Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample.

paper Cited Public

Authors: Hardin, Jill; He, Yungang; Javitz, Harold S; Wessel, Jennifer; Krasnow, Ruth E; Tildesley, Elizabeth; Hops, Hyman; Swan, Gary E; Bergen, Andrew W
Year: 2009
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
PMID: 19959688
DOI: 10.1158/1055-9965.EPI-09-0960
PMCID: PMC3536862

#	Section	Preview
0	INTRODUCTION	Smoking was reported to underlie 4.8 million premature deaths in the world in 2000 and were evenly…
1	INTRODUCTION	Nicotine withdrawal symptoms have been characterized using more than two dozen research based…
2	INTRODUCTION	This study utilizes a Rasch modeled nicotine withdrawal sensitivity score constructed from eight…
3	INTRODUCTION	history and withdrawal symptoms (16). Specifically respondents were asked: ‘During the first few…
4	INTRODUCTION	The SMOFAM Study previously conducted model free linkage analysis with several nicotine dependence…
5	INTRODUCTION	The MOR binds endogenous beta-endorphin, the release of which increases upon nicotine…
6	INTRODUCTION	Herein we present findings regarding an association between the Rasch modeled nicotine withdrawal…
7	MATERIALS AND METHODS — Cohort	Included in these analyses are subjects 11 to 15 years of age, their parents and siblings from the…
8	MATERIALS AND METHODS — Phenotypes	The phenotypic outcome measure used in the logistic regression analyses is relapse, which is defined…
9	MATERIALS AND METHODS — Linkage	Genotypes were determined for 739 dinucleotide microsatellite markers (14) on 158 pedigrees…
10	MATERIALS AND METHODS — SNP Selection, Genotyping and Linkage Disequilibrium Analyses	Existing OPRM1 SNP data were available from a candidate gene panel designed to interrogate nicotinic…
11	MATERIALS AND METHODS — Association testing	Logistic regression as implemented in Stata Version 9 (36) was used to assess the association…
12	MATERIALS AND METHODS — False Discovery Rate Analysis	To assign false discovery probabilities to individual OPRM1 SNPs included in the FBAT, false…
13	RESULTS	The sample for these genetic analyses consisted of 224 pedigrees (N=520 individuals) with complete…
14	RESULTS	The number of pedigrees with linkage scan data was 158 and the number of individuals in those…
15	RESULTS	Forty-six genotyped SNPs covering the OPRM1 genetic region in the SMOFAM sample were available for…
16	RESULTS	with complete OPRM1 SNP genotypes and nicotine withdrawal sensitivity scores. Eight of eighteen SNPs…
17	DISCUSSION	Our analyses of a multiplex smoking pedigree sample identified an increased risk of relapse…
18	DISCUSSION	In a study that characterized nicotine dependence and nicotine withdrawal symptoms among adolescent…
19	DISCUSSION	Our linkage analyses identified a MLS of 3.15 at 164.5 cM on chr6q26 for the nicotine withdrawal…

Name	Type
1,929 unrelated ever-smokers local	cohort
430 unrelated ever-smokers local	cohort
abstinence	phenotype
acquisition of smoking local	phenotype
acute nicotine withdrawal local	phenotype
ADHD	phenotype
adolescent smoking	phenotype
alcohol dependence	phenotype
appetite	phenotype
autism disorder local	phenotype
beta-endorphin	drug
bipolar disorder	phenotype
BMI	phenotype
chr11p15 local	variant
chr11q local	variant
chr6p local	variant
chr6q25.2 local	variant
chr6q25.3 local	variant
chr6q26 local	variant
cigarette liking after negative mood induction local	phenotype
cigarettes	phenotype
Clinical quitting sample (n=116) local	cohort
clinical trial of transdermal nicotine and nicotine nasal spray local	cohort
combined BMI-drug dependence-regular tobacco use trait local	phenotype
combined dependence phenotype for any drug class and regular tobacco usage local	phenotype
concentration	phenotype
Cravings and urges for tobacco local	phenotype
death	phenotype
depression	phenotype
dichotomized nicotine dependence local	phenotype
dopamine	drug
DRD2	gene
DRD2 SNP local	variant
DRD4	gene
DRD4 VNTR	variant
drug dependence	phenotype
Duration of quit attempts local	phenotype
Dutch adolescent smokers local	cohort
endorphin	drug
European population	cohort
Ever-smokers cohort (n=430) local	cohort
Fagerström Test for Nicotine Dependence	phenotype
insomnia	phenotype
irritability	phenotype
linkage sample of 49 pedigrees local	cohort
long-term smoking cessation local	phenotype
maintenance of smoking local	phenotype
major depressive disorder	phenotype
methamphetamine dependence	phenotype
mixed substance dependence local	phenotype
mood disorders	phenotype
Multiplex smoking pedigrees local	cohort
multiplex smoking pedigree sample local	cohort
National probability sample (n=204) local	cohort
nicotine	drug
nicotine addiction	phenotype
Nicotine craving	phenotype
nicotine dependence	phenotype
nicotine nasal spray	drug
nicotine patch	drug
nicotine withdrawal	phenotype
nicotine withdrawal sensitivity local	phenotype
Nicotine withdrawal sensitivity local	phenotype
nicotine withdrawal sensitivity score local	phenotype
Nicotine withdrawal sensitivity score local	phenotype
nicotine withdrawal trait local	phenotype
nucleus accumbens	anatomy
opioid dependence	phenotype
OPRM1	cohort
OPRM1 SNPs	variant
pedigrees	cohort
population based samples local	cohort
preference for nicotine local	phenotype
psychiatric disorders	phenotype
quit attempt symptoms local	phenotype
Rasch modeled nicotine withdrawal sensitivity score local	phenotype
regular smoking	phenotype
regular tobacco usage local	phenotype
reinforcing value of nicotine local	phenotype
relapse	phenotype
restlessness	phenotype
rs10485057	variant
rs12210856 local	variant
rs1799971	variant
rs1799972	variant
rs510769	variant
rs9282819 local	variant
schizophrenia	phenotype
short-term weight gain local	phenotype
SLC22A1 local	gene
SLC22A2 local	gene
SLC22A3 local	gene
SMOFAM local	cohort
SMOFAM dataset local	cohort
SMOFAM sample local	cohort
SMOFAM study local	cohort
SMOFAM Study local	cohort
smoking	phenotype
smoking behavior	phenotype
smoking cessation	phenotype
smoking initiation	phenotype
smoking intensity	phenotype
smoking relapse	phenotype
smoking related behaviors local	phenotype
smoking withdrawal	phenotype
strong desire or craving for a cigarette local	phenotype
Study cohort (1,644 smokers) local	cohort
substance use	phenotype
Sullivan Lab Evidence Project psychiatric genetics database local	cohort
Time to first cigarette in the morning local	phenotype
tobacco use	phenotype
tobacco use phenotypes local	phenotype
treatment related phenotypes local	phenotype
treatment seeking smoker samples local	cohort
withdrawal severity	phenotype

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In this knowledge base

Title	Year	PMID
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	2016	26392368
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	2016	27166759

External

Title	Authors	Journal	Year	Link
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	Schwantes-An TH et al.	—	2016	→
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	Yang J et al.	—	2016	→
Relationship Between Patients' Perceptions of Care Quality and Health Care Errors in 11 Countries: A Secondary Data Analysis.	Hincapie AL et al.	—	2016	→
To quit or not: Vulnerability of women to smoking tobacco.	Park SJ et al.	—	2016	→
OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study.	Chen YT et al.	—	2013	→
A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.	Verhagen M et al.	—	2012	→
Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers.	Ray R et al.	—	2011	→
Pharmacogenomics of the human µ-opioid receptor.	Kasai S et al.	—	2011	→
Proactive recruitment of cancer patients' social networks into a smoking cessation trial.	Bastian LA et al.	—	2011	→
Endogenous opiates and behavior: 2009.	Bodnar RJ	—	2010	→
Refining the tobacco dependence phenotype using the Wisconsin Inventory of Smoking Dependence Motives: II. Evidence from a laboratory self-administration assay.	Piasecki TM et al.	—	2010	→