Adolescent Suicidal Behavior and Substance Use: Developmental Mechanisms.

paper Cited Public

Authors: Dawes, Michael A; Mathias, Charles W; Richard, Dawn M; Hill-Kapturczak, Nathalie; Dougherty, Donald M
Year: 2008
Journal: Substance abuse : research and treatment
PMID: 20651946
DOI: 10.4137/sart.s1044
PMCID: PMC2907920

Adolescent suicidal behaviors and substance use are disturbingly common. Research suggests overlap of some of the etiological mechanisms for both adolescent suicidal behavior and substance use, yet clear understanding of the complex relations between these behaviors and their causal underpinnings is lacking. A growing body of evidence and a diathesis model (Mann et al. 1999; Mann, 2003) highlight the importance of impulse control as a proximal risk factor for adolescent suicidal and substance use behaviors. This literature review extends current theory on the relationships between adolescent suicidal behavior and substance use by: (1) examining how, when, and to what extent adolescent development is affected by poor impulse control, stressful life events, substance use behavior, and biological factors; (2) presenting proposed causal mechanisms by which these risk factors interact to increase risk for suicidal behaviors and substance use; and (3) proposing specific new hypotheses to extend the diathesis model to adolescents at risk for suicide and substance use. More specifically, new hypotheses are presented that predict bidirectional relationships between stressful life events and genetic markers of 5-HT dysregulation; substance use behavior and impulsivity; and substance use behavior and suicide attempts. The importance of distinguishing between different developmental trajectories of suicidal and substance use behaviors, and the effects of specific risk and protective mechanisms are discussed. Use of new statistical approaches that provide for the comparison of latent growth curves and latent class models is recommended to identify differences in developmental trajectories of suicidal behavior and substance use. Knowledge gained from these prospective longitudinal methods should lead to greater understanding on the timing, duration, and extent to which specific risk and protective factors influence the outcomes of suicidal behavior and substance use. In turn, findings from these studies should inform researchers who conduct future treatment and prevention studies.

#	Section	Preview
40	Approaches to the Study of Adolescent Suicidal Behavior and Substance Use — Longitudinal designs and statistics	(Muthén, 2001). For example, these techniques were used to identify different patterns of…
41	Approaches to the Study of Adolescent Suicidal Behavior and Substance Use — Longitudinal designs and statistics	In closing this section, we next present approaches and concepts that are important to the…
42	Approaches to the Study of Adolescent Suicidal Behavior and Substance Use — Laboratory behavioral assessment of impulse control	The use of multiple approaches to studying impulse control is important because previous research…
43	Approaches to the Study of Adolescent Suicidal Behavior and Substance Use — Laboratory behavioral assessment of impulse control	There are both theoretical and neuroanatomical differences that support the distinction between the…
44	Approaches to the Study of Adolescent Suicidal Behavior and Substance Use — Laboratory behavioral assessment of impulse control	on delay-discounting tasks. This model corresponds to impulsive choices made during…
45	Approaches to the Study of Adolescent Suicidal Behavior and Substance Use — Laboratory behavioral assessment of impulse control	Besides the theoretical and neuroanatomical distinctions described above, cross-sectional studies…
46	Approaches to the Study of Adolescent Suicidal Behavior and Substance Use — Laboratory behavioral assessment of impulse control	Odum et al. 2000; Petry, 2002). Finally, while different types of suicidal and drug-abusing…
47	Summary and Future Directions	As the suicidal behavior-substance abuse relationship is particularly common in adolescence, and is…

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In this knowledge base

Title	Year	PMID
Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism.	2017	28213124

External

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