Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity?

paper Cited Public

Authors: Niciu, Mark J; Henter, Ioline D; Sanacora, Gerard; Zarate, Carlos A
Year: 2014
Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
PMID: 24024876
DOI: 10.3109/15622975.2013.829585
PMCID: PMC4180366

#	Section	Preview
40	Methods — Glial cell-mediated glutamatergic dysfunction in co-occurring SUDs and depression — Ketamine as a glutamatergic probe in comorbidity	Although acute and transient ketamine-induced dysphoria is an identified adverse effect,…
41	Future directions/conclusions	Although astrocytes are now known to be critical in synaptic glutamate reuptake, microglia and…
42	Future directions/conclusions	There are several exciting avenues for future comorbidity research. First, preclinical models of…
43	Future directions/conclusions	Depressed subjects with co-morbid SUDs are at increased risk for suicide (Niciu et al. 2009).…
44	Future directions/conclusions	In summary, the evidence reviewed in this paper highlights the critical role of glia in the…

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In this knowledge base

Title	Year	PMID
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?	2018	29897633

External

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Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder.	Cabrera B et al.	—	2019	→
Characterization of the Hippocampal Neuroimmune Response to Binge-Like Ethanol Consumption in the Drinking in the Dark Model.	Grifasi IR et al.	—	2019	→
Compromised Dynamic Cerebral Autoregulation in Patients With Depression.	Luo MY et al.	—	2019	→
Altered serum levels of glial cell line-derived neurotrophic factor in male chronic schizophrenia patients with tardive dyskinesia.	Ye F et al.	—	2018	→
A Prospective Evaluation of Patient-Reported Opioid Utilization After Nonoperative Treatment of Fractures and Dislocations.	Zhu H et al.	—	2018	→
Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis.	Kim R et al.	—	2018	→
Chemogenetic Manipulation of Dorsal Hippocampal Astrocytes Protects Against the Development of Stress-enhanced Fear Learning.	Jones ME et al.	—	2018	→
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?	Prytkova I et al.	—	2018	→
Immune and Neuroprotective Effects of Physical Activity on the Brain in Depression.	Phillips C et al.	—	2018	→
Chronic Stress in Adolescents and Its Neurobiological and Psychopathological Consequences: An RDoC Perspective.	Sheth C et al.	—	2017	→
Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure.	Yates JR et al.	—	2017	→
In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [<sup>11</sup>C]ABP688 and [<sup>18</sup>F]FPEB.	DeLorenzo C et al.	—	2017	→
Astrocytes: a central element in neurological diseases.	Pekny M et al.	—	2016	→
Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core.	Scofield MD et al.	—	2016	→
HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling.	Samikkannu T et al.	—	2016	→
Reliability of 7T (1) H-MRS measured human prefrontal cortex glutamate, glutamine, and glutathione signals using an adapted echo time optimized PRESS sequence: A between- and within-sessions investigation.	Lally N et al.	—	2016	→
Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects.	Peng L et al.	—	2014	→