Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.
paper
Primary
Public
- Authors
- Dick, Danielle M; Cho, Seung Bin; Latendresse, Shawn J; Aliev, Fazil; Nurnberger, John I; Edenberg, Howard J; Schuckit, Marc; Hesselbrock, Victor M; Porjesz, Bernice; Bucholz, Kathleen; Wang, Jen-Chyong; Goate, Alison; Kramer, John R; Kuperman, Samuel
- Year
- 2014
- Journal
- Addiction biology
- PMID
- 23692184
- DOI
- 10.1111/adb.12066
- PMCID
- PMC3783626
Longitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional analyses of individuals at different ages. This has received little attention in genetic association analyses. In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25. We use data from 1070 individuals who participated in the prospective sample of the Collaborative Study on the Genetics of Alcoholism, in order to better understand the unfolding of genetic risk across development. Piecewise linear growth models were fit to model the influence of genotype on rate of increase in drunkenness from early adolescence to young adulthood (14-18 years), the change in drunkenness during the transition to adulthood (18-19 years) and the rate of change in drunkenness across young adulthood (≥ 19 years). Variation in GABRA2 was associated with an increase in drunkenness that occurred at the transition between adolescence and adulthood. The genotypic effect was more pronounced in females. These analyses illustrate the importance of longitudinal data to characterize how genetic effects unfold across development. The findings suggest that transitions across important developmental periods may alter the relative importance of genetic effects on patterns of alcohol use. The findings also suggest the importance of considering gender when evaluating genetic effects on drinking patterns in males and females.
Means and standard deviations of drunkenness (days per year)
Observed mean trajectories of drunkenness by genotype (rs279858) for European Americans
← Prev
21–25 of 25
| Name | Type |
|---|---|
| Achenbach Externalizing Scale local | phenotype |
| Add Health study | cohort |
| adolescents | cohort |
| adult alcohol dependence | phenotype |
| adult status local | phenotype |
| age 17–18 local | cohort |
| age 18–19 local | cohort |
| age 19–20 | cohort |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| alcohol-related outcomes | phenotype |
| Alcohol Use | phenotype |
| ALDH2 | gene |
| Asian-Americans local | cohort |
| attention deficit hyperactivity disorder | phenotype |
| autism | phenotype |
| bipolar disorder | phenotype |
| Clinical-level alcohol dependence (DSM symptom counts) local | phenotype |
| Clinical-level antisocial behavior (DSM symptom counts) local | phenotype |
| Clinical-level drug dependence (DSM symptom counts) local | phenotype |
| COGA family local | cohort |
| COGA samples local | cohort |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| Community comparison families | cohort |
| Dental clinics local | cohort |
| drinking | phenotype |
| Driver’s license registries local | cohort |
| drunkenness | phenotype |
| early adolescent alcohol dependence local | phenotype |
| early onset alcohol dependence | phenotype |
| elevated alcohol problems local | phenotype |
| endophenotype | phenotype |
| European ancestry | cohort |
| frequency of drinking 5 or more drinks in a 24 hour period local | phenotype |
| frequency of drinking any alcoholic beverages local | phenotype |
| frequency of drunkenness local | phenotype |
| GABRA2 | gene |
| GABRA2 major allele local | variant |
| GABRA2 minor allele local | variant |
| general externalizing disorders local | phenotype |
| General externalizing disorders local | phenotype |
| genetic variants | cohort |
| high risk alcohol use local | phenotype |
| high risk drinking behavior local | phenotype |
| homozygous major allele local | variant |
| Inpatient alcohol treatment program local | cohort |
| internalizing disorders | phenotype |
| Lifetime drinking local | phenotype |
| major allele local | variant |
| major depressive disorder | phenotype |
| Monoamine genes local | gene |
| Outpatient alcohol treatment program local | cohort |
| Phase IV Prospective Study local | cohort |
| Prospective Study | cohort |
| psychiatric disorders | phenotype |
| Risky drinking behaviors local | phenotype |
| rs279836 | variant |
| rs279845 | variant |
| rs279858 | variant |
| rs279867 local | variant |
| rs279871 | variant |
| rs497068 local | variant |
| schizophrenia | phenotype |
| self-reports of drunkenness local | phenotype |
| sex | phenotype |
| slope of drunkenness across adolescence local | phenotype |
| slope of drunkenness across young adulthood local | phenotype |
| specific genotype local | variant |
| Subclinical externalizing behavior local | phenotype |
| transition point ("jump") local | phenotype |
| Twin cohort | cohort |
| young adults | cohort |
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|---|---|---|---|---|
| Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample. | Moe JS et al. | — | 2025 | → |
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