Inhibiting NF-κB activation by small molecules as a therapeutic strategy.

paper Cited Public

Authors: Gupta, Subash C; Sundaram, Chitra; Reuter, Simone; Aggarwal, Bharat B
Year: 2010
Journal: Biochimica et biophysica acta
PMID: 20493977
DOI: 10.1016/j.bbagrm.2010.05.004
PMCID: PMC2955987

#	Section	Preview
0	1. Introduction	The nuclear factor-κB (NF-κB) signaling pathway plays a major role in the development,…
1	1. Introduction	NF-κB activation is tightly regulated mainly through its localization. In resting cells, NF-κB…
2	1. Introduction	proteasomal mediated degradation. This process releases and activates NF-κB which now translocates…
3	1. Introduction	Once in the nucleus, activated NF-κB undergoes a series of posttranslational modifications,…
4	1. Introduction	Activated NF-κB binds to specific DNA sequences in target genes, which are designated as κB…
5	1. Introduction	Due to the various levels of regulation, NF-κB signaling pathway can be potentially targeted at…
6	2. Inhibitors of the NF-κB activation pathway	Given NF-κB’s relevance in human diseases and the fact that many drugs interfere with NF-κB…
7	2. Inhibitors of the NF-κB activation pathway — 2.1. Inhibition of protein kinases	NF-κB activation requires the phosphorylation, polyubiquitination, and subsequent degradation of…
8	2. Inhibitors of the NF-κB activation pathway — 2.1. Inhibition of protein kinases	for interacting with IKK; compounds that have allosteric effects on IKK structure; and compounds…
9	2. Inhibitors of the NF-κB activation pathway — 2.1. Inhibition of protein kinases	activation. Specifically, mutations at the ATP-binding site or in the kinase activation loop can…
10	2. Inhibitors of the NF-κB activation pathway — 2.1. Inhibition of protein kinases	While activation of NF-κB by many stimuli depends on the phosphorylation of IκBs at N-terminal…
11	2. Inhibitors of the NF-κB activation pathway — 2.1. Inhibition of protein kinases	Besides phosphorylating and subsequently degrading the molecules that inhibit NF-κB, protein…
12	2. Inhibitors of the NF-κB activation pathway — 2.2. Inhibition of NF-κB activation by protein phosphatases	Because protein phosphorylation is a dynamic process whereby phosphatases counterbalance kinase…
13	2. Inhibitors of the NF-κB activation pathway — 2.2. Inhibition of NF-κB activation by protein phosphatases	While some PTPs stimulate NF-κB activation, other PTPs negatively regulate NF-κB activation. For…
14	2. Inhibitors of the NF-κB activation pathway — 2.3. Proteasome inhibitors and IκB ubiquitination blockers	The step before NF-κB leaves the cytoplasm involves the ubiquitination of IκB by the SCF-β-TrCP…
15	2. Inhibitors of the NF-κB activation pathway — 2.3. Proteasome inhibitors and IκB ubiquitination blockers	Several serine protease inhibitors with chymotrypsin-like specificity, including DCIC, TPCK, TLCK,…
16	2. Inhibitors of the NF-κB activation pathway — 2.3. Proteasome inhibitors and IκB ubiquitination blockers	Among IκB ubiquitination blockers, the YopJ protein of the bacterial pathogen Yersinia…
17	2. Inhibitors of the NF-κB activation pathway — 2.4. Blockage of NF-κB nuclear translocation	One approach for inhibiting NF-κB activation is to use small peptides that cross the cell membrane…
18	2. Inhibitors of the NF-κB activation pathway — 2.5. Blocking NF-κB activation by inhibitors of p65 acetylation	The activated p65 subunit of NF-κB undergoes acetylation in the nucleus at multiple lysine residues…
19	2. Inhibitors of the NF-κB activation pathway — 2.5. Blocking NF-κB activation by inhibitors of p65 acetylation	During the last 5 years, a number of compounds have been reported to inhibit NF-κB by inhibiting…

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Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway.	Zhang W et al.	—	2024	→
GSK3β/NF-κB -dependent transcriptional regulation of homeostatic hepatocyte <i>Tnf</i> production.	Grayck MR et al.	—	2024	→
Microbiota and Resveratrol: How Are They Linked to Osteoporosis?	Meyer C et al.	—	2024	→
Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity.	Sahu D et al.	—	2024	→
Okadaic acid enhances NfKB, TLR-4, caspase 3, ERK ½, c-FOS, and 8-OHdG signaling pathways activation in brain tissues of zebrafish larvae.	Topal A et al.	—	2024	→
Potential of oligonucleotide- and protein/peptide-based therapeutics in the management of toxicant/stressor-induced diseases.	Sadeghian I et al.	—	2024	→
Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia.	Glaser K et al.	—	2024	→
Pro-Inflammatory Activation Suppresses TRAIL-induced Apoptosis of Acute Myeloid Leukemia Cells.	Kobyakova MI et al.	—	2024	→
Relationship between the cGAS-STING and NF-κB pathways-role in neurotoxicity.	Zhong S et al.	—	2024	→
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid-B cell interactions.	Hao X et al.	—	2024	→
The Impact of Obesity-Related Genetic Variants on NF-κB Signaling in Cardiovascular Disease: A Systematic Review	Shafi V et al.	—	2024	—
The Role of the Nuclear Factor-Kappa B (NF-κB) Pathway in SARS-CoV-2 Infection.	Kesika P et al.	—	2024	→
The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke.	Lu W et al.	—	2024	→
Unveiling the Unexplored Multifactorial Potential of 5-Aminosalicylic Acid in Diabetic Wound Therapy.	Sanapalli BKR et al.	—	2024	→
Advanced phosphocreatine-grafted chitosan hydrogel promote wound healing by macrophage modulation.	Sheng W et al.	—	2023	→
Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential.	Subramaniyan V et al.	—	2023	→
Antiinflammatory effect of the ethanolic extract of Korean native herb <i>Potentilla rugulosa</i> Nakai in Bisphenol-a-stimulated A549 cells.	Choi YG et al.	—	2023	→
Comparative analyses of transcriptome sequencing and carcinogenic exposure toxicity of nicotine and 6-methyl nicotine in human bronchial epithelial cells.	Qi H et al.	—	2023	→
Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases.	Akinsulie OC et al.	—	2023	→
Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice.	Kim HH et al.	—	2023	→
Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells.	Wang W et al.	—	2023	→
Genomic characterization of thymic epithelial tumors reveals critical genes underlying tumorigenesis and poor prognosis.	Tan S et al.	—	2023	→
<i>Lavandula x intermedia</i>-A Bastard Lavender or a Plant of Many Values? Part II. Biological Activities and Applications of Lavandin.	Pokajewicz K et al.	—	2023	→
Low-level Cu-fortification of bovine lactoferrin: Focus on its effect on in vitro anti-inflammatory activity in LPS-stimulated macrophages.	Zhang Q et al.	—	2023	→
New Ideas for the Prevention and Treatment of Preeclampsia and Their Molecular Inspirations.	Sakowicz A et al.	—	2023	→
NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances.	Wu X et al.	—	2023	→
Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells.	Teichmann E et al.	—	2023	→
Oxidation of Quercetin and Kaempferol Markedly Amplifies Their Antioxidant, Cytoprotective, and Anti-Inflammatory Properties.	Speisky H et al.	—	2023	→
Rapamycin suppresses inflammation and increases the interaction between p65 and IκBα in rapamycin-induced fatty livers.	Ge C et al.	—	2023	→
Research progress of NF-κB signaling pathway and thrombosis.	Wang Z et al.	—	2023	→
Role of the Dietary Phytochemical Curcumin in Targeting Cancer Cell Signalling Pathways.	Mishra AP et al.	—	2023	→
Synthesis and evaluation of the effects of solid lipid nanoparticles of ivermectin and ivermectin on cuprizone-induced demyelination via targeting the TRPA1/NF-kB/GFAP signaling pathway.	Noori T et al.	—	2023	→
Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals.	Gado F et al.	—	2023	→
Tofacitinib combined with melanocyte protector α-MSH to treat vitiligo through dextran based hydrogel microneedles.	Liang J et al.	—	2023	→
Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells.	Pflug KM et al.	—	2023	→
Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.	Smith EJ et al.	—	2023	→
What Nutraceuticals Can Do for Duchenne Muscular Dystrophy: Lessons Learned from Amino Acid Supplementation in Mouse Models.	De Paepe B	—	2023	→
Advances in Immunosuppressive Agents Based on Signal Pathway.	Xu Z et al.	—	2022	→
An AAV-Based NF-κB-Targeting Gene Therapy (rAAV-DMP-miR533) to Inflammatory Diseases.	Luo T et al.	—	2022	→
Anti-Inflammatory, Antioxidative, and Nitric Oxide-Scavenging Activities of a Quercetin Nanosuspension with Polyethylene Glycol in LPS-Induced RAW 264.7 Macrophages.	Kang SG et al.	—	2022	→
Anti-inflammatory dihydroxanthones from a <i>Diaporthe</i> species.	Rohr M et al.	—	2022	→
Anti-Inflammatory Extract from Soil Algae <i>Chromochloris zofingiensis</i> Targeting TNFR/NF-κB Signaling at Different Levels.	Leitner PD et al.	—	2022	→
Cell-penetrating peptide-mediated delivery of therapeutic peptides/proteins to manage the diseases involving oxidative stress, inflammatory response and apoptosis.	Sadeghian I et al.	—	2022	→
Changes in Alcohol Consumption following Direct-Acting Antiviral Treatment for Hepatitis C in VA Patients with Comorbid Alcohol Use Disorder and PTSD.	Hoyt JE et al.	—	2022	→
Cisplatin Chemotherapy and Cochlear Damage: Otoprotective and Chemosensitization Properties of Polyphenols.	Fetoni AR et al.	—	2022	→
Computational model of brain endothelial cell signaling pathways predicts therapeutic targets for cerebral pathologies.	Gorick CM et al.	—	2022	→
Dietary Carotenoids in Head and Neck Cancer-Molecular and Clinical Implications.	Starska-Kowarska K	—	2022	→
Effects of Compounds Isolated from <i>Lindera erythrocarpa</i> on Anti-Inflammatory and Anti-Neuroinflammatory Action in BV2 Microglia and RAW264.7 Macrophage.	Yoon CS et al.	—	2022	→
Eriodictyol Suppresses <i>Porphyromonas gingivalis</i>-Induced Reactive Oxygen Species Production by Gingival Keratinocytes and the Inflammatory Response of Macrophages.	Maquera-Huacho PM et al.	—	2022	→
Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors.	Mediouni S et al.	—	2022	→
Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds.	Seong HS et al.	—	2022	→
Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone.	Tuli HS et al.	—	2022	→
NF-κB Signaling and Inflammation-Drug Repurposing to Treat Inflammatory Disorders?	Roberti A et al.	—	2022	→
On the Immunometabolic Role of NF-κB in Adipocytes.	Griffin MJ	—	2022	→
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021).	He M et al.	—	2022	→
Quercetin ameliorates Di (2-ethylhexyl) phthalate-induced nephrotoxicity by inhibiting NF-κB signaling pathway.	Ashari S et al.	—	2022	→
Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats.	Raish M et al.	—	2022	→
Targeting a transcription factor NF-κB by green tea catechins using <i>in silico</i> and <i>in vitro</i> studies in pancreatic cancer.	Suhail M et al.	—	2022	→
The ethanolic extract of Curcuma longa grown in Korea exhibits anti-neuroinflammatory effects by activating of nuclear transcription factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.	Kim KW et al.	—	2022	→
The Inhibitory Effects of Vanillin on the Growth of Melanoma by Reducing Nuclear Factor-κB Activation.	Pourhadi M et al.	—	2022	→
The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke.	Li R et al.	—	2022	→
The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis.	Jahan S et al.	—	2022	→
A cocoa (Theobroma cacao L.) extract impairs the growth, virulence properties, and inflammatory potential of Fusobacterium nucleatum and improves oral epithelial barrier function.	Ben Lagha A et al.	—	2021	→
A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells.	Jiang K et al.	—	2021	→
A polyphenolic cinnamon fraction exhibits anti-inflammatory properties in a monocyte/macrophage model.	Ben Lagha A et al.	—	2021	→
Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response.	Friess L et al.	—	2021	→
Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds.	Cykowiak M et al.	—	2021	→
Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues.	Wu W et al.	—	2021	→
C7ORF41 Regulates Inflammation by Inhibiting NF-<i>κ</i>B Signaling Pathway.	Zhou J et al.	—	2021	→
Camel Urine Promotes Sensitization to Doxorubicin by Inhibiting Epithelial-Mesenchymal Transition and Modulating NF-κB-Snail Signaling Pathway in Breast Cancer Cells.	Al-Mutairi MS et al.	—	2021	→
CARMA3 Promotes Colorectal Cancer Cell Motility and Cancer Stemness via YAP-Mediated NF-κB Activation.	Chang TY et al.	—	2021	→
Celecoxib repurposing in cancer therapy: molecular mechanisms and nanomedicine-based delivery technologies.	Khafaga AF et al.	—	2021	→
Cell signaling pathways as molecular targets to eliminate AML stem cells.	Rodrigues ACBDC et al.	—	2021	→
Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway.	Sim S et al.	—	2021	→
Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell.	Tien PT et al.	—	2021	→
Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth.	Kanzaki H et al.	—	2021	→
Diversity of NF-κB signalling and inflammatory heterogeneity in Rheumatic Autoimmune Disease.	Manou-Stathopoulou S et al.	—	2021	→
Effect of Diallyl Trisulfide on TNF-α-induced CCL2/MCP-1 Release in Genetically Different Triple-negative Breast Cancer Cells.	Kanga KJW et al.	—	2021	→
Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line.	Sousa C et al.	—	2021	→
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells.	Silva VR et al.	—	2021	→
Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury.	Kim S et al.	—	2021	→
Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock.	Molagoda IMN et al.	—	2021	→
Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties.	Ahmad MF et al.	—	2021	→
Ginger and turmeric lipid-solubles attenuate heated oil-induced hepatic inflammation via the downregulation of NF-kB in rats.	Zarei M et al.	—	2021	→
Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury.	Huang ZW et al.	—	2021	→
Identification of IκBα in Japanese eel Anguilla japonica that impairs the IKKα-dependent activation of NF-κB, AP1, and type I IFN signaling pathways.	Feng J et al.	—	2021	→
Immunomodulatory effect of pentagalloyl glucose in LPS-stimulated RAW264.7 macrophages and PAO1-induced Caenorhabditis elegans.	Zhang X et al.	—	2021	→
<i>Toxoplasma gondii</i>: A possible etiologic agent for Alzheimer's disease.	Nayeri T et al.	—	2021	→
Medroxyprogesterone acetate attenuates demyelination, modulating microglia activation, in a cuprizone neurotoxic demyelinating mouse model.	Mohammadi M et al.	—	2021	→
Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics.	Franz A et al.	—	2021	→
NF-κB and Pancreatic Cancer; Chapter and Verse.	Silke J et al.	—	2021	→
NF-κB, iNOS, IL-6, and collagen 1 and 5 expression in healthy and keratoconus corneal fibroblasts after 0.1% riboflavin UV-A illumination.	Berger T et al.	—	2021	→
Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-<i>κ</i>B/BCL-2 Signaling Pathway In Vitro and In Vivo.	Cai BQ et al.	—	2021	→
Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway.	Liu M et al.	—	2021	→
Stable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs.	Zhang S et al.	—	2021	→
Strategies for Targeting the NLRP3 Inflammasome in the Clinical and Preclinical Space.	Schwaid AG et al.	—	2021	→
Sustained Inhibition of NF-κB Activity Mitigates Retinal Vasculopathy in Diabetes.	Homme RP et al.	—	2021	→
TF-PROTACs Enable Targeted Degradation of Transcription Factors.	Liu J et al.	—	2021	→
The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next.	Song Y et al.	—	2021	→
The human amniotic fluid stem cell secretome triggers intracellular Ca<sup>2+</sup> oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells.	Balducci V et al.	—	2021	→
Therapeutic potential of alkaloids in autoimmune diseases: Promising candidates for clinical trials.	Khan H et al.	—	2021	→
The Role of Curcumin in Cancer Treatment.	Zoi V et al.	—	2021	→
The Toxic Mechanism of Gliotoxins and Biosynthetic Strategies for Toxicity Prevention.	Ye W et al.	—	2021	→
The Transcription Factor NF-κB Mediates Thyrotropin-Stimulated Expression of Thyroid Differentiation Markers.	Geysels RC et al.	—	2021	→
TLR4 and TNFR1 blockade dampen M1 macrophage activation and shifts them towards an M2 phenotype.	Sawoo R et al.	—	2021	→
Transcription factor NF-κB as target for SARS-CoV-2 drug discovery efforts using inflammation-based QSAR screening model.	Kanan T et al.	—	2021	→
3,4-<i>seco</i>-Dammarane Triterpenoid Saponins with Anti-Inflammatory Activity Isolated from the Leaves of <i>Cyclocarya paliurus</i>.	Liu W et al.	—	2020	→
Acetylharpagide Protects Mice from <i>Staphylococcus Aureus</i>-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.	Zhang Z et al.	—	2020	→
Antibacterial and anti-inflammatory activities of cardamom (Elettaria cardamomum) extracts: Potential therapeutic benefits for periodontal infections.	Souissi M et al.	—	2020	→
Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes.	Ziadlou R et al.	—	2020	→
Anti-Müllerian Hormone Type II Receptor Expression in Endometrial Cancer Tissue.	Gowkielewicz M et al.	—	2020	→
Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function.	Li YJ et al.	—	2020	→
Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway.	Kim DG et al.	—	2020	→
BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.	Huang HC et al.	—	2020	→
Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes.	Grenier D et al.	—	2020	→
Cancer gene therapy by NF-κB-activated cancer cell-specific expression of CRISPR/Cas9 targeting telomeres.	Dai W et al.	—	2020	→
Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker.	Chen YP et al.	—	2020	→
Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases.	Sehnert B et al.	—	2020	→
Cellular calcium and redox regulation: the mediator of vertebrate environmental sex determination?	Castelli MA et al.	—	2020	→
Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence.	Di Sotto A et al.	—	2020	→
Effects of 1,25-dihydroxyvitamin D3 on the Inflammatory Responses of Stromal Vascular Cells and Adipocytes from Lean and Obese Mice.	Park CY et al.	—	2020	→
Effects of dietary Antrodia cinnamomea fermented product supplementation on metabolism pathways of antioxidant, inflammatory, and lipid metabolism pathways-a potential crosstalk.	Lee MT et al.	—	2020	→
Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2.	Constanze B et al.	—	2020	→
Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality.	Choi H et al.	—	2020	→
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.	Dong X et al.	—	2020	→
Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells.	Somu C et al.	—	2020	→
Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade.	Weiss U et al.	—	2020	→
Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells.	Seledtsov VI et al.	—	2020	→
Interaction of an IκBα Peptide with 14-3-3.	Wolter M et al.	—	2020	→
In vitro benchmarking of NF-κB inhibitors.	Harrold AP et al.	—	2020	→
Involvement of the NF-κB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells.	Kim JH et al.	—	2020	→
Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases.	Sansone C et al.	—	2020	→
miRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia.	Phạm TL et al.	—	2020	→
Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi.	Ganbold T et al.	—	2020	→
NF-κB inhibitor with Temozolomide results in significant apoptosis in glioblastoma via the NF-κB(p65) and actin cytoskeleton regulatory pathways.	Avci NG et al.	—	2020	→
Nuclear Factor Kappa B in Autism Spectrum Disorder: A Systematic Review.	Liao X et al.	—	2020	→
Oxidative Stress and Cancer Development: Are Noncoding RNAs the Missing Links?	D'Souza LC et al.	—	2020	→
Pharmacological significance of the non-canonical NF-κB pathway in tumorigenesis.	Morgan D et al.	—	2020	→
Phlorotannins from <i>Fucus vesiculosus</i>: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway.	Catarino MD et al.	—	2020	→
PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells.	Dietel E et al.	—	2020	→
Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation.	Xie H et al.	—	2020	→
Small Molecule NF-κB Pathway Inhibitors in Clinic.	Ramadass V et al.	—	2020	→
Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity.	Stunnenberg M et al.	—	2020	→
Synthetic and medicinal chemistry of phthalazines: Recent developments, opportunities and challenges.	Zaib S et al.	—	2020	→
The Protective Effect of rhBNP on Postresuscitation Myocardial Dysfunction in a Rat Cardiac Arrest Model.	Yang M et al.	—	2020	→
Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases.	Zhou P et al.	—	2020	→
Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents.	Elkamhawy A et al.	—	2020	→
TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury.	Xu S et al.	—	2020	→
Transcription Factor Inhibition: Lessons Learned and Emerging Targets.	Chen A et al.	—	2020	→
Trichostatin A augments esophageal squamous cell carcinoma cells migration by inducing acetylation of RelA at K310 leading epithelia-mesenchymal transition.	Huang K et al.	—	2020	→
Unraveling the Role of Astrocytes in Subthalamic Nucleus Deep Brain Stimulation in a Parkinson's Disease Rat Model.	Campos ACP et al.	—	2020	→
Valorization of pomelo (Citrus grandis Osbeck) peel: A review of current utilization, phytochemistry, bioactivities, and mechanisms of action.	Tocmo R et al.	—	2020	→
Yerba Mate Extract in Microfibrillated Cellulose and Corn Starch Films as a Potential Wound Healing Bandage.	Aliabadi M et al.	—	2020	→
A Cell-Specific Nuclear Factor-Kappa B-Activating Gene Expression Strategy for Delivering Cancer Immunotherapy.	Wang D et al.	—	2019	→
Anti-Cancer Effects of Synergistic Drug-Bacterium Combinations on Induced Breast Cancer in BALB/c Mice.	Subramaniam M et al.	—	2019	→
Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway.	Zhao D et al.	—	2019	→
A tough and novel dual-response PAA/P(NiPAAM-co-PEGDMA) IPN hydrogels with ceramics by photopolymerization for consolidation of bone fragments following fracture.	de Lima GG et al.	—	2019	→
Azithromycin Polarizes Macrophages to an M2 Phenotype via Inhibition of the STAT1 and NF-κB Signaling Pathways.	Haydar D et al.	—	2019	→
Biologically Active <i>Ajuga</i> Species Extracts Modulate Supportive Processes for Cancer Cell Development.	Rauca VF et al.	—	2019	→
Building the drug-GO function network to screen significant candidate drugs for myasthenia gravis.	Li S et al.	—	2019	→
Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer's Disease.	Frederiksen HR et al.	—	2019	→
Collateral Sensitivity of Parthenolide via NF-κB and HIF-α Inhibition and Epigenetic Changes in Drug-Resistant Cancer Cell Lines.	Dawood M et al.	—	2019	→
Controlling Nuclear NF-κB Dynamics by β-TrCP-Insights from a Computational Model.	Benary U et al.	—	2019	→
Crosstalk between Fas and S1P<sub>1</sub> signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis.	Hutami IR et al.	—	2019	→
Curcumin as an Alternative Epigenetic Modulator: Mechanism of Action and Potential Effects.	Hassan FU et al.	—	2019	→
Danggui buxue tang inhibited mesangial cell proliferation and extracellular matrix accumulation through GAS5/NF-κB pathway.	Zhang R et al.	—	2019	→
Dl-3-<i>n</i>-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation.	Chen Y et al.	—	2019	→
Down-regulated expression of microRNA-338-5p contributes to neuropathology in Alzheimer's disease.	Qian Q et al.	—	2019	→
Edaravone attenuates traumatic brain injury through anti-inflammatory and anti-oxidative modulation.	Zhang M et al.	—	2019	→
EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.	Elkamhawy A et al.	—	2019	→
Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock.	Tunctan B et al.	—	2019	→
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer.	He RZ et al.	—	2019	→
Evodiamine inactivates NF-κB and potentiates the antitumor effects of gemcitabine on tongue cancer both in vitro and in vivo.	Guo Q et al.	—	2019	→
GABA<sub>B</sub> receptor activation attenuates inflammatory orofacial pain by modulating interleukin-1β in satellite glial cells: Role of NF-κB and MAPK signaling pathways.	Liu F et al.	—	2019	→
Gedunin Inhibits Oligomeric Aβ<sub>1-42</sub>-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling.	Tom S et al.	—	2019	→
Gentiopicroside (GENT) protects against sepsis induced by lipopolysaccharide (LPS) through the NF-κB signaling pathway.	Wang Q et al.	—	2019	→
Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF.	Nelson RK et al.	—	2019	→
INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response.	Drexel M et al.	—	2019	→
Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1.	Zhu H et al.	—	2019	→
Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma.	Ambrosini G et al.	—	2019	→
Intracerebral Hemorrhage Induces Inflammatory Gene Expression in Peripheral Blood: Global Transcriptional Profiling in Intracerebral Hemorrhage Patients.	Walsh KB et al.	—	2019	→
Ku80 gene knockdown by the CRISPR/Cas9 technique affects the biological functions of human thyroid carcinoma cells.	Fan Y et al.	—	2019	→
Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways.	Ai J et al.	—	2019	→
METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-<i>κ</i>B Signaling Pathway.	Wang J et al.	—	2019	→
Modulation of LPS-induced nitric oxide production in intestinal cells by hydroxytyrosol and tyrosol metabolites: Insight into the mechanism of action.	Serreli G et al.	—	2019	→
Multifactorial Regulation of Myometrial Contractility During Pregnancy and Parturition.	Mendelson CR et al.	—	2019	→
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.	Wang J et al.	—	2019	→
Neuroendocrine regulation of cholangiocarcinoma: A status quo review.	Sha M et al.	—	2019	→
Neuroprotective effects of glucomoringin-isothiocyanate against H<sub>2</sub>O<sub>2</sub>-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells.	Jaafaru MS et al.	—	2019	→
NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases.	Fiordelisi A et al.	—	2019	→
NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases.	Kanigur Sultuybek G et al.	—	2019	→
Novel Insights on the Toxicity of Phycotoxins on the Gut through the Targeting of Enteric Glial Cells.	Reale O et al.	—	2019	→
Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation.	Elkamhawy A et al.	—	2019	→
Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids.	Leláková V et al.	—	2019	→
Potential crosstalk of oxidative stress and immune response in poultry through phytochemicals - A review.	Lee MT et al.	—	2019	→
Replication of Crohn's Disease Mucosal <i>E. coli</i> Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation.	Tawfik A et al.	—	2019	→
Role of inflammatory signaling in atrial fibrillation.	Scott L et al.	—	2019	→
Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases.	Yeo IJ et al.	—	2019	→
RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis.	Oh SK et al.	—	2019	→
Shepherd's Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-<i>κ</i>B Pathways and Heme Oxygenase-1 Activation.	Peng J et al.	—	2019	→
Single Cell Based Phosphorylation Profiling Identifies Alterations in Toll-Like Receptor 7 and 9 Signaling in Patients With Primary Sjögren's Syndrome.	Davies R et al.	—	2019	→
Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities.	Wang W et al.	—	2019	→
Targeting the NF-κB/IκBα complex via fragment-based E-Pharmacophore virtual screening and binary QSAR models.	Kanan T et al.	—	2019	→
Tea polyphenols protect gingival keratinocytes against TNF-α-induced tight junction barrier dysfunction and attenuate the inflammatory response of monocytes/macrophages.	Lagha AB et al.	—	2019	→
The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers.	Gooding AJ et al.	—	2019	→
Tomato Powder Modulates NF-<i>κ</i>B, mTOR, and Nrf2 Pathways during Aging in Healthy Rats.	Sahin K et al.	—	2019	→
Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A.	Lin S et al.	—	2019	→
Activation of TNF-α/NF-κB axis enhances CRL4B<sup>DCAF</sup><sup>11</sup> E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells.	Zhang C et al.	—	2018	→
Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium.	Konkankit CC et al.	—	2018	→
Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers.	Soundararajan P et al.	—	2018	→
Anti-survivin effect of the small molecule inhibitor YM155 in RCC cells is mediated by time-dependent inhibition of the NF-κB pathway.	Sim MY et al.	—	2018	→
Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock.	Tunctan B et al.	—	2018	→
Cellular stress response mechanisms as therapeutic targets of ginsenosides.	Qi HY et al.	—	2018	→
Changes of <i>KEAP1/NRF2</i> and <i>IKB</i>/NF-<i>κ</i>B Expression Levels Induced by Cell-Free DNA in Different Cell Types.	Kostyuk SV et al.	—	2018	→
Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment.	Zhang J et al.	—	2018	→
Chemical modulation of transcription factors.	Wiedemann B et al.	—	2018	→
Curcumin Exerted Neuroprotection against Ozone-Induced Oxidative Damage and Decreased NF-<i>κ</i>B Activation in Rat Hippocampus and Serum Levels of Inflammatory Cytokines.	Nery-Flores SD et al.	—	2018	→
Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties.	Zhang L et al.	—	2018	→
Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer's disease.	Maione F et al.	—	2018	→
Effect of selected strains of lactobacilli on the antioxidant and anti-inflammatory properties of sourdough.	Galli V et al.	—	2018	→
Effects of histone deacetylase inhibitors on regenerative cell responses in human dental pulp cells.	Luo Z et al.	—	2018	→
Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.	Custodero C et al.	—	2018	→
Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.	Puar YR et al.	—	2018	→
Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2.	Paish HL et al.	—	2018	→
Ginseng oligopeptides protect against irradiation-induced immune dysfunction and intestinal injury.	He LX et al.	—	2018	→
Honeycomb-structured metasurfaces for the adaptive nesting of endothelial cells under hemodynamic loads.	Bachmann BJ et al.	—	2018	→
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.	Gupta SC et al.	—	2018	→
Inhibition of Inflammatory Changes in Human Myometrial Cells by Cell Penetrating Peptide and Small Molecule Inhibitors of NFκB.	Gurney LRI et al.	—	2018	→
Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses.	Chen X et al.	—	2018	→
K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression.	Choi JY et al.	—	2018	→
Mechanisms of NF-κB p65 and strategies for therapeutic manipulation.	Giridharan S et al.	—	2018	→
Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs.	Varga V et al.	—	2018	→
Murine Double Minute-2 Links Cell Cycle Control and Inflammation in Homeostasis and Disease.	Ebrahim M et al.	—	2018	→
Naringin attenuates liver damage in streptozotocin-induced diabetic rats.	Rodríguez V et al.	—	2018	→
Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1.	Wang Z et al.	—	2018	→
Neuroinflammation in Alzheimer's disease: Pleiotropic roles for cytokines and neuronal pentraxins.	Swanson A et al.	—	2018	→
NF-kappaB Regulates Redox Status in Breast Cancer Subtypes.	Pires BRB et al.	—	2018	→
NF-kappaB: Two Sides of the Same Coin.	Pires BRB et al.	—	2018	→
NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B.	Zhou J et al.	—	2018	→
NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells.	Stupina T et al.	—	2018	→
Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells.	Mohan CD et al.	—	2018	→
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.	Li J et al.	—	2018	→
N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway.	Mohan CD et al.	—	2018	→
Pathological histone acetylation in Parkinson's disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition.	Harrison IF et al.	—	2018	→
PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective.	Nallasamy P et al.	—	2018	→
Polydatin Prevents Lipopolysaccharide (LPS)-Induced Parkinson's Disease via Regulation of the AKT/GSK3β-Nrf2/NF-κB Signaling Axis.	Huang B et al.	—	2018	→
Repurposing Thioridazine (TDZ) as an anti-inflammatory agent.	Baig MS et al.	—	2018	→
Resolving gastric cancer aetiology: an update in genetic predisposition.	Lott PC et al.	—	2018	→
Role of the NFκB-signaling pathway in cancer.	Xia L et al.	—	2018	→
Silence of Stomatin-Like Protein 2 Represses Migration and Invasion Ability of Human Liver Cancer Cells via Inhibiting the Nuclear Factor Kappa B (NF-κB) Pathway.	Zhu W et al.	—	2018	→
Synovial fibroblast-targeting liposomes encapsulating an NF-κB-blocking peptide ameliorates zymosan-induced synovial inflammation.	You C et al.	—	2018	→
Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors.	Prescott JA et al.	—	2018	→
The inhibitory effects of plumbagin on the NF-қB pathway and CCL2 release in racially different triple-negative breast cancer cells.	Messeha SS et al.	—	2018	→
The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII.	Farina AR et al.	—	2018	→
The Science behind Microgreens as an Exciting New Food for the 21st Century.	Choe U et al.	—	2018	→
The silencing of ApoC3 suppresses oxidative stress and inflammatory responses in placenta cells from mice with preeclampsia via inhibition of the NF-κB signaling pathway.	Li FH et al.	—	2018	→
Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF-κB in glomerular mesangial cells.	Tsai KD et al.	—	2018	→
Accumulation of myeloid-derived suppressor cells (MDSCs) induced by low levels of IL-6 correlates with poor prognosis in bladder cancer.	Yang G et al.	—	2017	→
Aging: Molecular Pathways and Implications on the Cardiovascular System.	de Almeida AJPO et al.	—	2017	→
Anti-Cancer Phytometabolites Targeting Cancer Stem Cells.	Torquato HF et al.	—	2017	→
Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative.	Sotillo WS et al.	—	2017	→
Anti-Inflammatory Effects of a Mytilus coruscus α-d-Glucan (MP-A) in Activated Macrophage Cells via TLR4/NF-κB/MAPK Pathway Inhibition.	Liu F et al.	—	2017	→
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-κB and Nrf2 Signaling Pathways.	Mandal A et al.	—	2017	→
Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression.	Guesmi F et al.	—	2017	→
Black tea theaflavins attenuate Porphyromonas gingivalis virulence properties, modulate gingival keratinocyte tight junction integrity and exert anti-inflammatory activity.	Ben Lagha A et al.	—	2017	→
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	Chen M et al.	—	2017	→
Chemokine Receptor Signaling and the Hallmarks of Cancer.	Lacalle RA et al.	—	2017	→
Conditional, Genetically Encoded, Small Molecule-Regulated Inhibition of NFκB Signaling in RPE Cells.	Vu KT et al.	—	2017	→
Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.	Kunnumakkara AB et al.	—	2017	→
Effects of VitabridC<sup>12</sup> on Skin Inflammation.	Lee JH et al.	—	2017	→
Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization.	Qian Z et al.	—	2017	→
Evodiamine Inhibits Zymosan-Induced Inflammation In Vitro and In Vivo: Inactivation of NF-κB by Inhibiting IκBα Phosphorylation.	Fan X et al.	—	2017	→
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.	Shah F et al.	—	2017	→
Facile endothelium protection from TNF-α inflammatory insult with surface topography.	Stefopoulos G et al.	—	2017	→
Fas/S1P<sub>1</sub> crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis.	Hutami IR et al.	—	2017	→
Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through the MAPK and NF-κB pathways.	Jiang F et al.	—	2017	→
Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-κB in rats.	Madankumar A et al.	—	2017	→
hTERT promotes gastric intestinal metaplasia by upregulating CDX2 via NF-κB signaling pathway.	Chen BJ et al.	—	2017	→
Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB.	D'Ignazio L et al.	—	2017	→
Identification of novel NF-κB transcriptional targets in TNFα-treated HeLa and HepG2 cells.	Zhou F et al.	—	2017	→
IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC.	Chan LP et al.	—	2017	→
Immunomodulatory effects of xanthan gum in LPS-stimulated RAW 264.7 macrophages.	Liu F et al.	—	2017	→
Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy.	Meng G et al.	—	2017	→
Inhibition of IKK-NFκB pathway sensitizes lung cancer cell lines to radiation.	Tsolou A et al.	—	2017	→
Inhibition of IκBβ/NFκB signaling prevents LPS-induced IL1β expression without increasing apoptosis in the developing mouse lung.	McKenna S et al.	—	2017	→
Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.	Velagapudi R et al.	—	2017	→
KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells.	Stelma T et al.	—	2017	→
Models for the study of skin wound healing. The role of Nrf2 and NF-κB.	Ambrozova N et al.	—	2017	→
Molecular Genetic and Epigenetic Basis of Multiple Sclerosis.	Hojati Z	—	2017	→
Neoagaro-oligosaccharide monomers inhibit inflammation in LPS-stimulated macrophages through suppression of MAPK and NF-κB pathways.	Wang W et al.	—	2017	→
Neokestose suppresses the growth of human melanoma A2058 cells via inhibition of the nuclear factor‑κB signaling pathway.	Wu JS et al.	—	2017	→
NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells.	Pires BR et al.	—	2017	→
NF-κB controls four genes encoding core enzymes of tricarboxylic acid cycle.	Zhou F et al.	—	2017	→
NF‑κB inhibition is associated with OPN/MMP‑9 downregulation in cutaneous melanoma.	Guarneri C et al.	—	2017	→
Preventive effect of Gardenia jasminoides on HCl/ethanol induced gastric injury in mice.	Chen S et al.	—	2017	→
Protective effects of paeonol on inflammatory response in IL-1β-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-κB pathway.	Zhai KF et al.	—	2017	→
Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells.	Ameeramja J et al.	—	2017	→
Regulatory role of NADPH oxidase 2 in the polarization dynamics and neurotoxicity of microglia/macrophages after traumatic brain injury.	Wang J et al.	—	2017	→
Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: Comparison with TNF-α.	Buhrmann C et al.	—	2017	→
Rho-kinase inhibitor prevents acute injury against transient focal cerebral ischemia by enhancing the expression and function of GABA receptors in rats.	Huang L et al.	—	2017	→
Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death.	Ur Rahman MS et al.	—	2017	→
Small molecules to the rescue: Inhibition of cytokine signaling in immune-mediated diseases.	Gadina M et al.	—	2017	→
STC1 promotes cell apoptosis via NF-κB phospho-P65 Ser536 in cervical cancer cells.	Pan X et al.	—	2017	→
Stochastic dynamics of genetic broadcasting networks.	Potoyan DA et al.	—	2017	→
Study of the inhibitory effects on TNF-α-induced NF-κB activation of IMD0354 analogs.	Li YR et al.	—	2017	→
Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity.	Nandakumar N et al.	—	2017	→
Targeting Chromatin Remodeling in Inflammation and Fibrosis.	Yang J et al.	—	2017	→
Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.	Widen JC et al.	—	2017	→
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.	Rahimifard M et al.	—	2017	→
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.	Lu SY et al.	—	2017	→
Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.	Begalli F et al.	—	2017	→
X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B.	Vaine CA et al.	—	2017	→
A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway.	Franceschelli S et al.	—	2016	→
Anti-Inflammatory Potential of Ethyl Acetate Fraction of Moringa oleifera in Downregulating the NF-κB Signaling Pathway in Lipopolysaccharide-Stimulated Macrophages.	Arulselvan P et al.	—	2016	→
Anti-proliferative effect of RCE-4 from Reineckia carnea on human cervical cancer HeLa cells by inhibiting the PI3K/Akt/mTOR signaling pathway and NF-κB activation.	Bai C et al.	—	2016	→
Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption.	Xu L et al.	—	2016	→
Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase-dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes.	Xiao Y et al.	—	2016	→
Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back.	Yadav AK et al.	—	2016	→
Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.	Senol SP et al.	—	2016	→
Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.	de Mingo Á et al.	—	2016	→
Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β.	Saud SM et al.	—	2016	→
Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge.	Jiao WH et al.	—	2016	→
Effect of Cichorium intybus L. on the expression of hepatic NF-κB and IKKβ and serum TNF-α in STZ- and STZ+ niacinamide-induced diabetes in rats.	Rezagholizadeh L et al.	—	2016	→
Electrospun Microfiber Scaffolds with Anti-Inflammatory Tributanoylated N-Acetyl-d-Glucosamine Promote Cartilage Regeneration.	Kim C et al.	—	2016	→
Inflammatory and oxidative stress in rotavirus infection.	Guerrero CA et al.	—	2016	→
Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutual crosstalk between ROS and NF-kB.	Turillazzi E et al.	—	2016	→
Macrophages, Inflammation, and Lung Cancer.	Conway EM et al.	—	2016	→
Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor-κB Signaling for Cancer Treatment.	Zeligs KP et al.	—	2016	→
Molecular stripping, targets and decoys as modulators of oscillations in the NF-κB/IκBα/DNA genetic network.	Wang Z et al.	—	2016	→
Nanomedicine based curcumin and doxorubicin combination treatment of glioblastoma with scFv-targeted micelles: In vitro evaluation on 2D and 3D tumor models.	Sarisozen C et al.	—	2016	→
New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors.	Moarbess G et al.	—	2016	→
NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications.	Leibowitz SM et al.	—	2016	→
Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination.	Ali AA et al.	—	2016	→
Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo.	Nirvanappa AC et al.	—	2016	→
Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression.	Zhang S et al.	—	2016	→
Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-κB Factor as Prognostic Markers in Mammary Tumors.	Martins GR et al.	—	2016	→
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches.	Park MH et al.	—	2016	→
Skin aging and oxidative stress: Equol's anti-aging effects via biochemical and molecular mechanisms.	Lephart ED	—	2016	→
Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review.	Eitsuka T et al.	—	2016	→
Synthesis and anti-inflammatory activity evaluation of a novel series of 6-phenoxy-[1,2,4]triazolo[3,4-a]phthalazine-3-carboxamide derivatives.	Liu DC et al.	—	2016	→
The Anti-Atherosclerotic Effect of Naringin Is Associated with Reduced Expressions of Cell Adhesion Molecules and Chemokines through NF-κB Pathway.	Hsueh TP et al.	—	2016	→
The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias.	Carrà G et al.	—	2016	→
The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection.	Tonby K et al.	—	2016	→
Vitamin D inhibits the growth of and virulence factor gene expression by Porphyromonas gingivalis and blocks activation of the nuclear factor kappa B transcription factor in monocytes.	Grenier D et al.	—	2016	→
Activin suppresses LPS-induced Toll-like receptor, cytokine and inducible nitric oxide synthase expression in normal human melanocytes by inhibiting NF-κB and MAPK pathway activation.	Kim YI et al.	—	2015	→
A multi-targeted approach to suppress tumor-promoting inflammation.	Samadi AK et al.	—	2015	→
Angiogenin promotes U87MG cell proliferation by activating NF-κB signaling pathway and downregulating its binding partner FHL3.	Xia W et al.	—	2015	→
A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery.	Narayanan D et al.	—	2015	→
Cynandione A attenuates lipopolysaccharide-induced production of inflammatory mediators via MAPK inhibition and NF-κB inactivation in RAW264.7 macrophages and protects mice against endotoxin shock.	Kim SH et al.	—	2015	→
Dual Action of Myricetin on Porphyromonas gingivalis and the Inflammatory Response of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases.	Grenier D et al.	—	2015	→
Effect of NF-κB inhibition on chemoresistance in biliary-pancreatic cancer.	Uwagawa T et al.	—	2015	→
FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression.	Xu HD et al.	—	2015	→
Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation.	Kang H et al.	—	2015	→
IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.	Gaddipati S et al.	—	2015	→
Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system.	Al-Kurdi ZI et al.	—	2015	→
Inhibition of the NF-κB signaling pathway by a novel heterocyclic curcumin analogue.	Katsori AM et al.	—	2015	→
Investigation the mechanism of the apoptosis induced by lactacystin in gastric cancer cells.	Li Y et al.	—	2015	→
IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition.	Armstrong MJ et al.	—	2015	→
KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes.	Wang S et al.	—	2015	→
Natural Compounds: Role in Reversal of Epigenetic Changes.	Aggarwal R et al.	—	2015	→
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review.	Shih RH et al.	—	2015	→
Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.	Pillon NJ et al.	—	2015	→
Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences.	Patil KR et al.	—	2015	→
Peptide-based inhibition of IκB kinase/nuclear factor-κB pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes.	Oguiza A et al.	—	2015	→
Perfluorooctanoic acid enhances colorectal cancer DLD-1 cells invasiveness through activating NF-κB mediated matrix metalloproteinase-2/-9 expression.	Miao C et al.	—	2015	→
Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.	Blednov YA et al.	—	2015	→
Proanthocyanidin in red rice inhibits MDA-MB-231 breast cancer cell invasion via the expression control of invasive proteins.	Pintha K et al.	—	2015	→
Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: assessing the activity of flavonoids from the stem bark of Oroxylum indicum.	Tran TV et al.	—	2015	→
Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis.	Srinivasan M et al.	—	2015	→
Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis.	Song L et al.	—	2015	→
Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.	Maccari R et al.	—	2015	→
The endometriotic tissue lining the internal surface of endometrioma: hormonal, genetic, epigenetic status, and gene expression profile.	Sanchez AM et al.	—	2015	→
The inhibitory effects of Geranium thunbergii on interferon-γ- and LPS-induced inflammatory responses are mediated by Nrf2 activation.	Choi HJ et al.	—	2015	→
The major pathway by which polymeric formula reduces inflammation in intestinal epithelial cells: a microarray-based analysis.	Nahidi L et al.	—	2015	→
The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells.	Guzmán EA et al.	—	2015	→
Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes.	Barnes PJ	—	2015	→
The role of the NF-κB, SAPK/JNK, and TLR4 signalling pathways in the responses of RAW 264.7 cells to extremely low-intensity microwaves.	Glushkova OV et al.	—	2015	→
Transcriptomic Signatures of Auger Electron Radioimmunotherapy Using Nuclear Targeting (111)In-Trastuzumab for Potential Combination Therapies.	Li HK et al.	—	2015	→
Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-κB and Nrf2 signaling pathways.	Mandal A et al.	—	2015	→
Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-κB activation in the paw and spinal cord.	Ruiz-Miyazawa KW et al.	—	2015	→
Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases.	Ben Lagha A et al.	—	2015	→
ABC transporters in CSCs membranes as a novel target for treating tumor relapse.	Zinzi L et al.	—	2014	→
Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway.	Gupta SC et al.	—	2014	→
Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products.	Shi H et al.	—	2014	→
Anti-inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide-activated macrophages.	Ghosh C et al.	—	2014	→
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA.	Zou Z et al.	—	2014	→
Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.	Vander Broek R et al.	—	2014	→
Click hybridization of immune cells and polyamidoamine dendrimers.	Xu L et al.	—	2014	→
Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151.	Gallagher SJ et al.	—	2014	→
Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma.	Arthur AE et al.	—	2014	→
Dilazep synergistically reactivates latent HIV-1 in latently infected cells.	Zeng H et al.	—	2014	→
Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols.	Gupta SC et al.	—	2014	→
Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock.	Sari AN et al.	—	2014	→
Future nanomedicine for the diagnosis and treatment of osteoarthritis.	Eichaker LR et al.	—	2014	→
IKK2 inhibition attenuates laser-induced choroidal neovascularization.	Lu H et al.	—	2014	→
Interplay between DNA repair and inflammation, and the link to cancer.	Kidane D et al.	—	2014	→
In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans.	García-Lafuente A et al.	—	2014	→
In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.	Bowles RD et al.	—	2014	→
Marine low molecular weight natural products as potential cancer preventive compounds.	Stonik VA et al.	—	2014	→
NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process.	Tolani B et al.	—	2014	→
Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans.	Robinson G et al.	—	2014	→
Novel lung adenocarcinoma and nuclear factor-kappa B (NF-κB) inhibitors: synthesis and evaluation of lantadene congeners.	Suthar SK et al.	—	2014	→
Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation.	Wei N et al.	—	2014	→
Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice.	Velázquez KT et al.	—	2014	→
Reinforcing targeted therapeutics with phenotypic stability factors.	Yaswen P	—	2014	→
Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells.	Buhrmann C et al.	—	2014	→
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.	Li Y et al.	—	2014	→
Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth.	Basavarajappa HD et al.	—	2014	→
The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-α-induced VCAM-1, ICAM-1 and CX3CL1 expression.	Chang CC et al.	—	2014	→
The effect of antifibrotic drug halofugine on Th17 cells in concanavalin A-induced liver fibrosis.	Liang J et al.	—	2014	→
The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors.	Sarisozen C et al.	—	2014	→
TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ.	Zhang Y et al.	—	2014	→
Transferrin-targeted polymeric micelles co-loaded with curcumin and paclitaxel: efficient killing of paclitaxel-resistant cancer cells.	Abouzeid AH et al.	—	2014	→
Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosis.	Lu L et al.	—	2014	→
Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells.	Yeh CH et al.	—	2014	→
Activation of NF-κB after chronic ethanol intake and haemorrhagic shock/resuscitation in mice.	Maraslioglu M et al.	—	2013	→
A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF-κB pathway.	Pan J et al.	—	2013	→
All-trans retinoic acid inhibits craniopharyngioma cell growth: study on an explant cell model.	Li Q et al.	—	2013	→
Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-kappa B signaling.	Lee ST et al.	—	2013	→
A new labdane diterpenoid with anti-inflammatory activity from Thuja orientalis.	Kim TH et al.	—	2013	→
Anti-cancer activity of anti-GLUT1 antibody-targeted polymeric micelles co-loaded with curcumin and doxorubicin.	Abouzeid AH et al.	—	2013	→
Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling.	Wu X et al.	—	2013	→
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease.	Barnes PJ	—	2013	→
Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana.	Hernández-Abreu O et al.	—	2013	→
Epigallocatechin-3-gallate exerts protective effects against heat stress through modulating stress-responsive transcription factors in poultry.	Orhan C et al.	—	2013	→
Erucin exerts anti-inflammatory properties in murine macrophages and mouse skin: possible mediation through the inhibition of NFκB signaling.	Cho HJ et al.	—	2013	→
Establishment of stable reporter expression for in vivo imaging of nuclear factor-κB activation in mouse liver.	Yan S et al.	—	2013	→
Functional Toll-like receptor 4 expressed in lactotrophs mediates LPS-induced proliferation in experimental pituitary hyperplasia.	Sabatino ME et al.	—	2013	→
GILZ overexpression inhibits endothelial cell adhesive function through regulation of NF-κB and MAPK activity.	Cheng Q et al.	—	2013	→
Health promoting effects of brassica-derived phytochemicals: from chemopreventive and anti-inflammatory activities to epigenetic regulation.	Wagner AE et al.	—	2013	→
Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells.	Zhao Y et al.	—	2013	→
Hyperhomocysteinemia-Induced Monocyte Chemoattractant Protein-1 Promoter DNA Methylation by Nuclear Factor-κB/DNA Methyltransferase 1 in Apolipoprotein E-Deficient Mice.	Wang J et al.	—	2013	→
Identification of NF-κB Inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF.	Jiang M et al.	—	2013	→
Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors.	Guerrero CA et al.	—	2013	→
MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation.	Hwang YJ et al.	—	2013	→
Modulators of HIF1α and NFkB in Cancer Treatment: Is it a Rational Approach for Controlling Malignant Progression?	Tafani M et al.	—	2013	→
NF-κBP65 promotes invasion and metastasis of oesophageal squamous cell cancer by regulating matrix metalloproteinase-9 and epithelial-to-mesenchymal transition.	Wang F et al.	—	2013	→
Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment.	Gupta SC et al.	—	2013	→
Osteoprotegerin exerts its pro-inflammatory effects through nuclear factor-κB activation.	Nahidi L et al.	—	2013	→
Peptide inhibitor of NF-κB translocation ameliorates experimental atherosclerosis.	Mallavia B et al.	—	2013	→
Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-κB signaling.	Yin QQ et al.	—	2013	→
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer.	Campbell LM et al.	—	2013	→
Resveratrol induces nuclear factor-κB activity in human cardiac cells.	Palomer X et al.	—	2013	→
Rhododendrin ameliorates skin inflammation through inhibition of NF-κB, MAPK, and PI3K/Akt signaling.	Jeon YJ et al.	—	2013	→
Si-Wu-tang extract stimulates bone formation through PI3K/Akt/NF-κB signaling pathways in osteoblasts.	Wu CM et al.	—	2013	→
Spongiatriol inhibits nuclear factor kappa B activation and induces apoptosis in pancreatic cancer cells.	Guzmán E et al.	—	2013	→
Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging.	Maqbool A et al.	—	2013	→
The nuclear factor kappa-B signaling pathway as a therapeutic target against thyroid cancers.	Li X et al.	—	2013	→
TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.	Workman LM et al.	—	2013	→
TNF receptor-associated factor 6 regulates proliferation, apoptosis, and invasion of glioma cells.	Peng Z et al.	—	2013	→
Vitamin D analogue TX 527 down-regulates the NF-κB pathway and controls the proliferation of endothelial cells transformed by Kaposi sarcoma herpesvirus.	González-Pardo V et al.	—	2013	→
1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes.	Lee HY et al.	—	2012	→
3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.	Yadav VR et al.	—	2012	→
Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin.	Rosales-Corral SA et al.	—	2012	→
A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages.	Zhang T et al.	—	2012	→
Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6.	Qu X et al.	—	2012	→
Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth.	Tu SP et al.	—	2012	→
Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.	Switzer CH et al.	—	2012	→
Dynamic roles for NF-κB in HTLV-I and HIV-1 retroviral pathogenesis.	Chan JK et al.	—	2012	→
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.	Yang Y et al.	—	2012	→
Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.	Schepetkin IA et al.	—	2012	→
Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells.	Vrba J et al.	—	2012	→
Inhibition of rotavirus infection in cultured cells by N-acetyl-cysteine, PPARγ agonists and NSAIDs.	Guerrero CA et al.	—	2012	→
Inhibitory kappa B Kinases as targets for pharmacological regulation.	Gamble C et al.	—	2012	→
Involvement of TNFα-induced TLR4-NF-κB and TLR4-HIF-1α feed-forward loops in the regulation of inflammatory responses in glioma.	Tewari R et al.	—	2012	→
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.	Matta H et al.	—	2012	→
Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the suppression of TRAF6 polyubiquitination [corrected].	Chen Q et al.	—	2012	→
Natural chalcones as dual inhibitors of HDACs and NF-κB.	Orlikova B et al.	—	2012	→
NF-κB and the link between inflammation and cancer.	DiDonato JA et al.	—	2012	→
NF-κB as a potential therapeutic target in microbial diseases.	Vitiello M et al.	—	2012	→
Prognostic significance of kappaB-Ras1 expression in gliomas.	Lin H et al.	—	2012	→
Relevance of new drug discovery to reduce NF-κB activation in cardiovascular disease.	Madonna R et al.	—	2012	→
Relevance of systems pharmacology in drug discovery.	Cucurull-Sanchez L et al.	—	2012	→
Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes.	Busch F et al.	—	2012	→
Resveratrol protects quail hepatocytes against heat stress: modulation of the Nrf2 transcription factor and heat shock proteins.	Sahin K et al.	—	2012	→
Role of T cell-nuclear factor κB in transplantation.	Molinero LL et al.	—	2012	→
Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway.	Lu CN et al.	—	2012	→
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase.	Shao L et al.	—	2012	→
Targeting nuclear factor-κB suppresses the negative effect of toll-like receptor 4 signaling on antimetastasis therapy based on targeting αvβ3.	Zhu JH et al.	—	2012	→
The NF-κB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells.	Astarci E et al.	—	2012	→
The spin trap 5,5-dimethyl-1-pyrroline N-oxide inhibits lipopolysaccharide-induced inflammatory response in RAW 264.7 cells.	Zhai Z et al.	—	2012	→
Tocotrienols fight cancer by targeting multiple cell signaling pathways.	Kannappan R et al.	—	2012	→
WITHDRAWN: Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells.	Reuter S et al.	—	2012	→
Alpinumisoflavone induces apoptosis and suppresses extracellular signal-regulated kinases/mitogen activated protein kinase and nuclear factor-κB pathways in lung tumor cells.	Namkoong S et al.	—	2011	→
An artificial copper complex incorporating a cell-penetrating peptide inhibits nuclear factor-κB (NF-κB) activation.	Kanemaru Y et al.	—	2011	→
Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation.	Wang LJ et al.	—	2011	→
Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.	Gupta SC et al.	—	2011	→
Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression.	Dong A et al.	—	2011	→
Cancer and diet: How are they related?	Sung B et al.	—	2011	→
Chemosensitization of tumors by resveratrol.	Gupta SC et al.	—	2011	→
Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells.	Yang Y et al.	—	2011	→
Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-κB and Bcl-2 families.	El-Kady A et al.	—	2011	→
Deregulation of Aiolos expression in chronic lymphocytic leukemia is associated with epigenetic modifications.	Billot K et al.	—	2011	→
Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines.	Yasui Y et al.	—	2011	→
Epigenetic changes induced by curcumin and other natural compounds.	Reuter S et al.	—	2011	→
HDACi: cellular effects, opportunities for restorative dentistry.	Duncan HF et al.	—	2011	→
Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells.	Shin HJ et al.	—	2011	→
Irradiation at 636 nm positively affects diabetic wounded and hypoxic cells in vitro.	Sekhejane PR et al.	—	2011	→
Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not.	Verhelst K et al.	—	2011	→
NF-κB in cancer: a matter of life and death.	Aggarwal BB et al.	—	2011	→
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.	Iguchi-Hashimoto M et al.	—	2011	→
Plexin-B1 activates NF-κB and IL-8 to promote a pro-angiogenic response in endothelial cells.	Yang YH et al.	—	2011	→
Resveratrol inhibits proliferation and survival of Epstein Barr virus-infected Burkitt's lymphoma cells depending on viral latency program.	De Leo A et al.	—	2011	→
Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents.	Gupta SC et al.	—	2011	→
Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.	Dragoni S et al.	—	2011	→
Water extract of Cynanchi atrati Radix regulates inflammation and apoptotic cell death through suppression of IKK-mediated NF-κB signaling.	Jeon J et al.	—	2011	→
Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.	Gupta SC et al.	—	2010	→
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.	Gupta SC et al.	—	2010	→