Parent, sibling and peer associations with subtypes of psychiatric and substance use disorder comorbidity in offspring.
- Authors
- McCutcheon, Vivia V; Scherrer, Jeffrey F; Grant, Julia D; Xian, Hong; Haber, Jon Randolph; Jacob, Theodore; Bucholz, Kathleen K
- Year
- 2013
- Journal
- Drug and alcohol dependence
- PMID
- 22921146
- DOI
- 10.1016/j.drugalcdep.2012.07.015
- PMCID
- PMC3514649
BACKGROUND: Parental substance use disorder (SUD) is associated with a range of negative offspring outcomes and psychopathology, but the clustering of these outcomes into subtypes has seldom been examined, nor have the familial and environmental contexts of these subtypes been reported. The present study examines the clustering of offspring lifetime substance use and psychiatric disorders into subtypes and characterizes them in terms of familial and non-familial influences using an offspring-of-twins design. METHOD: Telephone-administered diagnostic interviews were used to collect data on psychiatric disorders and SUD from 488 twin fathers, 420 biological mothers and 831 offspring. Latent class analysis (LCA) was used to derive subtypes of lifetime comorbidity in offspring. Familial risk and environmental variables associated with each subtype (i.e., parenting, childhood physical or sexual abuse, perceived sibling and peer substance use) were identified using multinomial logistic regression. RESULTS: Four classes identified by LCA were characterized as (1) unaffected, (2) alcohol abuse/dependence, (3) alcohol abuse/dependence comorbid with anxiety and depression, and (4) alcohol, cannabis abuse/dependence and nicotine dependence comorbid with conduct disorder. Inconsistent parenting, childhood physical/sexual abuse, and perceived sibling and peer substance use were significantly associated with profiles of offspring comorbidity after adjusting for familial vulnerability. Some associations were specific (i.e., perceived peer alcohol use to the AUD class), while others were general (peer smoking to all 3 comorbidity classes). CONCLUSIONS: We observed distinct subtypes of psychiatric and SUD comorbidity in adolescents and young adults. Subtypes of offspring psychopathology have varied associations with parental psychopathology, family environment, and sibling and peer behaviors.
Data collection timeline
LLM interpretation
This figure is a timeline diagram illustrating a data collection schedule from 1987 to 2004. It lists the "Year," "Key measure(s)," and "Subjects" for four distinct time points: 1987, 1992, 2002, and 2003-2004. The timeline shows a transition from collecting data solely from twins to including offspring and biological mothers in the final phase.
Results of latent class analysis of offspring substance use and psychiatric disorder (N=831).AUD=alcohol abuse or dependenceMJABDEP=marijuana abuse or dependenceND=nicotine dependenceCD=conduct disorderANX=anxiety disorder (social phobia, panic disorder, or generalized anxiety disorder)MDD=major depressive disorderBased on patterns of endorsement probabilities, Class 1 (grey line) was defined as ‘Unaffected’, Class 2 (dashed line) was defined as ‘AUD’, Class 3 (dotted line) was defined as ‘AUD-MDD-ANX’ and Class 4 (solid line) was defined as substance use disorder ‘(SUD)-CD’, see text for details.Numbers in parenthesis are the proportion of offspring in each class
LLM interpretation
This line graph displays the probability of diagnosis for six psychiatric and substance use disorders across four latent classes of offspring (N=831). The x-axis lists the disorders (AUD, MJABDEP, ND, CD, ANX, MDD), while the y-axis represents the probability of diagnosis from 0.0 to 1.0. Class 1 (Unaffected) shows near-zero probability for most conditions, while Class 4 (SUD-CD) shows the highest probabilities for AUD and MJABDEP, and Class 3 (AUD-MDD-ANX) peaks at MDD.
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| Drug use disorders and post-traumatic stress disorder over 25 adult years: role of psychopathology in relational networks. | Balan S et al. | — | 2013 | → |
| Longitudinal determinants of substance use disorders. | Brook JS et al. | — | 2013 | → |