An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology.
paper
Cited
Public
- Authors
- Lynskey, Michael T; Agrawal, Arpana; Henders, Anjali; Nelson, Elliot C; Madden, Pamela A F; Martin, Nicholas G
- Year
- 2012
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 22874079
- DOI
- 10.1017/thg.2012.41
- PMCID
- PMC3717485
Cannabis is the most widely used illicit drug throughout the developed world and there is consistent evidence of heritable influences on multiple stages of cannabis involvement including initiation of use and abuse/dependence. In this paper, we describe the methodology and preliminary results of a large-scale interview study of 3,824 young adult twins (born 1972-1979) and their siblings. Cannabis use was common with 75.2% of males and 64.7% of females reporting some lifetime use of cannabis while 24.5% of males and 11.8% of females reported meeting criteria for DSM-IV cannabis abuse or dependence. Rates of other drug use disorders and common psychiatric conditions were highly correlated with extent of cannabis involvement and there was consistent evidence of heritable influences across a range of cannabis phenotypes including early (β€15 years) opportunity to use (h 2 = 72%), early (β€16 years) onset use (h 2 = 80%), using cannabis 11+ times lifetime (h 2 = 76%), and DSM abuse/dependence (h 2 = 72%). Early age of onset of cannabis use was strongly associated with increased rates of subsequent use of other illicit drugs and with illicit drug abuse/dependence; further analyses indicating that some component of this association may have been mediated by increasing exposure to and opportunity to use other illicit drugs.
Age of onset of cannabis use and rates of illicit drug use and cannabis/other illicit drug abuse/dependence (other abuse/dependence includes cocaine, stimulants, & hallucinogens abuse/dependence) in 2,601 cannabis users.
Hazards of cocaine exposure opportunity as a function of varying age at first use (onset) of cannabis use in 2,601 cannabis users.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cannabis use disorder: from neurobiology to treatment. | Le Foll B et al. | β | 2024 | β |
| Evidence for sex differences in the impact of cytochrome P450 genotypes on early subjective effects of cannabis. | Davis CN et al. | β | 2024 | β |
| Big Five personality traits and illicit drug use: Specificity in trait-drug associations. | Dash GF et al. | β | 2023 | β |
| Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence. | Buzzi B et al. | β | 2023 | β |
| Shared genetic and environmental etiology between substance use disorders and suicidal behavior. | Edwards AC et al. | β | 2023 | β |
| An Epidemiologic, Longitudinal, and Discordant-Twin Study of the Association Between Gambling Disorder and Suicidal Behaviors. | Slutske WS et al. | β | 2022 | β |
| Are prescription misuse and illicit drug use etiologically distinct? A genetically-informed analysis of opioids and stimulants. | Dash GF et al. | β | 2022 | β |
| Perceived racial and social class discrimination and cannabis involvement among Black youth and young adults. | Ahuja M et al. | β | 2022 | β |
| Variations of cannabis-related adverse mental health and addiction outcomes across adolescence and adulthood: A scoping review. | Kaur N et al. | β | 2022 | β |
| Adolescent Gender Identity, Sexual Orientation, and Cannabis Use: Potential Mediations by Internalizing Disorder Risk. | Buttazzoni A et al. | β | 2021 | β |
| Typologies of illicit drug use in mid-adulthood: a quasi-longitudinal latent class analysis in a community-based sample of twins. | Dash GF et al. | β | 2021 | β |
| Associations between racial and socioeconomic discrimination and risk behaviors among African-American adolescents and young adults: a latent class analysis. | Xie TH et al. | β | 2020 | β |
| Comparing the potential causal influence of two indicators of early alcohol use on later alcohol use disorder symptoms. | Davis CN et al. | β | 2020 | β |
| Deconstructing the neurobiology of cannabis use disorder. | Ferland JN et al. | β | 2020 | β |
| High-Intensity Drinking in Adult Australian Twins. | Dash GF et al. | β | 2020 | β |
| Sex differences in the relative influence of marital status and parenthood on alcohol use disorder symptoms: A multilevel discordant twin design. | Dash GF et al. | β | 2020 | β |
| Big Five personality traits and alcohol, nicotine, cannabis, and gambling disorder comorbidity. | Dash GF et al. | β | 2019 | β |
| Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors. | Richmond-Rakerd LS et al. | β | 2019 | β |
| Genetic and environmental influences on gambling disorder liability: a replication and combined analysis of two twin studies. | Davis CN et al. | β | 2019 | β |
| Genetic Epidemiology of Liability for Alcohol-Induced Blacking and Passing Out. | Davis CN et al. | β | 2019 | β |
| Identifying subtypes of cannabis users based on simultaneous polysubstance use. | Davis CN et al. | β | 2019 | β |
| Personality-obesity associations are driven by narrow traits: A meta-analysis. | Vainik U et al. | β | 2019 | β |
| Genome-wide association meta-analysis of age at first cannabis use. | MinicΔ CC et al. | β | 2018 | β |
| Nonmedical prescription opioids and pathways of drug involvement in the US: Generational differences. | Wall M et al. | β | 2018 | β |
| Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design. | Hines LA et al. | β | 2018 | β |
| Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not. | Aas M et al. | β | 2018 | β |
| The Genetic Relationship Between Psychological Distress, Somatic Distress, Affective Disorders, and Substance Use in Young Australian Adults: A Multivariate Twin Study. | Chang LH et al. | β | 2018 | β |
| The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity. | Struik D et al. | β | 2018 | β |
| Transition to drug co-use among adolescent cannabis users: The role of decision-making and mental health. | Lopez-Quintero C et al. | β | 2018 | β |
| Cannabis and Depression: A Twin Model Approach to Co-morbidity. | Smolkina M et al. | β | 2017 | β |
| Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis. | Richmond-Rakerd LS et al. | β | 2016 | β |
| Cannabis Involvement and Nonsuicidal Self-Injury: A Discordant Twin Approach. | Few LR et al. | β | 2016 | β |
| Commentary on Salom et al. (2016): Early onset substance use-a key target for prevention and early intervention. | Cheetham A et al. | β | 2016 | β |
| Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. | Sherva R et al. | β | 2016 | β |
| Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions? | Hines LA et al. | β | 2016 | β |
| Trait-based assessment of borderline personality disorder using the NEO Five-Factor Inventory: Phenotypic and genetic support. | Few LR et al. | β | 2016 | β |
| Early onset alcohol use and self-harm: a discordant twin analysis. | Few LR et al. | β | 2015 | β |
| Genetic and Environmental Interplay in Adolescent Substance Use Disorders. | Hines LA et al. | β | 2015 | β |
| Progression in substance use initiation: A multilevel discordant monozygotic twin design. | Richmond-Rakerd LS et al. | β | 2015 | β |
| The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. | Hines LA et al. | β | 2015 | β |
| The Gateway Hypothesis of substance abuse: developmental, biological and societal perspectives. | Kandel D et al. | β | 2015 | β |
| The relationship between cannabis involvement and suicidal thoughts and behaviors. | Delforterie MJ et al. | β | 2015 | β |
| The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders. | Grant JD et al. | β | 2015 | β |
| ADHD symptoms, autistic traits, and substance use and misuse in adult Australian twins. | De Alwis D et al. | β | 2014 | β |
| Developing public health regulations for marijuana: lessons from alcohol and tobacco. | Pacula RL et al. | β | 2014 | β |
| Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders. | Few LR et al. | β | 2014 | β |
| Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology? | Maciejewski DF et al. | β | 2014 | β |
| A genetic perspective on the proposed inclusion of cannabis withdrawal in DSM-5. | Verweij KJ et al. | β | 2013 | β |
| Attention problems in childhood and adult substance use. | GalΓ©ra C et al. | β | 2013 | β |
| Changes in cannabis use among young people: impact on mental health. | Copeland J et al. | β | 2013 | β |
| Do early experiences with cannabis vary in cigarette smokers? | Agrawal A et al. | β | 2013 | β |
| Is the relationship between early-onset cannabis use and educational attainment causal or due to common liability? | Verweij KJ et al. | β | 2013 | β |