Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.
paper
Cited
Public
- Authors
- Pietrzykowski, Andrzej Z; Friesen, Ryan M; Martin, Gilles E; Puig, Sylvie I; Nowak, Cheryl L; Wynne, Patricia M; Siegelmann, Hava T; Treistman, Steven N
- Year
- 2008
- Journal
- Neuron
- PMID
- 18667155
- DOI
- 10.1016/j.neuron.2008.05.032
- PMCID
- PMC2714263
Tolerance represents a critical component of addiction. The large-conductance calcium- and voltage-activated potassium channel (BK) is a well-established alcohol target, and an important element in behavioral and molecular alcohol tolerance. We tested whether microRNA, a newly discovered class of gene expression regulators, plays a role in the development of tolerance. We show that in adult mammalian brain, alcohol upregulates microRNA miR-9 and mediates posttranscriptional reorganization in BK mRNA splice variants by miR-9-dependent destabilization of BK mRNAs containing 3'UTRs with a miR-9 Recognition Element (MRE). Different splice variants encode BK isoforms with different alcohol sensitivities. Computational modeling indicates that this miR-9-dependent mechanism contributes to alcohol tolerance. Moreover, this mechanism can be extended to include regulation of additional miR-9 targets relevant to alcohol abuse. Our results describe a mechanism of multiplex regulation of stability of alternatively spliced mRNA by microRNA in drug adaptation and neuronal plasticity.
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| 60 | Experimental Procedures β HEK cell transfection | HEK293 were cultured in DMEM medium with 10% fetal bovine serum and, for transfection, confluentβ¦ |
| 61 | Experimental Procedures β HEK cell transfection | In miRNA experiments, BK 3βUTR+/β plasmids (0.0442 fmol/well) were transfected alone, or withβ¦ |
| 62 | Experimental Procedures β HEK cell transfection | For electrophysiological analysis cells were transfected with a BK variant (BKALCOREX, BK-STREX orβ¦ |
| 63 | Experimental Procedures β Electrophysiology | For a full description of electrophysiological recordings including whole-cell and single-channelβ¦ |
| 64 | Experimental Procedures β Computational modeling of the miR-9 regulation of BK transcripts | For a full description of computational modeling of miR-9 regulation of BK transcripts, includingβ¦ |
| 65 | Experimental Procedures β Statistical Analysis | For a full description of statistical analysis see Supplementary Materials. P < 0.05 was defined asβ¦ |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| BK channels and alcohol tolerance: Insights from studies on <i>Drosophila</i>, nematodes, rodents and cell lines: A systematic review. | Ignat LA et al. | β | 2025 | β |
| Change of Spiny Neuron Structure in the Basal Ganglia Song Circuit and Its Regulation by miR-9 during Song Development. | Jarrell H et al. | β | 2025 | β |
| Epigenetic Insights into Substance Use Disorder and Associated Psychiatric Conditions. | Ngo AL et al. | β | 2025 | β |
| Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes. | Okeoma CM et al. | β | 2025 | β |
| Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps. | Upreti D et al. | β | 2025 | β |
| Paraoxonase 3 regulates the pore-forming Ξ± subunit of the large-conductance K<sup>+</sup> channel. | Whelan SCM et al. | β | 2025 | β |
| BK ZERO isoform HEK293 stably transfected cell lines differing 3'UTRs to assess miR-9 regulation. | Cordero Padilla K et al. | β | 2024 | β |
| Ethanol's interaction with BK channel Ξ± subunit residue K361 does not mediate behavioral responses to alcohol in mice. | Okhuarobo A et al. | β | 2024 | β |
| Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders (FASDs). | Darbinian N et al. | β | 2024 | β |
| <i>Kcnma1</i> alternative splicing in mouse kidney: regulation during development and by dietary K<sup>+</sup> intake. | Whelan SCM et al. | β | 2024 | β |
| Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. | Popova D et al. | β | 2023 | β |
| Bioinformatic analysis predicts that ethanol exposure during early development causes alternative splicing alterations of genes involved in RNA post-transcriptional regulation. | Fuentes-Beals C et al. | β | 2023 | β |
| Ethanol-induced AMPA alterations are mediated by mGLU5 receptors through miRNA upregulation in hippocampal slices. | Gerace E et al. | β | 2023 | β |
| Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. | Wang JQ et al. | β | 2023 | β |
| miR-9 utilizes precursor pathways in adaptation to alcohol in mouse striatal neurons. | Mead EA et al. | β | 2023 | β |
| The role of microRNAs in the pathophysiology of human central nervous system: A focus on neurodegenerative diseases. | Rezaee D et al. | β | 2023 | β |
| Current and Future Perspectives of Noncoding RNAs in Brain Function and Neuropsychiatric Disease. | Kyzar EJ et al. | β | 2022 | β |
| Inhibition of BK<sub>Ca</sub> channels protects neonatal hearts against myocardial ischemia and reperfusion injury. | Sanghvi S et al. | β | 2022 | β |
| MicroRNA is a potential target for therapies to improve the physiological function of skeletal muscle after trauma. | Gu XY et al. | β | 2022 | β |
| MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy. | Mohammadi AH et al. | β | 2022 | β |
| MicroRNAs in drug addiction: Current status and future perspectives. | Zhao Y et al. | β | 2022 | β |
| Noncoding RNA therapeutics for substance use disorder. | Seyednejad SA et al. | β | 2022 | β |
| Sleep Modulates Alcohol Toxicity in <i>Drosophila</i>. | De Nobrega AK et al. | β | 2022 | β |
| Translational relevance of forward genetic screens in animal models for the study of psychiatric disease. | Sheardown E et al. | β | 2022 | β |
| Alcohol induced impairment/abnormalities in brain: Role of MicroRNAs. | Sushma et al. | β | 2021 | β |
| Analysis of mir-9 Expression Pattern in Rat Retina during Postnatal Development. | PΓΆstyΓ©ni E et al. | β | 2021 | β |
| Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders. | Chivero ET et al. | β | 2021 | β |
| Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence. | Liu Y et al. | β | 2021 | β |
| Epigenetic and non-coding regulation of alcohol abuse and addiction. | Farris SP et al. | β | 2021 | β |
| Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. | Lim Y et al. | β | 2021 | β |
| MiR-9-5p Regulates Genes Linked to Cerebral Calcification in the Osteogenic Differentiation Model and Induces Generalized Alteration in the Ion Channels. | Bezerra DP et al. | β | 2021 | β |
| Non-Invasive microRNA Profiling in Saliva can Serve as a Biomarker of Alcohol Exposure and Its Effects in Humans. | Mead EA et al. | β | 2021 | β |
| Role of microRNAs in the pathophysiology of addiction. | Gowen AM et al. | β | 2021 | β |
| Transcriptional analysis of the response of C. elegans to ethanol exposure. | Sterken MG et al. | β | 2021 | β |
| Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence. | Drake J et al. | β | 2020 | β |
| Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration. | Choi MR et al. | β | 2020 | β |
| Evolution of Plasticity in Response to Ethanol between Sister Species with Different Ecological Histories (<i>Drosophila melanogaster</i> and <i>D. simulans</i>). | Signor SA | β | 2020 | β |
| Genome-wide analysis of MicroRNA-messenger RNA interactome in ex-vivo gill filaments, Anguilla japonica. | Ng HM et al. | β | 2020 | β |
| Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor. | Bahi A et al. | β | 2020 | β |
| Methamphetamine leads to the alterations of microRNA profiles in the nucleus accumbens of rats. | Yang J et al. | β | 2020 | β |
| Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening. | Li B et al. | β | 2020 | β |
| Protein Translation and Psychiatric Disorders. | Laguesse S et al. | β | 2020 | β |
| Regulatory Role of MicroRNAs in Brain Development and Function. | Yapijakis C | β | 2020 | β |
| Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies. | Odegaard KE et al. | β | 2020 | β |
| Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging. | Singh T et al. | β | 2020 | β |
| Sex Differences in the Expression of the Ξ±5 Subunit of the GABA<sub>A</sub> Receptor in Alcoholics with and without Cirrhosis of the Liver. | Janeczek P et al. | β | 2020 | β |
| Ago2 and Dicer1 are involved in METH-induced locomotor sensitization in mice via biogenesis of miRNA. | Liu D et al. | β | 2019 | β |
| Assessing the role of long-noncoding RNA in nucleus accumbens in subjects with alcohol dependence | McMichael GO et al. | β | 2019 | β |
| Brain Regional and Temporal Changes in BDNF mRNA and microRNA-206 Expression in Mice Exposed to Repeated Cycles of Chronic Intermittent Ethanol and Forced Swim Stress. | Solomon MG et al. | β | 2019 | β |
| Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. | Pucci M et al. | β | 2019 | β |
| How alcohol drinking affects our genes: an epigenetic point of view. | CiafrΓ¨ S et al. | β | 2019 | β |
| <i>KCNMA1</i>-linked channelopathy. | Bailey CS et al. | β | 2019 | β |
| miRNA profiling of urinary exosomes to assess the progression of acute kidney injury. | Sonoda H et al. | β | 2019 | β |
| Noninvasive assessment of fetal central nervous system insult: Potential application to prenatal diagnosis. | Goetzl L et al. | β | 2019 | β |
| Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats. | Martinez M et al. | β | 2019 | β |
| Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice. | Most D et al. | β | 2019 | β |
| Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires. | Bofill-De Ros X et al. | β | 2019 | β |
| Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach. | Tsamou M et al. | β | 2018 | β |
| A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo. | Scott LL et al. | β | 2018 | β |
| Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. | Jacobsen JHW et al. | β | 2018 | β |
| Calcium- and voltage-gated BK channels in vascular smooth muscle. | Dopico AM et al. | β | 2018 | β |
| Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster. | Signor S et al. | β | 2018 | β |
| Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning. | Boschen KE et al. | β | 2018 | β |
| Epigenetic Mechanisms of Alcohol Neuroadaptation: Insights from <i>Drosophila</i>. | Ramirez-Roman ME et al. | β | 2018 | β |
| Integrated microRNA and mRNA analysis in the pathogenic filamentous fungus Trichophyton rubrum. | Wang L et al. | β | 2018 | β |
| Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. | Osterndorff-Kahanek EA et al. | β | 2018 | β |
| Mesenchymal stem cell differentiation: Control by calcium-activated potassium channels. | Pchelintseva E et al. | β | 2018 | β |
| MicroR-9-5p suppresses EV71 replication through targeting NFΞΊB of the RIG-I-mediated innate immune response. | Li B et al. | β | 2018 | β |
| MicroRNAs regulate synaptic plasticity underlying drug addiction. | Smith ACW et al. | β | 2018 | β |
| miRNA-regulated transcription associated with mouse strains predisposed to hypnotic effects of ethanol. | Vestal B et al. | β | 2018 | β |
| Potential Role of Extracellular Vesicles in the Pathophysiology of Drug Addiction. | Rao PSS et al. | β | 2018 | β |
| Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders. | Oliver RJ et al. | β | 2018 | β |
| Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons. | Dopico AM et al. | β | 2018 | β |
| Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology. | Chastain LG et al. | β | 2017 | β |
| Association of the PLCB1 gene with drug dependence. | Cabana-DomΓnguez J et al. | β | 2017 | β |
| Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in <i>Caenorhabditis elegans</i>. | Scott LL et al. | β | 2017 | β |
| Comparative analysis of cytokine/chemokine regulatory networks in patients with hippocampal sclerosis (HS) and focal cortical dysplasia (FCD). | Srivastava A et al. | β | 2017 | β |
| Emerging roles for ncRNAs in alcohol use disorders. | Mayfield RD | β | 2017 | β |
| ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in <i>C. elegans</i>. | Oh KH et al. | β | 2017 | β |
| Gene expression profiling in the human alcoholic brain. | Warden AS et al. | β | 2017 | β |
| Genetics and genomics of alcohol responses in Drosophila. | Park A et al. | β | 2017 | β |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | β | 2017 | β |
| <i>Drosophila</i>: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse. | De Nobrega AK et al. | β | 2017 | β |
| MicroRNA expression signature of methamphetamine use and addiction in the rat nucleus accumbens. | Sim MS et al. | β | 2017 | β |
| MiR-218 targets MeCP2 and inhibits heroin seeking behavior. | Yan B et al. | β | 2017 | β |
| Molecular structure and function of big calcium-activated potassium channels in skeletal muscle: pharmacological perspectives. | Maqoud F et al. | β | 2017 | β |
| Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. | Sadakierska-Chudy A et al. | β | 2017 | β |
| Reprogramming of mPFC transcriptome and function in alcohol dependence. | Heilig M et al. | β | 2017 | β |
| The BAF (BRG1/BRM-Associated Factor) chromatin-remodeling complex exhibits ethanol sensitivity in fetal neural progenitor cells and regulates transcription at the miR-9-2 encoding gene locus. | Burrowes SG et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| 17Beta-Estradiol Inhibits Calcium-Activated Potassium Channel Expressions in Rat Whole Bladder. | Kim DY et al. | β | 2016 | β |
| Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability <i>In vitro</i> and Spatial Working Memory <i>In vivo</i>. | Weth-Malsch D et al. | β | 2016 | β |
| Alcohol Regulates BK Surface Expression via Wnt/Ξ²-Catenin Signaling. | VelΓ‘zquez-Marrero C et al. | β | 2016 | β |
| All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders. | O'Connor RM et al. | β | 2016 | β |
| BK Channels and the Control of the Pituitary. | Duncan PJ et al. | β | 2016 | β |
| BK Channels in the Central Nervous System. | Contet C et al. | β | 2016 | β |
| Calcium activated KβΊ channels in the electroreceptor of the skate confirmed by cloning. Details of subunits and splicing. | King BL et al. | β | 2016 | β |
| Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior. | Codocedo JF et al. | β | 2016 | β |
| Epigenetic Modifications, Alcoholic Brain and Potential Drug Targets. | Jangra A et al. | β | 2016 | β |
| Expression of 14-3-3 transcript isoforms in response to ethanol exposure and their regulation by miRNAs. | Mathew DE et al. | β | 2016 | β |
| Immediate-early alcohol-responsive miRNA expression in Drosophila. | Ghezzi A et al. | β | 2016 | β |
| MicroRNA-9 Mediates the Cell Apoptosis by Targeting Bcl2l11 in Ischemic Stroke. | Wei N et al. | β | 2016 | β |
| MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population. | BarragΓ‘n R et al. | β | 2016 | β |
| MicroRNAs as regulators of drug abuse and immunity. | Zhang K et al. | β | 2016 | β |
| Modulation of BK Channels by Ethanol. | Dopico AM et al. | β | 2016 | β |
| Molecular mechanisms underlying alcohol-drinking behaviours. | Ron D et al. | β | 2016 | β |
| Plasma miRNA Profiles in Pregnant Women Predict Infant Outcomes following Prenatal Alcohol Exposure. | Balaraman S et al. | β | 2016 | β |
| Posttranscriptional and Posttranslational Regulation of BK Channels. | Shipston MJ et al. | β | 2016 | β |
| Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. | Johnson JR et al. | β | 2016 | β |
| Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption. | Most D et al. | β | 2016 | β |
| The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis. | Teppen TL et al. | β | 2016 | β |
| The role of miR-9 during neuron differentiation of mouse retinal stem cells. | Qi X | β | 2016 | β |
| Transcriptome Profiling Reveals Disruption of Innate Immunity in Chronic Heavy Ethanol Consuming Female Rhesus Macaques. | Sureshchandra S et al. | β | 2016 | β |
| Turing Revisited: Decoding the microRNA Messages in Brain Extracellular Vesicles for Early Detection of Neurodevelopmental Disorders. | Gillet V et al. | β | 2016 | β |
| Aberrant histone acetylation promotes mitochondrial respiratory suppression in the brain of alcoholic rats. | Jung ME et al. | β | 2015 | β |
| Alcohol Withdrawal and Cerebellar Mitochondria. | Jung ME | β | 2015 | β |
| Applying the new genomics to alcohol dependence. | Farris SP et al. | β | 2015 | β |
| Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches. | Prosser RA et al. | β | 2015 | β |
| Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. | Gedik H et al. | β | 2015 | β |
| BK Channel Ξ²1 Subunit Contributes to Behavioral Adaptations Elicited by Chronic Intermittent Ethanol Exposure. | Kreifeldt M et al. | β | 2015 | β |
| Corticostriatal microRNAs in addiction. | Heyer MP et al. | β | 2015 | β |
| Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons. | Bekdash RA et al. | β | 2015 | β |
| Epigenetic modulation of brain gene networks for cocaine and alcohol abuse. | Farris SP et al. | β | 2015 | β |
| High postnatal susceptibility of hippocampal cytoskeleton in response to ethanol exposure during pregnancy and lactation. | Reis KP et al. | β | 2015 | β |
| Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence. | Mamdani M et al. | β | 2015 | β |
| Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior. | Kamii H et al. | β | 2015 | β |
| Investigation of microRNA expression profiles associated with human alcoholic cardiomyopathy. | Jing L et al. | β | 2015 | β |
| MicroRNA-10a-5p and microRNA-34c-5p in laryngeal epithelial premalignant lesions: differential expression and clinicopathological correlation. | Hu Y et al. | β | 2015 | β |
| MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. | Darcq E et al. | β | 2015 | β |
| MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting NavΞ²2 protein coding region in rat with chronic brain hypoperfusion. | Sun LH et al. | β | 2015 | β |
| microRNAs That Promote or Inhibit Memory Formation in Drosophila melanogaster. | Busto GU et al. | β | 2015 | β |
| MiR-125b protects against ethanol-induced apoptosis in neural crest cells and mouse embryos by targeting Bak 1 and PUMA. | Chen X et al. | β | 2015 | β |
| Revisiting Chaos Theorem to Understand the Nature of miRNAs in Response to Drugs of Abuse. | Taki FA et al. | β | 2015 | β |
| Role of microRNAs in Alcohol-Induced Multi-Organ Injury. | Natarajan SK et al. | β | 2015 | β |
| Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal Neurons. | Palacio S et al. | β | 2015 | β |
| Up-Regulatory Effects of Curcumin on Large Conductance Ca2+-Activated K+ Channels. | Chen Q et al. | β | 2015 | β |
| A genetic variant in the microRNA-146a gene is associated with susceptibility to alcohol use disorders. | Novo-Veleiro I et al. | β | 2014 | β |
| Alcohol withdrawal is associated with a downregulation of large-conductance CaΒ²βΊ-activated KβΊ channels in rat inferior colliculus neurons. | N'Gouemo P et al. | β | 2014 | β |
| Converging actions of alcohol on liver and brain immune signaling. | Szabo G et al. | β | 2014 | β |
| Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival. | Pang X et al. | β | 2014 | β |
| Effects of Acute Prenatal Exposure to Ethanol on microRNA Expression are Ameliorated by Social Enrichment. | Ignacio C et al. | β | 2014 | β |
| Epigenetic mechanisms of drug addiction. | Nestler EJ | β | 2014 | β |
| Epigenetic signaling in psychiatric disorders. | PeΓ±a CJ et al. | β | 2014 | β |
| Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior. | Dopico AM et al. | β | 2014 | β |
| Large conductance voltage- and Ca2+-gated potassium (BK) channel Ξ²4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases. | VelΓ‘zquez-Marrero C et al. | β | 2014 | β |
| Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. | Prins SA et al. | β | 2014 | β |
| Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model. | Balaraman S et al. | β | 2014 | β |
| MaxiK channel and cell signalling. | Toro L et al. | β | 2014 | β |
| MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendrites. | Bicker S et al. | β | 2014 | β |
| MicroRNAs and ethanol toxicity. | Miranda RC | β | 2014 | β |
| miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-ΞΊB pathway. | Zhang Y et al. | β | 2014 | β |
| miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family. | Hogan EM et al. | β | 2014 | β |
| Molecular basis of alcoholism. | Most D et al. | β | 2014 | β |
| Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans. | Robinson G et al. | β | 2014 | β |
| Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring. | Finegersh A et al. | β | 2014 | β |
| Proteomic approaches and identification of novel therapeutic targets for alcoholism. | Gorini G et al. | β | 2014 | β |
| RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain. | Farris SP et al. | β | 2014 | β |
| Stress-related alcohol consumption in heavy drinkers correlates with expression of miR-10a, miR-21, and components of the TAR-RNA-binding protein-associated complex. | Beech RD et al. | β | 2014 | β |
| Susceptibility to ethanol withdrawal seizures is produced by BK channel gene expression. | Ghezzi A et al. | β | 2014 | β |
| Synaptic adaptations by alcohol and drugs of abuse: changes in microRNA expression and mRNA regulation. | Most D et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies. | Bettinger JC et al. | β | 2014 | β |
| Transgenerational epigenetics and brain disorders. | Rachdaoui N et al. | β | 2014 | β |
| When less is more--microRNAs and psychiatric disorders. | Kolshus E et al. | β | 2014 | β |
| A DNA element regulates drug tolerance and withdrawal in Drosophila. | Li X et al. | β | 2013 | β |
| Adult-specific functions of animal microRNAs. | Sun K et al. | β | 2013 | β |
| Alcohol-induced histone acetylation reveals a gene network involved in alcohol tolerance. | Ghezzi A et al. | β | 2013 | β |
| Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence. | Tapocik JD et al. | β | 2013 | β |
| Differential Effects of Chronic and Chronic-Intermittent Ethanol Treatment and Its Withdrawal on the Expression of miRNAs. | van Steenwyk G et al. | β | 2013 | β |
| Differential Expression of miR-130a in Postmortem Prefrontal Cortex of Subjects with Alcohol Use Disorders. | Wang F et al. | β | 2013 | β |
| Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. | Balaraman S et al. | β | 2013 | β |
| Epigenetic control of gene expression in the alcoholic brain. | Ponomarev I | β | 2013 | β |
| Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs). | SΓ‘nchez-Mora C et al. | β | 2013 | β |
| Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease. | Mulligan MK et al. | β | 2013 | β |
| Functional mapping of the neuronal substrates for drug tolerance in Drosophila. | Ghezzi A et al. | β | 2013 | β |
| General principals of miRNA biogenesis and regulation in the brain. | O'Carroll D et al. | β | 2013 | β |
| Genetic studies of acute tolerance, rapid tolerance, and drinking in the dark in the LXS recombinant inbred strains. | Radcliffe RA et al. | β | 2013 | β |
| MicroRNA expression profile and functional analysis reveal that miR-382 is a critical novel gene of alcohol addiction. | Li J et al. | β | 2013 | β |
| microRNAs and the regulation of neuronal plasticity under stress conditions. | Schouten M et al. | β | 2013 | β |
| miRNA in the regulation of ion channel/transporter expression. | Wang Z | β | 2013 | β |
| Modulation of BK channel by MicroRNA-9 in neurons after exposure to HIV and methamphetamine. | Tatro ET et al. | β | 2013 | β |
| Molecular tolerance of voltage-gated calcium channels is evident after short exposures to alcohol in vasopressin-releasing nerve terminals. | Pietrzykowski AZ et al. | β | 2013 | β |
| Neurobiological signatures of alcohol dependence revealed by protein profiling. | Gorini G et al. | β | 2013 | β |
| Nicotine addiction reduces the large-conductance Ca(2+)-activated potassium channels expression in the nucleus accumbens. | Ma L et al. | β | 2013 | β |
| Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation. | Manzardo AM et al. | β | 2013 | β |
| Rab-3 and unc-18 interactions in alcohol sensitivity are distinct from synaptic transmission. | Johnson JR et al. | β | 2013 | β |
| Signaling pathways mediating alcohol effects. | Ron D et al. | β | 2013 | β |
| Striatal modulation of BDNF expression using microRNA124a-expressing lentiviral vectors impairs ethanol-induced conditioned-place preference and voluntary alcohol consumption. | Bahi A et al. | β | 2013 | β |
| Suppression and epigenetic regulation of MiR-9 contributes to ethanol teratology: evidence from zebrafish and murine fetal neural stem cell models. | Pappalardo-Carter DL et al. | β | 2013 | β |
| The role of Ξ±-synuclein in the pathophysiology of alcoholism. | Janeczek P et al. | β | 2013 | β |
| A role for dynamin in triggering ethanol tolerance. | Krishnan HR et al. | β | 2012 | β |
| Chronic intermittent ethanol exposure and its removal induce a different miRNA expression pattern in primary cortical neuronal cultures. | Guo Y et al. | β | 2012 | β |
| Claudin-14 regulates renal CaβΊβΊ transport in response to CaSR signalling via a novel microRNA pathway. | Gong Y et al. | β | 2012 | β |
| Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression. | Duncan JR | β | 2012 | β |
| Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons. | Saba R et al. | β | 2012 | β |
| Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens. | Marty VN et al. | β | 2012 | β |
| Epigenetics-beyond the genome in alcoholism. | Starkman BG et al. | β | 2012 | β |
| Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos. | Soares AR et al. | β | 2012 | β |
| Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. | Mellios N et al. | β | 2012 | β |
| Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain. | Contet C | β | 2012 | β |
| Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. | Eipper-Mains JE et al. | β | 2012 | β |
| Linear motifs: lost in (pre)translation. | Weatheritt RJ et al. | β | 2012 | β |
| MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics. | Kryger R et al. | β | 2012 | β |
| MicroRNAs and Fetal Brain Development: Implications for Ethanol Teratology during the Second Trimester Period of Neurogenesis. | Miranda RC | β | 2012 | β |
| MicroRNAs control neurobehavioral development and function in zebrafish. | Tal TL et al. | β | 2012 | β |
| MicroRNAs in learning, memory, and neurological diseases. | Wang W et al. | β | 2012 | β |
| MicroRNAs in neuronal function and dysfunction. | Im HI et al. | β | 2012 | β |
| MicroRNAs in Neurotoxicity. | Kaur P et al. | β | 2012 | β |
| Neuronal responses to physiological stress. | Kagias K et al. | β | 2012 | β |
| Non-coding RNAs--novel targets in neurotoxicity. | Tal TL et al. | β | 2012 | β |
| On the role of low-dose effects and epigenetics in toxicology. | Smirnova L et al. | β | 2012 | β |
| Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. | Balaraman S et al. | β | 2012 | β |
| Specific Roles of MicroRNAs in Their Interactions with Environmental Factors. | Wang J et al. | β | 2012 | β |
| The dynorphin/ΞΊ-opioid receptor system and its role in psychiatric disorders. | Tejeda HA et al. | β | 2012 | β |
| The Emerging Role of Non-Coding RNAs in Drug Addiction. | Sartor GC et al. | β | 2012 | β |
| The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders. | Chan AW et al. | β | 2012 | β |
| The role of metabotropic glutamate receptors in addiction: evidence from preclinical models. | Duncan JR et al. | β | 2012 | β |
| Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics. | Nunez YO et al. | β | 2012 | β |
| Homeostatic control of neural activity: a Drosophila model for drug tolerance and dependence. | Ghezzi A et al. | β | 2011 | β |
| Identification and quantification of full-length BK channel variants in the developing mouse cochlea. | Sakai Y et al. | β | 2011 | β |
| Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells. | Ohya S et al. | β | 2011 | β |
| MicroRNA-9: functional evolution of a conserved small regulatory RNA. | Yuva-Aydemir Y et al. | β | 2011 | β |
| MicroRNA function in the nervous system. | Fiore R et al. | β | 2011 | β |
| MicroRNAs in addiction: adaptation's middlemen? | Li MD et al. | β | 2011 | β |
| miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2. | Yadav S et al. | β | 2011 | β |
| miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells. | Kuhn S et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| NeurimmiRs: microRNAs in the neuroimmune interface. | Soreq H et al. | β | 2011 | β |
| Neuronal fast activating and meningeal silent modulatory BK channel splice variants cloned from rat. | Poulsen AN et al. | β | 2011 | β |
| Regulation of ion transport by microRNAs. | Elvira-Matelot E et al. | β | 2011 | β |
| Regulation of MiR-124, Let-7d, and MiR-181a in the accumbens affects the expression, extinction, and reinstatement of cocaine-induced conditioned place preference. | Chandrasekar V et al. | β | 2011 | β |
| The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear. | VelΓ‘zquez-Marrero C et al. | β | 2011 | β |
| Transcriptional and epigenetic mechanisms of addiction. | Robison AJ et al. | β | 2011 | β |
| Up-regulation of microRNAs in brain of human alcoholics. | Lewohl JM et al. | β | 2011 | β |
| Alcoholism and alternative splicing of candidate genes. | Sasabe T et al. | β | 2010 | β |
| BK channels play a counter-adaptive role in drug tolerance and dependence. | Ghezzi A et al. | β | 2010 | β |
| Cellular and mitochondrial effects of alcohol consumption. | Manzo-Avalos S et al. | β | 2010 | β |
| Context-dependent functions of specific microRNAs in neuronal development. | Gao FB | β | 2010 | β |
| Dominant-negative regulation of cell surface expression by a pentapeptide motif at the extreme COOH terminus of an Slo1 calcium-activated potassium channel splice variant. | Chiu YH et al. | β | 2010 | β |
| Expression of BK-type calcium-activated potassium channel splice variants during chick cochlear development. | Kim JM et al. | β | 2010 | β |
| H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. | Nelson EC et al. | β | 2010 | β |
| Highly specific alternative splicing of transcripts encoding BK channels in the chicken's cochlea is a minor determinant of the tonotopic gradient. | Miranda-Rottmann S et al. | β | 2010 | β |
| Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations. | Bell TJ et al. | β | 2010 | β |
| MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. | Delaloy C et al. | β | 2010 | β |
| MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide. | Kutty RK et al. | β | 2010 | β |
| MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field. | Dinan TG | β | 2010 | β |
| MicroRNAs: master regulators of ethanol abuse and toxicity? | Miranda RC et al. | β | 2010 | β |
| Neuroscience of alcoholism: molecular and cellular mechanisms. | Moonat S et al. | β | 2010 | β |
| New insights into the roles of microRNAs in drug addiction and neuroplasticity. | Dreyer JL | β | 2010 | β |
| Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. | Guidi M et al. | β | 2010 | β |
| Presynaptic targets for acute ethanol sensitivity. | Barclay JW et al. | β | 2010 | β |
| Striatal microRNA controls cocaine intake through CREB signalling. | Hollander JA et al. | β | 2010 | β |
| The role of microRNAs in drug addiction: a big lesson from tiny molecules. | Pietrzykowski AZ | β | 2010 | β |
| The role of the large-conductance voltage-dependent and calcium-activated potassium (BK(Ca)) channels in the regulation of rat ductus arteriosus tone. | Sun F et al. | β | 2010 | β |
| BK Channels: mediators and models for alcohol tolerance. | Treistman SN et al. | β | 2009 | β |
| Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system. | Wynne PM et al. | β | 2009 | β |
| Escalating ethanol intake is associated with altered corticostriatal BDNF expression. | Logrip ML et al. | β | 2009 | β |
| Fetal alcohol spectrum disorders: the epigenetic perspective. | Haycock PC | β | 2009 | β |
| Fine-tuning neural gene expression with microRNAs. | Schratt G | β | 2009 | β |
| In vitro and in vivo models of acute alcohol exposure. | Dolganiuc A et al. | β | 2009 | β |
| MicroRNA expression in head and neck cancer associates with alcohol consumption and survival. | Avissar M et al. | β | 2009 | β |
| MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. | Dolganiuc A et al. | β | 2009 | β |
| microRNAs at the synapse. | Schratt G | β | 2009 | β |
| MicroRNAs in brain development and physiology. | Coolen M et al. | β | 2009 | β |
| microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity. | Chandrasekar V et al. | β | 2009 | β |
| Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease. | St Laurent G et al. | β | 2009 | β |
| Regulating the regulators: mechanisms controlling the maturation of microRNAs. | Ding XC et al. | β | 2009 | β |
| Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. | Mulholland PJ et al. | β | 2009 | β |
| miXED messages in ion channel modulation. | Levitan IB | β | 2008 | β |
| The molecular basis of tolerance. | Pietrzykowski AZ et al. | β | 2008 | β |