Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.
paper
Cited
Public
- Authors
- Verplaetse, Terril L; Cosgrove, Kelly P; Tanabe, Jody; McKee, Sherry A
- Year
- 2021
- Journal
- Journal of neuroscience research
- PMID
- 32333417
- DOI
- 10.1002/jnr.24625
- PMCID
- PMC7584757
Over the last 10Β years, rates of alcohol use disorder (AUD) have increased in women by 84% relative to a 35% increase in men. Rates of alcohol use and high-risk drinking have also increased in women by 16% and 58% relative to a 7% and 16% increase in men, respectively, over the last decade. This robust increase in drinking among women highlights the critical need to identify the underlying neural mechanisms that may contribute to problematic alcohol consumption across sex/gender (SG), especially given that many neuroimaging studies are underpowered to detect main or interactive effects of SG on imaging outcomes. This narrative review aims to explore the recent neuroimaging literature on SG differences in brain function and structure as it pertains to alcohol across positron emission tomography, magnetic resonance imaging, and functional magnetic resonance imaging modalities in humans. Additional work using magnetic resonance spectroscopy, diffusion tensor imaging, and event-related potentials to examine SG differences in AUD will be covered. Overall, current researchΒ on the neuroimaging ofΒ AUD, alcohol consumption, or risk of AUD is limited, and findings are mixed regarding the effect of SG on neurochemical, structural, and functional mechanisms associated with AUD. We address SG disparities in the neuroimaging of AUD and propose a call to action to include women in brain imaging research. Future studies are crucial to our understanding of the neurobiological underpinnings of AUD across neural systems and the vulnerability for AUD among women and men.
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| Name | Type |
|---|---|
| [11C]carfentanil local | drug |
| [11C]LY2795050 local | drug |
| [11C]raclopride local | drug |
| 30-year longitudinal cohort local | cohort |
| ABCD study | cohort |
| abstinent men with AUD local | cohort |
| Abstinent men with AUD local | cohort |
| abstinent women with AUD local | cohort |
| Abstinent women with AUD local | cohort |
| ACC | anatomy |
| Acute alcohol administration local | drug |
| Acute Alcohol Ingestion local | phenotype |
| Acute alcohol use local | drug |
| acute withdrawal | phenotype |
| addiction | phenotype |
| adolescent alcohol use | phenotype |
| Adolescent AUD local | phenotype |
| adolescent binge drinkers (boys) local | cohort |
| adolescent binge drinkers (girls) local | cohort |
| Adolescent female drinkers local | phenotype |
| adolescent females with family history of AUD local | cohort |
| Adolescent male AUD local | phenotype |
| adolescent males with family history of AUD local | cohort |
| Adolescent-onset Alcohol Use Disorder local | phenotype |
| adolescent-onset AUD local | phenotype |
| adolescents | cohort |
| adult alcohol dependence | phenotype |
| adulthood | cohort |
| Adult men with AUD local | cohort |
| adults | cohort |
| Adult women with AUD local | cohort |
| affective processing local | phenotype |
| alcohol | phenotype |
| Alcohol abstinence | phenotype |
| alcohol cue reactivity local | phenotype |
| Alcohol-dependent men and women local | cohort |
| alcoholism | phenotype |
| alcohol-motivated behavior local | phenotype |
| alcohol picture cues local | drug |
| alcohol-related disinhibition local | phenotype |
| Alcohol-related Health Consequences local | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol withdrawal | phenotype |
| Alvanzo et al., 2017 local | cohort |
| amphetamine | drug |
| amygdala | anatomy |
| anterior cingulate cortex | anatomy |
| Anterior ventral Prefrontal Cortex local | anatomy |
| anxiety | phenotype |
| arcuate fasciculus local | anatomy |
| AUD | phenotype |
| AUDIT | phenotype |
| AUD men local | cohort |
| AUD-related pathology local | phenotype |
| AUD women local | cohort |
| behavioral deficits | phenotype |
| binge drinking | phenotype |
| brain morphometry | phenotype |
| brain volume | anatomy |
| brain white matter | anatomy |
| caudate nucleus | anatomy |
| cerebellar volume | anatomy |
| Cerebral ventricle local | anatomy |
| Chrnb2 | gene |
| chronic alcoholism | phenotype |
| chronic heavy alcohol use cohort local | cohort |
| cigarettes | phenotype |
| cingulate cortex | anatomy |
| cognition | phenotype |
| cognitive control | phenotype |
| corpus callosum | anatomy |
| cortex | anatomy |
| cortical thickness | phenotype |
| Cortical thickness decrease local | phenotype |
| Cortical thickness increase local | phenotype |
| cortico-limbic areas local | anatomy |
| cortico-limbic brain regions local | anatomy |
| cortico-limbic pathways local | anatomy |
| Corticostriatal-limbic circuits local | anatomy |
| craving | phenotype |
| D2/D3 receptor local | phenotype |
| default-mode network | anatomy |
| depression | phenotype |
| Detoxified individuals with alcohol dependence local | cohort |
| disinhibition | phenotype |
| dopamine | drug |
| dorsal ACC | anatomy |
| dorsolateral prefrontal cortex | anatomy |
| DRD2 | gene |
| DRD3 | gene |
| drinkers | phenotype |
| drinking | phenotype |
| Drinking in adolescence local | phenotype |
| Earlier initiation of drinking local | phenotype |
| early alcohol use | phenotype |
| e-cigarettes | drug |
| Error-related negativity amplitude | phenotype |
| estradiol | drug |
| euphoria | phenotype |
| excessive alcohol consumption | phenotype |
| Executive control regions local | anatomy |
| extreme capsule local | anatomy |
| family history negative | phenotype |
| Family history negative controls local | cohort |
| family history positive | phenotype |
| Family history positive for AUD local | phenotype |
| family structure | phenotype |
| Female AUD adolescents local | cohort |
| Female binge drinkers local | cohort |
| Female healthy controls local | cohort |
| Female heavy drinkers local | cohort |
| frequency of alcohol use | phenotype |
| Frontal activation local | phenotype |
| frontal cortex | anatomy |
| GABA | phenotype |
| Gorka 2019 study local | cohort |
| gray matter | anatomy |
| Gray matter atrophy local | phenotype |
| gray matter concentration local | phenotype |
| gray matter injury local | phenotype |
| Gray matter loss local | phenotype |
| gray matter volume loss local | phenotype |
| happy faces local | phenotype |
| Head injury | phenotype |
| Healthy adult men local | cohort |
| Healthy adult women local | cohort |
| healthy controls | cohort |
| healthy controls cohort local | cohort |
| healthy control women | cohort |
| healthy men | cohort |
| healthy men cohort local | cohort |
| Healthy social drinkers local | cohort |
| Healthy women local | cohort |
| healthy women cohort local | cohort |
| heavy drinking | phenotype |
| Heavy drinking men local | cohort |
| Heavy drinking women local | cohort |
| Hippocampal shrinkage local | phenotype |
| hippocampus | anatomy |
| human alcoholics | phenotype |
| Human Connectome Project | cohort |
| inferior frontal gyrus | anatomy |
| inhibitory control | phenotype |
| inhibitory processing | phenotype |
| Inhibitory processing deficits local | phenotype |
| insula | anatomy |
| kappa opioid receptor | drug |
| KOR | drug |
| KOR availability local | phenotype |
| left medial orbitofrontal cortex | anatomy |
| left paracentral lobule local | anatomy |
| Left Paracentral Lobule local | anatomy |
| Lifetime alcohol consumption local | phenotype |
| lifetime alcohol use | phenotype |
| limbic processing local | anatomy |
| Long-term alcohol abstinent men with AUD local | cohort |
| Low alcohol use local | phenotype |
| Male alcoholics | phenotype |
| Male AUD adolescents local | cohort |
| male binge drinkers local | cohort |
| Male binge drinkers local | cohort |
| Male healthy controls local | cohort |
| male light drinkers local | cohort |
| marijuana | phenotype |
| Maximum Habitual Alcohol Intake | phenotype |
| medial forebrain bundle | anatomy |
| medial prefrontal cortex | anatomy |
| men | cohort |
| men with Alcohol Use Disorder local | cohort |
| middle frontal gyrus | anatomy |
| Moderate to chronic alcohol use local | phenotype |
| moderate-to-heavy drinking local | phenotype |
| Moderate to high alcohol use local | phenotype |
| mood disorders | phenotype |
| MOR | drug |
| mu opioid receptor | drug |
| NAcc | anatomy |
| N-acetylaspartate | drug |
| naltrexone | drug |
| National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) local | cohort |
| NCS-AS local | cohort |
| negative mood | phenotype |
| negative reinforcement | phenotype |
| Neural substrates local | anatomy |
| neuronal loss | phenotype |
| neuropsychological decline local | phenotype |
| nicotine | drug |
| NIH | cohort |
| non-alcoholic men local | cohort |
| non-alcoholic women local | cohort |
| Non-dependent drinkers local | cohort |
| non-dependent social-drinking women local | cohort |
| nucleus accumbens | anatomy |
| octogenarian men local | cohort |
| Older men local | cohort |
| opioid receptor availability local | phenotype |
| orbitofrontal cortex | anatomy |
| Orbitofrontal gyrus local | anatomy |
| P3 amplitude reactivity to alcohol cues local | phenotype |
| P3 increase local | phenotype |
| Padula 2015 study local | cohort |
| pallidum | anatomy |
| parental income | phenotype |
| Past Year Drinking local | phenotype |
| Performance monitoring deficits local | phenotype |
| PFC | anatomy |
| PFC volume increase local | phenotype |
| PFC volume reduction local | phenotype |
| physiologic deficits local | phenotype |
| Physiologic deficits local | phenotype |
| positive alcohol expectancies | phenotype |
| positive reinforcement | phenotype |
| positive subjective effects of alcohol local | phenotype |
| posterior cingulate cortex | anatomy |
| precentral gyrus | anatomy |
| prefrontal cortex | anatomy |
| Premenopausal women local | cohort |
| problematic alcohol use | phenotype |
| progesterone | drug |
| psychiatric disorders | phenotype |
| psychopathology | phenotype |
| Psychosocial factors | phenotype |
| putamen | anatomy |
| Recent alcohol consumption | phenotype |
| recently detoxified alcohol-dependent women cohort local | cohort |
| Recently detoxified AUD individuals local | cohort |
| recently detoxified men cohort local | cohort |
| Reduced cortical thickness local | phenotype |
| Reduced gray matter volume local | phenotype |
| Reduced white matter volume local | phenotype |
| relapse | phenotype |
| reward region local | anatomy |
| reward system | anatomy |
| right lingual gyrus | anatomy |
| right medial frontal gyrus | anatomy |
| right middle frontal gyrus | anatomy |
| Right postcentral gyrus local | anatomy |
| right posterior insula local | anatomy |
| right precentral gyrus | anatomy |
| Rivas-Grajales et al., 2018 local | cohort |
| salience network | anatomy |
| same-sex controls local | cohort |
| Same-sex controls local | cohort |
| Same-sex healthy controls local | cohort |
| Sawyer 2019 study local | cohort |
| Sedative drug use local | phenotype |
| serotonin | drug |
| sex | phenotype |
| sex differences | phenotype |
| sex hormones | drug |
| sex steroid hormones local | drug |
| sleep | phenotype |
| smoking status | phenotype |
| Social aspects local | phenotype |
| Social drinkers | phenotype |
| social drinking local | phenotype |
| Social drinking men local | phenotype |
| Social-drinking men local | cohort |
| spatial working memory | phenotype |
| Squeglia 2011 cohort local | cohort |
| Squeglia 2012 cohort local | cohort |
| stop-signal reaction time | phenotype |
| stress | phenotype |
| Stress pathophysiology local | phenotype |
| Stress-related drinking behavior local | phenotype |
| Stress-related neurocircuitry local | phenotype |
| striatal DA release local | phenotype |
| striatum | anatomy |
| Subclinical drinkers local | cohort |
| substance use | phenotype |
| superior frontal cortex | anatomy |
| superior longitudinal fasciculus | anatomy |
| supramarginal gyrus | anatomy |
| temporal | anatomy |
| Temporal white matter local | anatomy |
| testosterone | drug |
| thalamus | anatomy |
| tobacco use | phenotype |
| total brain volume | anatomy |
| Total ventricular volume local | anatomy |
| ventral striatal D2/D3 receptor availability local | phenotype |
| ventral striatum | anatomy |
| ventromedial prefrontal cortex | anatomy |
| VTA | anatomy |
| white matter | anatomy |
| White matter alterations local | phenotype |
| women | cohort |
| Women drinkers local | cohort |
| women with Alcohol Use Disorder local | cohort |
| Women with AUD local | cohort |
| Worse cognitive performance local | phenotype |
| young adults | cohort |
| young adult social drinkers local | cohort |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| COVID-19 pandemic stressors are associated with reported increases in frequency of drunkenness among individuals with a history of alcohol use disorder. | 2023 | 37803048 |
External
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| Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning Among Young Adults: Protocol for a 21-Day Diary Study. | Linden-Carmichael AN et al. | β | 2025 | β |
| A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective. | Kirsch DE et al. | β | 2025 | β |
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