Early onset alcohol use and self-harm: a discordant twin analysis.

paper Cited Public

Authors: Few, Lauren R; Werner, Kimberly B; Sartor, Carolyn E; Grant, Julia D; Trull, Timothy J; Nock, Matthew K; Bucholz, Kathleen K; Deitz, Sarah K; Glowinski, Anne L; Martin, Nicholas G; Nelson, Elliot C; Statham, Dixie J; Madden, Pamela A F; Heath, Andrew C; Lynskey, Michael T; Agrawal, Arpana
Year: 2015
Journal: Alcoholism, clinical and experimental research
PMID: 26463647
DOI: 10.1111/acer.12889
PMCID: PMC4729363

#	Section	Preview
20	Discussion	Self-harm is associated with considerable costs, individually, socially and economically, and…
21	Discussion	In terms of the link between EAU and self-harm, the prevalence of EAU was substantially higher among…
22	Discussion	The prevalence of self-harm was also examined in the full sample and across four groups, which…
23	Discussion	would be expected that twin pairs - who share genes and the familial environment - would exhibit…
24	Discussion	In these more stringent analyses within discordant twin pairs, the risk for SA among those reporting…
25	Discussion	Therefore, these unshared individual-specific influences may be critical in understanding the link…
26	Discussion	With this said, we did not examine intermediate variables, or individual-specific consequences of…
27	Discussion	later SA. Wetherill and colleagues (2013) found differences in activation of brain regions…
28	Discussion	For NSSI, results from the discordant twin analysis demonstrated substantially increased risk for…
29	Discussion	genetic influences are shared (rG=0.35). Notably, previous work has found limited evidence for…
30	Discussion	alcohol use. Self-reported impulsivity, and more specifically negative urgency, has also been linked…
31	Discussion	There are several limitations of the current study, namely the use of retrospective reporting of…
32	Discussion	study. Additionally, due to lack of power, it was not possible to examine potential differences in…
33	Discussion	In conclusion, the results of the current study confirm previous research demonstrating an…

Name	Type
adolescents	cohort
adolescent sample	cohort
adult sample	cohort
African‑American Cohort local	cohort
age at first drink	phenotype
alcohol	phenotype
alcohol abuse	phenotype
alcohol dependence	phenotype
Alcohol Use	phenotype
Alcohol Use Disorder	phenotype
anhedonia	phenotype
Australian Caucasian Cohort local	cohort
Australian population	cohort
Australian Twin Registry	cohort
Being Drunk local	phenotype
borderline personality disorder	phenotype
burning local	phenotype
cannabis use	phenotype
Concordant Twin Pairs local	cohort
conduct disorder	phenotype
current study	cohort
cutting local	phenotype
depression	phenotype
disinhibition	phenotype
drinking heavily local	drug
early alcohol use	phenotype
Early sex	phenotype
early smoking	phenotype
early substance use	phenotype
EAU local	drug
EAU exposed twin in discordant pairs local	cohort
European‑American Cohort local	cohort
excessive alcohol consumption	phenotype
Excessive Alcohol Use local	drug
Familial support local	phenotype
Family history of excessive alcohol use local	phenotype
family history of suicide local	phenotype
Family history of suicide local	phenotype
feeling depressed local	phenotype
fighting	phenotype
frontal cortex	anatomy
full sample	cohort
hanging local	phenotype
heavy drinking	phenotype
Hurting animals local	phenotype
impulsivity	phenotype
inhibitory control	phenotype
Later-onset Users local	cohort
lifetime alcohol use	phenotype
Lifetime non-drinkers local	phenotype
marijuana	phenotype
medication ingestion local	phenotype
MSM local	cohort
MZF local	cohort
negative urgency	phenotype
non-drinking controls local	cohort
non-suicidal self-injury local	phenotype
Non-suicidal self-injury local	phenotype
Non‑suicidal self‑injury local	phenotype
Non-suicidal Self-Injury local	phenotype
Non-Suicidal Self-Injury local	phenotype
Non‑Suicidal Self‑Injury local	phenotype
NSSI local	phenotype
other substances	phenotype
participants	cohort
Peer approval of alcohol local	phenotype
peer delinquency	phenotype
peer use	phenotype
physical abuse	phenotype
Poor Clinical Outcomes local	phenotype
poor inhibitory control	phenotype
positive parenting	phenotype
risk-taking behavior	phenotype
Risky Behavior count local	phenotype
SA	phenotype
Same-sex monozygotic twins local	cohort
Same-sex Twins local	cohort
self-harm	phenotype
self-reported impulsivity	phenotype
sex	phenotype
Shoplifting local	phenotype
singletons	cohort
strange thoughts local	phenotype
study cohort	cohort
suicide	phenotype
Twin cohort	cohort
Twin pairs concordant for Excessive alcohol use local	cohort
Twin pairs concordant for no Excessive alcohol use local	cohort
Unexposed twin in discordant pairs local	cohort
using drugs local	drug

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