancer Cells. | Selvam AK et al. | β | 2025 | β |
| Investigating the role of oncogenic FAM83A as a prognostic biomarker in lung adenocarcinoma: Insights from smoker and non-smoker cohorts. | Singh P et al. | β | 2025 | β |
| In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model. | Sharma N et al. | β | 2025 | β |
| Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC. | Liu S et al. | β | 2025 | β |
| KDM1A Facilitates Oncogenic Potential in Colorectal Cancer Progression Through the Activation of AXIN/GSK3Ξ²/Ξ²-Catenin Signaling Pathways: Evidence From Integrated Transcriptomics and InΒ Vitro Studies. | Natarajan SR et al. | β | 2025 | β |
| Knockdown of long non-coding RNA BISPR attenuates the proinflammatory cytokine IL-6 production in human microglia. | Wang Y et al. | β | 2025 | β |
| KnowYourCG: Facilitating base-level sparse methylome interpretation. | Goldberg DC et al. | β | 2025 | β |
| Large-scale serum protein biomarkers discovery associated with function and clinical milestones in Duchenne muscular dystrophy. | Ikelaar NA et al. | β | 2025 | β |
| Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis. | Seasock MJ et al. | β | 2025 | β |
| Leveraging artificial intelligence and machine learning in kinase inhibitor development: advances, challenges, and future prospects. | Elgawish MS et al. | β | 2025 | β |
| Limitations in PPARΞ±-dependent mitochondrial programming restrain the differentiation of human stem cell-derived Ξ² cells. | Lietzke AC et al. | β | 2025 | β |
| LINE-1 retrotransposition in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and cell non-autonomous programmed cell death. | Korada S et al. | β | 2025 | β |
| Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response. | Bukhari Z et al. | β | 2025 | β |
| Lipidomic and transcriptomic profiling reveal alterations in the coexistence of gestational diabetes mellitus and preeclampsia impacting maternal and neonatal outcomes. | Zhang C et al. | β | 2025 | β |
| Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity. | Anandakrishnan N et al. | β | 2025 | β |
| LncRNACNVIntegrateR: a novel framework for correlating long non-coding RNAs with copy number variation abnormalities and disease progression. | Tyagi N et al. | β | 2025 | β |
| LncRNA HSCHARME is altered in human cardiomyopathies and promotes stem cell-derived cardiomyogenesis via splicing regulation. | Buonaiuto G et al. | β | 2025 | β |
| LncRNA MEG3/CTCF-CXCR4 axis functions in the regulation of breast cancer cell migration. | Elhassan G et al. | β | 2025 | β |
| Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes. | Smithmyer ME et al. | β | 2025 | β |
| Longitudinal single-cell analysis reveals treatment-resistant stem and mast cells with potential treatments for pediatric AML. | Ohlstrom D et al. | β | 2025 | β |
| Long-Term Exposure to Real-Life Polyethylene Terephthalate Nanoplastics Induces Carcinogenesis In Vitro. | GutiΓ©rrez-GarcΓa J et al. | β | 2025 | β |
| Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder. | PΓ©rez Baca MDR et al. | β | 2025 | β |
| Loss of MFAP5 and Its Effect on Skin Homeostasis and Wound Healing. | Han C et al. | β | 2025 | β |
| Low-dose methotrexate as a potential treatment for schizophrenia via astrocytic and neuroimmune modulation. | Lima TSA et al. | β | 2025 | β |
| Lower <i>SYNJ2BP</i> Gene Expression Is Associated With Poor Survival Outcome and Treatment Response in Clear Cell Renal Cell Carcinoma: A Bioinformatics Analysis. | Saulsbury MD et al. | β | 2025 | β |
| <i>ACE</i> gene and male infertility: a South Slavic case-control study and multi-omics data integration. | Kunej T et al. | β | 2025 | β |
| <i>Akkermansia muciniphila</i> reverses neuronal atrophy in <i>Negr1</i> knockout mice with depression-like phenotypes. | Hwang HG et al. | β | 2025 | β |
| <i>Brugia malayi</i> miRNAs and potential targets within the feline host (<i>Felis catus</i>). | Burkman E et al. | β | 2025 | β |
| <i>CPSF1</i> Is Co-Amplified with <i>MYC</i> but Is Independently Associated with Alternative Polyadenylation in Cancer. | Alahmari AA | β | 2025 | β |
| <i>LNC01089</i>-<i>LINC00963</i>/miR-1244-5p/<i>IGF1</i> ceRNA Axis Regulate FOXO Signaling Pathway in Breast Cancer Patients: A Biomarker Discovery Investigation. | Rezaei M et al. | β | 2025 | β |
| <i>TP53</i> Splice Mutations Have Tumour-Independent Effects on Genomic Stability and Prognosis: An In Silico Study. | Bhandarkar AA et al. | β | 2025 | β |
| <i>VEGFB</i> is a potential therapeutic target for Alzheimer's disease: Insights from integrative multi-omics analysis. | Ye H et al. | β | 2025 | β |
| Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation. | Sagie S et al. | β | 2025 | β |
| Lymphoid gene expression supports neuroprotective microglia function. | Ayata P et al. | β | 2025 | β |
| Machine Learning-Based Ensemble Feature Selection and Nested Cross-Validation for miRNA Biomarker Discovery in Usher Syndrome. | Thelagathoti RK et al. | β | 2025 | β |
| Machine learning-driven dissection of the obesity-ccRCC interface: FCGR2A emerges as a central coordinator of tumor-immune crosstalk. | He Z et al. | β | 2025 | β |
| Machine Learning-Driven Identification of Blood-Based Biomarkers and Therapeutic Agents for Personalized Ischemic Stroke Management. | Liu J et al. | β | 2025 | β |
| Macrophages foster anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction. | Fuchs K et al. | β | 2025 | β |
| Maize miRNAs Might Regulate Human Genes Involved in Prostate Cancer: An In Silico Approach. | VΓ‘zquez-Cadena X et al. | β | 2025 | β |
| Major toxin composition of particulate matter from a coal-fired power plant and its proteomics-associated toxicological profiles in the lungs of balb/c mice. | Techapichetvanich P et al. | β | 2025 | β |
| Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune Response. | Chen J et al. | β | 2025 | β |
| Mapping NK cell diversity in response to COVID-19 and mRNA vaccination. | Kishi Y et al. | β | 2025 | β |
| Mass spectrometry combined with machine learning identifies novel protein signatures as demonstrated with multisystem inflammatory syndrome in children. | GuzmΓ‘n Rivera J et al. | β | 2025 | β |
| Maternal medication use in pregnancy and offspring ASD risk: A prescription-wide, target-informed study. | Zaks N et al. | β | 2025 | β |
| Maturation of human cardiac organoids enables complex disease modeling and drug discovery. | Pocock MW et al. | β | 2025 | β |
| MBC PathNet: integration and visualization of networks connecting functionally related pathways predicted from transcriptomic and proteomic datasets. | Hansen J et al. | β | 2025 | β |
| MCSP<sup>+</sup> metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization. | Guetter S et al. | β | 2025 | β |
| Mesenchymal Stromal Cells Mitigate Prolonged Cardiopulmonary Bypass-Induced Neuroinflammation. | Kobayashi K et al. | β | 2025 | β |
| Metabolic patterns predispose human pluripotent stem cells to spatial organization of cell fate. | Deng C et al. | β | 2025 | β |
| Metabolic reprogramming of interleukin-17-producing Ξ³Ξ΄ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions. | Kao YS et al. | β | 2025 | β |
| Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy. | Cagnone G et al. | β | 2025 | β |
| Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity. | Daman AW et al. | β | 2025 | β |
| Microenvironmental conditions and serum availability alter primary human macrophage NF-ΞΊB inflammatory response and function. | Channer B et al. | β | 2025 | β |
| Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state. | HyvΓ€rinen T et al. | β | 2025 | β |
| microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism. | Ismaeel A et al. | β | 2025 | β |
| MicroRNA Signatures in Serous Ovarian Cancer: A Comparison of Prognostic Marker Targets in African Americans and Caucasians. | Muinde JM et al. | β | 2025 | β |
| MicroRNAs modulated by DPP-4 inhibitor and bedtime NPH insulin therapy in individuals with type 2 diabetes. | Santos AS et al. | β | 2025 | β |
| miR-101-3p overexpression suppresses NSCLC progression through Immune-Related gene CALCRL regulation and lncRNA NEAT1 axis. | Tabassum G et al. | β | 2025 | β |
| miR-210 locus deletion disrupts cellular homeostasis: an integrated genetic study. | Preda MB et al. | β | 2025 | β |
| miR-221/222-3p act as potential circulating factors in heart failure to stimulate cancer progression. | Xu R et al. | β | 2025 | β |
| Mitochondrial dysfunction in PRRSV-2-infected macrophages. | Vu Manh TP et al. | β | 2025 | β |
| m<sup>6</sup>A alters ribosome dynamics to initiate mRNA degradation. | Murakami S et al. | β | 2025 | β |
| Modulation of Estrogen Receptor Activity by the Phytoalexin Tuberosin Produced from Elicited Kudzu (<i>Pueraria lobata</i>). | Belgodere JA et al. | β | 2025 | β |
| Modulation of the Apolipoprotein M/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms. | Tolerico M et al. | β | 2025 | β |
| Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models. | Lee YJ et al. | β | 2025 | β |
| Molecular and Functional Divergence of Zebrafish Sox Paralogs Controlling Endoderm Formation and Left-Right Patterning. | Johal S et al. | β | 2025 | β |
| Molecular and imaging biomarker responses to brain mutant HTT lowering in a mouse model of Huntington disease. | Caron NS et al. | β | 2025 | β |
| Molecular exploration of host-pathogen interactions in severe <i>Pseudomonas aeruginosa</i> infection through a multi-level data integration approach. | Messina F et al. | β | 2025 | β |
| Molecular predictors of treatment resistance and recurrence following neoadjuvant therapy in rectal cancer. | Huang F et al. | β | 2025 | β |
| Molecular signals associated with intraperitoneal chemotherapy resistance in gastric cancer with peritoneal metastasis through PIPS GC trial integrated translational research. | Seo WJ et al. | β | 2025 | β |
| Monogenic Contributions to Familial Endometriosis: A Scoping Review. | Joshy LE et al. | β | 2025 | β |
| Multidimensional tumor-blood profiling uncovers systemic lymphocyte-monocyte imbalance in pituitary neuroendocrine tumors. | Dai Y et al. | β | 2025 | β |
| Multifaceted disruption of AMPA receptor signaling by <i>CACNG8</i> variants: Integrated evidence from human genetics and molecular simulation. | Alibrandi S et al. | β | 2025 | β |
| Multi-level expression profiling of cardiac and musculoskeletal Schwann cells in young and old mice. | Haider S et al. | β | 2025 | β |
| Multimodal spatial transcriptomic characterization of mouse kidney injury and repair. | Xuanyuan Q et al. | β | 2025 | β |
| Multi-Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures. | Nguyen JH et al. | β | 2025 | β |
| Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies. | Heming M et al. | β | 2025 | β |
| Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks. | Raju S et al. | β | 2025 | β |
| Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer's disease. | Liu S et al. | β | 2025 | β |
| Multiomics analysis of GSTP1 knockdown pancreatic cancer cells reveals key regulators of redox and metabolic homeostasis. | Duttenhefner JN et al. | β | 2025 | β |
| Multi-omics analysis reveals intratumoral microbiota as modulators of the immune environment within thyroid cancer. | Liang Z et al. | β | 2025 | β |
| Multi-omics and functional characterization of the tumor-killing capacity of Imiquimod-activated plasmacytoid dendritic cells. | Gastaldi T et al. | β | 2025 | β |
| Multiomics Integration Reveals Microbial Gene Interactions Shaping Host Responses in a DSS-Induced Colitis Mouse Model. | Hong HH et al. | β | 2025 | β |
| Multi-omics tests identify novel shared genetic mechanisms of primary biliary cholestasis and sarcopenia. | Wang Z et al. | β | 2025 | β |
| Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice. | Magaye RR et al. | β | 2025 | β |
| Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy. | Lin K et al. | β | 2025 | β |
| Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish. | Wolford BN et al. | β | 2025 | β |
| Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma. | Kim S et al. | β | 2025 | β |
| Multiscale Interactome-Guided Discovery Candidate Herbs and Active Ingredients Against Hyperthyroidism by Biased Random Walk Algorithm. | Han SH et al. | β | 2025 | β |
| Multitissue single-cell analysis reveals differential cellular and molecular sensitivity between fructose and high-fat high-sucrose diets. | Chen YW et al. | β | 2025 | β |
| Multi-Transcriptome-Informed Network Pharmacology Reveals Novel Biomarkers and Therapeutic Candidates for Parkinson's Disease. | Pappu MAA et al. | β | 2025 | β |
| MYB and HIF1Ξ± crosstalk drives hypoxia-induced transcriptional reprogramming and adaptive signaling alterations in pancreatic cancer. | Anand S et al. | β | 2025 | β |
| Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging. | Pham J et al. | β | 2025 | β |
| Nelfb promotes dermal white adipose tissue formation through RNA polymerase II-mediated adipogenic gene regulation. | Mahapatra S et al. | β | 2025 | β |
| Network analysis of intrathecally synthesized proteins to unravel mechanisms of disease course in multiple sclerosis. | Welsh NC et al. | β | 2025 | β |
| Network Pharmacology-Based Characterization of Mecasin (KCHO-1) as a Multi-Target Modulator of Neuroinflammatory Pathways in Alzheimer's Disease. | Jo H et al. | β | 2025 | β |
| Neural stem cell-specific deficiency of (pro)renin receptor causes brain malformation and perinatal lethality in mice. | Hashimoto M et al. | β | 2025 | β |
| Neuraminidase as a novel therapeutic management strategy for Alzheimer's disease: evidenced through molecular docking, molecular dynamic simulation and gene expression analysis. | Alzarea SI et al. | β | 2025 | β |
| Neurodevelopment Genes Encoding Olduvai Domains Link Myalgic Encephalomyelitis to Neuropsychiatric Disorders. | Arcos-Burgos M et al. | β | 2025 | β |
| Neuron-derived extracellular vesicles reflect adaptive neuronal responses to cortical spreading depolarization: a biomarker study for migraine. | Sever-Bahcekapili M et al. | β | 2025 | β |
| Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function. | Zhang Y et al. | β | 2025 | β |
| Next-generation RNA sequencing of spatially mapped material from human body donors for testing the impact of fetal environments on the liver transcriptome. | Baghersad SS et al. | β | 2025 | β |
| Normal gastric tissue <i>Helicobacter pylori</i> infection is associated with tissue cell composition, and cell type-specific epigenetic age acceleration, mitotic tick rate, and repetitive element methylation alterations. | Vlasac I et al. | β | 2025 | β |
| Notable Differences in Clinical Features and Inflammatory Gene Expression Between Genital Lichen Sclerosus and Lichen Planus. | Poffet P et al. | β | 2025 | β |
| Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma. | Dalal M et al. | β | 2025 | β |
| NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice. | Park S et al. | β | 2025 | β |
| Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation. | Celik A et al. | β | 2025 | β |
| O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis. | Ahmed O et al. | β | 2025 | β |
| OmixLitMiner 2: Guided Literature Mining for Automated Categorization of Marker Candidates in Omics Studies. | Gocke A et al. | β | 2025 | β |
| Oncogenomic profiling in infant-toddler T-ALL identifies NKX2 family genes as drivers linked to favorable outcomes. | Delafoy M et al. | β | 2025 | β |
| Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal. | Simon RC et al. | β | 2025 | β |
| Osteoarthritis Bone Marrow MSCs Retain Regenerative Competence and Chemokine Responsiveness for Drug-Based In Situ Tissue Engineering. | Sonnleitner J et al. | β | 2025 | β |
| Overactivation of EGFR signaling in skeletal stem/progenitor cells promotes bone formation and repair. | Hu Y et al. | β | 2025 | β |
| OX40 and Regulatory Marker Alterations in Lesional and Non-Lesional Keloid Tissues. | Bar J et al. | β | 2025 | β |
| Oxidized phosphatidylcholines activate NOX1-mediated oxidative stress response and shift glucose metabolism in cardiac cells. | Licznerska AA et al. | β | 2025 | β |
| p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance. | Tamura A et al. | β | 2025 | β |
| Pan-Cancer Analysis Identifies a Ras-Related GTPase as a Potential Modulator of Cancer. | Hsueh HY et al. | β | 2025 | β |
| Pan-cancer gene set discovery via scRNA-seq for optimal deep learning based downstream tasks. | Kim JH et al. | β | 2025 | β |
| Particle Shape Modulates the Function of Adoptive Macrophage Transfers. | Kwan MMC et al. | β | 2025 | β |
| Peripheral immune cell-specific genes in Parkinson's disease uncovered by multi-omics with therapeutic implications. | Hong Y et al. | β | 2025 | β |
| Peripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model. | Lee C et al. | β | 2025 | β |
| Pharmacological activation of p53 induces dose-dependent changes in endothelial cell fate during angiogenic sprouting. | Al-Radi O et al. | β | 2025 | β |
| Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing <i>TNNT2</i> sarcomeric variants. | Coscarella IL et al. | β | 2025 | β |
| Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex. | Gupta K et al. | β | 2025 | β |
| Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism. | Godfrey WH et al. | β | 2025 | β |
| Phospho-Proteomic Analysis of Interleukin-13 Signaling in Airway Cells Reveals SRC Family Kinase Involvement in Interleukin-13-Induced Inflammatory Responses. | Shankar A et al. | β | 2025 | β |
| Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-Ξ² pathway in ALMS1 and BBS1 knockout models. | Bea-Mascato B et al. | β | 2025 | β |
| Phospho-Regulatory Network of the Right Open Reading Frame Kinase 1 (RIOK1), Its Functional Relevance, and Cancer Treatment Prospects. | Fahma A et al. | β | 2025 | β |
| Phthalate exposure and hepatocellular carcinoma: Unraveling mechanisms through network toxicology. | Zhan S et al. | β | 2025 | β |
| Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapy. | De Juan A et al. | β | 2025 | β |
| Phytic acid impairs macrophage inflammatory response in Echinococcus multilocularis infection. | Salzmann M et al. | β | 2025 | β |
| Pig Taste Cell-derived Organoids Synthesize Insulin. | Premathilake HU et al. | β | 2025 | β |
| Placental network differences among obstetric syndromes identified with an integrated multiomics approach. | Piekos SN et al. | β | 2025 | β |
| PNUTS:PP1 recruitment to Tox4 regulates chromosomal dispersal in Drosophila germline development. | Duncalf L et al. | β | 2025 | β |
| Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis. | Shen Z et al. | β | 2025 | β |
| Potential biomarker for screening nasopharyngeal carcinoma: three-microRNA panel in serum. | Li X et al. | β | 2025 | β |
| Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity. | Kim HJ et al. | β | 2025 | β |
| Preclinical characterisation of changes in cardiac function and circulating biomarkers following differential irradiation of thoracic volumes. | Kuburas R et al. | β | 2025 | β |
| Predicting immune responsiveness in ER-positive breast cancer for personalized therapy: a population-based study. | Stenmark Tullberg A et al. | β | 2025 | β |
| Preferential release of microRNAs via extracellular vesicles is associated with ductal carcinoma in situ to invasive breast cancer progression. | Elayapillai SP et al. | β | 2025 | β |
| Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats. | Dali O et al. | β | 2025 | β |
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| Prolonged immune activation in post-acute sequelae of SARS-CoV-2: neutrophil dynamics and therapeutic insights. | Yu M et al. | β | 2025 | β |
| PROM1 and EFTUD2 Expression in High-Grade Clear Cell Renal Cell Carcinoma as a Molecular Marker for Survival Rate. | Kasperczak M et al. | β | 2025 | β |
| PROS1 released by lung basal cells limits inflammation in epithelial and monocytes during SARS-CoV-2 infection. | Simakou T et al. | β | 2025 | β |
| Prostaglandin D<sub>2</sub> Synthase: A Novel Player in the Pathological Signaling Mechanism of the Aldosterone-Mineralocorticoid Receptor Pathway in the Heart. | Garg A et al. | β | 2025 | β |
| Protective potential of tween 80-functionalized chitosan-selenium nanoparticles containing quercetin against cisplatin neurotoxicity in PC12 cells: an in vitro and network pharmacology study. | Abadi B et al. | β | 2025 | β |
| PROTECT: Protein circadian time prediction using unsupervised learning. | Ansary Ogholbake A et al. | β | 2025 | β |
| Proteome atlas for mechanistic discovery and risk prediction of diabetic retinopathy. | Yang S et al. | β | 2025 | β |
| Proteome profiling indicates a link between mitochondrial pathways and the host-microbial sensor ELMO1 following <i>Salmonella</i> infection. | Achi SC et al. | β | 2025 | β |
| Proteomic analysis of 7-octenoic acid antifibrotic effects in TGF-Ξ²1 activated hepatic stellate cells. | Buakaew W et al. | β | 2025 | β |
| Proteomic analysis of exosomes from <i>Brucella abortus</i>-infected macrophages reveals possible mechanisms of immune evasion and host modulation. | Γlvarez F et al. | β | 2025 | β |
| Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition. | Toledo TM et al. | β | 2025 | β |
| Proteomic Characterization of Extracellular Vesicles from Human Neural Precursor Cells: A Promising Advanced Therapy for Neurodegenerative Diseases. | Stricker PEF et al. | β | 2025 | β |
| Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics. | Palm KCA et al. | β | 2025 | β |
| Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. | Mohanty I et al. | β | 2025 | β |
| Proteotoxic stress response drives T cell exhaustion and immune evasion. | Wang Y et al. | β | 2025 | β |
| Pseudouridine reprogramming in the human T-cell epitranscriptome: from primary to immortalized states. | Fanari O et al. | β | 2025 | β |
| Purinergic receptors play a key role in shock wave-induced proliferation. | Szwarc-Hofbauer D et al. | β | 2025 | β |
| PXR-dependant dysregulation of glucose metabolism induced by chronic exposure to NOAEL-level pesticide cocktail in mice. | Dauwe Y et al. | β | 2025 | β |
| Quaking Protein in Myelin Maintenance and Regeneration in the Central Nervous System. | Thomas L et al. | β | 2025 | β |
| Radiation Modifies Let-7 miRNA Binding to AGO2 Independent of Changes in Transcription to Influence Tumor Cell Radiosensitivity. | Ali T et al. | β | 2025 | β |
| Rational Design of Non-Toxic Multidrug Combinations Demonstrates Durable and Hypoxia-Enhanced Efficacy Against Renal Cell Carcinoma. | Mieville V et al. | β | 2025 | β |
| RECAP-seq: restriction enzyme-based CpG-methylated fragment amplification for early cancer detection. | Shin D et al. | β | 2025 | β |
| Reconstructed cell-type-specific rhythms in human brain link Alzheimer's pathology, circadian stress, and ribosomal disruption. | Hollis HC et al. | β | 2025 | β |
| Reduced JAG1 Expression Through miR-200 Overexpression or Crispr-Cas Mediated Knockout Impairs TNBC Growth and Metastasis. | Vaz M et al. | β | 2025 | β |
| Reduced surfactant protein B levels impede unfolding of the pulmonary blood-gas barrier during inspiration in mice. | Buchholz HM et al. | β | 2025 | β |
| Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-Ξ³-producing lymphocytes. | Zammit NW et al. | β | 2025 | β |
| Remodeling Cell Adhesion Releases Cardiac Potential of Human Pluripotent Stem Cells with Continuous Proliferation and Accelerated Maturation. | Liu W et al. | β | 2025 | β |
| Repeated Low-Level Inflammatory Challenge Leads to Alterations in the TNF-CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells InΒ Vitro. | Ritson M et al. | β | 2025 | β |
| Replication of the GWAS-Identified GALNT13 rs10196189 Polymorphism in Relation to Speed-Power Elite Active Athlete Status and Multidimensional Phenotypic Differences in Chinese Han Males: A Pilot Study. | Chen L et al. | β | 2025 | β |
| Reproducibility of PD patient-specific midbrain organoid data for <i>in vitro</i> disease modeling. | Zuccoli E et al. | β | 2025 | β |
| Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation. | RΓos I et al. | β | 2025 | β |
| Repurposing DPP-4 inhibitors as anticancer agents in KRAS-mutated pancreatic ductal adenocarcinoma. | Ramalingam PS et al. | β | 2025 | β |
| Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation. | Leesang TE et al. | β | 2025 | β |
| Revealing potential interfering genes between abdominal aortic aneurysm and periodontitis through machine learning and bioinformatics analysis. | Wu Z et al. | β | 2025 | β |
| Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells. | Arif T et al. | β | 2025 | β |
| RNA-Seq Uncovers Association of Endocrine-Disrupting Chemicals with Hub Genes and Transcription Factors in Aggressive Prostate Cancer. | Alwadi D et al. | β | 2025 | β |
| RORΞ³ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression. | Bleve A et al. | β | 2025 | β |
| RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure. | Elmore G et al. | β | 2025 | β |
| RXFP1, the relaxin receptor: Lost and found in translation. | Lal M et al. | β | 2025 | β |
| RXR Agonist V-125 Induces Distinct Transcriptional and Immunomodulatory Programs in Mammary Tumors of MMTV-Neu Mice Compared to Bexarotene. | Chowdhury AS et al. | β | 2025 | β |
| Scalable screening of ternary-code DNA methylation dynamics associated with human traits. | Goldberg DC et al. | β | 2025 | β |
| scDETECT: a novel statistical model accounting for cell type correlation in single-cell RNA-seq differential expression analysis. | Xu Y et al. | β | 2025 | β |
| scHLens: a web server for hierarchically and interactively exploring single cell RNA-seq data. | Xia J et al. | β | 2025 | β |
| scPOEM: robust co-embedding of peaks and genes revealing peak-gene regulation. | Zhong Y et al. | β | 2025 | β |
| Screening out microRNAs and Their Molecular Pathways with a Potential Role in the Regulation of Parvovirus B19 Infection Through In Silico Analysis. | Salvado VA et al. | β | 2025 | β |
| Search for Potential VDR/Partner Composite Elements in Regulatory DNA of Genes Associated with Respiratory Infections and Atopic Diseases. | Popov AV et al. | β | 2025 | β |
| Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism. | Ma R et al. | β | 2025 | β |
| Semaphorin 3A and 3F Promote Lumen Expansion in TIE2-Mutated Venous Malformation. | Schrenk S et al. | β | 2025 | β |
| Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses. | Ling AL et al. | β | 2025 | β |
| Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms. | Deng Y et al. | β | 2025 | β |
| Sex Differences in Brain Transcriptomes of Juvenile Cynomolgus Macaques. | Kabbej N et al. | β | 2025 | β |
| Sex differences in the single-nuclei hippocampal neurovascular unit transcriptomic response to type 2 diabetes. | Nuthikattu S et al. | β | 2025 | β |
| Sex-specific angiogenic responses in endothelial cells-role of the pluripotency factor OCT4. | Shin J et al. | β | 2025 | β |
| Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clusters | Bell RD et al. | β | 2025 | β |
| Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts. | Ehrenberg PK et al. | β | 2025 | β |
| Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism. | Perez Y et al. | β | 2025 | β |
| Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice. | Mazan-Mamczarz K et al. | β | 2025 | β |
| Single-cell expression profiling of bat wing development. | Lyu X et al. | β | 2025 | β |
| Single-cell image-based screens identify host regulators of Ebola virus infection dynamics. | Carlson RJ et al. | β | 2025 | β |
| Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix. | Lee HJ et al. | β | 2025 | β |
| Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma. | Veo B et al. | β | 2025 | β |
| Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience. | Liu Z et al. | β | 2025 | β |
| Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes. | Neo WH et al. | β | 2025 | β |
| Single-cell RNA profiling identifies immune cell population shifts in diabetes associated mucosal inflammation. | Alghamdi B et al. | β | 2025 | β |
| Single-cell RNA sequencing of baseline PBMCs predicts ICI efficacy and irAE severity in patients with NSCLC. | Kim GD et al. | β | 2025 | β |
| Single-cell RNA-sequencing of circulating tumour cells: A practical guide to workflow and translational applications. | Tieng FYF et al. | β | 2025 | β |
| Single-Cell Transcriptomic Changes in Patient-Derived Glioma and U87 Glioblastoma Cell Cultures Infected with the Oncolytic Virus VV-GMCSF-Lact. | Semenov DV et al. | β | 2025 | β |
| Single nucleus RNA sequencing profile analysis to reveal cell type specific common molecular drivers of Parkinson's disease and therapeutic agents. | Pappu MAA et al. | β | 2025 | β |
| Skeletal muscle dysfunction in severe burns: identification of essential genes and drug discovery. | Hailiang B et al. | β | 2025 | β |
| Small intestinal neuroendocrine tumors lack early genomic drivers, acquire DNA repair defects and harbor hallmarks of low REST expression. | Bolduan F et al. | β | 2025 | β |
| Small molecule disruption of RARΞ±/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer. | McCabe M et al. | β | 2025 | β |
| Small-RNA sequencing identifies serum microRNAs associated with abnormal electrocardiography findings in patients with Chagas disease. | Mueller M et al. | β | 2025 | β |
| Sorted-cell proteomics reveals an AT1-associated epithelial cornification phenotype and suggests endothelial redox imbalance in human bronchopulmonary dysplasia. | Ushakumary MG et al. | β | 2025 | β |
| Space-associated stem cell hallmarks of aging and resilience in astronauts. | Pham J et al. | β | 2025 | β |
| Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components. | Omdahl AR et al. | β | 2025 | β |
| SPaSE: Spatially resolved pathology scores using optimal transport on spatial transcriptomics data. | Rahman MN et al. | β | 2025 | β |
| Spatial Proteomics Reveals Distinct Protein Patterns in Cortical Migration Disorders Caused by LIN28A Overexpression and WNT Activation. | NavoliΔ J et al. | β | 2025 | β |
| Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain. | Zhang Z et al. | β | 2025 | β |
| Spectral divergence prioritizes key classes, genes, and pathways shared between substance use disorders and cardiovascular disease. | Castaneda E et al. | β | 2025 | β |
| Sphingosine kinase 2 suppresses neutrophil responses to promote viral persistence while attenuating immune pathology. | Vijayamahantesh V et al. | β | 2025 | β |
| STATH Downregulation and Poor Prognosis in Head and Neck Squamous Cell Carcinoma: Transcriptomic Analysis Reveals Poor Impact on Oral Health. | Elnagi A et al. | β | 2025 | β |
| Stochastic epigenetic mutation profiles as biomarkers of clinical activity in juvenile idiopathic arthritis: a multi-omic machine learning approach for gene prioritization. | Cavalca G et al. | β | 2025 | β |
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| Subtype- and race-specific variations in the immune landscape of breast cancer: therapeutic implications. | Sharma A et al. | β | 2025 | β |
| Surveying the Proteome-Wide Landscape of Mitoxantrone and Examining Drug Sensitivity in BRCA1-Deficient Ovarian Cancer Using Quantitative Proteomics. | Wallin S et al. | β | 2025 | β |
| SwitchTFI: identifying transcription factors driving cell differentiation. | Martini P et al. | β | 2025 | β |
| Synergistic anticancer effects of camptothecin and sotorasib in <i>KRAS</i>-mutated pancreatic ductal adenocarcinoma. | Ramalingam PS et al. | β | 2025 | β |
| Systematic analysis of the effects of splicing on the diversity of post-translational modifications in protein isoforms using PTM-POSE. | Crowl S et al. | β | 2025 | β |
| Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion. | Garreta E et al. | β | 2025 | β |
| Systematic profiling reveals distinct senescence signatures and regulators across human brain cell types. | Russo T et al. | β | 2025 | β |
| Tamoxifen induces PI3K activation in uterine cancer. | KΓΌbler K et al. | β | 2025 | β |
| Target and biomarker exploration portal for drug discovery. | Dewangan B et al. | β | 2025 | β |
| Targeted ferroptosis induction enhances chemotherapy efficacy in chemoresistant neuroblastoma. | MaΓ±as A et al. | β | 2025 | β |
| Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues. | Mellor KM et al. | β | 2025 | β |
| Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery. | Leddy O et al. | β | 2025 | β |
| Targeting phospholipase PLAG-15 promotes healthy aging in <i>C. elegans</i> via lysosomal-related genes. | van der Rijt S et al. | β | 2025 | β |
| TaxaGO: a novel, phylogenetically informed gene ontology enrichment analysis tool. | Bochalis E et al. | β | 2025 | β |
| TBC1D22B Regulates ER-to-Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer. | Martino F et al. | β | 2025 | β |
| Temporal Dynamics of the Plasma Proteomic Landscape Reveals Maladaptation in ME/CFS Following Exertion. | Germain A et al. | β | 2025 | β |
| TGF-Ξ² builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1<sup>+</sup> macrophages. | Henriques A et al. | β | 2025 | β |
| The anti-cancer transition-state inhibitor MTDIA inhibits human MTAP, inducing autophagy in humanized yeast. | Coorey NV et al. | β | 2025 | β |
| The blood-brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in Drosophila. | Dong Q et al. | β | 2025 | β |
| The Chromosome 19 microRNA Cluster Facilitates Cancer Stemness in Hepatocellular Carcinoma. | Underwood MT et al. | β | 2025 | β |
| The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1<sup>+</sup>CD8<sup>+</sup> T cells. | Humblin E et al. | β | 2025 | β |
| The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane. | Wang Y et al. | β | 2025 | β |
| The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism. | Krawczyk J et al. | β | 2025 | β |
| The dysregulation score method identifies epigenetic regulator genes that predict cancer prognosis and efficiency of cancer immunotherapy. | Lyu J et al. | β | 2025 | β |
| The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice. | Tomishima SA et al. | β | 2025 | β |
| The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible. | Stevers NO et al. | β | 2025 | β |
| The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets. | Solmonese L et al. | β | 2025 | β |
| The inflammatory architecture reflects the effects of pharmacological and genetic interventions on resolution of TLR2-mediated inflammation. | Kramer C et al. | β | 2025 | β |
| The LINC01612-DVL2-WNT axis promotes human endoderm differentiation. | Li M et al. | β | 2025 | β |
| The Mitochondrial Brown Adipose Tissue Maintenance Factor Nipsnap1 Interfaces Directly With the Ξ²-Oxidation Protein Machinery in Rodents. | Tsai PY et al. | β | 2025 | β |
| The molecular chaperone TRAP1 promotes translation of <i>Luc7I3</i> mRNA to enhance ovarian cancer cell proliferation. | De Lella S et al. | β | 2025 | β |
| The mouse neonatal small intestine is regionally specialized for protein absorption and transepithelial transport. | Block CL et al. | β | 2025 | β |
| The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions. | Hayashi A et al. | β | 2025 | β |
| The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome. | Jeon S et al. | β | 2025 | β |
| The RNA-binding protein YTHDF3 affects gastric cancer cell migration and response to paclitaxel by regulating EZRIN. | Mesquita P et al. | β | 2025 | β |
| The Role of ENHO in Pancreatic Adenocarcinoma: A Bioinformatics Approach. | Younis OM et al. | β | 2025 | β |
| The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives. | Alzamzami W | β | 2025 | β |
| The SARS-CoV-2 envelope PDZ binding motif acts as a virulence factor disrupting host's epithelial cell-cell junctions. | Alvarez F et al. | β | 2025 | β |
| The solute carrier superfamily interactome. | Frommelt F et al. | β | 2025 | β |
| The transcription complex p52-ETS1 is essential for germinal center formation. | Morgan D et al. | β | 2025 | β |
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| TIMAP downregulation in Burkitt's lymphoma reveals key molecules and signaling pathways in B-cell lymphomagenesis. | Obeidat M et al. | β | 2025 | β |
| Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect. | Vilaplana-Lopera N et al. | β | 2025 | β |
| TLR4 modulates simvastatin's impact on HDL cholesterol and glycemic control. | Tian X et al. | β | 2025 | β |
| TMED10 expression in human cutaneous malignant melanoma. | Annese T et al. | β | 2025 | β |
| Toll-like receptor 4 induces trained innate immune tolerance in the heart in a model of stress-induced cardiomyopathy. | Lim KRQ et al. | β | 2025 | β |
| Transcriptional regulatory logic orchestrating lymphoid and myeloid cell fate decisions. | Godini R et al. | β | 2025 | β |
| Transcriptional response to combination antiretroviral therapy predicts side effects and novel targets. | Lachmann A et al. | β | 2025 | β |
| Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors. | Roth R et al. | β | 2025 | β |
| Transcriptome alterations underlying metabolic dysfunction and liver disease in myotonic dystrophy type 1. | Fukumoto A et al. | β | 2025 | β |
| Transcriptome Combined with Mendelian Randomization to Identify and Validate Biomarkers Associated with Parthanatos in Sepsis. | Zhao H et al. | β | 2025 | β |
| Transcriptome-guided drug repurposing identifies selumetinib for an aggressive epithelial cancer. | Dorfer S et al. | β | 2025 | β |
| Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities. | Kolendowski B et al. | β | 2025 | β |
| Transcriptomic Approach in Understanding Fabry Nephropathy: A Review of the Literature and Proof-of-Concept. | Breznik N et al. | β | 2025 | β |
| Transcriptomic Differences Between Immortalized Oral and Skin Keratinocytes. | Han C et al. | β | 2025 | β |
| Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development. | Groves PL et al. | β | 2025 | β |
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| Transglutaminase 2 Stimulates Cell Proliferation and Modulates Transforming Growth Factor-Beta Signaling Pathway Independently of Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells. | Yamaguchi H et al. | β | 2025 | β |
| Transient alterations in nucleosome distribution and sensitivity to nuclease define the THP-1 monocyte-to-macrophage transition. | Benoit JM et al. | β | 2025 | β |
| Transient skin stretching stimulates immune surveillance and promotes vaccine delivery via hair follicles. | Benaouda F et al. | β | 2025 | β |
| Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms. | Oncins A et al. | β | 2025 | β |
| Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome. | Taylor MA et al. | β | 2025 | β |
| Triple-effect correction for Cell Painting data with contrastive and domain-adversarial learning. | Yan C et al. | β | 2025 | β |
| Tumor Immune Microenvironment-Associated Prognostic and Mifamurtide-Response Gene Signatures for Localized Osteosarcoma: A Correlative Study of the ISG/OS-2 Trial. | Palmerini E et al. | β | 2025 | β |
| Uncovering Novel Susceptible Genes and Therapeutic Targets of Prostate Cancer: a Multi-omics Study Integrating Summary-based Mendelian Randomization Analysis and Molecular Docking. | Qiu X et al. | β | 2025 | β |
| Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread. | Garner H et al. | β | 2025 | β |
| Unique and Conserved Endoplasmic Reticulum Stress Responses in Neuroendocrine Cells. | Rodrigues-Dos-Santos K et al. | β | 2025 | β |
| Unlocking hematopoietic stem cell potential: integrative computational approaches for genomic and transcriptomic analysis. | Raghav PK et al. | β | 2025 | β |
| Unprecedented lead tolerance in an urban lizard. | Blanchette A et al. | β | 2025 | β |
| Unraveling LINE-1 retrotransposition in head and neck squamous cell carcinoma. | Brea-Iglesias J et al. | β | 2025 | β |
| Unraveling the molecular landscape of pancreatic cancer: a systems biology approach to identify therapeutic targets. | Ahmadipour E et al. | β | 2025 | β |
| Unraveling the role of MAG, PTEN, and NOTCH1 in axonal regeneration: a network analysis and molecular dynamics study of siRNA/drugs/nanocarriers interactions. | Salimi A et al. | β | 2025 | β |
| Unravelling the therapeutic potential of dual TGFΞ²-1 and CXCR4 inhibition in breast cancer using computational strategies. | Haq BU et al. | β | 2025 | β |
| Unsupervised cell line embedding using pairwise drug response correlation. | Kim Y et al. | β | 2025 | β |
| Unsupervised machine learning-based stratification and immune deconvolution of liver hepatocellular carcinoma. | Reierson MM et al. | β | 2025 | β |
| Unsupervised Random Forest Identifies Important Genetic Prognostic Factors for Breast Cancer Survival Time. | Goldberg B et al. | β | 2025 | β |
| Unveiling CCL2 and CXCL1: Key biomarkers and therapeutic targets in idiopathic pulmonary fibrosis. | Pan J et al. | β | 2025 | β |
| Unveiling Epigenetic Regulatory Elements Associated with Breast Cancer Development. | Jardanowska-Kotuniak M et al. | β | 2025 | β |
| Urine cf-nucleosomes: A non-invasive window into human physiology and disease. | Lotem M et al. | β | 2025 | β |
| Urothelial Proteome Changes Underlying Overactive Bladder Associated With Bladder Outlet Obstruction. | Lee SY et al. | β | 2025 | β |
| Utilising multi-modal data-driven network analysis to identify monotherapy and combinational therapy targets in SOX2-dependent squamous cell lung cancer. | Hwang W et al. | β | 2025 | β |
| VDAC1 is a target for pharmacologically induced insulin hypersecretion in Ξ² cells. | Roy G et al. | β | 2025 | β |
| Venetoclax resistance in preclinical KMT2A-rearranged acute lymphoblastic leukemia models is characterized by high inter- and intra-model heterogeneity. | Richter A et al. | β | 2025 | β |
| Whole-exome sequencing for identification of specific gene mutations in an Indian cohort of triple-negative breast cancer patients. | Preeti P et al. | β | 2025 | β |
| Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features. | Lin B et al. | β | 2025 | β |
| Whole genome sequencing in adolescent idiopathic scoliosis cohort implicates multiple biological pathways. | Tuncay IO et al. | β | 2025 | β |
| Whole genome transcriptional analysis of intestinal biopsies and blood cells indicate genes involved in antioxidant defense systems, amino acid metabolism and antigen presentation in the pathogenesis of celiac disease. | Torinsson Naluai Γ et al. | β | 2025 | β |
| WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/Ξ²-catenin signaling. | Voss JH et al. | β | 2025 | β |
| WSTF nuclear autophagy regulates chronic but not acute inflammation. | Wang Y et al. | β | 2025 | β |