Mechanisms in the relation between GABRA2 and adolescent externalizing problems.

paper Cited Public

Authors: Wang, Frances L; Chassin, Laurie; Geiser, Christian; Lemery-Chalfant, Kathryn
Year: 2016
Journal: European child & adolescent psychiatry
PMID: 25804982
DOI: 10.1007/s00787-015-0703-7
PMCID: PMC4583314

#	Section	Preview
40	Discussion	However, our results and those of previous studies collectively suggest that GABRA2 is implicated in…
41	Discussion	We found that impulsivity uniquely predicted levels of hyperactive–inattentive symptoms, conduct…
42	Discussion	using/misusing alcohol [40, 41]. It is this alcohol misuse that likely leads to the development of…
43	Discussion	We found that disinhibition mediated the relation between GABRA2 genotype and adolescent alcohol…
44	Discussion	Similarly, the AA/AG genotypes also predicted adolescent-reported conduct problems and…
45	Discussion	In addition to indirect effects, GABRA2 genotype also had a direct effect on adolescent alcohol…
46	Discussion	Our results suggest that one possibility for the mixed findings is that GABRA2 may have more than…
47	Discussion	alcohol in our sample. This is in line with our findings because we only found a direct effect of…
48	Discussion	Moreover, it is important to note that if different alleles of GABRA2 do predict externalizing…
49	Discussion	be other intermediate phenotypes not tested in the current study that act as confounding variables.…
50	Discussion	Interestingly, GABRA2 did not have direct effects on hyperactive–inattentive symptoms or conduct…
51	Discussion	influence of genes on clinical outcomes [72]. It is possible that non-replications in the literature…
52	Discussion	The current study had several methodological strengths. Our use of multiple informants in the factor…
53	Discussion	There were also limitations. We examined single-gene associations, which have small effect sizes.…
54	Discussion	In summary, the current study replicated previous research which found that GABRA2 variation…
55	Discussion	in the literature among GABRA2 and externalizing problems. It would also suggest the importance of…

Name	Type
AA/AG genotype local	variant
A allele	cohort
addiction	phenotype
adolescent alcohol phenotypes local	phenotype
adolescent alcohol use	phenotype
adolescent conduct disorder local	phenotype
adolescent conduct problems	phenotype
adolescent externalizing symptoms local	phenotype
Adolescent hyperactive–inattentive symptoms local	phenotype
adolescent impulsivity local	phenotype
adolescent rule-breaking behaviors local	phenotype
adolescents	cohort
adolescent sample	cohort
adolescent sensation seeking local	phenotype
adolescents’ sensation seeking local	phenotype
adolescent substance use	phenotype
adult alcohol phenotypes local	phenotype
adult alcohol use disorders local	phenotype
adult antisocial behavior	phenotype
adult drug phenotypes local	phenotype
adult sample	cohort
adults’ lifetime alcohol problems local	phenotype
adult substance use disorders local	phenotype
adult substance use phenotypes local	phenotype
age	phenotype
alcohol	phenotype
Alcohol Dependence Symptoms	phenotype
alcoholism	phenotype
Alcohol Problems	phenotype
Alcohol Use Disorder	phenotype
AMR 1000 Genomes Phase 1 population local	cohort
ancestry	phenotype
attention deficit hyperactivity disorder	phenotype
barbiturates	drug
Baseline externalizing problems local	phenotype
behavioral disinhibition	phenotype
benzodiazepines	drug
Caucasian sample	cohort
Cognitive Control System local	anatomy
conduct disorder	phenotype
disinhibition	phenotype
dopamine	drug
drug	drug
drug dependence	phenotype
ethanol consumption	phenotype
EUR 1000 Genomes Phase 1 population local	cohort
externalizing disorders	phenotype
externalizing outcomes	phenotype
externalizing-related problems local	phenotype
families without parental alcoholism local	cohort
families with parental alcoholism local	cohort
Family History Density composite local	phenotype
Family history of drinking local	phenotype
fathers	cohort
FHD	cohort
first-generation local	cohort
GABA	phenotype
GABRA2	gene
GABRA2 AA/AG genotype local	variant
GABRA2 major haplotype local	variant
GABRA2 minor haplotype local	variant
GABRA2 polymorphism local	variant
G allele	variant
GG genotype local	variant
Grandparents local	cohort
higher impulsivity local	phenotype
higher sensation seeking local	phenotype
high-risk sample	cohort
Hispanic	phenotype
hyperactive–inattentive symptoms local	phenotype
Hyperactive-inattentive symptoms local	phenotype
Hyperactive–inattentive symptoms local	phenotype
impulsivity	phenotype
intermediate phenotypes	phenotype
Lifetime alcohol consequences local	phenotype
lifetime alcohol use	phenotype
low trait anxiety local	phenotype
mid-adolescent rule-breaking behaviors local	phenotype
mothers	cohort
negative affect	phenotype
NEO impulsiveness local	phenotype
NEO-Impulsiveness local	phenotype
NEO impulsivity local	phenotype
non-Hispanic Caucasian local	cohort
Non-Hispanic Caucasian local	phenotype
non-Hispanic Caucasian ancestry local	cohort
non-Hispanic Caucasian ancestry local	phenotype
Non-Hispanic Caucasian ancestry local	phenotype
non-Hispanic Caucasian population local	cohort
Non-Hispanic Caucasians local	cohort
novelty seeking	phenotype
parents	cohort
participants	cohort
personality/temperament local	phenotype
personality traits	phenotype
positive subjective alcohol effects local	phenotype
positive subjective response local	phenotype
problem behavior	phenotype
race/ethnicity	phenotype
Recanting local	phenotype
reward system	anatomy
rs279858	variant
rule-breaking behaviors local	phenotype
second-generation local	cohort
self-reported ethnicity local	phenotype
sex	phenotype
SNP	cohort
Study cohort (N=292) local	cohort
substance use	phenotype
symptoms	phenotype
T1 alcohol problems local	phenotype
T1 conduct problems local	phenotype
T1 hyperactive–inattentive symptoms local	phenotype
T1 symptoms local	phenotype
T2 alcohol problems local	phenotype
T2 conduct problems local	phenotype
T2 hyperactive–inattentive symptoms local	phenotype
third-generation local	cohort
Third Generation Longitudinal Study of Familial Alcoholism local	cohort
trait anxiety	phenotype
ventral tegmental area	anatomy

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Mechanisms in the relation between GABRA2 and adolescent externalizing problems.

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