Edenberg, Howard J

Also known as: Edenberg, H, Edenberg, Howard, Edenberg, H J

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

Research Summary

Howard J. Edenberg’s research centers on the genetics and neurobiology of substance‑use disorders, especially alcohol use disorder (AUD), using large‑scale GWAS, polygenic‑score analyses, and functional genomics. He has contributed dozens of genome‑wide risk loci for AUD, nicotine dependence, and obsessive‑compulsive disorder, demonstrated how AUD‑associated variants drive cell‑type‑specific transcriptional and chromatin changes in the human caudate (including dysregulated medium‑spiny neurons, microglia, and astrocytes), and linked polygenic risk to clinical outcomes such as suicide attempts, remission trajectories, developmental patterns of drinking, and gene‑environment interplay (e.g., genetic nurture, social support). His work also bridges genetics to mechanistic studies in human iPSC‑derived neurons and microglia, revealing how variants in genes like KCNJ6 (GIRK2) modulate neuronal excitability and ethanol responses.

Title	Year	PMID
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	2016	26392368
Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.	2016	26809998
Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats.	2016	27061086
Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures.	2016	27003187
Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.	2016	27588522
Statistical modeling for sensitive detection of low-frequency single nucleotide variants.	2016	27556804
Translating genome-wide association findings into new therapeutics for psychiatry.	2016	27786187
Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.	2015	26087834
Are genetic variants for tobacco smoking associated with cannabis involvement?	2015	25770649
Association of substance dependence phenotypes in the COGA sample.	2015	24832863
Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers.	2015	24164917
Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.	2015	25978827
Gender modulates the development of theta event related oscillations in adolescents and young adults.	2015	26102560
Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.	2015	25542586
Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample.	2015	25486392
Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior.	2015	25918995
Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.	2015	25516156
Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.	2015	25821660
Positive Selection on Loci Associated with Drug and Alcohol Dependence.	2015	26270548
An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction.	2014	25257461

Resolved affiliation

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

May be outdated — new papers have been added.

Raw imported affiliations (112)

Affiliation
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. edenberg@iu.edu.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana.
Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN.
Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA.
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Molecular Biology, Indiana University, Indianapolis, IN, United States of America.
Department of Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Psychiatry and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Department of Psychology, University of Texas at Austin (Mallard, Grotzinger, Harden); Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam (Savage); Department of Psychiatry, Washington University School of Medicine, Saint Louis (Johnson, Anokhin, Agrawal); Department of Psychiatry (Huang, Jennings, Palmer, Sanchez-Roige) and Institute for Genomic Medicine (Palmer), University of California San Diego, La Jolla; Virginia Institute for Psychiatric and Behavioral Genetics, Richmond (Edwards); Department of Biological Psychiatry, Vrije Universiteit Amsterdam (Hottenga, Nivard, de Geus, Boomsma); Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tenn. (Gustavson, Davis, Sanchez-Roige); Department of Psychology, Virginia Commonwealth University, Richmond (Dick); Department of Biochemistry and Molecular Biology (Edenberg) and Department of Medical and Molecular Genetics (Lai), Indiana University School of Medicine, Indianapolis; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City (Kramer); Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, N.Y. (Meyers, Pandey); Department of Psychiatry and Behavioral Sciences and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tenn. (Davis); Division of Psychiatry, University of Edinburgh, Edinburgh, U.K. (Clarke).
Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: edenberg@iu.edu.